A putative leucine-rich repeat receptor kinase involved in brassinosteroid signal transduction.

Brassinosteroids are a class of growth-promoting regulators that play a key role throughout plant development. Despite their importance, nothing is known of the mechanism of action of these steroid hormones. We describe the identification of 18 Arabidopsis dwarf mutants that are unable to respond to exogenously added brassinosteroid, a phenotype that might be expected for brassinosteroid signaling mutants. All 18 mutations define alleles of a single previously described gene, BRI1. We cloned BRI1 and examined its expression pattern. It encodes a ubiquitously expressed putative receptor kinase. The extracellular domain contains 25 tandem leucine-rich repeats that resemble repeats found in animal hormone receptors, plant disease resistance genes, and genes involved in unknown signaling pathways controlling plant development.

• Publication year

  1997

• Venue

  Cell

• Publication date

  1997-09-05

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.1016/S0092-8674(00)80357-8PMID 9298904
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Conservation of function between mammalian and plant steroid 5α-reductases

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  1997influential reference
• Signaling in plant-microbe interactions.

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  1992influential reference
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  1991cited by this paper
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  1991cited by this paper
• The signal peptide.

  1990cited by this paper
• Basic local alignment search tool.

  1990cited by this paper
• The signal peptide.

  1990cited by this paper
• Signal transduction by receptors with tyrosine kinase activity.

  1990cited by this paper
• The Toll gene of Drosophila, required for dorsal-ventral embryonic polarity, appears to encode a transmembrane protein.

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