Cytokines in non-genotoxic hepatocarcinogenesis.

No abstract is available for this paper.

• Publication year

  1999

• Venue

  Carcinogenesis

• Publication date

  1999-08-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1093/CARCIN/20.8.1397PMID 10426783
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Suppression of mouse hepatocyte apoptosis by peroxisome proliferators : role of PPARα and TNFα

  2000cited by this paper
• Kupffer cell oxidant production is central to the mechanism of peroxisome proliferators.

  1999cited by this paper
• IL-6 produced by Kupffer cells induces STAT protein activation in hepatocytes early during the course of systemic listerial infections.

  1998cited by this paper
• JNK or IKK, AP-1 or NF-κB, which are the targets for MEK kinase 1 action?

  1998cited by this paper
• Signal transduction through NF-kappa B.

  1998cited by this paper
• The non-genotoxic hepatocarcinogen nafenopin suppresses rodent hepatocyte apoptosis induced by TGFbeta1, DNA damage and Fas.

  1998cited by this paper
• Signal transduction through NF-κB

  1998cited by this paper
• WY-14 643 rapidly activates nuclear factor kappaB in Kupffer cells before hepatocytes.

  1998cited by this paper
• Apoptosis and Hepatocarcinogenesis

  1998cited by this paper
• Deficient liver regeneration after carbon tetrachloride injury in mice lacking type 1 but not type 2 tumor necrosis factor receptor.

  1998cited by this paper
• Hepatocyte death in hepatocarcinogenesis

  1998cited by this paper
• JNK or IKK, AP-1 or NF-kappaB, which are the targets for MEK kinase 1 action?

  1998cited by this paper
• Regulation of apoptosis in mouse hepatocytes and alteration of apoptosis by nongenotoxic carcinogens.

  1998cited by this paper
• Immune Pathogenesis of Hepatocellular Carcinoma

  1998cited by this paper
• Tumor necrosis factor primes hepatocytes for DNA replication in the rat

  1998cited by this paper
• Evidence for the suppression of apoptosis by the peroxisome proliferator activated receptor alpha (PPAR alpha).

  1998cited by this paper
• Initiation of liver growth by tumor necrosis factor: deficient liver regeneration in mice lacking type I tumor necrosis factor receptor.

  1997cited by this paper
• Amino acid residues in both the DNA-binding and ligand-binding domains influence transcriptional activity of the human peroxisome proliferator-activated receptor alpha.

  1997cited by this paper
• Kupffer cell depletion abolishes induction of interleukin‐10 and permits sustained overexpression of tumor necrosis factor alpha messenger RNA in the regenerating rat liver

  1997cited by this paper
• Induction of early‐immediate genes by tumor necrosis factor α contribute to liver repair following chemical‐induced hepatotoxicity

  1997cited by this paper
• Antibodies to tumor necrosis factor alpha prevent increases in cell replication in liver due to the potent peroxisome proliferator, WY-14,643.

  1997cited by this paper
• The role of peroxisome proliferator activated receptor alpha in peroxisome proliferation, physiological homeostasis, and chemical carcinogenesis.

  1997cited by this paper
• Role of PPAR alpha in the mechanism of action of the nongenotoxic carcinogen and peroxisome proliferator Wy-14,643.

  1997cited by this paper
• Tumour necrosis factor alpha (TNF alpha) suppresses apoptosis and induces DNA synthesis in rodent hepatocytes: a mediator of the hepatocarcinogenicity of peroxisome proliferators?

  1997cited by this paper
• Liver cell proliferation induced by nafenopin and cyproterone acetate is not associated with increases in activation of transcription factors NF-kappaB and AP-1 or with expression of tumor necrosis factor alpha.

  1997cited by this paper
• Perturbation of the mitosis/apoptosis balance: A fundamental mechanism in toxicology

  1997cited by this paper
• Recent update on the PPAR alpha-null mouse.

  1997cited by this paper
• A Combinatorial Approach Defines Specificities of Members of the Caspase Family and Granzyme B

  1997cited by this paper
• TNF-alpha downregulates the peroxisome proliferator activated receptor-alpha and the mRNAs encoding peroxisomal proteins in rat liver.

  1997cited by this paper
• Treatment of rats with the peroxisome proliferator ciprofibrate results in increased liver NF-kappaB activity.

  1997cited by this paper
• Liver Regeneration

  1997cited by this paper
• Cell death induction by TNF: a matter of self control.

  1997cited by this paper
• Cloning of a disintegrin metalloproteinase that processes precursor tumour-necrosis factor-α

  1997cited by this paper
• Kupffer cells are causally responsible for the mitogenic effect of peroxisome proliferators.

  1997cited by this paper
• Nonparenchymal cells from regenerating rat liver generate interleukin-1alpha and -1beta: a mechanism of negative regulation of hepatocyte proliferation.

  1997cited by this paper
• Perturbation of the mitosis/apoptosis balance: a fundamental mechanism in toxicology.

  1997cited by this paper
• Nonparenchymal cells from regenerating rat liver generate interleukin‐1α and ‐1β: A mechanism of negative regulation of hepatocyte proliferation

  1997cited by this paper
• Recent update on the PPARα-null mouse

  1997cited by this paper
• A metalloproteinase disintegrin that releases tumour-necrosis factor-alpha from cells.

  1997cited by this paper
• Tumour necrosis factor alpha and interleukin 1 signalling: do MAPKK kinases connect it all?

  1997cited by this paper
• Dissection of TNF receptor 1 effector functions: JNK activation is not linked to apoptosis while NF-kappaB activation prevents cell death.

  1996cited by this paper
• Liver Failure and Defective Hepatocyte Regeneration in Interleukin-6-Deficient Mice

  1996cited by this paper
• Peroxisome proliferators activate Kupffer cells in vivo.

  1996cited by this paper
• Dissection of TNF Receptor 1 Effector Functions: JNK Activation Is Not Linked to Apoptosis While NF-κB Activation Prevents Cell Death

  1996cited by this paper
• Hepatocyte proliferation induced in rats by lead nitrate is suppressed by several tumor necrosis factor α inhibitors

  1996cited by this paper
• Differential expression of peroxisome proliferator-activated receptors (PPARs): tissue distribution of PPAR-alpha, -beta, and -gamma in the adult rat.

  1996cited by this paper
• Possible roles of nonparenchymal cells in hepatocyte proliferation induced by lead nitrate and by tumor necrosis factor α

  1996cited by this paper
• FADD/MORT1 Is a Common Mediator of CD95 (Fas/APO-1) and Tumor Necrosis Factor Receptor-induced Apoptosis (*)

  1996cited by this paper
• Recent progress in the tumor necrosis factor-alpha field.

  1996cited by this paper
• Activation of Hepatic NF-κB by Phenobarbital in Rats

  1996cited by this paper
• Recent Progress in the Tumor Necrosis Factor-α Field

  1996cited by this paper
• Treatment of rats with the peroxisome proliferator ciprofibrate results in increased liver NF-kB activity

  1996cited by this paper
• NON-GENOTOXIC HEPATOCARCINOGENS STIMULATE DNA SYNTHESIS AND SUPPRESS APOPTOSIS BUT IN DIFFERENT HEPATOCYTE POPULATIONS

  1996cited by this paper
• Activation of hepatic NF-kappaB by phenobarbital in rats.

  1996cited by this paper
• Identification and characterization of DNA elements implicated in the regulation of CYP4A1 transcription.

  1995cited by this paper
• Targeted disruption of the alpha isoform of the peroxisome proliferator-activated receptor gene in mice results in abolishment of the pleiotropic effects of peroxisome proliferators

  1995cited by this paper
• 7 – Apoptosis and hepatocarcinogenesis

  1995cited by this paper
• Rapid activation of the stat3 transcription complex in liver regeneration

  1995cited by this paper
• Suppression of liver cell apoptosis in vitro by the non-genotoxic hepatocarcinogen and peroxisome proliferator nafenopin

  1994cited by this paper
• Tumor necrosis factor receptor-mediated signaling pathways

  1994cited by this paper
• Mechanistically-based Human Hazard Assessment of Peroxisome Proliferator-induced Hepatocarcinogenesis

  1994cited by this paper
• Interleukin-6, but not tumour necrosis factor-alpha, increases lipogenesis in rat hepatocyte primary cultures.

  1994cited by this paper
• Roles of growth factors and of tumor necrosis factor-alpha on liver cell proliferation induced in rats by lead nitrate.

  1994cited by this paper
• Relationship between Hepatocyte Necrosis, Proliferation, and Initiation Induced by Diethylnitrosamine in the Male F344 Rat

  1993cited by this paper
• Tumor necrosis factor-alpha is a direct hepatocyte mitogen in the rat.

  1993cited by this paper
• The involvement of Kupffer cells in carbon tetrachloride toxicity.

  1993cited by this paper
• Relationship between hepatocyte necrosis, proliferation, and initiation induced by diethylnitrosamine in the male F344 rat.

  1993cited by this paper
• Tumor necrosis factor stimulates DNA synthesis of mouse hepatocytes in primary culture and is suppressed by transforming growth factor β and interleukin 6

  1992cited by this paper
• Induction of apoptosis in cultured hepatocytes and in regressing liver by transforming growth factor beta 1.

  1992cited by this paper
• A novel heterodimeric cysteine protease is required for interleukin-1βprocessing in monocytes

  1992cited by this paper
• The mouse peroxisome proliferator activated receptor recognizes a response element in the 5′ flanking sequence of the rat acyl CoA oxidase gene.

  1992cited by this paper
• Production of macrophage colony‐stimulating factor by adult murine parenchymal liver cells (hepatocytes)

  1992cited by this paper
• Antibodies to tumor necrosis factor-alpha inhibit liver regeneration after partial hepatectomy.

  1992cited by this paper
• The two different receptors for tumor necrosis factor mediate distinct cellular responses.

  1991cited by this paper
• Peroxisome proliferation and nongenotoxic carcinogenesis: Commentary on a symposium

  1991cited by this paper
• Peroxisome proliferation and nongenotoxic carcinogenesis: commentary on a symposium.

  1991cited by this paper
• Apoptosis in cultured rat hepatocytes: the effects of tumour necrosis factor alpha and interferon gamma.

  1991cited by this paper
• Kupffer cell–derived cytokines induce the synthesis of a leukocyte chemotactic peptide, interleukin‐8, in human hepatoma and primary hepatocyte cultures

  1991cited by this paper
• Effects of interleukin-6 and leukemia inhibitory factor on the acute phase response and DNA synthesis in cultured rat hepatocytes.

  1991cited by this paper
• Autocrine activity of interleukin 6 secreted by hepatocarcinoma cell lines.

  1991cited by this paper
• Induction of hepatocyte mitosis in intact adult rat by interleukin-1 alpha and interleukin-6.

  1991cited by this paper
• Effects of cytokines on the liver

  1991cited by this paper
• Too many rodent carcinogens: mitogenesis increases mutagenesis.

  1990cited by this paper
• Reversible alteration in the expression of the gap junctional protein connexin 32 during tumor promotion in rat liver and its role during cell proliferation.

  1990cited by this paper
• Cell proliferation and promotion of rat liver carcinogenesis: different effect of hepatic regeneration and mitogen induced hyperplasia on the development of enzyme-altered foci.

  1990cited by this paper
• Biologically active products of stimulated liver macrophages (Kupffer cells).

  1990cited by this paper
• Biology of multifunctional cytokines: IL 6 and related molecules (IL 1 and TNF)

  1990cited by this paper
• Integration of hepatitis B virus DNA and its implications for hepatocarcinogenesis.

  1990cited by this paper
• Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators

  1990cited by this paper
• Biology of interleukin 1

  1988cited by this paper
• Interleukin-1 beta is a potent growth inhibitor of adult rat hepatocytes in primary culture.

  1988cited by this paper
• Comparison of the effects of the hypolipidaemic agents ICI 53072 and clofibrate with those of phenobarbitone on liver size, blood flow and DNA content in the rat

  1983cited by this paper
• 2,3,7,8-tetrachlorodibenzo-p-dioxin and related halogenated aromatic hydrocarbons: examination of the mechanism of toxicity.

  1982cited by this paper
• Adaptive liver growth induced by xenobiotic compounds: its nature and mechanism.

  1979cited by this paper

• To Investigate the Causal Relationship between Rheumatological Diseases and Pancreatic Cancer Risk Based on Mendelian Randomization

  2024cites this paper
• Tumour Necrosis Factor Alpha (TNF-α) and Oral Squamous Cell Carcinoma

  2023cites this paper
• Harnessing Tumor Necrosis Factor Alpha to Achieve Effective Cancer Immunotherapy

  2021cites this paper
• Molecular mechanisms underlying rheumatoid arthritis and cancer development and treatment.

  2020cites this paper
• Tumor Necrosis Factor α Blockade: An Opportunity to Tackle Breast Cancer

  2020cites this paper
• Collaboration and competition: ethics in toxicology.

  2018cites this paper
• Hepatocyte-specific PPARA expression exclusively promotes agonist-induced cell proliferation without influence from nonparenchymal cells.

  2017cites this paper
• Prediction and visualization of the carcinogenic potential of chemicals with short-term omics assays

  2017cites this paper
• Influence of dietary fructose on lipid profile and glycaemic control in healthy individuals

  2016cites this paper
• The EpiDerm™ 3D human reconstructed skin micronucleus (RSMN) assay: Historical control data and proof of principle studies for mechanistic assay adaptations.

  2016cites this paper
• Pathophysiological Roles of Reactive Oxygen and Nitrogen Species

  2014cites this paper
• Paeoniflorin protects cells from GalN/TNF-α-induced apoptosis via ER stress and mitochondria-dependent pathways in human L02 hepatocytes.

  2014cites this paper
• Cross-Platform Toxicogenomics for the Prediction of Non-Genotoxic Hepatocarcinogenesis in Rat

  2014cites this paper
• Protective effect of cornel iridoid glycoside in D-galactosamine/tumor necrosis factor-α-injured L02 hepatocytes and its mechanism

  2014cites this paper
• Clinical aspects of tumor necrosis factor-α signaling in hepatocellular carcinoma.

  2014cites this paper
• Mechanism for hepato-protective action of Liangxue Huayu Recipe (LHR): blockade of mitochondrial cytochrome c release and caspase activation.

  2013cites this paper
• Analyse du rôle de la voie p53 dans la réponse des sarcomes des tissus mous au traitement par TNF-alpha

  2011cites this paper
• Alcohol, Retinoic Acid, and Cancer

  2011cites this paper
• Origins of Injection-Site Sarcomas in Cats: The Possible Role of Chronic Inflammation—A Review

  2011cites this paper
• Stem cell biology in health and disease

  2010cites this paper
• Accelerated hepatocellular carcinoma development in mice expressing the Pim-3 transgene selectively in the liver

  2010cites this paper
• Interaction of hepatitis C virus core protein with Hsp60 triggers the production of reactive oxygen species and enhances TNF-alpha-mediated apoptosis.

  2009cites this paper
• The Chronically Inflamed Microenvironment and Cancer Stem Cells

  2009cites this paper
• How the study of Helicobacter infection can contribute to the understanding of carcinoma development.

  2009cites this paper
• PPARs and Cancer

  2008cites this paper
• Effect of Punarnavine, an Alkaloid from Boerhaavia diffusa, on Cell-Mediated Immune Responses and TIMP-1 in B16F-10 Metastatic Melanoma-Bearing Mice

  2007cites this paper
• Experimental Models of Cytokines and Cancer Prevention

  2007cites this paper
• Non‐Genotoxic Causes of Cancer

  2007cites this paper
• Hepatitis C virus: from oxygen free radicals to hepatocellular carcinoma

  2007cites this paper
• Tumour necrosis factor-α as a tumour promoter

  2006cites this paper
• Over-expressed estrogen receptor-α up-regulates hTNF-α gene expression and down-regulates β-catenin signaling activity to induce the apoptosis and inhibit proliferation of LoVo colon cancer cells

  2006cites this paper
• Tumour necrosis factor-alpha as a tumour promoter.

  2006cites this paper
• Oxidative damage, pro-inflammatory cytokines, TGF-alpha and c-myc in chronic HCV-related hepatitis and cirrhosis.

  2006cites this paper
• Proteomic analysis of the transition from quiescent to proliferating stages in rat liver hepatectomy model

  2006cites this paper
• Over-expressed estrogen receptor-alpha up-regulates hTNF-alpha gene expression and down-regulates beta-catenin signaling activity to induce the apoptosis and inhibit proliferation of LoVo colon cancer cells.

  2006cites this paper
• Comparative study of cytotoxicity and oxidative stress induced by deoxynivalenol, zearalenone or fumonisin B1 in human intestinal cell line Caco-2.

  2005cites this paper
• Cytokines in cancer immunity and immunotherapy

  2004cites this paper
• The Induction of Prostaglandin E2 Production, Interleukin-6 Production, Cell Cycle Arrest, and Cytotoxicity in Primary Oral Keratinocytes and KB Cancer Cells by Areca Nut Ingredients Is Differentially Regulated by MEK/ERK Activation*

  2004cites this paper
• PPARalpha agonist-induced rodent tumors: modes of action and human relevance.

  2003cites this paper
• Misconceptions about the Causes of Cancer

  2003cites this paper
• Expression of hepatoma‐derived growth factor in hepatocarcinogenesis

  2003cites this paper
• The role of investigative molecular toxicology in early stage drug development

  2003cites this paper
• Tumour necrosis factor alpha: a potential target for the therapy of solid tumours.

  2003cites this paper
• Tumour necrosis factor α: a potential target for the therapy of solid tumours

  2003cites this paper
• PPARα Agonist-Induced Rodent Tumors: Modes of Action and Human Relevance

  2003cites this paper
• Downregulation of lactoferrin by PPARalpha ligands: role in perturbation of hepatocyte proliferation and apoptosis.

  2002cites this paper
• Tumor necrosis factor or tumor promoting factor?

  2002cites this paper
• Downregulation of Lactoferrin by PPARα Ligands: Role in Perturbation of Hepatocyte Proliferation and Apoptosis

  2002influential citation
• PPARα and the regulation of cell division and apoptosis

  2002cites this paper
• PPAR alpha and the regulation of cell division and apoptosis.

  2002cites this paper
• FORUM Evidence for Cross Talk between PPAR and p38 MAP Kinase

  2002cites this paper
• Interleukin-1alpha up-regulation in vivo by a potent carcinogen 7,12-dimethylbenz(a)anthracene (DMBA) and control of DMBA-induced inflammatory responses.

  2002cites this paper
• The role of cytokines in the epithelial cancer microenvironment.

  2002cites this paper
• Evidence for cross talk between PPARalpha and p38 MAP kinase.

  2002cites this paper
• The effect of IFNγ on the hepatocyte: cell cycle and apoptosis

  2001cites this paper
• Mouse hepatocyte response to peroxisome proliferators: dependency on hepatic nonparenchymal cells and peroxisome proliferator activated receptor alpha (PPARalpha).

  2001cites this paper
• The functions of cytokines and their uses in toxicology

  2001cites this paper
• Inflammation and cancer: back to Virchow?

  2001cites this paper
• CHAPTER 38 – Pesticide Residues in Food and Cancer Risk: A Critical Analysis

  2001cites this paper
• Hepatocellular proliferation in response to a peroxisome proliferator does not require TNFalpha signaling.

  2001cites this paper
• Role of cytokines in non-genotoxic hepatocarcinogenesis: cause or effect?

  2001cites this paper
• The effect of IFNgamma on the hepatocyte: cell cycle and apoptosis.

  2001cites this paper
• Role of MAP kinase signalling pathways in the mode of action of peroxisome proliferators.

  2000cites this paper
• Role of hepatic non-parenchymal cells in the response of rat hepatocytes to the peroxisome proliferator nafenopin in vitro.

  2000cites this paper
• Paracelsus to parascience: the environmental cancer distraction.

  2000cites this paper
• Apoptosis and proliferation in nongenotoxic carcinogenesis: species differences and role of PPARalpha.

  2000cites this paper
• The role of protein kinase B and mitogen‐activated protein kinase in epidermal growth factor and tumor necrosis factor α–mediated rat hepatocyte survival and apoptosis

  2000cites this paper
• Proteomic analysis of differential protein expression in primary hepatocytes induced by EGF, tumour necrosis factor alpha or the peroxisome proliferator nafenopin.

  2000cites this paper
• Role for tumor necrosis factor α receptor 1 and interleukin‐1 receptor in the suppression of mouse hepatocyte apoptosis by the peroxisome proliferator nafenopin

  1999cites this paper