Reconstructing human origins in the genomic era

No abstract is available for this paper.

• Publication year

  2006

• Venue

  Nature reviews genetics

• Publication date

  2006-09-01

• Fields of study

  Biology, Medicine, History

• Identifiers
  DOI 10.1038/nrg1941PMID 16921345
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Fixation of the Human-Specific CMP-N-Acetylneuraminic Acid Hydroxylase Pseudogene and Implications of Haplotype Diversity for Human Evolution

  2006cited by this paper
• Deciphering the ancient and complex evolutionary history of human arylamine N-acetyltransferase genes.

  2006cited by this paper
• Possible Ancestral Structure in Human Populations

  2006cited by this paper
• How reliable are empirical genomic scans for selective sweeps?

  2006cited by this paper
• Haplotype trees and modern human origins.

  2005cited by this paper
• Deep Haplotype Divergence and Long-Range Linkage Disequilibrium at Xp21.1 Provide Evidence That Humans Descend From a Structured Ancestral Population

  2005cited by this paper
• Population genetics of CAPN10 and GPR35: implications for the evolution of type 2 diabetes variants.

  2005cited by this paper
• Evidence for archaic Asian ancestry on the human X chromosome.

  2005cited by this paper
• Interrogating multiple aspects of variation in a full resequencing data set to infer human population size changes.

  2005cited by this paper
• Stratigraphic placement and age of modern humans from Kibish, Ethiopia

  2005cited by this paper
• Evidence suggesting that Homo neanderthalensis contributed the H2 MAPT haplotype to Homo sapiens.

  2005cited by this paper
• The assimilation model, modern human origins in europe, and the extinction of neandertals

  2005cited by this paper
• The Heritage of Pathogen Pressures and Ancient Demography in the Human Innate-Immunity CD209/CD209L Region

  2005cited by this paper
• A common inversion under selection in Europeans

  2005cited by this paper
• Heterogeneous Patterns of Variation Among Multiple Human X-Linked Loci

  2004cited by this paper
• Population History and Natural Selection Shape Patterns of Genetic Variation in 132 Genes

  2004cited by this paper
• Compound haplotypes at Xp11.23 and human population growth in Eurasia

  2004cited by this paper
• Maximum-Likelihood Estimation of Demographic Parameters Using the Frequency Spectrum of Unlinked Single-Nucleotide Polymorphisms

  2004cited by this paper
• A structured ancestral population for the evolution of modern humans.

  2004cited by this paper
• Recent developments in genetic data analysis: what can they tell us about human demographic history?

  2004cited by this paper
• Early Dispersals of Homo from Africa

  2004cited by this paper
• Evidence for a complex demographic history of chimpanzees.

  2004cited by this paper
• The Allele Frequency Spectrum in Genome-Wide Human Variation Data Reveals Signals of Differential Demographic History in Three Large World Populations

  2004cited by this paper
• Global patterns of human mitochondrial DNA and Y-chromosome structure are not influenced by higher migration rates of females versus males

  2004cited by this paper
• Genetic evidence for unequal effective population sizes of human females and males.

  2004cited by this paper
• The distribution of the ancestral haplotype in finite stepping‐stone models with population expansion

  2004cited by this paper
• The application of molecular genetic approaches to the study of human evolution

  2003cited by this paper
• Gene diversity patterns at 10 X-chromosomal loci in humans and chimpanzees.

  2003cited by this paper
• A haplotype map of the human genome

  2003cited by this paper
• Linkage disequilibrium in human populations

  2003cited by this paper
• The mosaic that is our genome

  2003cited by this paper
• Low nucleotide diversity in chimpanzees and bonobos.

  2003cited by this paper
• The study of structured populations — new hope for a difficult and divided science

  2003cited by this paper
• Haplotypes in the dystrophin DNA segment point to a mosaic origin of modern human diversity.

  2003cited by this paper
• The Effects of Genetic and Geographic Structure on Neutral Variation

  2003cited by this paper
• A haplotype map of the human genome.

  2003cited by this paper
• Human population structure and its effects on sampling Y chromosome sequence variation.

  2003cited by this paper
• Human evolution: Out of Ethiopia

  2003cited by this paper
• Linkage disequilibrium in human populations

  2003cited by this paper
• Inferences about human demography based on multilocus analyses of noncoding sequences.

  2002cited by this paper
• Out of Africa again and again

  2002cited by this paper
• Evidence for population growth in humans is confounded by fine-scale population structure.

  2002cited by this paper
• DNA sequence variation in a 3.7-kb noncoding sequence 5' of the CYP1A2 gene: implications for human population history and natural selection.

  2002cited by this paper
• Sequence variation and haplotype structure at the human HFE locus.

  2002cited by this paper
• Human demographic history: refining the recent African origin model.

  2002cited by this paper
• A strong signature of balancing selection in the 5′ cis-regulatory region of CCR5

  2002cited by this paper
• Genetics and the Search for Modern Human Origins

  2002cited by this paper
• A Diffusion Wave out of Africa

  2002cited by this paper
• Sequence variability of a human pseudogene.

  2001cited by this paper
• The discovery of single-nucleotide polymorphisms--and inferences about human demographic history.

  2001cited by this paper
• A highly variable segment of human subterminal 16p reveals a history of population growth for modern humans outstide Africa.

  2001cited by this paper
• Testing multiregionality of modern human origins.

  2001cited by this paper
• Contrasting patterns of polymorphisms at the ABO-secretor gene (FUT2) and plasma alpha(1,3)fucosyltransferase gene (FUT6) in human populations.

  2001cited by this paper
• Human populations show reduced DNA sequence variation at the factor IX locus.

  2001cited by this paper
• Linkage disequilibrium in the human genome

  2001cited by this paper
• Global patterns of human DNA sequence variation in a 10-kb region on chromosome 1.

  2001cited by this paper
• Gene genealogies in a metapopulation.

  2001cited by this paper
• Gene conversion and different population histories may explain the contrast between polymorphism and linkage disequilibrium levels.

  2001cited by this paper
• Great ape DNA sequences reveal a reduced diversity and an expansion in humans

  2001cited by this paper
• High levels of sequence polymorphism and linkage disequilibrium at the telomere of 12q: implications for telomere biology and human evolution.

  2000cited by this paper
• The human career: Human biological and cultural origins

  2000cited by this paper
• Apolipoprotein E variation at the sequence haplotype level: implications for the origin and maintenance of a major human polymorphism.

  2000cited by this paper
• Evidence for variable selective pressures at MC1R.

  2000cited by this paper
• Adjusting the focus on human variation.

  2000cited by this paper
• Genetic perspectives on human origins and differentiation.

  2000cited by this paper
• Worldwide DNA sequence variation in a 10-kilobase noncoding region on human chromosome 22.

  2000cited by this paper
• Mitochondrial genome variation and the origin of modern humans

  2000cited by this paper
• Y chromosome sequence variation and the history of human populations

  2000cited by this paper
• When did the human population size start increasing?

  2000cited by this paper
• Inference in molecular population genetics

  2000cited by this paper
• A human population bottleneck can account for the discordance between patterns of mitochondrial versus nuclear DNA variation.

  1999cited by this paper
• Sequence variation in the human angiotensin converting enzyme

  1999cited by this paper
• Population growth of human Y chromosomes: a study of Y chromosome microsatellites.

  1999cited by this paper
• Is selection responsible for the low level of variation in the last intron of the ZFY locus?

  1999cited by this paper
• X chromosome evidence for ancient human histories.

  1999cited by this paper
• Out of Africa and back again: nested cladistic analysis of human Y chromosome variation.

  1998cited by this paper
• Genetic traces of ancient demography.

  1998cited by this paper
• Haplotype structure and population genetic inferences from nucleotide-sequence variation in human lipoprotein lipase.

  1998cited by this paper
• Archaic African and Asian lineages in the genetic ancestry of modern humans.

  1997cited by this paper
• Mitochondrial and nuclear genes present conflicting portraits of human origins.

  1997cited by this paper
• Inferring coalescence times from DNA sequence data.

  1997cited by this paper
• The History and Geography of Human Genes

  1996cited by this paper
• The history and geography of human genes

  1995cited by this paper
• GENETIC EVIDENCE FOR A PLEISTOCENE POPULATION EXPLOSION

  1995cited by this paper
• Statistical tests of neutrality of mutations.

  1993cited by this paper
• The human career : human biological and cultural origins

  1991cited by this paper
• Branching pattern in the evolutionary tree for human mitochondrial DNA.

  1991cited by this paper
• African populations and the evolution of human mitochondrial DNA.

  1991cited by this paper
• Pairwise comparisons of mitochondrial DNA sequences in stable and exponentially growing populations.

  1991cited by this paper
• The Human Revolution: Behavioural and Biological Perspectives on the Origins of Modern Humans

  1991cited by this paper
• The effect of change in population size on DNA polymorphism.

  1989cited by this paper
• The human career

  1989cited by this paper
• Genetic and fossil evidence for the origin of modern humans.

  1988cited by this paper
• Intraspecific Phylogeography: The Mitochondrial DNA Bridge Between Population Genetics and Systematics

  1987cited by this paper
• Mitochondrial DNA and human evolution

  1987cited by this paper
• Evolutionary relationship of DNA sequences in finite populations.

  1983cited by this paper
• On the genealogy of large populations

  1982cited by this paper
• On the number of segregating sites in genetical models without recombination.

  1975cited by this paper
• Omo human skeletal remains.

  1969cited by this paper
• Early Homo sapiens Remains from the Omo River Region of South-west Ethiopia: Omo Human Skeletal Remains

  1969cited by this paper

• Human dispersal into East Eurasia: ancient genome insights and the need for research on physiological adaptations

  2025cites this paper
• Allelic Cataloging of RHD-RHCE Reference Sequences Using Targeted Long-Read Sequencing.

  2025cites this paper
• Revisiting the Amdo Sprachbund: Genes, languages, and beyond

  2022cites this paper
• African mitochondrial haplogroup L7: a 100,000-year-old maternal human lineage discovered through reassessment and new sequencing

  2022cites this paper
• Constructing Authenticity into Population Brands

  2021cites this paper
• Analysis of allele frequencies of the selected 15 autosomal STR markers in Tikrit population – Iraq with comparison to Middle Eastern, African, and Europeans

  2021cites this paper
• Accurate depiction of uncertainty in ancient DNA research: The case of Neandertal ancestry in Africa

  2021cites this paper
• Landscape and Climatic Variations Shaped Secondary Contacts amid Barn Owls of the Western Palearctic

  2021cites this paper
• Genetik und Anthropologie

  2020cites this paper
• Genomic signals found using RNA sequencing show signatures of selection and subtle population differentiation in walleye (Sander vitreus) in a large freshwater ecosystem

  2020cites this paper
• A Population-Genetic Perspective on the Similarities and Differences among Worldwide Human Populations

  2020cites this paper
• Gene flow as a simple cause for an excess of high‐frequency‐derived alleles

  2020cites this paper
• Genomic signals found using RNA sequencing support conservation of walleye (Sander vitreus) in a large freshwater ecosystem

  2020cites this paper
• Allelic Variation of Bnax.Vte4.B and its Association with α-/γ-Tocopherol Ratio in Brassica napus L

  2019cites this paper
• Whole-genome sequence analysis of a Pan African set of samples reveals archaic gene flow from an extinct basal population of modern humans into sub-Saharan populations

  2019cites this paper
• Graph Embedding Method Based Genetical Trajectory Reveals Migration History Among East Asians

  2019cites this paper
• Running title : Associative Transcriptomics platform for B . napus

  2019cites this paper
• The Metabolic Ghetto: An Evolutionary Perspective on Nutrition, Power Relations and Chronic Disease

  2019cites this paper
• Population Genomic Analyses of DNA from Ancient Remains

  2019cites this paper
• Large-scale whole-genome sequencing of three diverse Asian populations in Singapore

  2018cites this paper
• Validation of an updated Associative Transcriptomics platform for the polyploid crop species Brassica napus by dissection of the genetic architecture of erucic acid and tocopherol isoform variation in seeds

  2017cites this paper
• Carriers of mitochondrial DNA macrohaplogroup L3 basal lineages migrated back to Africa from Asia around 70,000 years ago

  2017cites this paper
• Comparison of Single Genome and Allele Frequency Data Reveals Discordant Demographic Histories

  2017cites this paper
• Accuracy of Demographic Inferences from the Site Frequency Spectrum: The Case of the Yoruba Population

  2017cites this paper
• Populations as brands in medical research: placing genes on the global genetic atlas

  2017cites this paper
• The Late Quaternary Hominins of Africa: The Skeletal Evidence from MIS 6-2

  2016cites this paper
• Late Stone Age human remains from Ishango (Democratic Republic of Congo): New insights on Late Pleistocene modern human diversity in Africa.

  2016cites this paper
• Mitochondrial haplogroups and expression studies of commonly used human cell lines.

  2016cites this paper
• Populations as brands in medical research: placing genes on the global genetic atlas

  2016cites this paper
• Africa from MIS 6-2: The Florescence of Modern Humans

  2016cites this paper
• Ancient pathogen-driven adaptation triggers increased susceptibility to non-celiac wheat sensitivity in present-day European populations

  2016cites this paper
• The DAU cluster: a comparative analysis of 18 RHD alleles, some forming partial D antigens

  2016cites this paper
• Accuracy of demographic inferences from site frequency spectrum: the case of the yoruba population

  2016cites this paper
• Landscape variability in tool-use and edge damage formation in South African Middle Stone Age lithic assemblages

  2016cites this paper
• The Trans-Atlantic slave trade and the introduction of human diseases: the case of schistosomiasis

  2016cites this paper
• USP38, FREM3, SDC1, DDC, and LOC727982 Gene Polymorphisms and Differential Susceptibility to Severe Malaria in Tanzania

  2015influential citation
• African Glucose-6-Phosphate Dehydrogenase Alleles Associated with Protection from Severe Malaria in Heterozygous Females in Tanzania

  2015cites this paper
• Interleukin-37 gene variants segregated anciently coexist during hominid evolution

  2015cites this paper
• The Biogeographic Roots of World Inequality. Animals, Disease, and Human Settlement Patterns in Africa and the Americas before 1492

  2015cites this paper
• MATRIX THINKING: AN ADAPTATION AT THE FOUNDATION OF HUMAN SCIENCE, RELIGION, AND ART

  2015cites this paper
• Contemporary Human Genetic Variation

  2015cites this paper
• Ancestry, admixture and fitness in Colombian genomes

  2015cites this paper
• The Evolution and Functional Impact of Human Deletion Variants Shared with Archaic Hominin Genomes

  2015cites this paper
• Tracing Sephardic Jewry Through Genetics: Crypto-Jews and the Second Diaspora

  2015influential citation
• Climatic variability, plasticity, and dispersal: A case study from Lake Tana, Ethiopia.

  2015cites this paper
• Positive Selection on Loci Associated with Drug and Alcohol Dependence

  2015cites this paper
• Reconstructing Human History Using Autosomal, Y-Chromosomal and Mitochondrial Markers

  2015cites this paper
• Exploring Population Size Changes Using SNP Frequency Spectra

  2015cites this paper
• Collinearity analysis of Brassica A and C genomes based on an updated inferred unigene order

  2015cites this paper
• Palaeoclimates, plasticity, and the early dispersal of Homo sapiens

  2015cites this paper
• Whole-genome sequence analyses of Western Central African Pygmy hunter-gatherers reveal a complex demographic history and identify candidate genes under positive natural selection

  2015cites this paper
• An Evolutionary Analysis of Antigen Processing and Presentation across Different Timescales Reveals Pervasive Selection

  2014cites this paper
• Reconsideration of the "Out of Africa" Concept as Not Having Enough Proof

  2014cites this paper
• Mapping PAMP Responses and Disease Resistance in Brassicas

  2014cites this paper
• Ancient humans and the origin of modern humans.

  2014cites this paper
• Genetic ancestry of a Moroccan population as inferred from autosomal STRs

  2014cites this paper
• Ancient and Recent Selective Pressures Shaped Genetic Diversity at AIM2-Like Nucleic Acid Sensors

  2014cites this paper
• Introgression and phenotypic assimilation in Zimmerius flycatchers (Tyrannidae): population genetic and phylogenetic inferences from genome-wide SNPs.

  2014cites this paper
• Vertical-axis Continents

  2014cites this paper
• Prospecção de marcadores microssatélites, análise de viriabilidade e estrutura genética populacional de arara-azul-grande Anodorhynchus hyacinthinus (Latham, 1790) com ênfase na região do mosaico dos Carajás-PA

  2014cites this paper
• Inferring population size changes with sequence and SNP data: lessons from human bottlenecks

  2013cites this paper
• The Process of Modern Human Origins

  2013cites this paper
• Peopling the last new worlds: The first colonisation of Sahul and the Americas

  2013cites this paper
• Admixture increases diversity in managed honey bees: Reply to De la Rúa et al. (2013)

  2013cites this paper
• Evolutionary analysis of the contact system indicates that kininogen evolved adaptively in mammals and in human populations.

  2013influential citation
• Long‐Standing Balancing Selection in the THBS4 Gene: Influence on Sex‐Specific Brain Expression and Gray Matter Volumes in Alzheimer Disease

  2013cites this paper
• Global Patterns of Diversity and Selection in Human Tyrosinase Gene

  2013cites this paper
• Origins of the Australian and New Guinean Aborigines

  2013cites this paper
• Evolutionary Constraints in the β-Globin Cluster: The Signature of Purifying Selection at the δ-Globin (HBD) Locus and Its Role in Developmental Gene Regulation

  2013cites this paper
• Understanding Human Cranial Variation in Light of Modern Human Origins

  2013cites this paper
• Genetic evidence for the colonization of Australia

  2013cites this paper
• Human dispersal across diverse environments of Asia during the Upper Pleistocene

  2013cites this paper
• Neutral genomic regions refine models of recent rapid human population growth

  2013cites this paper
• A Trans-Specific Polymorphism in ZC3HAV1 Is Maintained by Long-Standing Balancing Selection and May Confer Susceptibility to Multiple Sclerosis

  2012cites this paper
• The environmental context for the origins of modern human diversity: a synthesis of regional variability in African climate 150,000-30,000 years ago.

  2012cites this paper
• Re-Examining the Out-of-Africa Theory and the Origin of Europeoids (Caucasoids). Part 2. SNPs, Haplogroups and Haplotypes in the Y-Chromosome of Chimpanzee and Humans

  2012cites this paper
• Population genetic nature of copy number variation.

  2012cites this paper
• [Screening and identification of 36 new STR loci in human Y chromosome].

  2012cites this paper
• Associative transcriptomics of traits in the polyploid crop species Brassica napus

  2012cites this paper
• Investigating genome wide patterns of natural selection in eukaryotes

  2012cites this paper
• Genotyping for cytokine polymorphisms in a Northern Ivory Coast population reveals a high frequency of the heterozygote genotypes for the TNF‐α‐308G/A SNP

  2012cites this paper
• The peopling of Southern Africa: a genetics approach

  2012influential citation
• An Introduction to Genetics

  2012cites this paper
• The Upper Paleolithic Human Remains of Nazlet Khater 2 (Egypt) and Past Modern Human Diversity

  2012cites this paper
• The evolution of human adiposity and obesity: where did it all go wrong?

  2012cites this paper
• The origin, global distribution, and functional impact of the human 8p23 inversion polymorphism

  2012cites this paper
• Resequencing data provide no evidence for a human bottleneck in Africa during the penultimate glacial period.

  2012cites this paper
• The population genetics of Quechuas, the largest native South American group: autosomal sequences, SNPs, and microsatellites evidence high level of diversity.

  2012cites this paper
• Endothelial nitric oxide synthase intron 4 VNTR gene polymorphisms in European and African populations

  2012cites this paper
• References to publications of

  2012cites this paper
• The Date of Interbreeding between Neandertals and Modern Humans

  2012cites this paper
• Genetic analysis of uniparental and autosomal markers in human populations

  2012cites this paper
• Modern Origins: A North African Perspective

  2012cites this paper
• Hereditary Breast Cancer in Sub-Saharan Africa

  2012cites this paper
• Extensive Population Structure in San, Khoe, and Mixed Ancestry Populations from Southern Africa Revealed by 44 Short 5-SNP Haplotypes

  2012cites this paper
• The Capital Economy in Hominin Evolution

  2012cites this paper
• Gene Genealogies Within a Fixed Pedigree, and the Robustness of Kingman’s Coalescent

  2012influential citation
• Management increases genetic diversity of honey bees via admixture.

  2012cites this paper
• Global genetic variation at OAS1 provides evidence of archaic admixture in Melanesian populations.

  2012cites this paper
• Loss and Gain of Function in SERPINB11: An Example of a Gene under Selection on Standing Variation, with Implications for Host-Pathogen Interactions

  2012cites this paper