Immune Pathogenesis of Hepatocellular Carcinoma

Hepatocellular carcinoma (HCC) is a common complication of chronic hepatitis B virus (HBV) infection. The pathogenetic mechanisms potentially responsible for HCC during chronic HBV infection are not well defined. This study demonstrates that chronic immune-mediated liver cell injury triggers the development of HCC in the absence of viral transactivation, insertional mutagenesis, and genotoxic chemicals. These results strongly suggest that the immune response to HBV is both necessary and sufficient to cause liver cancer during chronic HBV infection, and that all other procarcinogenic events associated with HCC are probably dependent on this process.

• Publication year

  1998

• Venue

  Journal of Experimental Medicine

• Publication date

  1998-07-20

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1084/JEM.188.2.341PMID 9670046PMCID 2212453
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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