Pbx modulation of Hox homeodomain amino-terminal arms establishes different DNA-binding specificities across the Hox locus

No abstract is available for this paper.

• Publication year

  1996

• Venue

  Molecular and Cellular Biology

• Publication date

  1996-04-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1128/MCB.16.4.1734PMID 8657149PMCID PMC231160
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Hox homeodomain proteins exhibit selective complex stabilities with Pbx and DNA.

  1996influential reference
• Pbx proteins display hexapeptide-dependent cooperative DNA binding with a subset of Hox proteins.

  1995influential reference
• The pentapeptide motif of Hox proteins is required for cooperative DNA binding with Pbx1, physically contacts Pbx1, and enhances DNA binding by Pbx1

  1995cited by this paper
• Both Pbx1 and E2A-Pbx1 bind the DNA motif ATCAATCAA cooperatively with the products of multiple murine Hox genes, some of which are themselves oncogenes

  1995influential reference
• The hexapeptide LFPWMR in Hoxb-8 is required for cooperative DNA binding with Pbx1 and Pbx2 proteins.

  1995cited by this paper
• Ultrabithorax protein is necessary but not sufficient for full activation of decapentaplegic expression in the visceral mesoderm.

  1995cited by this paper
• Overexpression of HOXB4 in hematopoietic cells causes the selective expansion of more primitive populations in vitro and in vivo.

  1995cited by this paper
• Extradenticle protein is a selective cofactor for the Drosophila homeotics: role of the homeodomain and YPWM amino acid motif in the interaction.

  1995cited by this paper
• The POU domain: versatility in transcriptional regulation by a flexible two-in-one DNA-binding domain.

  1995cited by this paper
• Guidebook to the Homeobox Genes

  1995cited by this paper
• Segmental expression of Hoxb-1 is controlled by a highly conserved autoregulatory loop dependent upon exd/pbx.

  1995cited by this paper
• extradenticle determines segmental identities throughout Drosophila development.

  1995cited by this paper
• Cooperative interactions between HOX and PBX proteins mediated by a conserved peptide motif

  1995cited by this paper
• The expression pattern of the murine Hoxa-10 gene and the sequence recognition of its homeodomain reveal specific properties of Abdominal B-like genes

  1995cited by this paper
• Hox genes in vertebrate development.

  1994cited by this paper
• Fusion with E2A converts the Pbx1 homeodomain protein into a constitutive transcriptional activator in human leukemias carrying the t(1;19) translocation

  1994cited by this paper
• The DNA binding specificity of Ultrabithorax is modulated by cooperative interactions with extradenticle, another homeoprotein.

  1994cited by this paper
• Specificity of HOX protein function depends on DNA-protein and protein-protein interactions, both mediated by the homeo domain.

  1994cited by this paper
• Combining evolutionary information and neural networks to predict protein secondary structure

  1994cited by this paper
• Regulation of a decapentaplegic midgut enhancer by homeotic proteins.

  1994cited by this paper
• Transformation properties of the E2a-Pbx1 chimeric oncoprotein: fusion with E2a is essential, but the Pbx1 homeodomain is dispensable

  1994cited by this paper
• Heterodimerization of the yeast homeodomain transcriptional regulators alpha 2 and a1 induces an interfacial helix in alpha 2.

  1994cited by this paper
• Hox proteins have different affinities for a consensus DNA site that correlate with the positions of their genes on the hox cluster

  1994cited by this paper
• DNA-binding and transcriptional regulatory properties of hepatic leukemia factor (HLF) and the t(17;19) acute lymphoblastic leukemia chimera E2A-HLF

  1994cited by this paper
• Coordinate regulation of downstream genes by extradenticle and the homeotic selector proteins.

  1994cited by this paper
• Fusion with E2A alters the transcriptional properties of the homeodomain protein PBX1 in t(1;19) leukemias.

  1994influential reference
• Functional differences between HOX proteins conferred by two residues in the homeodomain N-terminal arm

  1994cited by this paper
• extradenticle raises the DNA binding specificity of homeotic selector gene products.

  1994influential reference
• The degree of variation in DNA sequence recognition among four Drosophila homeotic proteins.

  1994cited by this paper
• Homeodomain-DNA recognition.

  1994cited by this paper
• DETERMINATION OF THE NMR SOLUTION STRUCTURE OF AN ANTENNAPEDIA HOMEODOMAIN-DNA COMPLEX

  1993cited by this paper
• Nucleotides flanking a conserved TAAT core dictate the DNA binding specificity of three murine homeodomain proteins

  1993cited by this paper
• Cooperative binding of an Ultrabithorax homeodomain protein to nearby and distant DNA sites

  1993cited by this paper
• Ectopic expression and function of the Antp and Scr homeotic genes: the N terminus of the homeodomain is critical to functional specificity.

  1993cited by this paper
• E2A expression, nuclear localization, and in vivo formation of DNA- and non-DNA-binding species during B-cell development

  1993influential reference
• The segment identity functions of Ultrabithorax are contained within its homeo domain and carboxy-terminal sequences.

  1993influential reference
• Functional analysis of the mouse homeobox gene HoxB9 in Drosophila development.

  1993cited by this paper
• Functional specificity of the Antennapedia homeodomain.

  1993cited by this paper
• extradenticle, a regulator of homeotic gene activity, is a homolog of the homeobox-containing human proto-oncogene pbx1.

  1993cited by this paper
• Cooperative interactions between the Caenorhabditis elegans homeoproteins UNC-86 and MEC-3.

  1993cited by this paper
• Pbx1 is converted into a transcriptional activator upon acquiring the N-terminal region of E2A in pre-B-cell acute lymphoblastoid leukemia.

  1993cited by this paper
• Determination of the nuclear magnetic resonance solution structure of an Antennapedia homeodomain-DNA complex.

  1993cited by this paper
• Homeobox genes and axial patterning.

  1992cited by this paper
• Homeobox genes in normal hematopoiesis and leukemia.

  1992cited by this paper
• Human and Drosophila Homeodomain Proteins That Enhance the DNA-Binding Activity of Serum Response Factor

  1992cited by this paper
• The Oct-1 POU domain mediates interactions between Oct-1 and other POU proteins

  1992cited by this paper
• Mapping functional specificity in the Dfd and Ubx homeo domains.

  1992cited by this paper
• 37 A Combinatorial Regulatory Circuit in Budding Yeast

  1992cited by this paper
• Differential DNA binding properties of three human homeodomain proteins.

  1992cited by this paper
• Accurate modeling of protein conformation by automatic segment matching.

  1992cited by this paper
• Antp‐type homeodomains have distinct DNA binding specificities that correlate with their different regulatory functions in embryos.

  1992cited by this paper
• PBX2 and PBX3, new homeobox genes with extensive homology to the human proto-oncogene PBX1

  1991cited by this paper
• Crystal structure of a MAT alpha 2 homeodomain-operator complex suggests a general model for homeodomain-DNA interactions.

  1991cited by this paper
• Murine genes related to the Drosophila AbdB homeotic genes are sequentially expressed during development of the posterior part of the body.

  1991cited by this paper
• Characterization of a cofactor that regulates dimerization of a mammalian homeodomain protein.

  1991cited by this paper
• vHNF1 is a homeoprotein that activates transcription and forms heterodimers with HNF1.

  1991cited by this paper
• POU-domain proteins Pit-1 and Oct-1 interact to form a heteromeric complex and can cooperate to induce expression of the prolactin promoter.

  1991cited by this paper
• DNA binding specificity of homeodomains.

  1991influential reference
• Optimal DNA sequence recognition by the Ultrabithorax homeodomain of Drosophila.

  1991cited by this paper
• High-affinity binding sites for the Deformed protein are required for the function of an autoregulatory enhancer of the Deformed gene.

  1991cited by this paper
• The POU-specific domain of Pit-1 is essential for sequence-specific, high affinity DNA binding and DNA-dependent Pit-1-Pit-1 interactions.

  1990cited by this paper
• What determines the specificity of action of Drosophila homeodomain proteins?

  1990cited by this paper
• Functional dissection of Ultrabithorax proteins in D. melanogaster.

  1990cited by this paper
• A new homeobox gene contributes the DNA binding domain of the t(1;19) translocation protein in pre-B ALL.

  1990cited by this paper
• Specific DNA binding of the two chicken Deformed family homeodomain proteins, Chox-1.4 and Chox-a.

  1990cited by this paper
• Expression of HOX homeogenes in human neuroblastoma cell culture lines.

  1990cited by this paper
• Protein–DNA contacts in the structure of a homeodomain–DNA complex determined by nuclear magnetic resonance spectroscopy in solution.

  1990influential reference
• Mutations in the Drosophila gene extradenticle affect the way specific homeo domain proteins regulate segmental identity.

  1990cited by this paper
• Differences and similarities in DNA-binding preferences of MyoD and E2A protein complexes revealed by binding site selection.

  1990cited by this paper
• Crystal structure of an engrailed homeodomain-DNA complex at 2.8 A resolution: a framework for understanding homeodomain-DNA interactions.

  1990cited by this paper
• The specificities of Sex combs reduced and Antennapedia are defined by a distinct portion of each protein that includes the homeodomain.

  1990cited by this paper
• Analysis of the human liver/bone/kidney alkaline phosphatase promoter in vivo and in vitro.

  1990cited by this paper
• Chromosomal translocation t(1;19) results in synthesis of a homeobox fusion mRNA that codes for a potential chimeric transcription factor.

  1990cited by this paper
• The human HOX gene family.

  1989cited by this paper
• Hox and HOM: homologous gene clusters in insects and vertebrates.

  1989cited by this paper
• A single amino acid can determine the DNA binding specificity of homeodomain proteins.

  1989cited by this paper
• The Oct-1 homoeodomain directs formation of a multiprotein-DNA complex with the HSV transactivator VP16

  1989cited by this paper
• DNA specificity of the bicoid activator protein is determined by homeodomain recognition helix residue 9.

  1989cited by this paper
• The Hox-1.3 homeo box protein is a sequence-specific DNA-binding phosphoprotein.

  1989cited by this paper
• A homeodomain substitution changes the regulatory specificity of the deformed protein in Drosophila embryos.

  1989cited by this paper
• Isolation and sequence‐specific DNA binding of the Antennapedia homeodomain.

  1988cited by this paper
• The sequence specificity of homeodomain-DNA interaction.

  1988cited by this paper
• Divergent homeo box proteins recognize similar DNA sequences in Drosophila

  1988cited by this paper
• An all atom force field for simulations of proteins and nucleic acids

  1986cited by this paper
• A NEW FORCE FIELD FOR MOLECULAR MECHANICAL SIMULATION OF NUCLEIC ACIDS AND PROTEINS

  1984influential reference
• Protein folding by restrained energy minimization and molecular dynamics.

  1983cited by this paper

• The role of HOXA1 in cancer and targeted therapy

  2025cites this paper
• Homeobox Transcription Factor HOXB4 Distinctly Modulates Th2 and Th9 Cell Differentiation

  2025cites this paper
• Role of Hox genes in insect development and evolution.

  2025cites this paper
• HOX genes and tumor metastasis: epigenetic regulatory mechanisms.

  2025cites this paper
• PBX-dependent and independent Hox programs establish and maintain motor neuron terminal Identity

  2025cites this paper
• Chromosomal Aberration t(14;17)(q32;q21) Simultaneously Activates HOXB5 and miR10a in Triple-Hit B-Cell Lymphoma

  2023influential citation
• X-chromosome target specificity diverged between dosage compensation mechanisms of two closely related Caenorhabditis species

  2023cites this paper
• TALE transcription factors: Cofactors no more.

  2022cites this paper
• NANOGP1, a tandem duplicate of NANOG, exhibits partial functional conservation in human naïve pluripotent stem cells

  2022cites this paper
• Retinoic acid control of pax8 during renal specification of Xenopus pronephros involves hox and meis3

  2022cites this paper
• The transcription factor PBX3 promotes tumor cell growth through transcriptional suppression of the tumor suppressor p53

  2021cites this paper
• A Computer-Based Methodology to Design Non-Standard Peptides Potentially Able to Prevent HOX-PBX1-Associated Cancer Diseases

  2021cites this paper
• Establishment of the TALE-code reveals aberrantly activated homeobox gene PBX1 in Hodgkin lymphoma

  2021cites this paper
• MEIS1 in Hematopoiesis and Cancer. How MEIS1-PBX Interaction Can Be Used in Therapy

  2021cites this paper
• Axial skeleton anterior-posterior patterning is regulated through feedback regulation between Meis transcription factors and retinoic acid

  2020cites this paper
• HOXA9 promotes MYC-mediated leukemogenesis by maintaining gene expression for multiple anti-apoptotic pathways

  2020cites this paper
• Elevated HOX gene expression in acute myeloid leukemia is associated with NPM1 mutations and poor survival

  2019cites this paper
• TALE factors use two distinct functional modes to control an essential zebrafish gene expression program

  2018cites this paper
• The cis-regulatory logic underlying abdominal Hox-mediated repression versus activation of regulatory elements in Drosophila

  2018cites this paper
• High level of homeobox A9 and PBX homeobox 3 expression in gastric cancer correlates with poor prognosis

  2017cites this paper
• The transcription factor HOXB7 regulates ERK kinase activity and thereby stimulates the motility and invasiveness of pancreatic cancer cells

  2017cites this paper
• Altered HOX Gene Expression in Human Skin and Breast Cancer Cells

  2017cites this paper
• Silencing Pre-B-cell leukemia homeobox 3 decreases the proliferation of human glioma cells in vitro and in vivo

  2017cites this paper
• The Role of Six1 in Transcriptional Regulation during Myogenesis

  2017cites this paper
• MicroRNA-98 Attenuates Cell Migration and Invasion in Glioma by Directly Targeting Pre-B Cell Leukemia Homeobox 3

  2017cites this paper
• Molecular dynamics simulations show altered secondary structure of clawless in binary complex with DNA providing insights into aristaless-clawless-DNA ternary complex formation

  2017cites this paper
• Molecular processes involved in B cell acute lymphoblastic leukaemia

  2017cites this paper
• Conserved Non-Coding Element m2de3 Directed Gene Expression During Development

  2017cites this paper
• Molecular and developmental impact of RNA processing on mammalian Hox genes

  2016cites this paper
• Mechanisms of Specificity for Hox Factor Activity

  2016cites this paper
• The role of vertebrate conserved non-coding elements in hindbrain development and evolution

  2016cites this paper
• Regulation of Silk Genes by Hox and Homeodomain Proteins in the Terminal Differentiated Silk Gland of the Silkworm Bombyx mori

  2016cites this paper
• A comprehensive gene expression analysis at sequential stages of in vitro cardiac differentiation from isolated MESP1-expressing-mesoderm progenitors

  2016cites this paper
• HOXB9 induction of mesenchymal-to-epithelial transition in gastric carcinoma is negatively regulated by its hexapeptide motif

  2015cites this paper
• Fusion of the Genes EWSR1 and PBX3 in Retroperitoneal Leiomyoma with t(9;22)(q33;q12)

  2015cites this paper
• HOXB5 induces invasion and migration through direct transcriptional up-regulation of β-catenin in human gastric carcinoma.

  2015cites this paper
• Estrogen receptor alpha signaling promotes Sle1-induced loss of tolerance and immune cell activation and is responsible for sex bias in B6.Sle1 congenic mice.

  2015cites this paper
• Tlx3 Promotes Glutamatergic Neuronal Subtype Specification through Direct Interactions with the Chromatin Modifier CBP

  2015cites this paper
• Pbx3 and Meis1 cooperate through multiple mechanisms to support Hox-induced murine leukemia

  2015cites this paper
• Identification of several potential chromatin binding sites of HOXB7 and its downstream target genes in breast cancer

  2015cites this paper
• Title Pbx 1 activates Fgf 10 in the mesenchyme of developing lungs

  2014cites this paper
• Deciphering human gene regulation using computational and statistical methods

  2014cites this paper
• Validation of two novel mouse models of conditional Meis1 deletion to study roles in adult mouse hematopoiesis

  2014cites this paper
• Downregulation of prdm16 is critical for HOXB4-mediated benign HSC expansion in vivo

  2014cites this paper
• Pbx1 activates Fgf10 in the mesenchyme of developing lungs

  2014cites this paper
• Characterization of Creb-regulated transcription coactivator 1 (Crtc1) during embryogenesis of Zebrafish (Danio rerio)

  2014influential citation
• PBX3 is overexpressed in gastric cancer and regulates cell proliferation

  2014cites this paper
• Étude de la voie HOX-Flt3 dans les leucémies de type pré-B induites par E2A-Pbx1

  2014cites this paper
• Inability of HOXB4 to enhance self-renewal of malignant B cells: favorable profile for the expansion of autologous hematopoietic stem cells.

  2014cites this paper
• Hoxa9 collaborates with E2A‐PBX1 in mouse B cell leukemia in association with Flt3 activation and decrease of B cell gene expression

  2014cites this paper
• CBFB-MYH11 hypomethylation signature and PBX3 differential methylation revealed by targeted bisulfite sequencing in patients with acute myeloid leukemia

  2014cites this paper
• Role of the Trithorax (MLL): HOX Axis in HSC Development, Function, and Leukemia

  2014cites this paper
• Hox regulation of transcription: More complex(es)

  2014cites this paper
• Targeting HOX transcription factors in prostate cancer

  2014cites this paper
• Université de Montréal-Thèse numérique

  2013cites this paper
• Hematopoietic Stem Cell Self-renewal, the Transcription Factor HoxB4, and the Polycomb and Trithorax Group Epigenetic Regulator Complexes

  2013influential citation
• PBX3 is an important cofactor of HOXA9 in leukemogenesis.

  2013cites this paper
• Characterization of the putative CALM/AF10 collaborator Meis1 in leukemia development

  2013cites this paper
• IGFBP3, a Transcriptional Target of Homeobox D10, Is Correlated with the Prognosis of Gastric Cancer

  2013cites this paper
• Contribution of Distinct Homeodomain DNA Binding Specificities to Drosophila Embryonic Mesodermal Cell-Specific Gene Expression Programs

  2013cites this paper
• The abrogation of the HOXB7/PBX2 complex induces apoptosis in melanoma through the miR-221&222-c-FOS pathway

  2013cites this paper
• Analysis of the DNA-binding profile and function of TALE homeoproteins reveals their specialization and specific interactions with Hox genes/proteins.

  2013cites this paper
• Biochemistry of the tale transcription factors PREP, MEIS, and PBX in vertebrates

  2013cites this paper
• PBX 3 is an important cofactor of HOXA 9 in leukemogenesis *

  2013cites this paper
• Structure-aided prediction of mammalian transcription factor complexes in conserved non-coding elements

  2013cites this paper
• Role of HOXA9 and VEZF1 in Endothelial Biology

  2013cites this paper
• The DNA binding profile of TALE proteins in the embryo: contrast with in vitro studies and functional implications

  2013cites this paper
• RAR&ggr; is essential for retinoic acid induced chromatin remodeling and transcriptional activation in embryonic stem cells

  2013cites this paper
• Genetic and Functional Modularity of Hox Activities in the Specification of Limb-Innervating Motor Neurons

  2013cites this paper
• Antagonism Versus Cooperativity with TALE Cofactors at the Base of the Functional Diversification of Hox Protein Function

  2013cites this paper
• Conserved Non-Coding Element Derived Regulation of the Meis2.2 Homeobox Gene During Embryonic Development

  2013cites this paper
• Hox transcriptional specificity despite a single class of cofactors: Are flexible interaction modes the key?

  2013cites this paper
• Elucidation of the physical and functional interactions between the MEIS1A and the CREB and CRTC transcription factors

  2012influential citation
• Discovery, optimization and validation of an optimal DNA-binding sequence for the Six1 homeodomain transcription factor

  2012cites this paper
• Cardiovascular defects in a mouse model of HOXA1 syndrome.

  2012cites this paper
• Transgenic studies on homeobox genes in nervous system development: spina bifida in Isl1 transgenic mice

  2012cites this paper
• miR-495 is a tumor-suppressor microRNA down-regulated in MLL-rearranged leukemia

  2012cites this paper
• Hox Gene Expression in Ovarian Cancer

  2012cites this paper
• Hox Proteins Display a Common and Ancestral Ability to Diversify Their Interaction Mode with the PBC Class Cofactors

  2012cites this paper
• Structural Determinants of DNA-binding Specificity for Hox Proteins

  2012cites this paper
• Research resource: the pdx1 cistrome of pancreatic islets.

  2012cites this paper
• Characterization of the DNA-binding Properties of the Mohawk Homeobox Transcription Factor*

  2012cites this paper
• Refining Positional Identity in the Vertebrate Hindbrain

  2012cites this paper
• Cdx1 is essential for the initiation of HoxC8 expression during early embryogenesis

  2012cites this paper
• The homeodomain region controls the phenotype of HOX-induced murine leukemia.

  2012cites this paper
• Wnt Signaling Promotes Neuronal Differentiation from Mesenchymal Stem Cells Through Activation of Tlx3

  2011cites this paper
• Promotion of cortico-cerebral precursors expansion by artificial miRNAs against the Emx 2 locus

  2011cites this paper
• Identification and embryonic expression of a highly conserved Meis-linked gene

  2011cites this paper
• Genome-Wide Analysis of the Binding of the Hox Protein Ultrabithorax and the Hox Cofactor Homothorax in Drosophila

  2011cites this paper
• Ancient Pbx-Hox signatures define hundreds of vertebrate developmental enhancers

  2011cites this paper
• Application de la complémentation de fluorescence bi-moléculaire à l'étude du mode d'action des protéines Hox in vivo

  2011cites this paper
• Pbx homeodomain proteins: TALEnted regulators of limb patterning and outgrowth

  2011cites this paper
• Pbx-dependent regulation of lbx gene expression in developing zebrafish embryos.

  2011cites this paper
• Cofactor binding evokes latent differences in DNA binding specificity between Hox proteins.

  2011cites this paper
• Cooperative Transcriptional Activation by Klf4, Meis2, and Pbx1

  2011cites this paper
• A Novel Gli3 Enhancer Controls the Gli3 Spatiotemporal Expression Pattern through a TALE Homeodomain Protein Binding Site

  2011cites this paper
• The Pbx Interaction Motif of Hoxa1 Is Essential for Its Oncogenic Activity

  2011cites this paper
• A novel role for the AAA ATPase spastin as a HOXA10 transcriptional corepressor in Ishikawa endometrial cells.

  2011cites this paper
• The role of Hox proteins in leukemogenesis: insights into key regulatory events in hematopoiesis.

  2011cites this paper
• The Hox cofactors Meis1 and Pbx act upstream of gata1 to regulate primitive hematopoiesis.

  2010cites this paper