TIGAR, TIGAR, burning bright

Cancers cells shift their metabolism towards glycolysis in order to help them support the biosynthetic demands necessary to sustain cell proliferation and growth, adapt to stress and avoid excessive reactive oxygen species (ROS) accumulation. While the p53 tumor suppressor protein is known to inhibit cell growth by inducing apoptosis, senescence and cell cycle arrest, recent studies have found that p53 is also able to influence cell metabolism. TIGAR is a p53 target that functions as a fructose-2,6-bisphosphatase, thereby lowering glycolytic flux and promoting antioxidant functions. By protecting cells from oxidative stress, TIGAR may mediate some of the tumor suppressor activity of p53 but could also contribute to tumorigenesis. Here we discuss the activities of TIGAR described so far, and the potential consequences of TIGAR expression on normal and tumor cells.

• Publication year

  2014

• Venue

  Cancer & Metabolism

• Publication date

  2014-01-03

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1186/2049-3002-2-1PMID 24383451PMCID 3892023
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Role of PFKFB3-driven glycolysis in vessel sprouting.

  2013cited by this paper
• Glutamine supports pancreatic cancer growth through a Kras-regulated metabolic pathway

  2013cited by this paper
• Loss of FBP1 by Snail-mediated repression provides metabolic advantages in basal-like breast cancer.

  2013cited by this paper
• Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells

  2013cited by this paper
• Knockdown of TIGAR by RNA interference induces apoptosis and autophagy in HepG2 hepatocellular carcinoma cells.

  2013cited by this paper
• ATM-NFκB axis-driven TIGAR regulates sensitivity of glioma cells to radiomimetics in the presence of TNFα

  2013cited by this paper
• Cytosolic p53 inhibits Parkin-mediated mitophagy and promotes mitochondrial dysfunction in the mouse heart

  2013cited by this paper
• Hexokinase 2 is required for tumor initiation and maintenance and its systemic deletion is therapeutic in mouse models of cancer.

  2013influential reference
• TAp73 enhances the pentose phosphate pathway and supports cell proliferation

  2013cited by this paper
• TIGAR Is Required for Efficient Intestinal Regeneration and Tumorigenesis

  2013influential reference
• Inhibition of the MUC1-C oncoprotein induces multiple myeloma cell death by down-regulating TIGAR expression and depleting NADPH.

  2012influential reference
• RNAi screening in glioma stem-like cells identifies PFKFB4 as a key molecule important for cancer cell survival

  2012cited by this paper
• Reciprocal regulation of p53 and malic enzymes modulates metabolism and senescence

  2012cited by this paper
• Mitochondrial localization of TIGAR under hypoxia stimulates HK2 and lowers ROS and cell death

  2012cited by this paper
• Tp53-induced Glycolysis and Apoptosis Regulator (TIGAR) Protects Glioma Cells from Starvation-induced Cell Death by Up-regulating Respiration and Improving Cellular Redox Homeostasis*

  2012influential reference
• Mutant p53 disrupts mammary tissue architecture via the mevalonate pathway.

  2012cited by this paper
• p53 opens the mitochondrial permeability transition pore to trigger necrosis.

  2012cited by this paper
• Functional metabolic screen identifies 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 as an important regulator of prostate cancer cell survival.

  2012cited by this paper
• p53-TIGAR axis attenuates mitophagy to exacerbate cardiac damage after ischemia.

  2012cited by this paper
• Regulatory role of p53 in cancer metabolism via SCO2 and TIGAR in human breast cancer.

  2012cited by this paper
• Links between metabolism and cancer.

  2012cited by this paper
• p53-TIGAR axis attenuates mitophagy to exacerbate cardiac damage after ischemia

  2012cited by this paper
• Oncogenic Kras maintains pancreatic tumors through regulation of anabolic glucose metabolism.

  2012cited by this paper
• Nrf2 redirects glucose and glutamine into anabolic pathways in metabolic reprogramming.

  2012influential reference
• Deconstructing p53 transcriptional networks in tumor suppression.

  2012cited by this paper
• Phosphofructokinase 1 Glycosylation Regulates Cell Growth and Metabolism

  2012influential reference
• SP1 plays a pivotal role for basal activity of TIGAR promoter in liver cancer cell lines

  2011cited by this paper
• Possible Existence of Lysosome-Like Organella within Mitochondria and Its Role in Mitochondrial Quality Control

  2011cited by this paper
• Selective killing of cancer cells with a small molecule targeting stress response to ROS

  2011cited by this paper
• Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis

  2011influential reference
• Promoter Hypermethylation Mediated Downregulation of FBP1 in Human Hepatocellular Carcinoma and Colon Cancer

  2011cited by this paper
• Regulation of cancer cell metabolism

  2011cited by this paper
• Brusatol enhances the efficacy of chemotherapy by inhibiting the Nrf2-mediated defense mechanism

  2011cited by this paper
• Mieap, a p53-Inducible Protein, Controls Mitochondrial Quality by Repairing or Eliminating Unhealthy Mitochondria

  2011cited by this paper
• Carnitine palmitoyltransferase 1C promotes cell survival and tumor growth under conditions of metabolic stress.

  2011cited by this paper
• p53 regulates biosynthesis through direct inactivation of glucose-6-phosphate dehydrogenase

  2011cited by this paper
• TP53 induced glycolysis and apoptosis regulator (TIGAR) knockdown results in radiosensitization of glioma cells.

  2011cited by this paper
• Inhibition of Pyruvate Kinase M2 by Reactive Oxygen Species Contributes to Cellular Antioxidant Responses

  2011cited by this paper
• The Role of p53 in Metabolic Regulation.

  2011cited by this paper
• Inhibition of c-Met downregulates TIGAR expression and reduces NADPH production leading to cell death

  2011cited by this paper
• p53 regulation of metabolic pathways.

  2010cited by this paper
• HIF-1: upstream and downstream of cancer metabolism.

  2010cited by this paper
• An RNA-directed nucleoside anti-metabolite, 1-(3-C-ethynyl-beta-d-ribo-pentofuranosyl)cytosine (ECyd), elicits antitumor effect via TP53-induced Glycolysis and Apoptosis Regulator (TIGAR) downregulation.

  2010cited by this paper
• p53 and TIGAR regulate cardiac myocyte energy homeostasis under hypoxic stress.

  2010influential reference
• Hypoxia-inducible factors and the response to hypoxic stress.

  2010cited by this paper
• Glutaminase 2, a novel p53 target gene regulating energy metabolism and antioxidant function

  2010influential reference
• Analysis of mouse models of cytochrome c oxidase deficiency owing to mutations in Sco2.

  2010cited by this paper
• Phosphate-activated glutaminase (GLS2), a p53-inducible regulator of glutamine metabolism and reactive oxygen species

  2010influential reference
• Crypt stem cells as the cells-of-origin of intestinal cancer

  2009cited by this paper
• Tumor protein 53-induced nuclear protein 1 is a major mediator of p53 antioxidant function.

  2009cited by this paper
• Tumor suppressors and cell metabolism: a recipe for cancer growth.

  2009cited by this paper
• Modulation of intracellular ROS levels by TIGAR controls autophagy

  2009cited by this paper
• Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

  2009cited by this paper
• c-Myc suppression of miR-23 enhances mitochondrial glutaminase and glutamine metabolism

  2009cited by this paper
• Activation of p53 by Nutlin-3a, an antagonist of MDM2, induces apoptosis and cellular senescence in adult T-cell leukemia cells

  2009cited by this paper
• A nucleocytoplasmic malate dehydrogenase regulates p53 transcriptional activity in response to metabolic stress

  2009cited by this paper
• p53 and metabolism

  2009cited by this paper
• Structural and Biochemical Studies of TIGAR (TP53-induced Glycolysis and Apoptosis Regulator)*

  2009cited by this paper
• Single Lgr5 stem cells build crypt–villus structures in vitro without a mesenchymal niche

  2009cited by this paper
• Aberrant methylation of human L- and M-fructose 1,6-bisphosphatase genes in cancer.

  2008cited by this paper
• Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction

  2008cited by this paper
• Regulation of autophagy by cytoplasmic p53

  2008cited by this paper
• Drug development of MET inhibitors: targeting oncogene addiction and expedience

  2008cited by this paper
• p53 target genes sestrin1 and sestrin2 connect genotoxic stress and mTOR signaling.

  2008cited by this paper
• Hypoxia-Inducible Factor 1 and Dysregulated c-Myc Cooperatively Induce Vascular Endothelial Growth Factor and Metabolic Switches Hexokinase 2 and Pyruvate Dehydrogenase Kinase 1

  2007cited by this paper
• Mutation of RRM2B, encoding p53-controlled ribonucleotide reductase (p53R2), causes severe mitochondrial DNA depletion

  2007cited by this paper
• Defining the role of mTOR in cancer.

  2007cited by this paper
• Constitutive mTOR activation in TSC mutants sensitizes cells to energy starvation and genomic damage via p53

  2007cited by this paper
• p53 Regulates Mitochondrial Respiration

  2006cited by this paper
• TIGAR, a p53-inducible regulator of glycolysis and apoptosis.

  2006influential reference
• Selective killing of oncogenically transformed cells through a ROS-mediated mechanism by beta-phenylethyl isothiocyanate.

  2006cited by this paper
• Reactive oxygen species in cancer cells: live by the sword, die by the sword.

  2006cited by this paper
• Hypoxic regulation of PFKFB-3 and PFKFB-4 gene expression in gastric and pancreatic cancer cell lines and expression of PFKFB genes in gastric cancers.

  2006influential reference
• AMP-activated protein kinase induces a p53-dependent metabolic checkpoint.

  2005cited by this paper
• 6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase gene family overexpression in human lung tumor.

  2005cited by this paper
• Glycolytic enzymes can modulate cellular life span.

  2005cited by this paper
• Identification of novel p53 target genes in ionizing radiation response.

  2005cited by this paper
• The Mitochondrial SDHD Gene Is Required for Early Embryogenesis, and Its Partial Deficiency Results in Persistent Carotid Body Glomus Cell Activation with Full Responsiveness to Hypoxia

  2004cited by this paper
• Interaction of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFK-2/FBPase-2) with glucokinase activates glucose phosphorylation and glucose metabolism in insulin-producing cells.

  2004cited by this paper
• 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase: head-to-head with a bifunctional enzyme that controls glycolysis.

  2004cited by this paper
• Hypoxia induces transcription of 6‐phosphofructo‐2‐kinase/fructose‐2,6‐biphosphatase‐4 gene via hypoxia‐inducible factor‐1α activation

  2004influential reference
• 6-Phosphofructo-2-kinase (pfkfb3) Gene Promoter Contains Hypoxia-inducible Factor-1 Binding Sites Necessary for Transactivation in Response to Hypoxia*

  2004influential reference
• The PP2A-associated protein alpha4 is an essential inhibitor of apoptosis.

  2004cited by this paper
• The PP2A-Associated Protein α4 Is an Essential Inhibitor of Apoptosis

  2004cited by this paper
• p53-Induced Up-Regulation of MnSOD and GPx but not Catalase Increases Oxidative Stress and Apoptosis

  2004cited by this paper
• The Tumor Suppressor p53 Down-Regulates Glucose Transporters GLUT1 and GLUT4 Gene Expression

  2004influential reference
• Hypoxic regulation of the 6‐phosphofructo‐2‐kinase/fructose‐2,6‐bisphosphatase gene family (PFKFB‐1–4) expression in vivo

  2003cited by this paper
• Akt Enhances Mdm2-mediated Ubiquitination and Degradation of p53*

  2002cited by this paper
• Live or let die: the cell's response to p53

  2002cited by this paper
• High expression of inducible 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (iPFK-2; PFKFB3) in human cancers.

  2002cited by this paper
• PFK-2/FBPase-2: maker and breaker of the essential biofactor fructose-2,6-bisphosphate.

  2001cited by this paper
• Characterization of Glucokinase-binding Protein Epitopes by a Phage-displayed Peptide Library

  2001cited by this paper
• Activation of the HIF pathway in cancer.

  2001cited by this paper
• A ribonucleotide reductase gene involved in a p53-dependent cell-cycle checkpoint for DNA damage

  2000cited by this paper
• Deregulation of Glucose Transporter 1 and Glycolytic Gene Expression by c-Myc*

  2000cited by this paper
• A ribonucleotide reductase gene is a transcriptional target of p53 and p73

  2000cited by this paper
• Surfing the p53 network

  2000cited by this paper
• Fructose‐2,6‐bisphosphate and control of carbohydrate metabolism in eukaryotes

  1999influential reference
• An ATP/ADP-Dependent Molecular Switch Regulates the Stability of p53-DNA Complexes

  1999influential reference
• Promoter specificity and stability control of the p53-related protein p73

  1999cited by this paper

• Fructose-1,6-bisphosphatase 1 in cancer: Dual roles, mechanistic insights, and therapeutic potential - A comprehensive review.

  2025cites this paper
• The importance of TP53 status in cancer therapy: The example of chronic lymphocytic leukemia

  2025cites this paper
• p21, ccng1, foxo3b, and fbxw7 contribute to p53-dependent cell cycle arrest

  2025cites this paper
• Warburg-like Metabolic Reprogramming in Endometriosis: From Molecular Mechanisms to Therapeutic Approaches

  2025cites this paper
• E2F8-induced GRPEL2 promoted colorectal cancer progression via targeting TIGAR

  2025cites this paper
• Deciphering the Controversial Role of TP53 Inducible Glycolysis and Apoptosis Regulator (TIGAR) in Cancer Metabolism as a Potential Therapeutic Strategy

  2025influential citation
• The Impact of TP53-Induced Glycolysis and Apoptosis Regulator on Prognosis in Hepatocellular Carcinoma: Association with Tumor Microenvironment and Ferroptosis

  2024cites this paper
• P53 and the Ultraviolet Radiation-Induced Skin Response: Finding the Light in the Darkness of Triggered Carcinogenesis

  2024cites this paper
• Mitochondrial metabolism: A moving target in hepatocellular carcinoma therapy

  2024cites this paper
• p53 and TIGAR promote redox control to protect against metabolic dysfunction-associated steatohepatitis

  2024cites this paper
• Elemental profiles in distant tissues during tumor progression

  2023cites this paper
• Redox-Responsive Polymeric Nanoparticle for Nucleic Acid Delivery and Cancer Therapy: Progress, Opportunities and Challenges.

  2023cites this paper
• The Warburg effect: a score for many instruments in the concert of cancer and cancer niche cells

  2023cites this paper
• Reactive oxygen species and its manipulation strategies in cancer treatment.

  2023cites this paper
• Sphingosine 1 phosphate lyase inhibition rescues cognition in diabetic mice by promoting anti-inflammatory microglia.

  2023cites this paper
• LKB1-Dependent Regulation of TPI1 Creates a Divergent Metabolic Liability between Human and Mouse Lung Adenocarcinoma

  2023cites this paper
• Noncanonical functions of Ku may underlie essentiality in human cells

  2023cites this paper
• Haemophilus ducreyi Infection Induces Oxidative Stress, Central Metabolic Changes, and a Mixed Pro- and Anti-inflammatory Environment in the Human Host

  2022influential citation
• Out of the cycle: Impact of cell cycle aberrations on cancer metabolism and metastasis

  2022cites this paper
• Bcl-2 and p53 immunophenotypes in colorectal adenocarcinoma in type 2 diabetes mellitus versus non-diabetic patients

  2022cites this paper
• Pathological implications of metabolic reprogramming and its therapeutic potential in medulloblastoma

  2022influential citation
• Mechanism of reduced muscle atrophy via ketone body (D)-3-hydroxybutyrate

  2022cites this paper
• Mitochondrial and metabolic alterations in cancer cells.

  2022cites this paper
• TIGAR drives colorectal cancer ferroptosis resistance through ROS/AMPK/SCD1 pathway.

  2022cites this paper
• LDHA induces EMT gene transcription and regulates autophagy to promote the metastasis and tumorigenesis of papillary thyroid carcinoma

  2021cites this paper
• Structure, regulation, and biological functions of TIGAR and its role in diseases

  2021cites this paper
• Why may citrate sodium significantly increase the effectiveness of transarterial chemoembolization in hepatocellular carcinoma?

  2021cites this paper
• Receptor based virtual screening of potential novel inhibitors of tigar [TP53 (tumour protein 53)-induced glycolysis and apoptosis regulator.

  2021cites this paper
• Expression of TIGAR and its correlation with clinicopathology, prognosis, and 18F-FDG PET/CT parameters in patients with resectable pancreatic ductal adenocarcinoma.

  2021cites this paper
• TCF19 and p53 regulate transcription of TIGAR and SCO2 in HCC for mitochondrial energy metabolism and stress adaptation

  2021cites this paper
• In silico identification of potential inhibitor for TP53-induced glycolysis and apoptosis regulator in head and neck squamous cell carcinoma

  2021cites this paper
• TP53-Induced Glycolysis and Apoptosis Regulator (TIGAR) Is Upregulated in Lymphocytes Stimulated with Concanavalin A

  2021cites this paper
• Cancer metabolism: looking forward

  2021cites this paper
• Heme Oxygenase-1 Signaling and Redox Homeostasis in Physiopathological Conditions

  2021cites this paper
• TIGAR impedes compression‐induced intervertebral disc degeneration by suppressing nucleus pulposus cell apoptosis and autophagy

  2020cites this paper
• Metabolic pathway alterations in microvascular endothelial cells in response to hypoxia

  2020cites this paper
• TP53 mutations in head and neck cancer cells determine the Warburg phenotypic switch creating metabolic vulnerabilities and therapeutic opportunities for stratified therapies

  2020cites this paper
• The Role of TIGAR-mediated Metabolic Processes in Autophagy and Cell Survival

  2020cites this paper
• Exploring the multiple roles of guardian of the genome: P53

  2020cites this paper
• Pharmacological Effects and Toxicogenetic Impacts of Omeprazole: Genomic Instability and Cancer

  2020cites this paper
• Dynamic ROS Control by TIGAR Regulates the Initiation and Progression of Pancreatic Cancer

  2020cites this paper
• NADPH Protects against Kainic Acid-induced Excitotoxicity via Autophagy-lysosome Pathway in Rat Striatum and Primary Cortical Neurons.

  2020cites this paper
• Untangling the Metabolic Reprogramming in Brain Cancer: Discovering Key Molecular Players Using Mass Spectrometry.

  2019cites this paper
• Interconnection between Metabolism and Cell Cycle in Cancer.

  2019cites this paper
• Gluconeogenesis in Cancer: Function and Regulation of PEPCK, FBPase, and G6Pase.

  2019cites this paper
• p53 as a hub in cellular redox regulation and therapeutic target in cancer

  2019cites this paper
• Ursodeoxycholic acid inhibits uptake and vasoconstrictor effects of taurocholate in human placenta

  2019cites this paper
• The role of tumor suppressor p53 in metabolism and energy regulation, and its implication in cancer and lifestyle-related diseases.

  2019cites this paper
• TIGAR promotes growth, survival and metastasis through oxidation resistance and AKT activation in glioblastoma

  2019cites this paper
• Molecular cloning and modeling of the Tp53-induced glycolysis and apoptotic regulator (TIGAR) from the Pacific white shrimp Litopenaeus vannamei and its expression in response to hypoxia.

  2019cites this paper
• Genome-scale CRISPR knockout screen identifies TIGAR as a modifier of PARP inhibitor sensitivity

  2019cites this paper
• Energetic costs regulated by cell mechanics and confinement are predictive of migration path during decision-making

  2019cites this paper
• LKB1/p53/TIGAR/autophagy-dependent VEGF expression contributes to PM2.5-induced pulmonary inflammatory responses

  2019cites this paper
• Metabolic remodeling by TIGAR overexpression is a therapeutic target in esophageal squamous-cell carcinoma

  2019cites this paper
• Intérêt de l’utilisation de stratégies anti-métaboliques pour le traitement du cancer du sein

  2019cites this paper
• Control of metabolism by p53 – Cancer and beyond

  2018cites this paper
• How the Warburg effect supports aggressiveness and drug resistance of cancer cells?

  2018cites this paper
• TIGAR mediates the inhibitory role of hypoxia on ROS production and apoptosis in rat nucleus pulposus cells.

  2018cites this paper
• Targeting FBPase is an emerging novel approach for cancer therapy

  2018influential citation
• Toxicogenetic study of omeprazole and the modulatory effects of retinol palmitate and ascorbic acid on Allium cepa.

  2018cites this paper
• Toxicogenetic study of omeprazole and the modulatory effects of retinol palmitate 2 and ascorbic acid on Allium cepa 3 4

  2018cites this paper
• Spatiotemporal Control of Acetyl-CoA Metabolism in Chromatin Regulation.

  2018cites this paper
• Met is involved in TIGAR-regulated metastasis of non-small-cell lung cancer

  2018cites this paper
• Loss of TIGAR Induces Oxidative Stress and Meiotic Defects in Oocytes from Obese Mice *

  2018cites this paper
• Beta-Hydroxybutyrate Promotes Proliferation, Migration and Stemness in a Subpopulation of 5FU Treated SW480 Cells: Evidence for Metabolic Plasticity in Colon Cancer

  2018cites this paper
• Combined Modulation of Tumor Metabolism by Metformin and Diclofenac in Glioma

  2018cites this paper
• Metabolic Plasticity of Tumor Cell Mitochondria

  2018cites this paper
• Fenton reactions drive nucleotide and ATP syntheses in cancer

  2018cites this paper
• A Pharmacometabolomic Approach to Predict Response to Metformin in Early-Phase Type 2 Diabetes Mellitus Patients

  2018cites this paper
• Cryptotanshinone induces ROS-mediated apoptosis in human gastric cancer cells

  2017cites this paper
• Recommended Guidelines for Validation, Quality Control, and Reporting of TP53 Variants in Clinical Practice.

  2017cites this paper
• 1H NMR metabolomic signatures related to giant cell tumor of the bone

  2017cites this paper
• Metabolomics of cancer cell cultures to assess the effects of dietary phytochemicals

  2017cites this paper
• Exploiting tumour addiction with a serine and glycine-free diet

  2017cites this paper
• Overexpression of hypoxia-inducible factor and metabolic pathways: possible targets of cancer

  2017cites this paper
• Overexpression of TIGAR predicts poor prognosis in elderly patients with cytogenetically normal acute myeloid leukemia ( CN-AML )

  2017cites this paper
• The role of TIGAR in Parkinson´s Disease

  2017influential citation
• MPI depletion enhances O-GlcNAcylation of p53 and suppresses the Warburg effect

  2017cites this paper
• Verbesina encelioides: cytotoxicity, cell cycle arrest, and oxidative DNA damage in human liver cancer (HepG2) cell line

  2016cites this paper
• Metabolic reprogramming identifies the most aggressive lesions at early phases of hepatic carcinogenesis

  2016influential citation
• Residual breast cancer metabolic phenotype after docetaxel treatment

  2016cites this paper
• TIGAR cooperated with glycolysis to inhibit the apoptosis of leukemia cells and associated with poor prognosis in patients with cytogenetically normal acute myeloid leukemia

  2016cites this paper
• Akt mediates TIGAR induction in HeLa cells following PFKFB3 inhibition

  2016cites this paper
• Accumulated Metabolites of Hydroxybutyric Acid Serve as Diagnostic and Prognostic Biomarkers of Ovarian High-Grade Serous Carcinomas.

  2016cites this paper
• TP53-induced glycolysis and apoptosis regulator protects from spontaneous apoptosis and predicts poor prognosis in chronic lymphocytic leukemia.

  2016cites this paper
• TP53-inducible Glycolysis and Apoptosis Regulator (TIGAR) Metabolically Reprograms Carcinoma and Stromal Cells in Breast Cancer*

  2016influential citation
• Redox-Related Mechanisms to Rebalance Cancer-Deregulated Cell Growth.

  2016cites this paper
• Downregulation of caveolin-1 upregulates the expression of growth factors and regulators in co-culture of fibroblasts with cancer cells

  2015cites this paper
• Diverting Glycolysis to Combat Oxidative Stress

  2015cites this paper
• Hitting cancers' weak spots: vulnerabilities imposed by p53 mutation.

  2015cites this paper
• TP53 Regulates Metabolic Genes

  2015cites this paper
• High variability of genomic instability and gene expression profiling in different HeLa clones

  2015cites this paper
• Metabolic Fluxes in Cancer Metabolism

  2015cites this paper
• SIRTain regulators of premature senescence and accelerated aging

  2015cites this paper
• p53- and p73-independent activation of TIGAR expression in vivo

  2015cites this paper
• Therapeutic Targeting of the Warburg Effect in Pancreatic Cancer Relies on an Absence of p53 Function.

  2015cites this paper
• Drivers of the Warburg phenotype.

  2015cites this paper
• The p53 Target Gene SIVA Enables Non-Small Cell Lung Cancer Development.

  2015cites this paper
• Association of cancer metabolism-related proteins with oral carcinogenesis – indications for chemoprevention and metabolic sensitizing of oral squamous cell carcinoma?

  2014cites this paper
• Restricting carbohydrates to fight head and neck cancer—is this realistic?

  2014cites this paper