NMDAR channel segments forming the extracellular vestibule inferred from the accessibility of substituted cysteines.

No abstract is available for this paper.

• Publication year

  1999

• Venue

  Neuron

• Publication date

  1999-03-01

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1016/S0896-6273(00)80710-2PMID 10197535
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• N-terminal domains in the NR2 subunit control desensitization of NMDA receptors.

  1998cited by this paper
• Glycine-independent NMDA receptor desensitization: localization of structural determinants.

  1998cited by this paper
• Adjacent asparagines in the NR2‐subunit of the NMDA receptor channel control the voltage‐dependent block by extracellular Mg2+

  1998cited by this paper
• State-dependent Accessibility and Electrostatic Potential in the Channel of the Acetylcholine Receptor

  1998cited by this paper
• The location of the gate in the acetylcholine receptor channel.

  1998cited by this paper
• Excitatory amino acids.

  1998cited by this paper
• The macro- and microarchitectures of the ligand-binding domain of glutamate receptors.

  1998cited by this paper
• Contribution of the beta subunit M2 segment to the ion-conducting pathway of the acetylcholine receptor.

  1998cited by this paper
• Different Mechanisms of Ca2+ Transport in NMDA and Ca2+-permeable AMPA Glutamate Receptor Channels

  1998cited by this paper
• Substituted-cysteine accessibility method.

  1998cited by this paper
• Block and modulation of N-methyl-D-aspartate receptors by polyamines and protons: role of amino acid residues in the transmembrane and pore-forming regions of NR1 and NR2 subunits.

  1997cited by this paper
• The Topology of Glutamate Receptors

  1997cited by this paper
• Neurodegeneration in Lurcher mice caused by mutation in δ2 glutamate receptor gene

  1997cited by this paper
• On the use of thiol-modifying agents to determine channel topology.

  1996cited by this paper
• Structure of the NMDA receptor channel M2 segment inferred from the accessibility of substituted cysteines.

  1996cited by this paper
• Multiple Structural Elements Determine Subunit Specificity of Mg2+ Block in NMDA Receptor Channels

  1996cited by this paper
• Identification of a high affinity divalent cation binding site near the entrance of the NMDA receptor channel.

  1996cited by this paper
• Differential contribution of the NR1‐ and NR2A‐subunits to the selectivity filter of recombinant NMDA receptor channels.

  1996cited by this paper
• Structural conservation of ion conduction pathways in K channels and glutamate receptors.

  1995cited by this paper
• Structural basis for explaining open-channel blockade of the NMDA receptor

  1995cited by this paper
• Molecular design of the N-methyl-D-aspartate receptor binding site for phencyclidine and dizolcipine.

  1995cited by this paper
• Mapping the binding-site crevice of the dopamine D2 receptor by the substituted-cysteine accessibility method.

  1995cited by this paper
• K+ pore structure revealed by reporter cysteines at inner and outer surfaces.

  1995cited by this paper
• Fractional calcium currents through recombinant GluR channels of the NMDA, AMPA and kainate receptor subtypes.

  1995cited by this paper
• Dimensions of the narrow portion of a recombinant NMDA receptor channel.

  1995cited by this paper
• Ligand- and voltage-gated ion channels

  1995cited by this paper
• Topology profile for a glutamate receptor: three transmembrane domains and a channel-lining reentrant membrane loop.

  1995cited by this paper
• Electrostatic potential of the acetylcholine binding sites in the nicotinic receptor probed by reactions of binding-site cysteines with charged methanethiosulfonates.

  1994cited by this paper
• Identification of acetylcholine receptor channel-lining residues in the entire M2 segment of the alpha subunit.

  1994cited by this paper
• Transmembrane topology of two kainate receptor subunits revealed by N-glycosylation.

  1994cited by this paper
• N-glycosylation site tagging suggests a three transmembrane domain topology for the glutamate receptor GluR1.

  1994cited by this paper
• Determinants of Ca2+ permeability in both TM1 and TM2 of high affinity kainate receptor channels: diversity by RNA editing.

  1993cited by this paper
• Fractional contribution of calcium to the cation current through glutamate receptor channels.

  1993cited by this paper
• Molecular neurobiology of glutamate receptors.

  1992cited by this paper
• Identification by mutagenesis of a Mg2+ -block site of the NMDA receptor channel

  1992cited by this paper
• Control by asparagine residues of calcium permeability and magnesium blockade in the NMDA receptor.

  1992cited by this paper
• Apparent desensitization of NMDA responses in Xenopus oocytes involves calcium-dependent chloride current.

  1990cited by this paper
• Flip and flop: a cell-specific functional switch in glutamate-operated channels of the CNS.

  1990cited by this paper
• Excitatory amino acid receptors in the vertebrate central nervous system.

  1989cited by this paper
• The excitatory amino acid receptors: their classes, pharmacology, and distinct properties in the function of the central nervous system.

  1989cited by this paper
• Ion-channel entrances influence permeation. Net charge, size, shape, and binding considerations.

  1986cited by this paper
• Excitatory amino acids and central synaptic transmission

  1984cited by this paper
• Ionic channels of excitable membranes

  1984cited by this paper

• Modeling and Simulation of the NMDA Receptor at Coarse-Grained and Atomistic Levels.

  2024cites this paper
• Structural insights into NMDA receptor pharmacology

  2023cites this paper
• Two gates mediate NMDA receptor activity and are under subunit-specific regulation

  2023cites this paper
• The pathogenic N650K variant in the GluN1 subunit regulates the trafficking, conductance, and pharmacological properties of NMDA receptors.

  2022cites this paper
• Structure, Function, and Pharmacology of Glutamate Receptor Ion Channels

  2021cites this paper
• NMDA receptor channel gating control by the pre-M1 helix

  2020cites this paper
• The NMDA Receptor Antibody Paradox: A Possible Approach to Developing Immunotherapies Targeting the NMDA Receptor

  2020cites this paper
• Hodgkin–Huxley–Katz Prize Lecture: Genetic and pharmacological control of glutamate receptor channel through a highly conserved gating motif

  2020cites this paper
• Structural basis of AMPA receptor inhibition by 4-BCCA.

  2020cites this paper
• Structural basis of AMPA receptor inhibition by trans‐4‐butylcyclohexane carboxylic acid

  2020cites this paper
• The functional role of polyamines in eukaryotic cells.

  2019cites this paper
• De novo GRIN variants in NMDA receptor M2 channel pore‐forming loop are associated with neurological diseases

  2019cites this paper
• Human Mutation

  2019cites this paper
• Structure, function, and allosteric modulation of NMDA receptors

  2018cites this paper
• Cadmium opens GluK2 kainate receptors with cysteine substitutions at the M3 helix bundle crossing

  2018influential citation
• The LILI Motif of M3-S2 Linkers Is a Component of the NMDA Receptor Channel Gate

  2018cites this paper
• N-Methyl-D-Aspartate Receptors

  2018cites this paper
• NMDA Receptors in the Central Nervous System.

  2017cites this paper
• Probing the Structural Dynamics of the NMDA Receptor Activation by Coarse-Grained Modeling.

  2017cites this paper
• Functional Evaluation of a De Novo GRIN2A Mutation Identified in a Patient with Profound Global Developmental Delay and Refractory Epilepsy

  2017cites this paper
• Molecular Mechanism of Disease-Associated Mutations in the Pre-M1 Helix of NMDA Receptors and Potential Rescue Pharmacology

  2017cites this paper
• All atom NMDA receptor transmembrane domain model development and simulations in lipid bilayers and water

  2017cites this paper
• Gating Motions and Stationary Gating Properties of Ionotropic Glutamate Receptors: Computation Meets Electrophysiology

  2017cites this paper
• Preferential Inhibition of Tonically over Phasically Activated NMDA Receptors by Pregnane Derivatives

  2016cites this paper
• Modulation of NMDA channel gating by Ca2+ and Cd2+ binding to the external pore mouth

  2016cites this paper
• Actions of Bupivacaine, a Widely Used Local Anesthetic, on NMDA Receptor Responses

  2015cites this paper
• Regulation of N -Methyl- d -Aspartate Receptors by Spermine and Ifenprodil

  2015cites this paper
• Block of NMDA receptor channels by endogenous neurosteroids: implications for the agonist induced conformational states of the channel vestibule

  2015cites this paper
• Cysteine Substitution of Transmembrane Domain Amino Acids Alters the Ethanol Inhibition of GluN1/GluN2A N-Methyl-D-Aspartate Receptors

  2015cites this paper
• Cysteine Modification: Probing Channel Structure, Function and Conformational Change.

  2015cites this paper
• Substitution of Transmembrane Domain Amino Acids Alters the Ethanol Inhibition of GluN 1 / GluN 2 A N-Methyl-D-Aspartate Receptors

  2015cites this paper
• Binding of ArgTX-636 in the NMDA receptor ion channel.

  2015cites this paper
• Polyamines

  2015cites this paper
• Cysteine Substitution of Transmembrane Domain Amino Acids Alters the Ethanol Inhibition of GluN1/GluN2A N-Methyl-d-Aspartate Receptors

  2015cites this paper
• Calcium permeability of ligand-gated Ca2+ channels.

  2014cites this paper
• Functional Analysis of a De Novo GRIN2A Missense Mutation Associated with Early-onset Epileptic Encephalopathy

  2014cites this paper
• Positions in the glun2c-containing nmdar regulate alcohol sensitivity and ion channel gating

  2014influential citation
• Glutamate receptor pores

  2014cites this paper
• Influence of GluN2 subunit identity on NMDA receptor function

  2013cites this paper
• An NMDA receptor gating mechanism developed from MD simulations reveals molecular details underlying subunit-specific contributions.

  2013cites this paper
• Probing the activation sequence of NMDA receptors with lurcher mutations

  2012cites this paper
• Emerging approaches to probing ion channel structure and function

  2012cites this paper
• Rôle du trafic des récepteurs NMDA au cours de la maturation et plasticité synaptique

  2012cites this paper
• 6.2 Structure-Function Correlates of Glutamate-Gated Ion Channels

  2012cites this paper
• A single GluN2 subunit residue controls NMDA receptor channel properties via intersubunit interaction

  2011cites this paper
• Role of PTEN nuclear translocation in excitotoxic and ischemic neuronal injuries following stroke

  2011cites this paper
• Argiotoxin in the closed AMPA receptor channel: experimental and modeling study.

  2011cites this paper
• Fatty acid modulation and polyamine block of GluK2 kainate receptors analyzed by scanning mutagenesis

  2010cites this paper
• Molecular structure of ionotropic glutamate receptors.

  2010cites this paper
• Glutamate Receptor Ion Channels: Structure, Regulation, and Function

  2010cites this paper
• Specific Sites within the Ligand-Binding Domain and Ion Channel Linkers Modulate NMDA Receptor Gating

  2010cites this paper
• Mechanistic basis of NMDA receptor channel property variation

  2010influential citation
• Origin and Molecular Evolution of Ionotropic Glutamate Receptors

  2009cites this paper
• Neuroprotection by Tosyl-Polyamine Derivatives through the Inhibition of Ionotropic Glutamate Receptors

  2009cites this paper
• Modeling of peptides connecting the ligand‐binding and transmembrane domains in the GluR2 glutamate receptor

  2009cites this paper
• Activation Mechanisms of the NMDA Receptor

  2009cites this paper
• The Pore Region of N-Methyl-d-aspartate Receptors Differentially Influences Stimulation and Block by Spermine

  2008cites this paper
• Molecular determinants of the anticonvulsant felbamate binding site in the N-methyl-D-aspartate receptor.

  2008cites this paper
• The NR 1 M 3 Domain Mediates Allosteric Coupling in the N-Methyl-D-aspartate Receptor

  2008cites this paper
• Structure and Function of the NMDA Receptor

  2008cites this paper
• The Activation Gate and Gating Mechanism of the NMDA Receptor

  2008influential citation
• Experimental studies of N-methyl-D- aspartate receptor NR3 subunits

  2008cites this paper
• Functional Interactions of Alcohol-sensitive Sites in the N-Methyl-d-aspartate Receptor M3 and M4 Domains*

  2008cites this paper
• Clinically Tolerated Strategies for NMDA Receptor Antagonism

  2008cites this paper
• The NR1 M3 Domain Mediates Allosteric Coupling in the N-Methyl-D-aspartate Receptor

  2008cites this paper
• Experimental Studies of N-methyl-D- aspartate Receptor NR3 Subunits

  2008cites this paper
• Evidence that Xenon does not produce open channel blockade of the NMDA receptor.

  2008cites this paper
• Studies on the structure of the channel pore of NMDA receptor and development of its channel blocker

  2008cites this paper
• Residues accessible in the binding-site crevice of transmembrane helix 6 of the CB2 cannabinoid receptor.

  2008cites this paper
• Differential effects of linear and cyclic polyamines on NMDA receptor activities.

  2008influential citation
• Subunit-specific Contribution of Pore-forming Domains to NMDA Receptor Channel Structure and Gating

  2007cites this paper
• A Domain Linking the AMPA Receptor Agonist Binding Site to the Ion Pore Controls Gating and Causes lurcher Properties when Mutated

  2007influential citation
• Cleft-type cyclophanes confer neuroprotection against excitatory neurotoxicity in vitro and in vivo through inhibition of NMDA receptors.

  2007cites this paper
• Ion channels of glutamate receptors: structural modeling

  2007cites this paper
• Cyclophane and acyclic cyclophane: novel channel blockers of N-methyl-D-aspartate receptor.

  2007cites this paper
• Insights into structure and function of ionotropic glutamate receptor channels: Starting from channel block

  2007cites this paper
• Extracellular proton-modulated pore-blocking effect of the anticonvulsant felbamate on NMDA channels.

  2007cites this paper
• NR3A Modulates the Outer Vestibule of the “NMDA” Receptor Channel

  2006influential citation
• Probing N-Methyl-d-aspartate Receptor Desensitization with the Substituted-Cysteine Accessibility Method

  2006influential citation
• The neuropharmacological basis for the use of memantine in the treatment of Alzheimer's disease.

  2006cites this paper
• The chemical biology of clinically tolerated NMDA receptor antagonists

  2006cites this paper
• Glutamate receptors at atomic resolution

  2006cites this paper
• Pharmacological Implications of Two Distinct Mechanisms of Interaction of Memantine with N-Methyl-d-aspartate-Gated Channels

  2005cites this paper
• Differential Effects on Current Kinetics by Point Mutations in the lurcher Motif of NR1/NR2A Receptors

  2005cites this paper
• Glutamate receptor ion channels.

  2005cites this paper
• Molecular Determinants of Glycine-Independent Desensitization of NR1/NR2A Receptors

  2005cites this paper
• State-dependent changes in the electrostatic potential in the pore of a GluR channel.

  2005cites this paper
• AMPA receptor ligands: Synthetic and pharmacological studies of polyamines and polyamine toxins

  2004cites this paper
• Block of AMPA Receptor Desensitization by a Point Mutation outside the Ligand-Binding Domain

  2004cites this paper
• K channel gating by an affinity-switching selectivity filter.

  2004cites this paper
• The outer pore of the glutamate receptor channel has 2-fold rotational symmetry.

  2004cites this paper
• Sites in the fourth membrane-associated domain regulate alcohol sensitivity of the NMDA receptor.

  2004cites this paper
• Role of Distinct NMDA Receptor Subtypes at Central Synapses

  2004cites this paper
• PERMEANT ION AND SUBUNIT DEPENDENCE OF EXTERNAL Mg2+ BLOCK OF NMDA RECEPTORS

  2004cites this paper
• Using the immune system to target epilepsy.

  2004cites this paper
• Site within N-Methyl-D-aspartate receptor pore modulates channel gating.

  2004cites this paper
• Recent Advances in Epilepsy Research

  2004cites this paper
• Anthraquinone Polyamines: Novel Channel Blockers to Study N-Methyl-d-Aspartate Receptors

  2004cites this paper
• Structure and gating of the glutamate receptor ion channel.

  2004influential citation
• Halothane Inhibits an Intermediate Conductance Ca2+-activated K+ Channel by Acting at the Extracellular Side of the Ionic Pore

  2003cites this paper