Immunological aspects in the neurobiology of suicide: elevated microglial density in schizophrenia and depression is associated with suicide.

No abstract is available for this paper.

• Publication year

  2008

• Venue

  Journal of Psychiatric Research

• Publication date

  Unknown publication date

• Fields of study

  Medicine, Psychology

• Identifiers
  DOI 10.1016/J.JPSYCHIRES.2006.10.013PMID 17174336
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Microglia serve as a neuroimmune substrate for stress-induced potentiation of CNS pro-inflammatory cytokine responses.

  2007cited by this paper
• Distribution of HLA-DR-positive microglia in schizophrenia reflects impaired cerebral lateralization

  2006cited by this paper
• Increased Plasma Nitric Oxide Metabolites in Suicide Attempters

  2006cited by this paper
• Increased plasma nitric oxide level associated with suicide attempt in depressive patients.

  2006cited by this paper
• Differences in activation of the dorsal raphe nucleus depending on performance of suicide.

  2005cited by this paper
• Quantitative analysis of activated microglia, ramified and damage of processes in the frontal and temporal lobes of chronic schizophrenics.

  2005cited by this paper
• Impaired decision making in suicide attempters.

  2005cited by this paper
• Decreases in peripheral-type benzodiazepine receptors in postmortem brains of chronic schizophrenics

  2005cited by this paper
• [The immunology of psychiatric disorders].

  2005cited by this paper
• Hypothalamic nitric oxide synthase in affective disorder: focus on the suprachiasmatic nucleus.

  2005cited by this paper
• Dopamine and noradrenaline control distinct functions in rodent microglial cells.

  2005cited by this paper
• Psychische Erkrankungen und Immunsystem

  2005cited by this paper
• Immunological aetiology of major psychiatric disorders: evidence and therapeutic implications.

  2005cited by this paper
• The many faces of nitric oxide in schizophrenia. A review.

  2005cited by this paper
• Cytokine networks in patients with schizophrenia and their possible role in its pathophysiology

  2004cited by this paper
• [Cytokine network in patients with schizophrenia and its significance for the pathophysiology of the illness].

  2004cited by this paper
• Degeneration of microglial cells in frontal and temporal lobes of chronic schizophrenics.

  2004cited by this paper
• Chlorpromazine and loxapine reduce interleukin-1beta and interleukin-2 release by rat mixed glial and microglial cell cultures.

  2004cited by this paper
• The Neurobiology of Suicide and Suicidality

  2003cited by this paper
• GABA B receptor subunit expression in glia.

  2003cited by this paper
• The neurobiology of suicide and suicidality.

  2003cited by this paper
• Effects of norepinephrine on rat cultured microglial cells that express alpha1, alpha2, beta1 and beta2 adrenergic receptors.

  2002cited by this paper
• Functional expression of corticotropin‐releasing hormone (CRH) receptor 1 in cultured rat microglia

  2002cited by this paper
• Effects of norepinephrine on rat cultured microglial cells that express α1, α2, β1 and β2 adrenergic receptors

  2002cited by this paper
• Microglial derived nitric oxide decreases serotonin content in rat basophilic leukemia (RBL-2H3) cells.

  2002cited by this paper
• Local distribution of microglia in the normal adult human central nervous system differs by up to one order of magnitude

  2001cited by this paper
• AMPA–Kainate Subtypes of Glutamate Receptor in Rat Cerebral Microglia

  2000cited by this paper
• Increase in HLA‐DR Immunoreactive Microglia in Frontal and Temporal Cortex of Chronic Schizophrenics

  2000cited by this paper
• Expression of CD40 in the brain of Alzheimer's disease and other neurological diseases.

  2000cited by this paper
• Absence of neurodegeneration in the thalamus and caudate of elderly patients with schizophrenia.

  2000cited by this paper
• T-cell subsets in schizophrenia: a comparison between drug-naive first episode patients and chronic schizophrenic patients.

  1999cited by this paper
• Evidence for activation of microglia in patients with psychiatric illnesses.

  1999cited by this paper
• Accumulation of macrophages in the CSF of schizophrenic patients during acute psychotic episodes.

  1999cited by this paper
• Absence of neurodegeneration and neural injury in the cerebral cortex in a sample of elderly patients with schizophrenia.

  1998cited by this paper
• Psychoneuroimmunology and the cytokine action in the CNS: implications for psychiatric disorders.

  1998cited by this paper
• Dynamics of microglial activation in the spinal cord after cerebral infarction are revealed by expression of MHC class II antigen

  1998cited by this paper
• The psychological and psychiatric effects of rIL‐2 therapy: a controlled clinical trial

  1997cited by this paper
• Two widely used anti-DRα monoclonal antibodies bind to an intracellular C-terminal epitope

  1997cited by this paper
• Two widely used anti-DR alpha monoclonal antibodies bind to an intracellular C-terminal epitope.

  1997cited by this paper
• Role of nitric oxide in learning and memory and in monoamine metabolism in the rat brain

  1995cited by this paper
• Alterations in the N-methyl-D-aspartate (NMDA) receptor complex in the frontal cortex of suicide victims.

  1995cited by this paper
• Cytokine-specific central monoamine alterations induced by interleukin-1, -2 and -6.

  1994cited by this paper
• Possible association of interleukin-2 treatment with depression and suicide

  1993cited by this paper
• Interleukin‐2 Modulates Evoked Release of [3H]Dopamine in Rat Cultured Mesencephalic Cells

  1993cited by this paper
• Perivascular microglia defined.

  1990cited by this paper
• Expression of immune system-associated antigens by cells of the human central nervous system: relationship to the pathology of Alzheimer's disease.

  1988cited by this paper

• Glucocorticoid Treatment Dampens Kynurenine Pathway Activation and Cytokine Release in Immune Stimulated Human Microglia

  2026cites this paper
• Bidirectional Mendelian Randomization and Colocalization Study of Memory B Cells and Major Depressive Disorder

  2026cites this paper
• Synaptic effects of interleukin-6 on human iPSC-derived dopaminergic neurons.

  2026cites this paper
• Atomoxetine suppresses nitric oxide synthesis induced by lipopolysaccharide in BV-2 microglia cells through the modulation of STAT1 and STAT3.

  2026cites this paper
• Research Progress on the Biological Function and Homeostatic Disruption of Microglia in the Pathogenesis of Major Depressive Disorder.

  2026cites this paper
• Chronic starvation induces microglial cell depletion in an activity-based anorexia model

  2025cites this paper
• Gut microbiome-derived tryptophan metabolites predict relapse in alcohol use disorder.

  2025cites this paper
• Depression and Anxiety After Radiation-Induced Brain Injury: A Review of Current Research Progress

  2025cites this paper
• Microglia reactivity is brain region and sex specific in the context of chronic stress

  2025cites this paper
• Microglia as critical mediators linking perinatal immune stress to mental health trajectories

  2025cites this paper
• Immunostimulatory and immunomodulatory effects of duloxetine and venlafaxine on p38 MAPK and PI3K pathways.

  2025cites this paper
• Neuroimmune, metabolic and oxidative stress pathways in major depressive disorder

  2025cites this paper
• Changes in the distribution of elements in the liver and various brain regions in suicides from southeastern Poland

  2025cites this paper
• Targeting Neuroinflammation in Schizophrenia: A comprehensive review of mechanisms and pharmacological interventions.

  2025cites this paper
• Xiaoyao San against depression via glia-mediated neuroinflammation using network pharmacology and experimental validation

  2025cites this paper
• The (neuro)inflammatory system in anxiety disorders and PTSD: Potential treatment targets.

  2025cites this paper
• Hamayou () protein hydrolysate ameliorates depression by regulating the mitogen-activated protein kinase pathway.

  2025cites this paper
• Psychoneuroimmunoendocrinological and neuroanatomical basis of suicidal behavior: potential therapeutic strategies with a focus on transcranial magnetic stimulation (TMS)

  2025influential citation
• Inflammatory chemokines in adolescents’ suicide state with depressive disorders

  2025cites this paper
• Exercise improves depressive-like behavior in adolescent mice by regulating sphingosine and ceramide metabolism through microglial CerS1

  2025cites this paper
• Activation of Hippocampal ACE2 Prevents the Dysbiosis-induced Depression-like Behavior in Mice by Enhanced Neurogenesis and Neuroprotection via Mas Receptor

  2025cites this paper
• Characterizing the HLA region’s genetic architecture through local heritability and correlation analyses across complex traits in diverse ancestries

  2025cites this paper
• Anterior insular cortex regulates depression-like and ASD-like behaviors via the differential contribution of two subsets of microglia

  2025cites this paper
• TRPV1 Suppresses Microglial Inflammatory Activation to Ameliorate Schizophrenia-Associated Behaviors in Maternal Separation Rats.

  2025cites this paper
• Assessing the relationship between suicidality and inflammatory biomarkers: C-reactive protein/albumin and neutrophil/albumin ratios in an inpatient setting

  2025cites this paper
• Identification of blood transcriptome modules associated with suicidal ideation in patients with major depressive disorder

  2025cites this paper
• Comparison of the Kynurenine/Tryptophan Ratio with the Beck Suicide Intent Scale in Patients Admitted to the Emergency Department Due to Suicide Attempt

  2025cites this paper
• Acori Tatarinowii Rhizoma-Curcumae Radix Herbal pair ameliorates depression by regulating microglia M1/M2 polarization via TLR4/MyD88/NF-κB pathway.

  2025cites this paper
• Structural brain changes in the anterior cingulate cortex of major depressive disorder individuals with suicidal ideation: Evidence from the REST-meta-MDD project

  2025cites this paper
• U-shaped association between systemic immune-inflammatory index and depression in U.S. adults with hypertension.

  2025cites this paper
• Influence of antipsychotic drugs on microglia-mediated neuroinflammation in schizophrenia: perspectives in an astrocyte–microglia co-culture model

  2025cites this paper
• Comprehensive view of suicide: A neuro-immune-endocrine approach

  2025cites this paper
• Gene expression of psychiatric disorder-related kinesin superfamily proteins (Kifs) is potentiated in alternatively activated primary cultured microglia

  2025cites this paper
• Neuroinflammation in Schizophrenia: An Overview of Evidence and Implications for Pathophysiology.

  2025cites this paper
• Gender differences in gray matter volume of the anterior cingulate cortex and suicidal ideation in patients with major depressive disorder: evidence from the REST-meta-MDD project

  2025cites this paper
• Pharmacological mechanism and structure of ubiquitin proteases associated with depression: A review.

  2025cites this paper
• Zinc Ameliorates LPS-Induced Depressive-Like Behaviors Via Modulating Microglial Polarization.

  2025cites this paper
• Neuroglia in suicide.

  2025cites this paper
• The correlation of inflammation, tryptophan-kynurenine pathway, and suicide risk in adolescent depression

  2024cites this paper
• Tofacitinib prevents depressive-like behaviors through decreased hippocampal microgliosis and increased BDNF levels in both LPS-induced and CSDS-induced mice

  2024cites this paper
• Neurobiology and medico-legal aspects of suicides among older adults: a narrative review

  2024cites this paper
• Human monocyte‐derived microglia‐like (iMG) cells: A tool to explore microglial dynamics

  2024cites this paper
• Neurodevelopmental and Neuropsychiatric Disorders.

  2024cites this paper
• Altered transcriptomes, cell type proportions, and dendritic spine morphology in hippocampus of suicide decedents.

  2024cites this paper
• Efficacy of Pentoxifylline for the Treatment of Bipolar I/II Patients with Treatment-Resistant Depression: A Proof-of-Concept, Randomized, Double-Blind, Placebo-Controlled Trial.

  2024cites this paper
• The role of netrin G1-netrin-G-ligand-1 in schizophrenia

  2024cites this paper
• Glial Markers of Suicidal Behavior in the Human Brain—A Systematic Review of Postmortem Studies

  2024influential citation
• RNA-sequencing suggests extracellular matrix and vasculature dysregulation could impair neurogenesis in schizophrenia cases with elevated inflammation

  2024cites this paper
• Associations of the immune system in aggression traits and the role of microglia as mediators.

  2024cites this paper
• Polarization to M1-type microglia in the hippocampus is involved in depression-like behavior in a mouse model of olfactory dysfunction.

  2024cites this paper
• Inflammatory mediators in major depression and bipolar disorder

  2024cites this paper
• Antidepressant-like effect of riparin I and riparin II against CUMS-induced neuroinflammation via astrocytes and microglia modulation in mice

  2024cites this paper
• The inflammatory underpinning of depression: An historical perspective.

  2024cites this paper
• The Role of Inflammation in Depression and Beyond: A Primer for Clinicians

  2024cites this paper
• Higher Seasonal Variation of Systemic Inflammation in Bipolar Disorder

  2024cites this paper
• Inflammation-related abnormal dynamic brain activity correlates with cognitive impairment in first-episode, drug-naïve major depressive disorder.

  2024cites this paper
• Acupuncture may play a key role in anti-depression through various mechanisms in depression

  2024cites this paper
• Embers of the Past: Early Childhood Traumas Interact with Variation in P2RX7 Gene Implicated in Neuroinflammation on Markers of Current Suicide Risk

  2024cites this paper
• Shared and unique transcriptional changes in the orbitofrontal cortex in psychiatric disorders and suicide

  2024cites this paper
• Potential Involvement of Human Leukocyte Antigen-DR/DQ Polymorphisms with Schizophrenia Among Patients with Schizophrenia in Yemen.

  2024cites this paper
• Targeting autophagy to counteract neuroinflammation: a novel antidepressant strategy.

  2024cites this paper
• Neurobiological mechanisms in the kynurenine pathway and major depressive disorder

  2024cites this paper
• Neuronal deletion of Gtf2i results in developmental microglial alterations in a mouse model related to Williams syndrome

  2024cites this paper
• Neuroinflammation, Stress-Related Suicidal Ideation, and Negative Mood in Depression.

  2024cites this paper
• Individuals Who Had a Lifetime History of Suicide Attempts and Their Relationships With Inflammation, Severity of Depressive Symptoms, and Childhood Maltreatments

  2024cites this paper
• Abnormal choroid plexus, hippocampus, and lateral ventricles volumes as markers of treatment‐resistant major depressive disorder

  2024cites this paper
• High CSF neurogranin level is related to lifetime reports of passive suicidal ideation in a population-based sample of older adults.

  2024cites this paper
• Immunotherapy for depression: Recent insights and future targets.

  2024cites this paper
• The impact of stress on the behavior of C57BL/6 mice with liver injury: a comparative study

  2024cites this paper
• The Role of Stress in the Progression of Motor Neuron Disease: Mechanisms and Implications for Treatment

  2023cites this paper
• Choroid plexus volume is increased in mood disorders and associates with circulating inflammatory cytokines.

  2023cites this paper
• Major depressive disorder as a neuro-immune disorder: origin, mechanisms, and therapeutic opportunities.

  2023cites this paper
• A review on linking stress, depression, and insulin resistance via low-grade chronic inflammation

  2023cites this paper
• The role of microglia in depression

  2023cites this paper
• How fish consumption prevents the development of Major Depressive Disorder? A comprehensive review of the interplay between n-3 PUFAs, LTP and BDNF.

  2023cites this paper
• Nrf2 regulates iron-dependent hippocampal synapses and functional connectivity damage in depression

  2023cites this paper
• Diosmin ameliorates LPS-induced depression-like behaviors in mice: inhibition of inflammation and oxidative stress in the prefrontal cortex.

  2023cites this paper
• Ameliorative effects of Fingolimod (FTY720) on microglial activation and psychosis-related behavior in short term cuprizone exposed mice

  2023cites this paper
• Fight the Fire: Association of Cytokine Genomic Markers and Suicidal Behavior May Pave the Way for Future Therapies

  2023cites this paper
• Mechanistic insights into the anti-depressant effect of curcumin based on network pharmacology and experimental validation

  2023cites this paper
• Microglial Responses to Stress-Induced Depression: Causes and Consequences

  2023cites this paper
• Inflammation and viral infection as disease modifiers in schizophrenia

  2023cites this paper
• SARS-CoV-2 envelope protein triggers depression-like behaviors and dysosmia via TLR2-mediated neuroinflammation in mice

  2023cites this paper
• Increased pituitary adenylate cyclase-activating peptide genes expression in the prefrontal cortex in schizophrenia in relation to suicide

  2023cites this paper
• Ketamine – A New Antidepressant Drug with Anti-Inflammatory Properties

  2023cites this paper
• Breaking free from the inflammatory trap of depression: Regulating the interplay between immune activation and plasticity to foster mental health

  2023cites this paper
• Neuroinflammation and microglial expression in brains of social-isolation rearing model of schizophrenia

  2023cites this paper
• Pharmacological Mechanism of Ketamine in Suicidal Behavior Based on Animal Models of Aggressiveness and Impulsivity: A Narrative Review

  2023cites this paper
• Exploring the role of ketone bodies in the diagnosis and treatment of psychiatric disorders

  2023cites this paper
• A consideration of the increased risk of schizophrenia due to prenatal maternal stress, and the possible role of microglia.

  2023cites this paper
• Suicide and Inflammation.

  2023cites this paper
• Schizophrenia and oxidative stress from the perspective of bibliometric analysis

  2023cites this paper
• Vitamin D in Depression: A Potential Bioactive Agent to Reduce Suicide and Suicide Attempt Risk

  2023cites this paper
• [Immune mechanisms of complicity of somatic pathology in the pathogenesis of mental disorders].

  2023cites this paper
• Chemokine receptor 5 signaling in PFC mediates stress susceptibility in female mice

  2023cites this paper
• SARS-CoV-2 Envelope protein triggers depression and dysosmia via TLR2 mediated neuroinflammation

  2023cites this paper
• Brain Inflammatory Marker Abnormalities in Major Psychiatric Diseases: a Systematic Review of Postmortem Brain Studies

  2023cites this paper
• Neuro-immune crosstalk in depressive symptoms of multiple sclerosis.

  2023cites this paper
• Association of HLA class II alleles with suicidal behavior in a Transylvanian population

  2023cites this paper
• Microglia and Other Cellular Mediators of Immunological Dysfunction in Schizophrenia: A Narrative Synthesis of Clinical Findings

  2023influential citation