EDG‐1 links the PDGF receptor to Src and focal adhesion kinase activation leading to lamellipodia formation and cell migration

No abstract is available for this paper.

• Publication year

  2001

• Venue

  The FASEB Journal

• Publication date

  2001-12-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1096/fj.01-0523comPMID 11726541
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• Sphingosine 1-phosphate receptors.

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  2000influential reference
• Polarization of chemoattractant receptor signaling during neutrophil chemotaxis.

  2000influential reference
• Lysophosphatidic acid and sphingosine 1-phosphate stimulate endothelial cell wound healing.

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• Paxillin and focal adhesion signalling

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• Localization of the G protein betagamma complex in living cells during chemotaxis.

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  2000cited by this paper
• Ras and Rho GTPases: a family reunion.

  2000influential reference
• Sphingosine Kinase Expression Increases Intracellular Sphingosine-1-Phosphate and Promotes Cell Growth and Survival

  1999influential reference
• Pleiotropic Coupling of G Protein-coupled Receptors to the Mitogen-activated Protein Kinase Cascade

  1999cited by this paper
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  1999cited by this paper
• A cell's sense of direction.

  1999cited by this paper
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• Platelet-derived-growth-factor stimulation of the p42/p44 mitogen-activated protein kinase pathway in airway smooth muscle: role of pertussis-toxin-sensitive G-proteins, c-Src tyrosine kinases and phosphoinositide 3-kinase.

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• Sphingosine 1-phosphate induces angiogenesis: its angiogenic action and signaling mechanism in human umbilical vein endothelial cells.

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• Beta-arrestin-dependent formation of beta2 adrenergic receptor-Src protein kinase complexes.

  1999cited by this paper
• Role of PDGF-B and PDGFR-beta in recruitment of vascular smooth muscle cells and pericytes during embryonic blood vessel formation in the mouse.

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• Vascular endothelial cell adherens junction assembly and morphogenesis induced by sphingosine-1-phosphate.

  1999influential reference
• Induction and suppression of endothelial cell apoptosis by sphingolipids: a possible in vitro model for cell-cell interactions between platelets and endothelial cells.

  1999cited by this paper
• The Pathways Connecting G Protein-coupled Receptors to the Nucleus through Divergent Mitogen-activated Protein Kinase Cascades*

  1998cited by this paper
• G Proteins and Small GTPases: Distant Relatives Keep in Touch

  1998cited by this paper
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  1998cited by this paper
• Invasion of T‐lymphoma cells: cooperation between Rho family GTPases and lysophospholipid receptor signaling

  1998cited by this paper
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• Cellular functions regulated by Src family kinases.

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• Involvement of Sphingosine 1-Phosphate in Nerve Growth Factor-Mediated Neuronal Survival and Differentiation

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• Stimulation of cell migration by overexpression of focal adhesion kinase and its association with Src and Fyn.

  1996cited by this paper
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  1996cited by this paper
• Suppression of ceramide-mediated programmed cell death by sphingosine-1-phosphate

  1996cited by this paper
• A role for Rac in Tiaml-induced membrane ruffling and invasion

  1995influential reference
• Selective activation of the JNK signaling cascade and c-Jun transcriptional activity by the small GTPases Rac and Cdc42Hs.

  1995cited by this paper
• Reduced cell motility and enhanced focal adhesion contact formation in cells from FAK-deficient mice

  1995cited by this paper
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  1992cited by this paper

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