The evolutionary history of effectors downstream of Cdc42 and Rac

Cdc42 and Rac - ancient, highly conserved, small GTPases - mediate extracellular signals, triggering changes in transcription and in the actin cytoskeleton. Although dozens of proteins act downstream of these GTPases, a comparison of effector proteins from evolutionarily diverse organisms suggests that six groups of proteins serve as the core machinery for signaling from Cdc42 and Rac.

• Publication year

  2002

• Venue

  Genome Biology

• Publication date

  2002-01-14

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1186/gb-2002-3-2-reviews0002PMID 11864373PMCID 139012
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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