Intravitreal injection of AAV2 transduces macaque inner retina.

No abstract is available for this paper.

• Publication year

  2011

• Venue

  Investigative Ophthalmology and Visual Science

• Publication date

  2011-04-25

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1167/iovs.10-6250PMID 21310920PMCID PMC3088562
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  1984cited by this paper
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  1983cited by this paper
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