High von Willebrand factor concentration compensates a relative adhesion defect in uremic blood.

No abstract is available for this paper.

• Publication year

  1990

• Venue

  Blood

• Publication date

  1990-04-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1182/BLOOD.V75.7.1498.BLOODJOURNAL7571498PMID 2156581
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Abnormalities of cytoplasmic Ca2+ in platelets from patients with uremia.

  1989cited by this paper
• Plasma and platelet von Willebrand factor defects in uremia.

  1989cited by this paper
• Bleeding in renal failure.

  1988cited by this paper
• Plasma and platelet von Willebrand factor defects in uremia.

  1988cited by this paper
• Improvement in the haemostatic defect of uraemia after treatment with recombinant human erythropoietin.

  1987cited by this paper
• Platelet count and thrombopoietic activity in patients with chronic renal failure.

  1987cited by this paper
• The role of platelet membrane glycoproteins Ib and IIb‐IIIa in platelet adherence to human artery subendothelium

  1986cited by this paper
• Platelet Dysfunction in Uremia. Multifaceted Defect Partially Corrected by Dialysis

  1986cited by this paper
• Subendothelial Proteins and Platelet Adhesion: von Willebrand Factor and Fibronectin, Not Thrombospondin, Are involved in Platelet Adhesion to Extracellular Matrix of Human Vascular Endothelial Cells

  1986cited by this paper
• Enhanced in vitro platelet aggregation in hemodialysis patients.

  1986cited by this paper
• Evidence against a platelet cyclooxygenase defect in uraemic subjects on chronic haemodialysis

  1986cited by this paper
• Anemia of end-stage renal disease (ESRD).

  1985cited by this paper
• Differentiation of patients with subtype IIb‐like von Willebrand's disease by means of perfusion experiments with reconstituted blood

  1985cited by this paper
• Platelet dysfunction in uremia. Multifaceted defect partially corrected by dialysis.

  1985cited by this paper
• Von Willebrand factor in the vessel wall mediates platelet adherence.

  1985cited by this paper
• Fibronectin in artery subendothelium is important for platelet adhesion

  1985cited by this paper
• Low haematocrit and prolonged bleeding time in uraemic patients: effect of red cell transfusions

  1985cited by this paper
• Factor VIII/von Willebrand factor in subendothelium mediates platelet adhesion.

  1985cited by this paper
• Fibronectin in artery subendothelium is important for platelet adhesion.

  1985cited by this paper
• DDAVP enhances platelet adherence and platelet aggregate growth on human artery subendothelium.

  1984cited by this paper
• Factor VIII-von Willebrand factor requires calcium for facilitation of platelet adherence

  1984cited by this paper
• Adhesion of platelets to human artery subendothelium: effect of factor VIII-von Willebrand factor of various multimeric composition.

  1984cited by this paper
• Velocity profiles in annular perfusion chamber measured by laser-Doppler velocimetry.

  1984cited by this paper
• Factor VIII-von Willebrand factor requires calcium for facilitation of platelet adherence.

  1984cited by this paper
• Red blood cell deformability influences platelets--vessel wall interaction in flowing blood.

  1984cited by this paper
• Reduced platelet thromboxane formation in uremia. Evidence for a functional cyclooxygenase defect.

  1983cited by this paper
• Deamino-8-D-arginine vasopressin shortens the bleeding time in uremia.

  1983cited by this paper
• Red blood cell size is important for adherence of blood platelets to artery subendothelium.

  1983cited by this paper
• Red blood cell size is important for adherence of blood platelets to artery subendothelium

  1983cited by this paper
• Uraemic bleeding: role of anaemia and beneficial effect of red cell transfusions.

  1982cited by this paper
• URAEMIC BLEEDING: ROLE OF ANAEMIA AND BENEFICIAL EFFECT OF RED CELL TRANSFUSIONS

  1982cited by this paper
• Adenylate cyclase activity and cAMP content of human platelets in uraemia

  1982cited by this paper
• Elevated thrombocyte calcium content in uremia and its correction by 1 alpha(OH) vitamin D treatment.

  1982cited by this paper
• Elevated Thrombocyte Calcium Content in Uremia and Its Correction by 1α(OH) Vitamin D Treatment

  1982cited by this paper
• The Role of Factor VIII-von Willebrand Factor in Adhesion of Platelets to the Vessel Wall

  1982cited by this paper
• Factor VIII complex in uraemia and effects of haemodialysis.

  1981cited by this paper
• Binding of factor VIII-von Willebrand factor to human arterial subendothelium precedes increased platelet adhesion and enhances platelet spreading.

  1981cited by this paper
• Platelet adherence to subendothelium of human arteries in pulsatile and steady flow.

  1980cited by this paper
• Treatment of the bleeding tendency in uremia with cryoprecipitate.

  1980cited by this paper
• Increased factor VIII/von Willebrand factor antigen and von Willebrand factor activity in renal failure.

  1979cited by this paper
• Simultaneous measurement of aggregation, secretion, oxygen uptake, proton production, and intracellular metabolites in the same platelet suspension.

  1979cited by this paper
• Rheological Factors Influencing Platelet Interaction with Vessel Surfaces

  1979cited by this paper
• Human blood platelet adhesion to artery subendothelium is mediated by factor VIII–Von Willebrand factor bound to the subendothelium

  1979cited by this paper
• Platelet interaction with subendothelium in flowing rabbit blood: effect of blood shear rate.

  1979cited by this paper
• Protein and cell membrane iodinations with a sparingly soluble chloroamide, 1,3,4,6-tetrachloro-3a,6a-diphrenylglycoluril.

  1978cited by this paper
• Correction by factor VIII of the impaired platelet adhesion to subendothelium in von Willebrand disease.

  1978cited by this paper
• Bleeding in renal failure: altered platelet function in chronic uraemia only partially corrected by haemodialysis.

  1978cited by this paper
• Effect of shear rate on platelet interaction with subendothelium in citrated and native blood. I. Shear rate--dependent decrease of adhesion in von Willebrand's disease and the Bernard-Soulier syndrome.

  1978cited by this paper
• Bleeding in renal failure: is von Willebrand factor implicated?

  1977cited by this paper
• Bleeding in renal failure: a possible cause.

  1977cited by this paper
• The hemostatic plug.

  1977cited by this paper
• Effect of Physical Factors on Platelet Adhesion to Subendothelium

  1976cited by this paper
• Immunoradiometric Assay of Factor VIII Related Antigen, with Observations in 32 Patients with von Willebrand's Disease

  1976cited by this paper
• Platelet Adhesion, Release and Aggregation in Flowing Blood: Effects of Surface Properties and Platelet Function.

  1976cited by this paper
• Bleeding in renal failure: a possible cause.

  1976cited by this paper
• Physiological Experiments in Haemostasis and Thrombosis

  1975cited by this paper
• A Method for Assaying von Willebrand Factor (Ristocetin Cofactor)

  1975cited by this paper
• Dilution of haemophilic plasma used as a reagent in the determination of anti-haemophilic factor A (factor VIII).

  1974cited by this paper
• The role of blood flow in platelet adhesion, fibrin deposition, and formation of mural thrombi.

  1973cited by this paper
• Standardzed bleeding time in the study of drugs interfering with platelet function.

  1972cited by this paper
• Early Interactions Between Blood Cells and Severely Damaged Rabbit Aorta

  1971cited by this paper
• On coagulation and fibrinolysis in renal failure.

  1971cited by this paper
• Purification of human antihemophilic factor (factor VIII) by gel chromatography.

  1970cited by this paper
• Detection of the Carrier State in Hereditary Coagulation Disorders II

  1968cited by this paper
• SECONDARY THROMBOCYTOPATHIA. PLATELET FACTOR 3 IN VARIOUS DISEASE STATES.

  1963cited by this paper
• The Role of Red Cells in Haemostasis: the Relation between Haematocrit, Bleeding Time and Platelet Adhesiveness

  1961cited by this paper
• Bleeding tendency in uremia.

  1959cited by this paper
• Characterization of the anemia associated with chronic renal insufficiency.

  1958cited by this paper
• Bleeding tendency in uremia.

  1956cited by this paper

• Comparative evaluation of coagulation profiles across different stages of chronic kidney disease: A cross-sectional study.

  2025cites this paper
• Redefining haemostasis: Role of rotational thromboelastometry in critical care settings

  2025cites this paper
• One‐Year Risk of Bleeding in Patients on a Stable Warfarin Dose After Prosthetic Heart Valve Surgery

  2025cites this paper
• A comparative study on the haemostatic changes in kidney failure patients: Pre- and post- haemodialysis and haemodiafiltration.

  2024cites this paper
• The in-vitro influence of urea concentration on thromboelastrography in patients with and without end stage renal disease.

  2023cites this paper
• A Molecular Troika of Angiogenesis, Coagulopathy and Endothelial Dysfunction in the Pathology of Avascular Necrosis of Femoral Head: A Comprehensive Review

  2023cites this paper
• Pathophysiological Changes in the Hemostatic System and Antithrombotic Management in Kidney Transplant Recipients

  2022cites this paper
• Evaluation of novel coagulation and platelet function assays in patients with chronic kidney disease

  2022cites this paper
• Anemia-Induced Bleeding in Patients with Platelet Disorders.

  2021cites this paper
• Hemostatic Changes of Acute Kidney Injury in Patients With Cirrhosis: What Do They Mean?

  2020cites this paper
• Application of Desmopressin and conjugated estrogens to reduce the volume of blood loss during arthroplsty of the hip joint in patients with end stage renal disease

  2020cites this paper
• Contrast induced acute kidney injury and the role of beta-blockers in its prevention.

  2019cites this paper
• Evaluation of hemostasis in patients with end-stage renal disease

  2019cites this paper
• Bleeding and Hemostasis in Acute Renal Failure

  2019cites this paper
• Concepts and Controversies in Haemostasis and Thrombosis Associated with Liver Disease: Proceedings of the 7th International Coagulation in Liver Disease Conference

  2018cites this paper
• Hemostatic Abnormalities in Severe Renal Failure: Do They Bark or Bite?

  2018cites this paper
• University of Groningen Concepts and Controversies in Haemostasis and Thrombosis Associated with Liver Disease faculty of the 7th International Coagulation in Liver Disease

  2018cites this paper
• Oral antiplatelet drugs in patients with chronic kidney disease (CKD): a review

  2017cites this paper
• Platelets in liver and renal disease.

  2016cites this paper
• Coagulopathy of Renal Disease

  2016cites this paper
• Impact of Contrast-Induced Acute Kidney Injury After Percutaneous Coronary Intervention on Short- and Long-Term Outcomes: Pooled Analysis From the HORIZONS-AMI and ACUITY Trials

  2015cites this paper
• Early Prediction of Coagulopathy in Acquired Bleeding Disorders - Revisited Using Rotational Thromboelastometry

  2015cites this paper
• An Investigation of the Multifaceted Platelet Dysfunction in Dogs with Naturally-Occurring Chronic Kidney Disease

  2014cites this paper
• Alterações da hemostasia primária em cães azotêmicos* Alterations of Primary Hemostasis in Azotemic Dogs

  2013cites this paper
• Bleeding Diathesis in Hemodialysis Patients

  2013cites this paper
• Platelet function in bleeding disorders

  2013cites this paper
• Alterations of primary hemostasis in azotemic dogs.

  2013cites this paper
• Alterações da hemostasia primária em cães azotêmicos

  2013cites this paper
• Hemostatic defects in liver and renal dysfunction.

  2012cites this paper
• Platelets of patients with chronic kidney disease demonstrate deficient platelet reactivity in vitro

  2012cites this paper
• The role of hypercoagulability in the development of osteonecrosis of the femoral head

  2012cites this paper
• Platelet function as measured by the thromboelastrogram in end stage renal failure patients presenting for surgery – a pilot study.

  2012cites this paper
• Prevalence of abnormal in vitro closure time using the Platelet Function Analyzer-100 in chronic kidney disease patients and analysis of associated factors.

  2011cites this paper
• CHAPTER 33 – Acquired disorders affecting megakaryocytes and platelets

  2011cites this paper
• Uremic bleeding with pericardial and subconjunctival hemorrhage.

  2011cites this paper
• Anticoagulation in intermittent hemodialysis: pathways, protocols, and pitfalls.

  2011cites this paper
• Desmopressin Improves Platelet Dysfunction Measured by in vitro Closure Time in Uremic Patients

  2010cites this paper
• Treatment of Bleeding in Dialysis Patients

  2009cites this paper
• Superimposed coagulopathic conditions in cirrhosis: infection and endogenous heparinoids, renal failure, and endothelial dysfunction.

  2009cites this paper
• The effect of uremia on platelet contractile force, clot elastic modulus and bleeding time in hemodialysis patients.

  2007cites this paper
• Uremic bleeding: pathophysiology and clinical risk factors.

  2006cites this paper
• Thrombozytopathie und Blutungskomplikationen bei Urämie

  2006cites this paper
• Acquired von Willebrand syndrome: Features and management

  2006cites this paper
• [Thrombocytopathy and blood complications in uremia].

  2006cites this paper
• Troubles de l'hémostase au cours de l'insuffisance rénale chronique

  2006cites this paper
• Uremic platelet dysfunction: past and present.

  2005cites this paper
• Extensive bleeding during surgical treatment for gingival overgrowth in a patient on haemodialysis--a case report and review of the literature.

  2005cites this paper
• Hemodialysis, erythropoietin and megakaryocytopoiesis: factors in uremic thrombocytopathy and thrombophilia

  2004cites this paper
• ORIGINAL INVESTIGATIONS Pathogenesis and Treatment of Kidney Disease and Hypertension Inflammation, Endothelial Dysfunction, and Platelet Activation in Patients With Chronic Kidney Disease: The Chronic Renal Impairment in Birmingham (CRIB) Study

  2004cites this paper
• Platelet Dysfunction in Renal Failure

  2004cites this paper
• Inflammation, endothelial dysfunction, and platelet activation in patients with chronic kidney disease: the chronic renal impairment in Birmingham (CRIB) study.

  2004cites this paper
• Platelet dysfunction in renal failure.

  2004cites this paper
• Critical care in uraemic children

  2004cites this paper
• Aspirin Use Post-Acute Coronary Syndromes: Intolerance, Bleeding and Discontinuation

  2003cites this paper
• Acquired von Willebrand Syndrome: Its Pathophysiology, Laboratory Features and Management

  2003cites this paper
• Haemostatic effects of recombinant coagulation factor VIIa

  2002cites this paper
• Acquired von Willebrand Syndrome: Experience from 2 Years in a Single Laboratory Compared with Data from the Literature and an International Registry

  2002cites this paper
• Uremic medium causes expression, redistribution and shedding of adhesion molecules in cultured endothelial cells.

  2002cites this paper
• Uremic Bleeding: Pathophysiology, Diagnosis, and Management

  2001cites this paper
• Uremic Medium Disturbs the Hemostatic Balance of Cultured Human Endothelial Cells

  2001cites this paper
• Plasma and Platelet von Willebrand Factor Abnormalities in Patients With Uremia: Lack of Correlation With Uremic Bleeding

  2001cites this paper
• Comparison of Different Assays for von Willebrand Factor in Hemodialysis Patients

  2000cites this paper
• Abnormal platelet cytoskeletal assembly in hemodialyzed patients results in deficient tyrosine phosphorylation signaling.

  2000cites this paper
• Potential aetiological factors concerning the development of osteonecrosis of the femoral head

  2000cites this paper
• Thrombogenic Risk Factors for Cardiovascular Disease in Dialysis Patients

  1999cites this paper
• Uremic bleeding: pathogenesis and therapy.

  1998cites this paper
• Elevated plasma glycocalicin levels and decreased ristocetin-induced platelet agglutination in hemodialysis patients.

  1998cites this paper
• Fibrinogen, fibrin turnover, endothelial products and vascular surgery

  1997cites this paper
• Hemostatic and fibrinolytic response to desmopressin in uremic patients.

  1997cites this paper
• Bleeding and thrombosis in chronic uremia.

  1997cites this paper
• Hemostatic Disorder of Uremia: The Platelet Defect, Main Determinant of the Prolonged Bleeding Time, Is Correlated with Indices of Activation of Coagulation and Fibrinolysis

  1996cites this paper
• Uremic patients have decreased shear-induced platelet aggregation mediated by decreased availability of glycoprotein IIb-IIIa receptors.

  1996cites this paper
• Thrombogenicity of the human arterial wall after interventional thermal injury.

  1996cites this paper
• Effect of Deamino-8-D-Arginine Desmopressin in Uremic Bleeding

  1996cites this paper
• Disorders of platelet function.

  1996cites this paper
• Fibrinogen and markers of fibrinolysis and endothelial damage following resolution of critical limb ischaemia.

  1995cites this paper
• Platelet disorders in uraemia before and after haemodialysis under the influence of low dose aspirin.

  1995cites this paper
• Impaired high‐shear‐stress‐induced platelet aggregation in patients with chronic renal failure undergoing haemodialysis

  1995influential citation
• Platelet adhesion.

  1995cites this paper
• Impaired function of platelet membrane glycoprotein IIb-IIIa in end-stage renal disease.

  1994cites this paper
• Blood rheology and thrombotic mediators in peripheral arterial disease and revascularisation surgery

  1994cites this paper
• Regulation of Platelet Adhesion to the Vessel Wall

  1994cites this paper
• von Willebrand factor is not altered in azotemic dogs with prolonged bleeding time.

  1994cites this paper
• Techniques for Studying Blood Platelet Adhesion

  1994cites this paper
• Effect of recombinant human erythropoietin on plasma von Willebrand factor in chronic hemodialysis patients

  1994cites this paper
• Thrombosis and hemostasis in renal disease.

  1994cites this paper
• von Willebrand factor binding to collagen in patients with end-stage renal disease.

  1994cites this paper
• The Fibrinolytic System in the Hemolytic Uremic Syndrome: In Vivo and In Vitro Studies

  1994cites this paper
• Endothelium releases more von Willebrand factor and tissue-type plasminogen activator upon venous occlusion in patients with liver cirrhosis than in normals.

  1993cites this paper
• Multimeric pattern of plasma and platelet von willebrand factor is normal in uremic patients

  1993cites this paper
• Reversible activation defect of the platelet glycoprotein IIb-IIIa complex in patients with uremia.

  1993cites this paper
• Abnormal cytoskeletal assembly in platelets from uremic patients.

  1993cites this paper
• Diagnose und Therapie der angeborenen milden Thrombozytenfunktionsstörung: Ein Bericht über 14 Patienten

  1992cites this paper
• Desmopressin (d‐DAVP) effects on platelet rheology and von willebrand factor activities in uremia

  1992cites this paper
• Vessel wall proteins adhesive for platelets.

  1991cites this paper
• Chirurgische Großeingriffe bei Hämophilie A mit begleitender Thrombopathie

  1991cites this paper
• von Willebrand factor and the blood vessel wall.

  1991cites this paper
• Defects in platelet adhesion and aggregate formation in uremic bleeding disorder can be attributed to factors in plasma.

  1991cites this paper
• Treatment of Uremic Anemia with Recombinant Erythropoietin also Reduces the Defects in Platelet Adhesion and Aggregation Caused by Uremic Plasma

  1991cites this paper
• Reduction of platelet glycoprotein Ib in uraemia

  1991cites this paper