Ischaemic preconditioning-regulated miR-21 protects heart against ischaemia/reperfusion injury via anti-apoptosis through its target PDCD4.

No abstract is available for this paper.

• Publication year

  2010

• Venue

  Cardiovascular Research

• Publication date

  2010-08-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1093/cvr/cvq082PMID 20219857PMCID PMC2904662
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• Ischemic Preconditioning: From Molecular Mechanisms to Therapeutic Opportunities

  2008cited by this paper
• The endothelial-specific microRNA miR-126 governs vascular integrity and angiogenesis.

  2008cited by this paper
• Molecular mechanism of preconditioning

  2008cited by this paper
• Endogenous microRNAs induced by heat‐shock reduce myocardial infarction following ischemia–reperfusion in mice

  2008cited by this paper
• Future use of genomics in coronary artery disease.

  2007cited by this paper
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  2007cited by this paper
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  2007cited by this paper
• Altered microRNA expression in human heart disease.

  2007cited by this paper
• Antisense inhibition of human miRNAs and indications for an involvement of miRNA in cell growth and apoptosis

  2005cited by this paper
• Silencing of microRNAs in vivo with ‘antagomirs’

  2005cited by this paper
• The Widespread Impact of Mammalian MicroRNAs on mRNA Repression and Evolution

  2005cited by this paper
• MicroRNAs: a developing story.

  2005cited by this paper
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  2004cited by this paper
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  2003cited by this paper

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  2019cites this paper
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  2019cites this paper
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  2019cites this paper
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  2019cites this paper
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  2019cites this paper