Diabetic cardiomyopathy and its mechanisms: Role of oxidative stress and damage

Diabetic cardiomyopathy as an important threat to health occurs with or without coexistence of vascular diseases. The exact mechanisms underlying the disease remain incompletely clear. Although several pathological mechanisms responsible for diabetic cardiomyopathy have been proposed, oxidative stress is widely considered as one of the major causes for the pathogenesis of the disease. Hyperglycemia‐, hyperlipidemia‐, hypertension‐ and inflammation‐induced oxidative stress are major risk factors for the development of microvascular pathogenesis in the diabetic myocardium, which results in abnormal gene expression, altered signal transduction and the activation of pathways leading to programmed myocardial cell deaths. In the present article, we aim to provide an extensive review of the role of oxidative stress and anti‐oxidants in diabetic cardiomyopathy based on our own works and literature information available.

• Publication year

  2014

• Venue

  Journal of Diabetes Investigation

• Publication date

  2014-07-15

• Fields of study

  Medicine, Environmental Science

• Identifiers
  DOI 10.1111/jdi.12250PMID 25422760PMCID 4234223
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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