Light-Induced photoreceptor degeneration in the mouse involves activation of the small GTPase Rac1.

No abstract is available for this paper.

• Publication year

  2006

• Venue

  Investigative Ophthalmology and Visual Science

• Publication date

  2006-03-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1167/IOVS.05-0446PMID 16505058
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Palmitate-induced apoptosis in cultured bovine retinal pericytes: roles of NAD(P)H oxidase, oxidant stress, and ceramide.

  2005cited by this paper
• A Rac1/Phosphatidylinositol 3-Kinase/Akt3 Anti-apoptotic Pathway, Triggered by AlsinLF, the Product of the ALS2 Gene, Antagonizes Cu/Zn-superoxide Dismutase (SOD1) Mutant-induced Motoneuronal Cell Death*

  2005cited by this paper
• Statins Inhibit &bgr;-Adrenergic Receptor–Stimulated Apoptosis in Adult Rat Ventricular Myocytes via a Rac1-Dependent Mechanism

  2004cited by this paper
• Capsaicin-lnduced apoptosis of h-ras-transformed human breast epithelial cells is rac-dependentvia ros generation

  2004cited by this paper
• Retinitis pigmentosa: understanding the clinical presentation, mechanisms and treatment options

  2004cited by this paper
• Calcium-induced Calpain Mediates Apoptosis via Caspase-3 in a Mouse Photoreceptor Cell Line*

  2004cited by this paper
• Regulation of anoikis by Cdc42 and Rac1.

  2004cited by this paper
• DNA Synthesis and Neuronal Apoptosis Caused by Familial Alzheimer Disease Mutants of the Amyloid Precursor Protein Are Mediated by the p21 Activated Kinase PAK3

  2003cited by this paper
• Light-mediated activation of Rac-1 in photoreceptor outer segments.

  2003cited by this paper
• Inhibition of hypoxia/reoxygenation-induced oxidative stress in HGF-stimulated antiapoptotic signaling: role of PI3-K and Akt kinase upon rac1

  2003cited by this paper
• The catalytic domain of xPAK1 is sufficient to induce myosin II dependent in vivo cell fragmentation independently of other apoptotic events.

  2003cited by this paper
• Selenite-induced Survival of HuH7 Hepatoma Cells Involves Activation of Focal Adhesion Kinase-Phosphatidylinositol 3-Kinase-Akt Pathway and Rac1*

  2003cited by this paper
• Caspase-activated PAK-2 Is Regulated by Subcellular Targeting and Proteasomal Degradation*

  2003cited by this paper
• Neural remodeling in retinal degeneration.

  2003cited by this paper
• Caspase-Independent Photoreceptor Apoptosis in Mouse Models of Retinal Degeneration

  2003cited by this paper
• p21-Activated Kinase 5 (Pak5) Localizes to Mitochondria and Inhibits Apoptosis by Phosphorylating BAD

  2003cited by this paper
• Molecular ordering of ROS production, mitochondrial changes, and caspase activation during sodium salicylate-induced apoptosis.

  2003cited by this paper
• Rac proteins and the control of axon development.

  2003cited by this paper
• Death Receptor-Induced Activation of Initiator Caspase 8 Is Antagonized by Serine/Threonine Kinase PAK4

  2003cited by this paper
• Phosphoinositides, ezrin/moesin, and rac1 regulate fusion of rhodopsin transport carriers in retinal photoreceptors.

  2003cited by this paper
• Regulation of Akt-dependent cell survival by Syk and Rac.

  2003cited by this paper
• p21-activated kinases: three more join the Pak.

  2002cited by this paper
• Rho GTPases in cell biology

  2002cited by this paper
• Distribution of the small molecular weight GTP-binding proteins Rac1, Cdc42, RhoA and RhoB in the developing chick retina

  2002cited by this paper
• The role of Rho GTPases and associated kinases in regulating neurite outgrowth.

  2002cited by this paper
• Rac1 and RhoG promote cell survival by the activation of PI3K and Akt, independently of their ability to stimulate JNK and NF-κB

  2002cited by this paper
• The evolutionary history of effectors downstream of Cdc42 and Rac

  2002cited by this paper
• Activation of Rac GTPase by p75 Is Necessary for c-jun N-Terminal Kinase-Mediated Apoptosis

  2002cited by this paper
• Activation of Rac1 and the p38 Mitogen-activated Protein Kinase Pathway in Response to Arsenic Trioxide*

  2002cited by this paper
• Actin cytoskeleton regulation in neuronal morphogenesis and structural plasticity.

  2002cited by this paper
• Caspase-independent photoreceptor apoptosis in vivo and differential expression of apoptotic protease activating factor-1 and caspase-3 during retinal development

  2002cited by this paper
• The Small GTPase Rac Suppresses Apoptosis Caused by Serum Deprivation in Fibroblasts

  2001cited by this paper
• Light-induced Photoreceptor Apoptosis in Vivo Requires Neuronal Nitric-oxide Synthase and Guanylate Cyclase Activity and Is Caspase-3-independent*

  2001cited by this paper
• Rho signals to cell growth and apoptosis.

  2001cited by this paper
• Raf-MEK-Erk Cascade in Anoikis Is Controlled by Rac1 and Cdc42 via Akt

  2001cited by this paper
• Rac1 Protects Epithelial Cells against Anoikis*

  2001cited by this paper
• Characterization of cell death pathways in murine retinal neurodegeneration implicates cytochrome c release, caspase activation, and bid cleavage.

  2001cited by this paper
• Implication of the small GTPase Rac1 in the apoptosis induced by UV in Rat-2 fibroblasts.

  2001cited by this paper
• p21-activated protein kinase gamma-PAK suppresses programmed cell death of BALB3T3 fibroblasts.

  2001cited by this paper
• The Serine/Threonine Kinase PAK4 Prevents Caspase Activation and Protects Cells from Apoptosis*

  2001cited by this paper
• An Essential Role for Rac/Cdc42 GTPases in Cerebellar Granule Neuron Survival*

  2001cited by this paper
• GTPase RhoB: an early predictor of neuronal death after transient focal ischemia in mice.

  2001cited by this paper
• Evidence for a Role of Mixed Lineage Kinases in Neuronal Apoptosis

  2001cited by this paper
• p21-activated Protein Kinase γ-PAK Suppresses Programmed Cell Death of BALB3T3 Fibroblasts*

  2001cited by this paper
• Extinction of Rac1 and Cdc42Hs signalling defines a novel p53-dependent apoptotic pathway

  2000cited by this paper
• Rho GTPases: molecular switches that control the organization and dynamics of the actin cytoskeleton.

  2000cited by this paper
• The use of TaqMan RT-PCR assays for semiquantitative analysis of gene expression in CNS tissues and disease models.

  2000cited by this paper
• The Akt Proto-oncogene Links Ras to Pak and Cell Survival Signals*

  2000cited by this paper
• Inhibition of the Rac1 GTPase protects against nonlethal ischemia/reperfusion‐induced necrosis and apoptosis in vivo

  2000cited by this paper
• Akt Protein Kinase Inhibits Rac1-GTP Binding through Phosphorylation at Serine 71 of Rac1*

  2000cited by this paper
• Quantitative reverse transcription-polymerase chain reaction to study mRNA decay: comparison of endpoint and real-time methods.

  2000cited by this paper
• Apoptosis induced by Rac GTPase correlates with induction of FasL and ceramides production.

  2000cited by this paper
• Rescue of photoreceptor degeneration in rhodopsin-null Drosophila mutants by activated Rac1.

  2000cited by this paper
• Anti-apoptotic function of Rac in hematopoietic cells

  1999cited by this paper
• Stress, superoxide, and signal transduction.

  1999cited by this paper
• Signaling to Rho GTPases.

  1999cited by this paper
• Apoptotic cell death in retinal degenerations.

  1998cited by this paper
• The p21Rac/Cdc42-activated kinases (PAKs).

  1998cited by this paper
• Membrane targeting of p21‐activated kinase 1 (PAK1) induces neurite outgrowth from PC12 cells

  1998cited by this paper
• The small GTP-binding protein Cdc42 is required for nerve growth factor withdrawal-induced neuronal death.

  1998cited by this paper
• In vivo requirement of protein prenylation for maintenance of retinal cytoarchitecture and photoreceptor structure

  1995cited by this paper
• Identification of a Mouse p21Cdc42/Rac Activated Kinase (*)

  1995cited by this paper
• Apoptotic photoreceptor cell death in mouse models of retinitis pigmentosa.

  1994cited by this paper
• A brain serine/threonine protein kinase activated by Cdc42 and Rac1

  1994cited by this paper
• Apoptosis: Final common pathway of photoreceptor death in rd, rds, and mutant mice

  1993cited by this paper
• Apoptosis: final common pathway of photoreceptor death in rd, rds, and rhodopsin mutant mice.

  1993cited by this paper
• Interaction of small G proteins with photoexcited rhodopsin

  1990cited by this paper

• Halofuginone prevents outer retinal degeneration in a mouse model of light-induced retinopathy

  2024cites this paper
• Utility of the DHFR-based destabilizing domain across mouse models of retinal degeneration and aging

  2022cites this paper
• Intravitreal Administration of rhNGF Enhances Regenerative Processes in a Zebrafish Model of Retinal Degeneration

  2022cites this paper
• SUFFICIENT ACTIVITY OF THE UBIQUITIN PROTEASOME SYSTEM IN AGED MICE AND DURING RETINAL DEGENERATION SUPPORTS DHFR-BASED CONDITIONAL CONTROL OF PROTEIN ABUNDANCE IN THE RETINA

  2021cites this paper
• Food Supplements in the Treatment of Ophthalmic Diseases: Preclinical and Clinical Studies

  2020cites this paper
• The potential involvement of miR-204-3p-axon guidance network in methamphetamine-induced locomotor sensitization of mice.

  2019cites this paper
• Progenitor cell combination normalizes retinal vascular development in the oxygen-induced retinopathy (OIR) model.

  2019cites this paper
• Eye Drop Instillation of the Rac1 Modulator CNF1 Attenuates Retinal Gliosis and Ameliorates Visual Performance in a Rat Model of Hypertensive Retinopathy.

  2019cites this paper
• Retinogenesis of the Human Fetal Retina: An Apical Polarity Perspective

  2019cites this paper
• Enhancing the efficacy of AREDS antioxidants in light-induced retinal degeneration

  2017influential citation
• Mutations in the Drosophila splicing regulator Prp31 as a model for Retinitis pigmentosa 11

  2017influential citation
• Photoreceptor oxidative stress in hyperoxia-induced proliferative retinopathy accelerates rd8 degeneration

  2017cites this paper
• The bacterial toxin CNF1 as a tool to induce retinal degeneration reminiscent of retinitis pigmentosa

  2016cites this paper
• NADPH Oxidase Contributes to Photoreceptor Degeneration in Constitutively Active RAC1 Mice

  2016cites this paper
• Retinal Cell Biology NADPH Oxidase Contributes to Photoreceptor Degeneration in Constitutively Active RAC 1 Mice

  2016cites this paper
• microRNA regulatory circuits in a mouse model of inherited retinal degeneration

  2016cites this paper
• Functional regulation of neuronal nitric oxide synthase expression and activity in the rat retina.

  2014cites this paper
• Proliferation Potential of Müller Glia after Retinal Damage Varies between Mouse Strains

  2014cites this paper
• p21-activated kinase 7 is an oncogene in human osteosarcoma

  2014cites this paper
• MicroRNAs in Neuronal Communication

  2014cites this paper
• Effect of Light on Expression of Clock Genes in Xenopus laevis Melanophores

  2014cites this paper
• Transgenic expression of constitutively active RAC1 disrupts mouse rod morphogenesis.

  2014cites this paper
• The interaction network of rhodopsin involving the heterotrimeric G‐protein transducin and the monomeric GTPase Rac1 is determined by distinct binding processes

  2014cites this paper
• Developmental and Functional Expression of miRNA-Stability Related Genes in the Nervous System

  2013cites this paper
• A New and Reliable Guide for Studies of Neuronal Loss Based on Focal Lesions and Combinations of In Vivo and In Vitro Approaches

  2013cites this paper
• P-Rex2, a Rac-guanine nucleotide exchange factor, is expressed selectively in ribbon synaptic terminals of the mouse retina

  2013influential citation
• CDC42 Is Required for Tissue Lamination and Cell Survival in the Mouse Retina

  2013cites this paper
• Crumbs limits oxidase-dependent signaling to maintain epithelial integrity and prevent photoreceptor cell death

  2012influential citation
• A brief account of rho GTPases in retinal physiology and pathophysiology.

  2012cites this paper
• Blocking of Connexin-Mediated Communication Promotes Neuroprotection during Acute Degeneration Induced by Mechanical Trauma

  2012cites this paper
• Envolvimento de Rac1 na excitotoxicidade induzida por NMDA na retina de ratos.

  2011cites this paper
• Retinal degeneration modulates intracellular localization of CDC42 in photoreceptors

  2011cites this paper
• Connexin‐mediated communication controls cell proliferation and is essential in retinal histogenesis

  2010cites this paper
• Depleting Rac1 in mouse rod photoreceptors protects them from photo-oxidative stress without affecting their structure or function

  2009cites this paper
• Molecular mechanisms of transformation of SkQ mitotropic quinones and the search for new approaches to creation of selective free radical traps

  2009cites this paper
• Sistema Canabinóide e seu Possível Papel em Processos de Neuroproteção e Plasticidade: Estudos in vivo e in vitro

  2008cites this paper
• Distribution of small Rho GTPases in the developing rat submandibular gland

  2008cites this paper
• Immunohistochemical characterization of the chick marginal retina.

  2007cites this paper
• Transformation of adult retina from the regenerative to the axonogenesis state activates specific genes in various subsets of neurons and glial cells

  2007cites this paper