Type I Signal Peptidase and Protein Secretion in Staphylococcus aureus

No abstract is available for this paper.

• Publication year

  2012

• Venue

  Journal of Bacteriology

• Publication date

  2012-03-23

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1128/JB.00064-12PMID 22447899PMCID PMC3347181
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Initial efforts toward the optimization of arylomycins for antibiotic activity.

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  2011cited by this paper
• Synthesis and biological characterization of arylomycin B antibiotics.

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  2010influential reference
• Type I Signal Peptidase and Protein Secretion in Staphylococcus epidermidis

  2010cited by this paper
• In vitro and in vivo approaches to studying the bacterial signal peptide processing.

  2010cited by this paper
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  2010cited by this paper
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• Staphylococcus aureus pathogenesis: secretion systems, adhesins, and invasins.

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• CORRECTION

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• Mapping the Pathways to Staphylococcal Pathogenesis by Comparative Secretomics PATHWAYS FOR STAPHYLOCOCCAL PROTEIN TRANSPORT

  2006influential reference
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  2006cited by this paper
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