The BDNF Val66Met Polymorphism Impairs NMDA Receptor-Dependent Synaptic Plasticity in the Hippocampus

No abstract is available for this paper.

• Publication year

  2010

• Venue

  Journal of Neuroscience

• Publication date

  2010-06-30

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1523/JNEUROSCI.1405-10.2010PMID 20592208PMCID PMC2911131
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• A Genetic Variant BDNF Polymorphism Alters Extinction Learning in Both Mouse and Human

  2010cited by this paper
• Meta-analysis of the BDNF Val66Met polymorphism in major depressive disorder: effects of gender and ethnicity

  2010cited by this paper
• Metabotropic Glutamate Receptor-Mediated Long-Term Depression: Molecular Mechanisms

  2009cited by this paper
• BDNF modulation of NMDA receptors is activity dependent.

  2008cited by this paper
• Reviews: BDNF and Memory Formation and Storage

  2008cited by this paper
• BDNF gene: functional Val66Met polymorphism in mood disorders and schizophrenia.

  2008cited by this paper
• BDNF regulates the expression and traffic of NMDA receptors in cultured hippocampal neurons.

  2007cited by this paper
• Long-term depression: multiple forms and implications for brain function.

  2007influential reference
• Shift in induction mechanisms underlies an age-dependent increase in DHPG-induced synaptic depression at CA3 CA1 synapses.

  2007cited by this paper
• A GluR1-cGKII interaction regulates AMPA receptor trafficking.

  2007cited by this paper
• Genetic Variant BDNF (Val66Met) Polymorphism Alters Anxiety-Related Behavior

  2006cited by this paper
• BDNF-mediated neurotransmission relies upon a myosin VI motor complex

  2006cited by this paper
• Sortilin Controls Intracellular Sorting of Brain-Derived Neurotrophic Factor to the Regulated Secretory Pathway

  2005cited by this paper
• Paired-pulse depression of unitary quantal amplitude at single hippocampal synapses.

  2004cited by this paper
• LTP and LTD: an embarrassment of riches.

  2004cited by this paper
• The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function.

  2003influential reference
• Brain-Derived Neurotrophic Factor val66met Polymorphism Affects Human Memory-Related Hippocampal Activity and Predicts Memory Performance

  2003cited by this paper
• Presynaptic BDNF required for a presynaptic but not postsynaptic component of LTP at hippocampal CA1-CA3 synapses.

  2003influential reference
• Clathrin adaptor AP2 and NSF interact with overlapping sites of GluR2 and play distinct roles in AMPA receptor trafficking and hippocampal LTD.

  2002cited by this paper
• Short-term synaptic plasticity.

  2002cited by this paper
• Mechanism of TrkB-mediated hippocampal long-term potentiation.

  2002cited by this paper
• Association between the BDNF 196 A/G polymorphism and sporadic Alzheimer's disease

  2002cited by this paper
• Electrical stimuli patterned after the theta-rhythm induce multiple forms of LTP.

  2001cited by this paper
• Some forms of cAMP-mediated long-lasting potentiation are associated with release of BDNF and nuclear translocation of phospho-MAP kinase.

  2001influential reference
• BDNF Enhances Quantal Neurotransmitter Release and Increases the Number of Docked Vesicles at the Active Zones of Hippocampal Excitatory Synapses

  2001cited by this paper
• Metabotropic glutamate receptor activation causes a rapid redistribution of AMPA receptors.

  2001cited by this paper
• Visualization of changes in presynaptic function during long-term synaptic plasticity

  2001influential reference
• Long-term depression: a cascade of induction and expression mechanisms.

  2001cited by this paper
• DHPG-induced LTD in area CA1 of juvenile rat hippocampus; characterisation and sensitivity to novel mGlu receptor antagonists.

  1999influential reference
• Long-term potentiation--a decade of progress?

  1999cited by this paper
• Essential role for TrkB receptors in hippocampus-mediated learning.

  1999cited by this paper
• Brain-derived neurotrophic factor modulates hippocampal synaptic transmission by increasing N-methyl-D-aspartic acid receptor activity.

  1998cited by this paper
• BDNF acutely increases tyrosine phosphorylation of the NMDA receptor subunit 2B in cortical and hippocampal postsynaptic densities.

  1998cited by this paper
• Brain-derived neurotrophic factor rapidly enhances phosphorylation of the postsynaptic N-methyl-D-aspartate receptor subunit 1.

  1997cited by this paper
• ラット内耳における metabotropic glutamate receptor の発現

  1997cited by this paper
• Long-term depression in hippocampus.

  1996cited by this paper
• Virus-mediated gene transfer into hippocampal CA1 region restores long-term potentiation in brain-derived neurotrophic factor mutant mice.

  1996influential reference
• Recombinant BDNF rescues deficits in basal synaptic transmission and hippocampal LTP in BDNF knockout mice.

  1996cited by this paper
• Hippocampal long-term potentiation is impaired in mice lacking brain-derived neurotrophic factor.

  1995influential reference
• An Embarrassment of Riches

  1992cited by this paper
• Transmission between pairs of hippocampal slice neurons: quantal levels, oscillations, and LTP.

  1991influential reference
• Short-term synaptic plasticity.

  1989cited by this paper
• Quantal analysis of paired-pulse facilitation in guinea pig hippocampal slices.

  1987cited by this paper
• Shift in Induction Mechanisms Underlies an Age-dependent Increase in Dhpg-induced Synaptic Depression at Ca3–ca1 Synapses Hippocampal Slice Preparation and Electrophysiology

  year unknowninfluential reference

• Research on the Correlation between BDNF Val76Met Polymorphism and Susceptibility to Changes of Cognitive Function in Rats Induced by Microwave Radiation

  2025cites this paper
• Exploring Genetic and Epigenetic Markers for Predicting or Monitoring Response to Cognitive-Behavioral Therapy in Obsessive-Compulsive Disorder: A Systematic Review.

  2025cites this paper
• The Role of Brain Derived Neurotrophic Factor Polymorphism in Transcranial Magnetic Stimulation Response for Major Depressive Disorder.

  2025cites this paper
• BDNF levels in serum and CSF are associated with clinicoradiological characteristics of aggressive disease in MS patients

  2025cites this paper
• Bangpungtongsung-san alleviates depressive-like behavior and metabolic disturbances in high-fat diet-induced obesity: mechanisms involving inflammation, CREB/BDNF signaling, and NMDA receptor modulation

  2025cites this paper
• The impact of BDNF and CD4 + T cell crosstalk on depression

  2024cites this paper
• Interaction between BDNF Val66Met polymorphism and mismatch negativity for working memory capacity in schizophrenia

  2024cites this paper
• Median raphe glutamatergic neuron-mediated enhancement of GABAergic transmission and suppression of long-term potentiation in the hippocampus

  2024cites this paper
• NRN1 epistasis with BDNF and CACNA1C: mediation effects on symptom severity through neuroanatomical changes in schizophrenia

  2024cites this paper
• The relevance of BDNF for neuroprotection and neuroplasticity in multiple sclerosis

  2024cites this paper
• Diminished activity-dependent BDNF signaling differentially causes autism-like behavioral deficits in male and female mice

  2023cites this paper
• Moderate associations between BDNF Val66Met gene polymorphism, musical expertise, and mismatch negativity

  2023cites this paper
• BDNF Val66Met polymorphism is associated with consolidation of episodic memory during sleep.

  2023cites this paper
• Brain-derived neurotrophic factor genetic polymorphism rs6265 and creativity

  2023cites this paper
• Brain-derived neurotrophic factor gene polymorphism affects cognitive function and neurofilament light chain level in patients with subcortical ischaemic vascular dementia

  2023cites this paper
• The association between overnight recognition accuracy and slow oscillation-spindle coupling is moderated by BDNF Val66Met.

  2022cites this paper
• BDNF Therapeutic Mechanisms in Neuropsychiatric Disorders

  2022cites this paper
• Acute stress induces an aberrant increase of presynaptic release of glutamate and cellular activation in the hippocampus of BDNFVal/Met mice

  2022cites this paper
• BDNF Val66Met genotype and adolescent glucocorticoid treatment induce sex-specific disruptions to fear extinction and amygdala GABAergic interneuron expression in mice.

  2022cites this paper
• A Common Human Brain-Derived Neurotrophic Factor Polymorphism Leads to Prolonged Depression of Excitatory Synaptic Transmission by Isoflurane in Hippocampal Cultures

  2022cites this paper
• Brain-Derived Neurotropic Factor in Neurodegenerative Disorders

  2022cites this paper
• Can Neuropeptide S Be an Indicator for Assessing Anxiety in Psychiatric Disorders?

  2022cites this paper
• A common human brain-derived neurotrophic factor polymorphism leads to sustained depression of excitatory synaptic transmission by isoflurane in hippocampus

  2022cites this paper
• Variability in cTBS Aftereffects Attributed to the Interaction of Stimulus Intensity With BDNF Val66Met Polymorphism

  2021cites this paper
• BDNF Val66Met polymorphism as putative genetic substrate of music-induced plasticity in auditory prediction

  2021cites this paper
• Influence of Brain-Derived Neurotrophic Factor Genotype on Short-Latency Afferent Inhibition and Motor Cortex Metabolites

  2021influential citation
• Met carriers of the BDNF Val66Met polymorphism show reduced Glx/NAA in the pregenual ACC in two independent cohorts

  2021cites this paper
• Melamine disrupts spatial reversal learning and learning strategy via inhibiting hippocampal BDNF-mediated neural activity.

  2021cites this paper
• BDNF polymorphism and inter hemispheric balance of motor cortex excitability: a preliminary study.

  2021cites this paper
• Effect of brain-derived neurotrophic factor gene polymorphisms on motor performance and motor learning: A systematic review and meta-analysis.

  2021influential citation
• Brain-derived Neurotrophic Factor: a Key Gene Risk Factor and Potential Therapy Target in Bipolar Disorder

  2021cites this paper
• Influence of BDNF Val66Met polymorphism on excitatory-inhibitory balance and plasticity in human motor cortex.

  2021cites this paper
• Genetic and Neurophysiological Biomarkers of Neuroplasticity Inform Post-Stroke Language Recovery

  2021cites this paper
• Do Brain-Derived Neurotrophic Factor Genetic Polymorphisms Modulate the Efficacy of Motor Cortex Plasticity Induced by Non-invasive Brain Stimulation? A Systematic Review

  2021cites this paper
• Exercise prevents the impairment of learning and memory in prenatally phthalate-exposed male rats by improving the expression of plasticity-related proteins.

  2021cites this paper
• Contribution of the brain-derived neurotrophic factor and neurometabolites to the motor performance.

  2021cites this paper
• Brain-Derived Neurotrophic Factor (BDNF) Polymorphism and Depression-Suicide

  2021cites this paper
• Association Between Brain-Derived Neurotrophic Factor Val66Met Polymorphism and Methamphetamine Use Disorder: A Meta-Analysis

  2020cites this paper
• Neurotrophin & synaptogenesis

  2020cites this paper
• BDNF Gene's Role in Schizophrenia: From Risk Allele to Methylation Implications

  2020cites this paper
• Neuroplasticity and the Biological Role of Brain Derived Neurotrophic Factor in the Pathophysiology and Management of Depression

  2020cites this paper
• Neurotrophin and synaptogenesis

  2020cites this paper
• The role of brain-derived neurotrophic factor in neural circuit development and function

  2020cites this paper
• The BDNF Val66Met polymorphism (rs6265) enhances dopamine neuron graft efficacy and side-effect liability in rs6265 knock-in rats

  2020cites this paper
• Brain-Derived Neurotrophic Factor Val66Met polymorphism interacts with adolescent stress to alter hippocampal interneuron density and dendritic morphology in mice

  2020cites this paper
• Electroacupuncture on Trigeminal Nerve-Innervated Acupoints Ameliorates Poststroke Cognitive Impairment in Rats with Middle Cerebral Artery Occlusion: Involvement of Neuroprotection and Synaptic Plasticity

  2020cites this paper
• Kynurenine pathway is altered in BDNF Val66Met knock-in mice: effect of physical exercise.

  2020cites this paper
• The Role of BDNF on Neural Plasticity in Depression

  2020cites this paper
• Rapid anti‐depressant‐like effects of ketamine and other candidates: Molecular and cellular mechanisms

  2020cites this paper
• The BDNF Val66Met Polymorphism Modulates Resilience of Neurological Functioning to Brain Ageing and Dementia: A Narrative Review

  2020cites this paper
• Effects of aquatic exercise on insulin-like growth factor-1, brain-derived neurotrophic factor, vascular endothelial growth factor, and cognitive function in elderly women.

  2020cites this paper
• Neurobiology of BDNF in fear memory, sensitivity to stress, and stress-related disorders

  2020cites this paper
• Neuroprotective roles of neurotrophic growth factors in mood disorders

  2020cites this paper
• The implication of BDNF Val66Met polymorphism in progression from subjective cognitive decline to mild cognitive impairment and Alzheimer’s disease: a 9-year follow-up study

  2019cites this paper
• Future considerations for pediatric cancer survivorship: Translational perspectives from developmental neuroscience

  2019cites this paper
• BDNF Val66Met polymorphism moderates the association between sleep spindles and overnight visual recognition.

  2019cites this paper
• Glutamate as a Neural Stress Factor in Humans and Animals

  2019cites this paper
• Impact of APOE and BDNF Val66Met Gene Polymorphisms on Cognitive Functions in Patients with Amnestic Mild Cognitive Impairment

  2019cites this paper
• Brain-Derived Neurotrophic Factor: A Key Molecule for Memory in the Healthy and the Pathological Brain

  2019cites this paper
• The role of NMDA receptor in neurobiology and treatment of major depressive disorder: Evidence from translational research.

  2019cites this paper
• Genetics of stroke recovery: BDNF val66met polymorphism in stroke recovery and its interaction with aging.

  2019cites this paper
• BDNF pro-peptide: physiological mechanisms and implications for depression

  2019cites this paper
• Neurotrophic factors and neuroplasticity pathways in the pathophysiology and treatment of depression

  2018cites this paper
• BDNF Val66Met polymorphism is associated with altered activity-dependent modulation of short-interval intracortical inhibition in bilateral M1

  2018cites this paper
• Synaptic plasticity modulation by circulating peptides and metaplasticity: Involvement in Alzheimer's disease

  2018cites this paper
• Identification d'une forme phosphorylée de BDNF : un nouveau mécanisme de régulation de la plasticité synaptique et de la mémoire ?

  2018cites this paper
• Fronto-striatal plasticity processes in humans: glutamatergic and genetic mechanisms

  2018cites this paper
• Brain-derived neurotrophic factor Val66Met genotype and ovarian steroids interactively modulate working memory-related hippocampal function in women: a multimodal neuroimaging study

  2018cites this paper
• Associations between Variants in BDNF/BDNFOS Gene and Lumbar Disc Herniation Risk among Han Chinese People

  2018cites this paper
• The Role of the BDNF Val66Met Polymorphism in Recovery of Aphasia After Stroke

  2017cites this paper
• The Val66Met brain-derived neurotrophic factor gene variant interacts with early pain exposure to predict cortisol dysregulation in 7-year-old children born very preterm: Implications for cognition.

  2017cites this paper
• BDNF pro-peptide: a novel synaptic modulator generated as an N-terminal fragment from the BDNF precursor by proteolytic processing

  2017cites this paper
• Interplay between brain BDNF and glutamatergic systems: A brief state of the evidence and association with the pathogenesis of depression

  2017cites this paper
• BDNF val66met Polymorphism Impairs Hippocampal Long-Term Depression by Down-Regulation of 5-HT3 Receptors

  2017influential citation
• Neurotrophins and Proneurotrophins: Focus on Synaptic Activity and Plasticity in the Brain

  2017cites this paper
• The BDNF val-66-met Polymorphism Affects Neuronal Morphology and Synaptic Transmission in Cultured Hippocampal Neurons from Rett Syndrome Mice

  2017influential citation
• Influence of catch up growth on spatial learning and memory in a mouse model of intrauterine growth restriction

  2017cites this paper
• Brain-derived neurotrophic factor Val66Met genotype modulates amygdala habituation.

  2017cites this paper
• The BDNF Val66Met polymorphism enhances glutamatergic transmission but diminishes activity‐dependent synaptic plasticity in the dorsolateral striatum

  2017cites this paper
• Interaction of Brain-Derived Neurotrophic Factor Val66Met genotype and history of stress in regulation of prepulse inhibition in mice.

  2017cites this paper
• Brain-derived neurotrophic factor in mood disorders and antidepressant treatments.

  2017cites this paper
• Neuronal plasticity and neurotrophic factors in drug responses

  2017cites this paper
• The BDNF Val66Met polymorphism regulates glucocorticoid-induced corticohippocampal remodeling and behavioral despair

  2017cites this paper
• Research Progress of Brain-Derived Neurotrophic Factor in Alzheimer’s Disease

  2017cites this paper
• The BDNF Val66Met polymorphism moderates the effect of cognitive reserve on 36-month cognitive change in healthy older adults

  2017cites this paper
• BDNF Propeptide: A Novel Modulator of Synaptic Plasticity.

  2017cites this paper
• BDNF - a key transducer of antidepressant effects.

  2016cites this paper
• Activation of a synapse weakening pathway by human Val66 but not Met66 pro-brain-derived neurotrophic factor (proBDNF)

  2016cites this paper
• Brain-Derived Neurotrophic Factor Val66Met Human Polymorphism Impairs the Beneficial Exercise-Induced Neurobiological Changes in Mice

  2016cites this paper
• Translational profiling of stress-induced neuroplasticity in the CA3 pyramidal neurons of BDNF Val66Met mice

  2016cites this paper
• Altered Episodic Memory in Introverted Young Adults Carrying the BDNFMet Allele

  2016cites this paper
• The effects of senior brain health exercise program on basic physical fitness, cognitive function and BDNF of elderly women - a feasibility study

  2016cites this paper
• Slitrk Missense Mutations Associated with Neuropsychiatric Disorders Distinctively Impair Slitrk Trafficking and Synapse Formation

  2016cites this paper
• Neurobiological actions by three distinct subtypes of brain-derived neurotrophic factor: Multi-ligand model of growth factor signaling.

  2016cites this paper
• SorCS2 is required for BDNF-dependent plasticity in the hippocampus

  2016cites this paper
• Variant BDNF-Val66Met Polymorphism is Associated with Layer-Specific Alterations in GABAergic Innervation of Pyramidal Neurons, Elevated Anxiety and Reduced Vulnerability of Adolescent Male Mice to Activity-Based Anorexia

  2016cites this paper
• Prenatal Cocaine Exposure Upregulates BDNF-TrkB Signaling

  2016cites this paper
• Deconstructing brain-derived neurotrophic factor actions in adult brain circuits to bridge an existing informational gap in neuro-cell biology

  2016cites this paper
• Activity-dependent signaling: influence on plasticity in circuits controlling fear-related behavior.

  2016cites this paper
• Brain-Derived Neurotrophic Factor’s Neuroprotective Effects in Entorhinal Cortex

  2016cites this paper