Compromised Hormonal Counterregulation, Symptom Awareness, and Neurophysiological Function After Recurrent Short-Term Episodes of Insulin-Induced Hypoglycemia in IDDM Patients

No abstract is available for this paper.

• Publication year

  1993

• Venue

  Diabetes

• Publication date

  1993-04-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.2337/diab.42.4.610PMID 8384134
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Catecholamine Response During Human and Pork Insulin-Induced Hypoglycemia in IDDM Patients

  1992cited by this paper
• Physiological disturbances in hypoglycaemia: effect on subjective awareness.

  1991cited by this paper
• Reduced Neuroendocrine and Symptomatic Responses to Subsequent Hypoglycemia After 1 Episode of Hypoglycemia in Nondiabetic Humans

  1991cited by this paper
• Hypoglycaemia and diabetes control.

  1991cited by this paper
• Plasma Catecholamine Responses to Hypoglycemia in Children and Adolescents With IDDM

  1991cited by this paper
• Symptoms of Acute Insulin-Induced Hypoglycemia in Humans With and Without IDDM: Factor-Analysis Approach

  1991cited by this paper
• Changes in Brainstem Auditory Evoked Potentials During Insulin‐induced Hypoglycaemia in Type 1 Diabetic Patients

  1991cited by this paper
• Effect of Antecedent Glucose Control on Cerebral Function During Hypoglycemia

  1991cited by this paper
• Facilitated transport of glucose from blood to brain in man and the effect of moderate hypoglycaemia on cerebral glucose utilization

  1991cited by this paper
• Multifactorial Origin of Hypoglycemic Symptom Unawareness in IDDM: Association With Defective Glucose Counterregulation and Better Glycemic Control

  1991cited by this paper
• Counterregulatory adaptation to recurrent hypoglycemia in normal humans.

  1991cited by this paper
• Patients with Type 1 Diabetes Adapt Acutely to Sustained Mild Hypoglycaemia

  1991cited by this paper
• Deficient counterregulatory hormone responses during hypoglycemia in a patient with insulinoma.

  1991cited by this paper
• Importance of Insulin in Subjective, Cognitive, and Hormonal Responses to Hypoglycemia in Patients With IDDM

  1991cited by this paper
• Epidemiology of severe hypoglycemia in the diabetes control and complications trial. The DCCT Research Group.

  1991cited by this paper
• Auditory Brainstem and Middle Latency Evoked Responses in the Clinical Evaluation of Diabetes

  1991influential reference
• Cumulative cognitive impairment following recurrent severe hypoglycaemia in adult patients with insulin-treated diabetes mellitus

  1991cited by this paper
• Suppression of counterregulatory hormone response to hypoglycemia by insulin per se.

  1991cited by this paper
• Neurophysiological changes during insulin-induced hypoglycaemia and in the recovery period following glucose infusion in Type 1 (insulin-dependent) diabetes mellitus and in normal man

  1990cited by this paper
• Hypoglycemia in IDDM

  1990cited by this paper
• Mild Hypoglycemia and Impairment of Brain Stem and Cortical Evoked Potentials in Healthy Subjects

  1990cited by this paper
• Role of Brain in Counterregulation of Insulin-Induced Hypoglycemia in Dogs

  1989cited by this paper
• Adaptation to mild hypoglycaemia in normal subjects despite sustained increases in counter-regulatory hormones

  1989cited by this paper
• Hypoglycemia in IDDM

  1989cited by this paper
• Counterregulatory hormonal responses to hypoglycaemia in Type 1 (insulin-dependent) diabetes: evidence for diminished hypothalamic-pituitary hormonal secretion

  1988cited by this paper
• Modest decrements in plasma glucose concentration cause early impairment in cognitive function and later activation of glucose counterregulation in the absence of hypoglycemic symptoms in normal man.

  1988cited by this paper
• Effect of Intensive Insulin Therapy on Glycemic Thresholds for Counterregulatory Hormone Release

  1988cited by this paper
• Counterregulatory Hormone Responses Preserved After Long-Term Intravenous Insulin Infusion Compared to Continuous Subcutaneous Insulin Infusion

  1988cited by this paper
• Overview of counterregulation and its abnormalities in diabetes mellitus and other conditions.

  1988cited by this paper
• Defective glucose counterregulation after strict glycemic control of insulin-dependent diabetes mellitus.

  1987cited by this paper
• Influence of sympathetic nervous system on hypoglycaemic warning symptoms.

  1987cited by this paper
• Chronic hypoglycemia increases brain glucose transport.

  1986cited by this paper
• Evoked potentials in clinical medicine.

  1986cited by this paper
• Diabetic Autonomic Neuropathy: Present Insights and Future Prospects

  1986cited by this paper
• Insulin Binding to the Blood‐Brain Barrier in the Streptozotocin Diabetic Rat

  1986cited by this paper
• Lawrence Lecture. Hypoglycaemia and diabetes.

  1986cited by this paper
• Altered Recognition of Hypoglycaemic Symptoms in Type I Diabetes during Intensified Control with Continuous Subcutaneous Insulin Infusion

  1986cited by this paper
• Does central nervous system adaptation to antecedent glycemia occur in patients with insulin-dependent diabetes mellitus?

  1985cited by this paper
• Glucose counterregulation, hypoglycemia, and intensive insulin therapy in diabetes mellitus.

  1985cited by this paper
• A Reliable and Reproducible Test for Adequate Glucose Counterregulation in Type I Diabetes Mellitus

  1984cited by this paper
• Insulin injected into CNS structures or into the carotid artery: effect on carbohydrate homeostasis of the intact animal.

  1983cited by this paper
• Minireview. The hypothalamus and blood glucose regulation.

  1983cited by this paper
• Identification of type I diabetic patients at increased risk for hypoglycemia during intensive therapy.

  1983cited by this paper
• The hypothalamus and blood glucose regulation

  1983cited by this paper
• Metabolic fuel and amino acid transport into the brain in experimental diabetes mellitus.

  1982cited by this paper
• Akustisch evozierte Potentiale (AEP)

  1982influential reference
• Blood-brain glucose transfer: repression in chronic hyperglycemia.

  1981cited by this paper
• Hypoglycemic brain injury. I. Metabolic and light microscopic findings in rat cerebral cortex during profound insulin-induced hypoglycemia and in the recovery period following glucose administration.

  1980cited by this paper
• Closed-loop and Open-loop Devices for Blood Glucose Control in Normal and Diabetic Subjects

  1978cited by this paper
• Control and Diabetes

  1976cited by this paper
• Editorial: "Control" and diabetes.

  1976cited by this paper
• Studies on the Nature and Mode of Action of the Insulin-sensitive Glucoregulator Receptor in the Central Nervous System

  1975cited by this paper

• Cognitive Function in Children with Type 1 Diabetes: A Narrative Review

  2025cites this paper
• Association between recent real‐life exposure to hypoglycaemia and cognitive function during hypoglycaemia in people with type 1 diabetes: Findings from the Hypo‐RESOLVE clamp study

  2025cites this paper
• Association between recent exposure to continuous glucose monitoring‐recorded hypoglycaemia and counterregulatory and symptom responses to subsequent controlled hypoglycaemia in people with type 1 diabetes

  2024cites this paper
• Experimentally Induced Hypoglycemia-associated Autonomic Failure in Humans: Determinants, Designs, and Drawbacks

  2022cites this paper
• Benefits of the addition of continuous or flash glucose monitoring versus standard practice using self-monitored blood glucose and haemoglobin A1c in the primary care of diabetes mellitus: a systematic review protocol

  2021cites this paper
• Experimental Models of Impaired Hypoglycaemia-Associated Counter-Regulation.

  2020cites this paper
• A human randomized controlled trial comparing metabolic responses to single and repeated hypoglycemia in type 1 diabetes.

  2020cites this paper
• Intraperitoneal, subcutaneous and intravenous glucagon delivery and subsequent glucose response in rats: a randomized controlled crossover trial

  2018cites this paper
• Evaluation of Hypoglycaemia with Non-Invasive Sensors in People with Type 1 Diabetes and Impaired Awareness of Hypoglycaemia

  2018cites this paper
• Overnight Counter-Regulatory Hormone Levels and Next Day Glycemia in Adults with Type 1 Diabetes During Closed-Loop Insulin Delivery Versus Sensor-Augmented Pump with Low-Glucose Suspend

  2017cites this paper
• Self-reported Hypoglycaemia in Patients treated with Insulin: A Large Slovenian Retrospectively-prospective Study

  2017cites this paper
• Orexin signaling is necessary for hypoglycemia-induced prevention of conditioned place preference.

  2016cites this paper
• autonomic responses during repeated hypoglycemia knockout mice maintain glucose requirements but not Glucocorticoid-deficient corticotropin-releasing hormone

  2016cites this paper
• Challenges in Modelling Hypoglycaemia-Associated Autonomic Failure: A Review of Human and Animal Studies

  2016cites this paper
• Hypoglycemia.

  2013cites this paper
• Amelioration of Hypoglycemia Via Somatostatin Receptor Type 2 Antagonism in Recurrently Hypoglycemic Diabetic Rats

  2013cites this paper
• Adrenal Cortisol Response to One Microgram Adrenocorticotropin Stimulation Test in Children with Type - 1 Diabetes Mellitus

  2013cites this paper
• Hypoglycemia and Hypoglycemia Unawareness During and Following Exercise

  2012cites this paper
• Prevention and Correction of Hypoglycemia

  2011cites this paper
• The efficacy of continuous glucose monitoring systems in the management of blood glucose levels in Type 1 Diabetes mellitus

  2010cites this paper
• Hypoglycemia in Diabetes Mellitus

  2010cites this paper
• Kann die niedrig dosierte subkutane Glukagon-Gabe schwere Hypoglykämien bei Typ-1-Diabetes im Kindesalter verhindern und die Hospitalisationsrate senken?

  2008cites this paper
• Toxic and Metabolic Encephalopathies

  2008cites this paper
• Endocrine Disorders and the Heart

  2007cites this paper
• Impaired Awareness of Hypoglycaemia

  2007cites this paper
• Cognitive decline during acute hypoglycaemia

  2006cites this paper
• Effects of insulin treatment without and with recurrent hypoglycemia on hypoglycemic counterregulation and adrenal catecholamine-synthesizing enzymes in diabetic rats.

  2006cites this paper
• Treatment with Hypoglycemia: a-Glucosidase Inhibitor for Severe A Case Report

  2006cites this paper
• Glucocorticoid-deficient corticotropin-releasing hormone knockout mice maintain glucose requirements but not autonomic responses during repeated hypoglycemia.

  2006cites this paper
• Effects of diabetes and recurrent hypoglycemia on the regulation of the sympathoadrenal system and hypothalamo-pituitary-adrenal axis.

  2005cites this paper
• Differential adaptation of neurocognitive brain functions to recurrent hypoglycemia in healthy men.

  2005cites this paper
• Controlling diabetes: the need for intensive therapy and barriers in clinical management.

  2004cites this paper
• Impact of bedtime snack composition on prevention of nocturnal hypoglycemia in adults with type 1 diabetes undergoing intensive insulin management using lispro insulin before meals: a randomized, placebo-controlled, crossover trial.

  2003cites this paper
• Nebenwirkung der Diabetestherapie - Hypoglykämische Notfälle bei Typ 1- und Typ 2-Diabetespatienten

  2003cites this paper
• Modulation of hunger by plasma glucose and metformin.

  2003cites this paper
• Complications of Insulin Therapy

  2003cites this paper
• Hypoglycemia in children with type 1 diabetes: current issues and controversies

  2003cites this paper
• The role of beta-adrenergic sensitivity in the pathogenesis of hypoglycaemia unawareness.

  2002cites this paper
• Effects of recurrent hyperinsulinemia with and without hypoglycemia on counterregulation in diabetic rats.

  2002influential citation
• Effect of Near Physiologic Insulin Therapy on Hypoglycemia Counterregulation in Type-1 Diabetes

  2002cites this paper
• Symptoms of hypoglycaemia in people with diabetes

  2001cites this paper
• Hypoglycemia risk reduction in type 1 diabetes.

  2001cites this paper
• Effects of antecedent hypoglycemia, hyperinsulinemia, and excess corticosterone on hypoglycemic counterregulation.

  2001cites this paper
• Adaptation of cognitive function to hypoglycemia in healthy men.

  2000cites this paper
• Strict Glycemic Control Is Necessary But Not Practical in Most Children with Type 1 Diabetes

  2000cites this paper
• Treatment with alpha-glucosidase inhibitor for severe reactive hypoglycemia: a case report.

  2000cites this paper
• Treatment with α-Glucosidase Inhibitor for Severe Reactive Hypoglycemia

  2000cites this paper
• Insulinoma presenting as temporal lobe epilepsy.

  2000cites this paper
• Recovery of cognitive function and mood after severe hypoglycemia in adults with insulin-treated diabetes.

  2000cites this paper
• Impairment and recovery of elementary cognitive function induced by hypoglycemia in type-1 diabetic patients and healthy controls.

  2000cites this paper
• Hypoglycemia per se stimulates sympathetic neural as well as adrenomedullary activity, but, unlike the adrenomedullary response, the forearm sympathetic neural response is not reduced after recent hypoglycemia.

  1999cites this paper
• Hypoglycemia in adults.

  1999cites this paper
• [Cognitive risk from recurrent hypoglycemia in the diabetic].

  1998cites this paper
• Effect of Hypoglycemia on β-Adrenergic Sensitivity in Normal and Type 1 Diabetic Subjects

  1998cites this paper
• Substitution of night-time continuous subcutaneous insulin infusion therapy for bedtime NPH insulin in a multiple injection regimen improves counterregulatory hormonal responses and warning symptoms of hypoglycaemia in IDDM

  1998cites this paper
• Diabetes teaching program improves glycemic control and preserves perception of hypoglycemia.

  1998cites this paper
• Effect of Glycemic Control on Glucose Counterregulation During Hypoglycemia in NIDDM

  1998cites this paper
• Recurrent hypoglycemia does not impair the cortisol response to adrenocorticotropin infusion in healthy humans.

  1998cites this paper
• Hypoglycemia during intensified insulin therapy of young children.

  1998cites this paper
• Dramatic recovery of counter-regulatory hormone response to hypoglycaemia after intensive insulin therapy in poorly controlled Type I diabetes mellitus

  1998cites this paper
• Impact of nocturnal hypoglycemia on hypoglycemic cognitive dysfunction in type 1 diabetes.

  1998cites this paper
• Cognitive Impairment in Patients with Type 1 (Insulin-Dependent) Diabetes Mellitus

  1998cites this paper
• Hypoglycemia During Intensified Insulin Therapy of Young Children

  1998cites this paper
• Hypoglycemia During Intensified Insulin Therapy of Young Children

  1998cites this paper
• Hypoglycémies de l'adulte

  1998cites this paper
• A structural equation model for predictors of severe hypoglycaemia in patients with insulin-dependent diabetes mellitus.

  1997cites this paper
• A Biopsychobehavioral Model of Risk of Severe Hypoglycemia

  1997cites this paper
• Advances and prospects in glucose assay technology

  1997cites this paper
• Long-Term Intensive Therapy of IDDM Patients With Clinically Overt Autonomic Neuropathy: Effects on Hypoglycemia Awareness and Counterregulation

  1997cites this paper
• IDDM, Counterregulation, and the Brain

  1997cites this paper
• The role of sympathetic arousal in discrimination of insulin‐produced hypoglycemia

  1997cites this paper
• Counterregulatory hormone and symptom responses to hypoglycaemia in diabetic children

  1997cites this paper
• Contribution of Autonomic Neuropathy to Reduced Plasma Adrenaline Responses to Hypoglycemia in IDDM: Evidence for a Nonselective Defect

  1997cites this paper
• Differentiation of hypoglycaemia induced cognitive impairments. An electrophysiological approach.

  1997cites this paper
• Preservation of Physiological Responses to Hypoglycemia 2 Days After Antecedent Hypoglycemia in Patients With IDDM

  1997cites this paper
• Long-term intensive insulin therapy in IDDM: effects on HbA1c, risk for severe and mild hypoglycaemia, status of counterregulation and awareness of hypoglycaemia

  1996cites this paper
• Time course of the defective alpha-cell response to hypoglycemia in diabetic BB rats.

  1996cites this paper
• Impact of Recent Antecedent Hypoglycemia on Hypoglycemic Cognitive Dysfunction in Nondiabetic Humans

  1996cites this paper
• Management of hypoglycemia and diabetic ketoacidosis in pregnancy.

  1996cites this paper
• Prolactin and beta-endorphin responses to hypoglycemia are reduced in well-controlled insulin-dependent diabetes mellitus.

  1996cites this paper
• Insulin-associated modulation of neuroendocrine counterregulation, hypoglycemia perception, and cerebral function in insulin-dependent diabetes mellitus: evidence for an intrinsic effect of insulin on the central nervous system.

  1996cites this paper
• Evidence for a hypothalamic-pituitary versus adrenal cortical effect of glycemic control on counterregulatory hormone responses to hypoglycemia in insulin-dependent diabetes mellitus.

  1996cites this paper
• Prolactin and β-endorphin responses to hypoglycemia are reduced in well-controlled insulin-dependent diabetes mellitus

  1996cites this paper
• Time course of the defective α-cell response to hypoglycemia in diabetic BB rats

  1996cites this paper
• Improved counter-regulatory hormonal and symptomatic responses to hypoglycemia in patients with insulin-dependent diabetes mellitus after 3 months of less strict glycemic control.

  1996cites this paper
• Preserved counterregulatory hormone release and symptoms after short term hypoglycemic episodes in normal men.

  1995cites this paper
• Severe hypoglycaemia during intensive insulin therapy: a reversible phenomenon?

  1995cites this paper
• Cognitive function in patients with insulin-dependent diabetes mellitus during hyperglycemia and hypoglycemia.

  1995cites this paper
• Funny Spells in Neuroendocrine Disorders

  1995cites this paper
• Improvement of Impaired Counterregulatory Hormone Response and Symptom Perception by Snort-Term Avoidance ofHypogh

  1995cites this paper
• Effects of Recent, Short-Term Hyperglycemia on Responses to Hypoglycemia in Humans: Relevance to the Pathogenesis of Hypoglycemia Unawareness and Hyperglycemia-Induced Insulin Resistance

  1995cites this paper
• Improvement of Impaired Counterregulatory Hormone Response and Symptom Perception by Snort-Term Avoidance of Hypoglycemia in IDDM

  1995influential citation
• Prolonged but partial impairment of the hypoglycaemic physiological response following short-term hypoglycaemia in normal subjects

  1995cites this paper
• Reduced Awareness of Hypoglycemia in Adults With IDDM: A prospective study of hypoglycemic frequency and associated symptoms

  1995cites this paper
• Implication of insulin-like growth factors in the pathogenesis of diabetic neuropathy.

  1995cites this paper
• Hypoglycemia

  1994cites this paper
• Professionals' Beliefs About Useful Symptoms of Hypoglycemia

  1994cites this paper
• Hypoglycaemia unawareness in insulin‐dependent diabetes mellitus

  1994cites this paper
• Cerebral Glucose Metabolism in Type 1 Diabetic Patients

  1994cites this paper
• Decreased Adrenal Medullary Catecholamine Release in Spontaneously Diabetic BB-Wistar Rats: Role of Hypoglycemia

  1994cites this paper