Cadmium-Induced Ototoxicity in Rat Cochlear Organotypic Cultures

No abstract is available for this paper.

• Publication year

  2014

• Venue

  Neurotoxicity research

• Publication date

  2014-02-28

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.1007/s12640-014-9461-4PMID 24577639PMCID PMC9100876
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• A mutation in the cdh23 gene causes age-related hearing loss in Cdh23(nmf308/nmf308) mice.

  2012cited by this paper
• Kidney dysfunction and cadmium exposure--factors influencing dose-response relationships.

  2012cited by this paper
• Involvement of glutathione and enzymatic defense system against cadmium toxicity in Bradyrhizobium sp. strains (peanut symbionts)

  2012cited by this paper
• Genetic background effects on age-related hearing loss associated with Cdh23 variants in mice.

  2012cited by this paper
• Mefloquine Damage Vestibular Hair Cells in Organotypic Cultures

  2011cited by this paper
• Lead neurotoxicity in rat cochlear organotypic cultures

  2011cited by this paper
• Cisplatin ototoxicity in rat cochlear organotypic cultures.

  2011cited by this paper
• Mutations in Protocadherin 15 and Cadherin 23 Affect Tip Links and Mechanotransduction in Mammalian Sensory Hair Cells

  2011cited by this paper
• Co-administration of Cisplatin and Furosemide Causes Rapid and Massive Loss of Cochlear Hair Cells in Mice

  2011cited by this paper
• Manganese is toxic to spiral ganglion neurons and hair cells in vitro.

  2011cited by this paper
• Salicylate-induced degeneration of cochlea spiral ganglion neurons-apoptosis signaling.

  2010cited by this paper
• Reduction in cadmium-induced toxicity and c-Jun N-terminal kinase activation by glutathione in cultured mouse embryonic cells.

  2010cited by this paper
• Recent cadmium exposure among male partners may affect oocyte fertilization during in vitro fertilization (IVF)

  2010cited by this paper
• Chronic low-level Pb exposure during development decreases the expression of the voltage-dependent anion channel in auditory neurons of the brainstem.

  2010cited by this paper
• Mitochondrial autophagy promotes cellular injury in nephropathic cystinosis.

  2010cited by this paper
• Mechanisms of rapid sensory hair-cell death following co-administration of gentamicin and ethacrynic acid.

  2010cited by this paper
• Mechanisms of cadmium carcinogenesis.

  2009cited by this paper
• Cochlear homeostasis and its role in genetic deafness

  2009cited by this paper
• Ototoxic effects of mefloquine in cochlear organotypic cultures

  2009cited by this paper
• gene expression in cisplatin ototoxicity and protection with p53 inhibitor

  2009cited by this paper
• Heavy metals and noise exposure: health effects.

  2009cited by this paper
• Expression of kidney injury molecule-1 (Kim-1) in relation to necrosis and apoptosis during the early stages of Cd-induced proximal tubule injury.

  2009cited by this paper
• Hwanggunchungyitang prevents cadmium-induced ototoxicity through suppression of the activation of caspase-9 and extracellular signal-related kinase in auditory HEI-OC1 cells.

  2009cited by this paper
• Divergence to apoptosis from ROS induced cell cycle arrest: effect of cadmium.

  2009cited by this paper
• Cytotoxic effects of dimethyl sulphoxide (DMSO) on cochlear organotypic cultures.

  2008cited by this paper
• Cadmium-induced autophagy and apoptosis are mediated by a calcium signaling pathway

  2008cited by this paper
• The Protective Mechanism of Antioxidants in Cadmium-Induced Ototoxicity in Vitro and in Vivo

  2008cited by this paper
• Neurotoxicity of cadmium on immature hippocampus and a neuroprotective role for p38 MAPK.

  2008cited by this paper
• Substrate-dependent cadmium toxicity affecting energy-linked K+/86Rb transport inStaphylococcus aureus

  2008cited by this paper
• Influence of Drinking and/or Cooking with Jinzu River Water on the Development of Itai-Itai Disease

  2008cited by this paper
• Cadmium induces apoptotic cell death through p38 MAPK in brain microvessel endothelial cells.

  2008cited by this paper
• Cadmium Toxicity in Glutathione Mutants of Escherichia coli

  2008cited by this paper
• Cell death after co-administration of cisplatin and ethacrynic acid.

  2007cited by this paper
• Experiences in ototoxic investigations in aminoglycoside antibiotics

  2007cited by this paper
• Cadherin 23 and protocadherin 15 interact to form tip-link filaments in sensory hair cells

  2007cited by this paper
• Kidney injury molecule-1 is an early biomarker of cadmium nephrotoxicity.

  2007cited by this paper
• Identification and quantification of apoptosis in the kidney using morphology, biochemical and molecular markers

  2007cited by this paper
• Cadmium induces apoptosis in human embryonic kidney (HEK) 293 cells by caspase-dependent and -independent pathways acting on mitochondria.

  2007cited by this paper
• Cadmium induces mitochondria-dependent apoptosis of normal human hepatocytes

  2007cited by this paper
• Cadmium-induced Cancers in Animals and in Humans

  2007cited by this paper
• Manipulation of energy and redox states in the C6 glioma cells by buthionine sulfoxamine and N-acetylcysteine and the effect on cell survival to cadmium toxicity.

  2007cited by this paper
• Cadmium toxicity related to cysteine metabolism and glutathione levels in frog Rana ridibunda tissues.

  2006cited by this paper
• Cadmium: cellular effects, modifications of biomolecules, modulation of DNA repair and genotoxic consequences (a review).

  2006cited by this paper
• Cadmium-induced apoptosis in lymphoblastoid cell line: involvement of caspase-dependent and -independent pathways.

  2006cited by this paper
• Journal of Occupational Medicine and Toxicology the Toxicity of Cadmium and Resulting Hazards for Human Health

  2006cited by this paper
• Modulation of cadmium induced alterations in murine thymocytes by piperine: oxidative stress, apoptosis, phenotyping and blastogenesis.

  2006cited by this paper
• A transient increase in the activity of Src-family kinases induced by cell detachment delays anoikis of intestinal epithelial cells

  2005cited by this paper
• Estimation of cumulative cadmium intake causing Itai-itai disease.

  2005cited by this paper
• Determination of Cadmium and Lead in Different Cigarette Brands in Jordan

  2005cited by this paper
• Review of Cellular Changes in the Cochlea Due to Aminoglycoside Antibiotics.

  2005cited by this paper
• Mediating of caspase‐independent apoptosis by cadmium through the mitochondria‐ROS pathway in MRC‐5 fibroblasts

  2004cited by this paper
• Mechanisms of cadmium toxicity in terrestrial pulmonates: Programmed cell death and metallothionein overload

  2004cited by this paper
• Apoptosis and necrosis: two distinct events induced by cadmium in cortical neurons in culture

  2003cited by this paper
• Cadmium directly induced the opening of membrane permeability pore of mitochondria which possibly involved in cadmium-triggered apoptosis.

  2003cited by this paper
• Cadmium-induced changes in apoptotic gene expression levels and DNA damage in mouse embryos are blocked by zinc.

  2003cited by this paper
• Cadmium induces apoptosis in anterior pituitary cells that can be reversed by treatment with antioxidants.

  2003cited by this paper
• Cadmium alters the localization of N-cadherin, E-cadherin, and beta-catenin in the proximal tubule epithelium.

  2003cited by this paper
• Study of the activity of several brain enzymes like markers of the neurotoxicity induced by perinatal exposure to lead and/or cadmium.

  2003cited by this paper
• Influence of cadmium exposure on in vitro ovine gamete dysfunction.

  2002cited by this paper
• Cadmium induces apoptosis partly via caspase-9 activation in HL-60 cells.

  2002cited by this paper
• Effect of zinc ion on cadmium-induced auditory changes

  2002influential reference
• Occupational relevance of positive standard patch-test results in employed persons with an initial report of an occupational skin disease

  2002cited by this paper
• Protection against Anoikis and Down-regulation of Cadherin Expression by a Regulatable β-Catenin Protein*

  2002cited by this paper
• Leupeptin protects cochlear and vestibular hair cells from gentamicin ototoxicity.

  2002cited by this paper
• Effects of cadmium on the hearing system.

  2001influential reference
• Cadmium‐induced apoptosis and phenotypic changes in mouse thymocytes

  2001cited by this paper
• Cadmium distribution and toxicity in tissues of small rodents

  2001cited by this paper
• Opposite roles of ERK and p38 mitogen-activated protein kinases in cadmium-induced genotoxicity and mitotic arrest.

  2001cited by this paper
• Neurobehavioural effects of occupational exposure to cadmium: a cross sectional epidemiological study

  2000cited by this paper
• Cadmium induces caspase-mediated cell death: suppression by Bcl-2.

  2000cited by this paper
• Roles of JNK, p38 and ERK mitogen-activated protein kinases in the growth inhibition and apoptosis induced by cadmium.

  2000cited by this paper
• Evidence that E-cadherin may be a target for cadmium toxicity in epithelial cells.

  2000influential reference
• Stimulation of p38 Mitogen-activated Protein Kinase Is an Early Regulatory Event for the Cadmium-induced Apoptosis in Human Promonocytic Cells*

  2000cited by this paper
• The effect of combined administration of cadmium and furosemide on auditory function in the rat.

  1999influential reference
• Cadmium: a possible etiological factor in peripheral polyneuropathy.

  1999cited by this paper
• Insights into ototoxicity. Analogies to nephrotoxicity.

  1999cited by this paper
• Insights into Ototoxicity

  1999cited by this paper
• Abolishing cadmium toxicity in Chlorella vulgaris by ascorbic acid, calcium, glucose and reduced glutathione.

  1998cited by this paper
• Cadmium (Cd2+) disrupts E-cadherin-dependent cell-cell junctions in MDCK cells

  1997cited by this paper
• Parkinsonism after acute cadmium poisoning.

  1997cited by this paper
• Oxidative stress-mediated neurotoxicity of cadmium.

  1996cited by this paper
• In vivo studies of cadmium-induced apoptosis in testicular tissue of the rat and its modulation by a chelating agent.

  1996cited by this paper
• Zinc-and/or cadmium-induced intestinal metallothionein and copper metabolism in adult rats

  1996cited by this paper
• Protective roles of glutathione in the toxicity of mercury and cadmium compounds to C6 glioma cells.

  1996cited by this paper
• Cd(2+)-induced injury in CNS white matter.

  1996cited by this paper
• The World Health Organization study on health effects of exposure to cadmium: morbidity studies.

  1992cited by this paper
• The World Health Organization study on health effects of exposure to cadmium: morbidity studies.

  1992cited by this paper
• Exogenous glutathione decreases cellular cadmium uptake and toxicity.

  1992cited by this paper
• Effects of copper, cadmium and nickel on liver and kidney glutathione redox cycle of rats (Rattus sp.).

  1992cited by this paper
• Cadmium (Cd2+) disrupts intercellular junctions and actin filaments in LLC-PK1 cells.

  1991cited by this paper
• Pathological Study on Beagles after Long-term Oral Administration of Cadmium

  1991cited by this paper
• Effects of fasting on cadmium toxicity, glutathione metabolism, and metallothionein synthesis in rats.

  1990cited by this paper
• Nephrotoxic and ototoxic agents.

  1990cited by this paper
• A morphometric and x-ray energy dispersive approach to monitoring pH-altered cadmium toxicity inAnabaena flos-aquae

  1990cited by this paper
• Metal toxicity and the respiratory tract.

  1990cited by this paper
• Neuropsychological effects of occupational exposure to cadmium.

  1989cited by this paper
• Glutathione and metallothioneins as cellular defense against cadmium toxicity in cultured Chinese hamster cells.

  1988cited by this paper
• Chelating-agent suppression of cadmium-induced hepatotoxicity.

  1987cited by this paper
• Glutathione, a first line of defense against cadmium toxicity

  1987cited by this paper
• Glutathione content and GSH S-transferase activity in midgut gland of Procambarus clarkii. Sex differences, the effect of fasting, and their implications in cadmium toxicity.

  1987cited by this paper

• Clinical Doses of Gadodiamide Have No Damaging Effects on Cochlear Tissue In Vitro and In Vivo.

  2025cites this paper
• Which Environmental Pollutants Are Toxic to Our Ears?—Evidence of the Ototoxicity of Common Substances

  2024cites this paper
• Plasma Ionomic Profile and Interaction Patterns in Coronary Artery Disease Patients

  2024cites this paper
• The role of calcium, Akt and ERK signaling in cadmium-induced hair cell death.

  2023cites this paper
• The role of calcium, Akt and ERK signaling in cadmium-induced hair cell death

  2023cites this paper
• 3,5,6-Trichloro-2-pyridinol confirms ototoxicity in mouse cochlear organotypic cultures and induces cytotoxicity in HEI-OC1 cells.

  2023cites this paper
• The Concurrent Effect of Lead and Noise on Noise-Induced Hearing Loss at 4 kHz Frequency: An Experimental Study

  2022cites this paper
• Metformin attenuates cadmium-induced degeneration of spiral ganglion neuron via restoring autophagic flux in primary culture.

  2022cites this paper
• N-acetylcysteine protect inner hair cells from cisplatin by alleviated celluar oxidative stress and apoptosis.

  2022cites this paper
• Salidroside protects inner ear hair cells and spiral ganglion neurons from manganese exposure by regulating ROS levels and inhibiting apoptosis.

  2019cites this paper
• Mechanotransduction Activity Facilitates Hair Cell Toxicity Caused by the Heavy Metal Cadmium

  2019cites this paper
• Environmental ototoxicants, a potential new class of chemical stressors

  2019cites this paper
• Association between cadmium exposure and hearing impairment: a population-based study in Korean adults

  2019cites this paper
• ENVIRONMENTAL EXPOSURES TO LOW LEVEL OF CADMIUM AND LEAD AND HEARING IMPAIRMENT IN IRAQI PATIENTS

  2018cites this paper
• Comparison of Pure-Tone Average Methods for Estimation of Hearing Loss Caused by Environmental Exposure to Lead and Cadmium: Does the Pure-Tone Average Method Which Uses Low-Frequency Ranges Underestimate the Actual Hearing Loss Caused by Environmental Lead and Cadmium Exposure?

  2018influential citation
• Paraquat initially damages cochlear support cells leading to anoikis‐like hair cell death

  2018cites this paper
• Environmental exposure to cadmium—a risk for health of the general population in industrialized countries and preventive strategies

  2018cites this paper
• Carbaryl‐induced ototoxicity in rat postnatal cochlear organotypic cultures

  2017influential citation
• N-Acetylcysteine protects inner ear hair cells and spiral ganglion neurons from manganese exposure by regulating ROS levels.

  2017cites this paper
• Trimethyltin-induced cochlear degeneration in rat

  2016cites this paper
• Ototoxicity of Divalent Metals

  2016cites this paper
• New Insights into EDTA In Vitro Effects on Endothelial Cells and on In Vivo Labeled EDTA Biodistribution

  2016cites this paper
• Short-term cadmium exposure induces stress responses in frog (Pelophylax bergeri) skin organ culture.

  2015cites this paper
• University of Birmingham Translational biomarkers of neurotoxicity

  2015cites this paper
• Translational Biomarkers of Neurotoxicity: A Health and Environmental Sciences Institute Perspective on the Way Forward

  2015cites this paper
• Cobalt-Induced Ototoxicity in Rat Postnatal Cochlear Organotypic Cultures

  2015cites this paper
• Characteristic anatomical structures of rat temporal bone

  2015cites this paper
• Endogenous concentrations of biologically relevant metals in rat brain and cochlea determined by inductively coupled plasma mass spectrometry

  2014cites this paper
• Cellular localization and developmental changes of Zip8, Zip14 and transferrin receptor 1 in the inner ear of rats

  2014cites this paper