Primary structure of helodermin, a VIP‐secretin‐like peptide isolated from Gila monster venom

No abstract is available for this paper.

• Publication year

  1984

• Venue

  FEBS Letters

• Publication date

  1984-12-10

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1016/0014-5793(84)80607-9PMID 6439576
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Specific labelling by [125I]helodermin of high‐affinity VIP receptors in rat liver membranes

  1984cited by this paper
• Purification of a novel pancreatic secretory factor (PSF) and a novel peptide with VIP‐ and secretin‐like properties (helodermin) from Gila monster venom

  1984cited by this paper
• Evidence that helodermin, a newly extracted peptide from Gila monster venom, is a member of the secretin/VIP/PHI family of peptides with an original pattern of biological properties

  1984cited by this paper
• Interaction of Gila monster venom with secretin receptors in rat pancreatic membranes.

  1984cited by this paper
• Mechanism of C-terminal amide formation by pituitary enzymes

  1982cited by this paper
• Solid phase peptide synthesis. I. the synthesis of a tetrapeptide

  1963cited by this paper

• Targeting VIP and PACAP Receptor Signaling: New Insights into Designing Drugs for the PACAP Subfamily of Receptors

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• Peptide‐mediated mast cell activation: ligand similarities for receptor recognition and protease‐induced regulation

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• Mass spectrometry in natural product structure elucidation.

  2015cites this paper
• Potential PET Ligands for Imaging of Cerebral VPAC and PAC Receptors: Are Non-Peptide Small Molecules Superior to Peptide Compounds?

  2015cites this paper
• Sex and basic science. A Title IX position.

  2014cites this paper
• Medicinal chemistry of glucagon-like peptide receptor agonists.

  2013cites this paper
• Paracrine Regulation of Thyroid-Hormone Synthesis by C Cells

  2012cites this paper
• Vascular KATP Channel Modulation by S-Glutathionylation: A Novel Mechanism for Cellular Response to Oxidative Stress

  2011cites this paper
• Mast cell chymase reduces the toxicity of Gila monster venom, scorpion venom, and vasoactive intestinal polypeptide in mice.

  2011cites this paper
• Efeito de frações peptídicas do veneno da serpente Bothrops jararaca (Serpentes, Viperidae: Crotalinae) sobre a atividade enzimática dipeptidil-peptidase IV (DPP-IV) e sobre o receptor (GLP-1R) do peptídeo glucagon-símile tipo 1 (GLP-1)

  2010cites this paper
• Structure-activity relationship of vasoactive intestinal peptide (VIP): potent agonists and potential clinical applications

  2008cites this paper
• PKA-dependent activation of the vascular smooth muscle isoform of KATP channels by vasoactive intestinal polypeptide and its effect on relaxation of the mesenteric resistance artery.

  2008cites this paper
• Bioactive analogues and drug delivery systems of vasoactive intestinal peptide (VIP) for the treatment of asthma/COPD.

  2007cites this paper
• Helodermin-loaded nanoparticles: characterization and transport across an in vitro model of the follicle-associated epithelium.

  2007cites this paper
• Alpha-helical structure in the C-terminus of vasoactive intestinal peptide: functional and structural consequences.

  2004cites this paper
• Helospectin I and II evoke vasodilation in the intact peripheral microcirculation.

  2004cites this paper
• Isolation and characterization of four VIP-related peptides from red-bellied newt, Cynops pyrrhogaster.

  2004cites this paper
• Structure-activity relationship of synthetic truncated analogues of vasoactive intestinal peptide (VIP): an enhancement in the activity by a substitution with arginine.

  2004cites this paper
• Effects of preproglucagon-derived peptides and exendins on steroid-hormone secretion from dispersed adrenocortical cells of normal and streptozotocin-induced diabetic rats.

  2003cites this paper
• Cyclic AMP formation in chicken brain: effect of vasoactive intestinal peptide, peptide histidine-isoleucine (PHI), and some PHI-related peptides.

  2003cites this paper
• Development of Selective Ligands for Pac1, Vpac1 and Vpac2 Receptors

  2003cites this paper
• The origin and function of the pituitary adenylate cyclase-activating polypeptide (PACAP)/glucagon superfamily.

  2000cites this paper
• Secretin, glucagon, gastric inhibitory polypeptide, parathyroid hormone, and related peptides in the regulation of the hypothalamus- pituitary-adrenal axis.

  2000cites this paper
• THE ORIGIN AND FUNCTION OF THE PITUITARY ADENYLATE CYCLASE-ACTIVATING POLYPEPTIDE (PACAP)/GLUCAGON SUPERFAMILY

  2000cites this paper
• Identification of Key Residues for Interaction of Vasoactive Intestinal Peptide with Human VPAC1 and VPAC2Receptors and Development of a Highly Selective VPAC1Receptor Agonist

  2000cites this paper
• Evidence that the lizard helospectin peptides are O-glycosylated.

  2000cites this paper
• Functional characterization of a receptor for vasoactive-intestinal-peptide-related peptides in cultured dermal melanophores from Xenopus laevis.

  1999cites this paper
• Role of MaxiK channels in vasoactive intestinal peptide-induced relaxation of rat mesenteric artery.

  1999cites this paper
• Helospectin-Like Peptides: Immunochemical Localization and Effects on Isolated Cerebral Arteries and on Local Cerebral Blood Flow in the Cat

  1999cites this paper
• Glibenclamide-sensitive hypotension produced by helodermin assessed in the rat.

  1998cites this paper
• Molecular Cloning of the Helodermin and Exendin-4 cDNAs in the Lizard

  1998cites this paper
• Xenin--a review.

  1998cites this paper
• Neuropeptide families: evolutionary perspectives.

  1998cites this paper
• Glibenclamide-sensitive mechanism is involved in helodermin-produced vasodilatation in rat mesenteric artery.

  1997cites this paper
• Pre- and post-junctional effects of VIP-like peptides in guinea pig tracheal smooth muscle.

  1997cites this paper
• Localization and distribution of vasoactive neuropeptides in the human placenta.

  1996cites this paper
• Bioactive peptides from lizard venoms.

  1996cites this paper
• Characterization of the VIP receptor from SUP T1 lymphoblasts.

  1996cites this paper
• NMR spectroscopic evidence that helodermin, unlike other members of the secretin/VIP family of peptides, is substantially structured in water.

  1996cites this paper
• Characterization of VIP-and helodermin-preferring receptors on rat platelets.

  1996cites this paper
• Vasoactive intestinal polypeptide and other preprovasoactive intestinal polypeptide-derived peptides in the female and male genital tract: localization, biosynthesis, and functional and clinical significance.

  1995cites this paper
• A human orphan calcitonin receptor-like structure.

  1995cites this paper
• The Effect of Helodermin in Rat Dispersed Pancreatic Acini

  1995cites this paper
• Nitric oxide synthase-containing, peptide-containing, and acetylcholinesterase-positive nerves in the cat lower oesophagus

  1994cites this paper
• Use of 125I-[Y39]exendin-4 to characterize exendin receptors on dispersed pancreatic acini and gastric chief cells from guinea pig.

  1994cites this paper
• Helodermin, helospectin, and PACAP stimulate cyclic AMP formation in intact bone, isolated osteoblasts, and osteoblastic cell lines

  1994cites this paper
• Inhibitory Nonadrenergic, Noncholinergic Innervation of Airways Smooth Muscle: Role of Vasoactive Intestinal Peptide and Structurally Related Molecules

  1994cites this paper
• Chapter 10 – Regulatory Peptides of the Parasympathetic Vascular Innervation

  1993cites this paper
• Helospectin/helodermin-like peptides in guinea pig lung: distribution and dilatory effects.

  1993cites this paper
• Actions of Helodermatidae venom peptides and mammalian glucagon-like peptides on gastric chief cells.

  1993cites this paper
• Two salmon neuropeptides encoded by one brain cDNA are structurally related to members of the glucagon superfamily.

  1993cites this paper
• Action of pituitary adenylate cyclase-activating polypeptide on ion transport in guinea pig distal colon.

  1993cites this paper
• Exendin peptides.

  1992cites this paper
• Helospectin-like immunoreactivity in the esophagus.

  1992cites this paper
• Insulinotropic glucagonlike peptide-I(7-37)/(7-36)amide A new incretin hormone.

  1992cites this paper
• Helospectin-like peptides in the gastrointestinal tract: immunocytochemical localization and immunochemical characterization.

  1992cites this paper
• Evolution of the growth hormone-releasing factor (GRF) family of peptides.

  1992cites this paper
• Vasoactive intestinal peptide and helodermin inhibit the release of cyclo-oxygenase products induced by leukotriene D4 and bradykinin from guinea-pig perfused lung.

  1992cites this paper
• The distribution of pituitary adenylate cyclase-activating polypeptide-like immunoreactivity is distinct from helodermin- and helospectin-like immunoreactivities in the rat brain.

  1992cites this paper
• Unlike VIP, the VIP-related peptides PACAP, helodermin and helospectin suppress electrically evoked contractions of rat vas deferens.

  1992cites this paper
• Exendin-4, a new peptide from Heloderma suspectum venom, potentiates cholecystokinin-induced amylase release from rat pancreatic acini.

  1992cites this paper
• Pituitary adenylate cyclase activating peptide: A novel vasoactive intestinal peptide-like neuropeptide in the gut

  1992cites this paper
• Neuroendocrine regulation of cyclic AMP formation in osteoblastic cell lines (UMR‐106–01, ROS 17/2.8, MC3T3‐E1, and Saos‐2) and primary bone cells

  1992cites this paper
• Isolation and characterization of exendin-4, an exendin-3 analogue, from Heloderma suspectum venom. Further evidence for an exendin receptor on dispersed acini from guinea pig pancreas.

  1992cites this paper
• Helodermin- and helospectin-like immunoreactivities in the rat brain: an immunochemical and immunohistochemical study.

  1992cites this paper
• Exendin-3, a novel peptide from Heloderma horridum venom, interacts with vasoactive intestinal peptide receptors and a newly described receptor on dispersed acini from guinea pig pancreas. Description of exendin-3(9-39) amide, a specific exendin receptor antagonist.

  1991cites this paper
• Discovery of galanin

  1991cites this paper
• Enzymatic degradation of helodermin and vasoactive intestinal polypeptide.

  1991cites this paper
• Helodermin and islet hormone release in isolated rat pancreas

  1991cites this paper
• Pituitary adenylate cyclase-activating peptide (PACAP), a new vasoactive intestinal peptide (VIP)-like peptide in the respiratory tract

  1991cites this paper
• Effects of vasoactive intestinal peptide, helodermin and galanin on responses of guinea‐pig lung parenchyma to histamine, acetylcholine and leukotriene D4

  1991cites this paper
• Pituitary adenylate cyclase activating peptide (PACAP) in guinea-pig lung: distribution and dilatory effects

  1991cites this paper
• VIP receptors in human SUP-T1 lymphoblasts.

  1990cites this paper
• Effects of helodermin on fetal rat bone metabolism in vitro.

  1990cites this paper
• Isolation and characterization of helothermine, a novel toxin from Heloderma horridum horridum (Mexican beaded lizard) venom.

  1990cites this paper
• Vascular effects of helodermin, helospectin I and helospectin II: a comparison with vasoactive intestinal peptide (VIP)

  1990cites this paper
• Purification and structure of exendin-3, a new pancreatic secretagogue isolated from Heloderma horridum venom.

  1990cites this paper
• Is helodermin-like immunoreactivity in human thyroid C cells due to a salmon calcitonin-like substance?

  1990cites this paper
• The novel VIP-like hypothalamic polypeptide PACAP interacts with high affinity receptors in the human neuroblastoma cell line NB-OK.

  1990cites this paper
• Characterization of VIP- and helodermin-preferring receptors on human small cell lung carcinoma cell lines.

  1990cites this paper
• Non-Calcitonin Genes-Derived Neurohormonal Polypeptides in Normal and Pathologic Thyroid C Cells

  1990cites this paper
• Regulatory peptides in the thyroid gland.

  1989cites this paper
• Secretory actions of vasoactive intestinal polypeptide, peptide histidine isoleucine and helodermin in rat small intestine: the effects of putative VIP antagonists upon VIP-induced ion secretion.

  1989cites this paper
• Recent advances in brain-gut hormones.

  1989cites this paper
• Helodermin-like peptides in thyroid C cells: stimulation of thyroid hormone secretion and suppression of calcium incorporation into bone.

  1989cites this paper
• Decreased adenylate cyclase activation by helodermin and PGE1 in the lectin-resistant variant Wa4 of the mouse melanoma cell line B16.

  1989cites this paper
• Interaction of peptides related to VIP and secretin with guinea pig pancreatic acini.

  1989cites this paper
• Helodermin-like peptides in noradrenaline cells of adrenal medulla.

  1989cites this paper
• Effects of VIP and helodermin on thyroid hormone secretion in the mouse.

  1989cites this paper
• Peptide Receptors in Intestinal Epithelium

  1989cites this paper
• Sequences of Natural Gut Peptides, Related Peptides, and Their Precursors

  1989cites this paper
• Comparative Neuroendocrinology of Gut Peptides

  1989cites this paper
• Secretin

  1989cites this paper
• 7 Vasoactive intestinal peptide

  1989cites this paper
• Vasoactive intestinal peptide

  1989cites this paper
• Comparison of helodermin, VIP and PHI in pancreatic secretion and blood flow in dogs.

  1989cites this paper
• HT 29, a model cell line: stimulation by the vasoactive intestinal peptide (VIP); VIP receptor structure and metabolism.

  1988cites this paper
• Helodermin and Helospectin‐like Peptides Present in the Venom of the Lizards Heloderma horridum and Heloderma suspectum

  1988cites this paper
• Secretin and cholecystokinin

  1988cites this paper
• A new type of functional VIP receptor has an affinity for helodermin in human SUP‐T1 lymphoblasts

  1988cites this paper