Direct targeting of peptidergic amygdalar neurons by noradrenergic afferents: linking stress-integrative circuitry

No abstract is available for this paper.

• Publication year

  2013

• Venue

  Brain Structure and Function

• Publication date

  2013-11-23

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1007/s00429-013-0674-8PMID 24271021PMCID PMC4032379
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2009cited by this paper
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