Pericytes on the Tumor Vasculature: Jekyll or Hyde?

No abstract is available for this paper.

• Publication year

  2013

• Venue

  Cancer Microenvironment

• Publication date

  2013-04-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1007/s12307-012-0102-2PMID 22467426PMCID PMC3601214
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Vascular hyperpermeability, angiogenesis, and stroma generation.

  2012cited by this paper
• Tumor vessel stabilization and remodeling by anti-angiogenic therapy with bevacizumab

  2012cited by this paper
• Angiopoietin-1/Tie2 Signal Augments Basal Notch Signal Controlling Vascular Quiescence by Inducing Delta-Like 4 Expression through AKT-mediated Activation of β-Catenin*

  2011cited by this paper
• Targeting the ANG2/TIE2 axis inhibits tumor growth and metastasis by impairing angiogenesis and disabling rebounds of proangiogenic myeloid cells.

  2011cited by this paper
• Neuropilin-1 mediates PDGF stimulation of vascular smooth muscle cell migration and signalling via p130Cas

  2011cited by this paper
• Peg-and-socket junctions between smooth muscle cells and endothelial cells in femoral veins are stimulated to angiogenesis by prostaglandin E₂ and glycerols.

  2011cited by this paper
• Pericyte-Derived Sphinogosine 1-Phosphate Induces the Expression of Adhesion Proteins and Modulates the Retinal Endothelial Cell Barrier

  2011cited by this paper
• Angiopoietin-1 is essential in mouse vasculature during development and in response to injury.

  2011cited by this paper
• Connexin 43 connexon to gap junction transition is regulated by zonula occludens-1

  2011cited by this paper
• Normalization of the vasculature for treatment of cancer and other diseases.

  2011cited by this paper
• Vessel abnormalization: another hallmark of cancer? Molecular mechanisms and therapeutic implications.

  2011cited by this paper
• Dynamics of endothelial cell behavior in sprouting angiogenesis.

  2010cited by this paper
• From Vessel Sprouting to Normalization: Role of the Prolyl Hydroxylase Domain Protein/Hypoxia-Inducible Factor Oxygen-Sensing Machinery

  2010cited by this paper
• Vascular permeability to plasma, plasma proteins, and cells: an update

  2010cited by this paper
• Endothelial-derived PDGF-BB and HB-EGF coordinately regulate pericyte recruitment during vasculogenic tube assembly and stabilization.

  2010cited by this paper
• Complementary actions of inhibitors of angiopoietin-2 and VEGF on tumor angiogenesis and growth.

  2010cited by this paper
• Resistance to antiangiogenic therapy is directed by vascular phenotype, vessel stabilization, and maturation in malignant melanoma

  2010cited by this paper
• Resistance to antiangiogenic therapy is directed by vascular phenotype, vessel stabilization, and maturation in malignant melanoma

  2010cited by this paper
• MCP-1 promotes mural cell recruitment during angiogenesis in the aortic ring model

  2010cited by this paper
• Venular basement membranes ubiquitously express matrix protein low-expression regions: characterization in multiple tissues and remodeling during inflammation.

  2010cited by this paper
• Pericyte-specific expression of PDGF beta receptor in mouse models with normal and deficient PDGF beta receptor signaling

  2010cited by this paper
• S1P2, the G protein-coupled receptor for sphingosine-1-phosphate, negatively regulates tumor angiogenesis and tumor growth in

  2010cited by this paper
• The shunt problem: control of functional shunting in normal and tumour vasculature

  2010cited by this paper
• Repulsive axon guidance molecule Slit3 is a novel angiogenic factor.

  2009cited by this paper
• Pericyte recruitment during vasculogenic tube assembly stimulates endothelial basement membrane matrix formation.

  2009cited by this paper
• Pericyte coverage decreases invasion of tumour cells into blood vessels in prostate cancer xenografts

  2009cited by this paper
• EphrinB reverse signaling contributes to endothelial and mural cell assembly into vascular structures.

  2009cited by this paper
• Mechanisms of Vessel Branching: Filopodia on Endothelial Tip Cells Lead the Way

  2009cited by this paper
• Host-derived angiopoietin-2 affects early stages of tumor development and vessel maturation but is dispensable for later stages of tumor growth.

  2009cited by this paper
• Mural Cell Associated VEGF Is Required for Organotypic Vessel Formation

  2009cited by this paper
• Ultrastructural descriptions of pericyte/endothelium peg-socket interdigitations in the microvasculature of human gastric carcinomas.

  2009cited by this paper
• Overexpression of platelet-derived growth factor-BB increases tumor pericyte content via stromal-derived factor-1alpha/CXCR4 axis.

  2009cited by this paper
• COMP-Ang1 Potentiates the Antitumor Activity of 5-Fluorouracil by Improving Tissue Perfusion in Murine Lewis Lung Carcinoma

  2009cited by this paper
• Angiogenesis and vascular function in the ovary.

  2009cited by this paper
• Gap Junctions in the Control of Vascular Function

  2009cited by this paper
• Pericytes. Morphofunction, interactions and pathology in a quiescent and activated mesenchymal cell niche.

  2009cited by this paper
• Capillary defects and exaggerated inflammatory response in the airways of EphA2-deficient mice.

  2009cited by this paper
• VEGF-A induces angiogenesis by perturbing the cathepsin-cysteine protease inhibitor balance in venules, causing basement membrane degradation and mother vessel formation.

  2009cited by this paper
• Slit2–Robo4 signalling promotes vascular stability by blocking Arf6 activity

  2009cited by this paper
• Vascular normalization in Rgs5-deficient tumours promotes immune destruction

  2008cited by this paper
• A Role for VEGF as a Negative Regulator of Pericyte Function and Vessel Maturation

  2008cited by this paper
• Angiopoietin‐1 alters tumor growth by stabilizing blood vessels or by promoting angiogenesis

  2008cited by this paper
• Platelet-derived growth factor signaling through ephrin-b2 regulates hepatic vascular structure and function.

  2008cited by this paper
• Endothelial sprouting and angiogenesis: matrix metalloproteinases in the lead.

  2008cited by this paper
• Differential function of Tie2 at cell–cell contacts and cell–substratum contacts regulated by angiopoietin-1

  2008cited by this paper
• Soluble receptor-mediated selective inhibition of VEGFR and PDGFRβ signaling during physiologic and tumor angiogenesis

  2008cited by this paper
• A role for VEGF as a negative regulator of pericyte function and vessel maturation.

  2008cited by this paper
• Angiogenic factors FGF2 and PDGF-BB synergistically promote murine tumor neovascularization and metastasis.

  2007cited by this paper
• An intimate interplay between precocious, migrating pericytes and endothelial cells governs human fetal brain angiogenesis

  2007cited by this paper
• Tumorigenesis and Neoplastic Progression Caveolin-1 Is Critical for the Maturation of Tumor Blood Vessels through the Regulation of Both Endothelial Tube Formation and Mural Cell Recruitment

  2007cited by this paper
• Strengthening tight junctions of retinal microvascular endothelial cells by pericytes under normoxia and hypoxia involving angiopoietin-1 signal way

  2007cited by this paper
• AZD2171, a pan-VEGF receptor tyrosine kinase inhibitor, normalizes tumor vasculature and alleviates edema in glioblastoma patients.

  2007cited by this paper
• Tumor microvasculature and microenvironment: targets for anti-angiogenesis and normalization.

  2007cited by this paper
• Permeability properties of tumor surrogate blood vessels induced by VEGF-A

  2006cited by this paper
• Macrophages: obligate partners for tumor cell migration, invasion, and metastasis.

  2006cited by this paper
• Impaired pericyte recruitment and abnormal retinal angiogenesis as a result of angiopoietin-2 overexpression

  2006cited by this paper
• Connexin-dependent communication within the vascular wall: contribution to the control of arteriolar diameter.

  2006cited by this paper
• Localization of Ang-1, -2, Tie-2, and VEGF expression at endothelial-pericyte interdigitation in rat angiogenesis

  2006cited by this paper
• Venular basement membranes contain specific matrix protein low expression regions that act as exit points for emigrating neutrophils

  2006cited by this paper
• Hepatocyte growth factor mediates angiopoietin-induced smooth muscle cell recruitment.

  2006cited by this paper
• Breast cancer cells secreted platelet‐derived growth factor‐induced motility of vascular smooth muscle cells is mediated through neuropilin‐1

  2006cited by this paper
• Anti‐angiogenesis therapy can overcome endothelial cell anergy and promote leukocyte‐endothelium interactions and infiltration in tumors

  2006cited by this paper
• EphB4 controls blood vascular morphogenesis during postnatal angiogenesis

  2006cited by this paper
• Ephrin-B2 controls cell motility and adhesion during blood-vessel-wall assembly.

  2006cited by this paper
• Macrophages regulate the angiogenic switch in a mouse model of breast cancer.

  2006cited by this paper
• Coregulation of vascular tube stabilization by endothelial cell TIMP-2 and pericyte TIMP-3

  2006cited by this paper
• Pericytes limit tumor cell metastasis.

  2006cited by this paper
• Angiogenesis with pericyte abnormalities in a transgenic model of prostate carcinoma

  2005cited by this paper
• The phosphorylated form of connexin43 is up-regulated in breast hyperplasias and carcinomas and in their neoformed capillaries.

  2005cited by this paper
• Expression and regulation of murine macrophage angiopoietin-2.

  2005cited by this paper
• Expression and regulation of murine macrophage angiopoietin-2. Cell Immunol

  2005cited by this paper
• Essential Role for Sphingosine Kinases in Neural and Vascular Development

  2005cited by this paper
• In vitro and in vivo modulation of vascular barrier integrity by sphingosine 1-phosphate: mechanistic insights.

  2005cited by this paper
• Zonula occludens-1 alters connexin43 gap junction size and organization by influencing channel accretion.

  2005cited by this paper
• Cellular abnormalities of blood vessels as targets in cancer.

  2005cited by this paper
• Absence of Smooth Muscle Actin-Positive Pericyte Coverage of Tumor Vessels Correlates with Hematogenous Metastasis and Prognosis of Colorectal Cancer Patients

  2005cited by this paper
• Angiopoietin-2 stimulates migration of endothelial progenitors and their interaction with endothelium.

  2005cited by this paper
• Contribution of bone marrow-derived pericyte precursor cells to corneal vasculogenesis.

  2005cited by this paper
• Remodeling of Blood Vessels: Responses of Diameter and Wall Thickness to Hemodynamic and Metabolic Stimuli

  2005cited by this paper
• Brain pericytes contribute to the induction and up-regulation of blood-brain barrier functions through transforming growth factor-beta production.

  2005cited by this paper
• MMP-1 activation by serine proteases and MMP-10 induces human capillary tubular network collapse and regression in 3D collagen matrices

  2005cited by this paper
• Tie2 identifies a hematopoietic lineage of proangiogenic monocytes required for tumor vessel formation and a mesenchymal population of pericyte progenitors.

  2005cited by this paper
• Minocycline Exerts Multiple Inhibitory Effects on Vascular Endothelial Growth Factor–Induced Smooth Muscle Cell Migration: The Role of ERK1/2, PI3K, and Matrix Metalloproteinases

  2004cited by this paper
• Stromal Matrix Metalloproteinase-9 Regulates the Vascular Architecture in Neuroblastoma by Promoting Pericyte Recruitment

  2004cited by this paper
• Vascular endothelial growth factor is upregulated by interleukin-1β in human vascular smooth muscle cells via the P38 mitogen-activated protein kinase pathway

  2004cited by this paper
• Fibrin as a component of the tumor stroma: origins and biological significance

  2004cited by this paper
• Combined inhibition of VEGF‐ and PDGF‐signaling enforces tumor vessel regression by interfering with pericyte‐mediated endothelial cell survival mechanisms

  2004cited by this paper
• Kinetics of vascular normalization by VEGFR2 blockade governs brain tumor response to radiation: role of oxygenation, angiopoietin-1, and matrix metalloproteinases.

  2004cited by this paper
• Sphingosine 1-Phosphate Stimulates Smooth Muscle Cell Differentiation and Proliferation by Activating Separate Serum Response Factor Co-factors*

  2004cited by this paper
• Sphingosine 1-phosphate receptor regulation of N-cadherin mediates vascular stabilization.

  2004cited by this paper
• Structural and functional characteristics of S1P receptors

  2004cited by this paper
• Direct chemotactic action of angiopoietin-1 on mesenchymal cells in the presence of VEGF.

  2004cited by this paper
• Sphingosine 1-Phosphate Transactivates the Platelet-Derived Growth Factor β Receptor and Epidermal Growth Factor Receptor in Vascular Smooth Muscle Cells

  2004cited by this paper
• Vascular Normalization by Vascular Endothelial Growth Factor Receptor 2 Blockade Induces a Pressure Gradient Across the Vasculature and Improves Drug Penetration in Tumors

  2004cited by this paper
• Immunohistochemical investigation of collagen subtypes in human glioblastomas

  2004cited by this paper
• A pericyte‐derived angiopoietin‐1 multimeric complex induces occludin gene expression in brain capillary endothelial cells through Tie‐2 activation in vitro

  2004cited by this paper
• Early Contribution of Pericytes to Angiogenic Sprouting and Tube Formation

  2004cited by this paper
• Endostatin inhibits angiogenesis by stabilization of newly formed endothelial tubes

  2004cited by this paper
• Effects of hypoxia on endothelial/pericytic co-culture model of the blood-brain barrier.

  2004cited by this paper
• In Vivo Angiogenic Phenotype of Endothelial Cells and Pericytes Induced by Vascular Endothelial Growth Factor-A

  2004cited by this paper

• Understanding Neovascularization in Glioblastoma: Insights from the Current Literature

  2025cites this paper
• CXCL10 Secreted by Pericytes Mediates TNFα-Induced Vascular Leakage in Tumors and Enhances Extravasation of Nanoparticle-Based Chemotherapeutics

  2025cites this paper
• In-depth insight into tumor-infiltrating stromal cells linked to tertiary lymphoid structures and their prospective function in cancer immunotherapy

  2025cites this paper
• Fas Ligand enhances vessel maturation and inhibits vascular leakage associated with age-related macular degeneration

  2024cites this paper
• Tumor Microenvironment Modulation by Cancer-Derived Extracellular Vesicles

  2024cites this paper
• The Tumor Stroma of Squamous Cell Carcinoma: A Complex Environment That Fuels Cancer Progression

  2024cites this paper
• Targeting the lung tumour stroma: harnessing nanoparticles for effective therapeutic interventions

  2024cites this paper
• The Role of TAMs in the Regulation of Tumor Cell Resistance to Chemotherapy.

  2024cites this paper
• Perivascular niches: critical hubs in cancer evolution.

  2023cites this paper
• Advanced in vitro models for renal cell carcinoma therapy design.

  2023cites this paper
• Vascular response patterns to targeted therapies in murine breast cancer models with divergent degrees of malignancy

  2023cites this paper
• BMP9‐induced vascular normalisation improves the efficacy of immunotherapy against hepatitis B virus‐associated hepatocellular carcinoma

  2023cites this paper
• Vascular Co-Option and Other Alternative Modalities of Growth of Tumor Vasculature in Glioblastoma

  2022cites this paper
• Mechanism of Extracellular Vesicle Secretion Associated with TGF-β-Dependent Inflammatory Response in the Tumor Microenvironment

  2022cites this paper
• Comparison of the Behavior of Perivascular Cells (Pericytes and CD34+ Stromal Cell/Telocytes) in Sprouting and Intussusceptive Angiogenesis

  2022cites this paper
• Inducible endothelial leakiness in nanotherapeutic applications.

  2022cites this paper
• Pharmacological PDGFRβ inhibitors imatinib and sunitinib cause human brain pericyte death in vitro.

  2022cites this paper
• Combination of tumor vessel normalization and immune checkpoint blockade for breast cancer treatment via multifunctional nanocomplexes.

  2022cites this paper
• CD146+ Pericytes Subset Isolated from Human Micro-Fragmented Fat Tissue Display a Strong Interaction with Endothelial Cells: A Potential Cell Target for Therapeutic Angiogenesis

  2022cites this paper
• The Normal and Brain Tumor Vasculature: Morphological and Functional Characteristics and Therapeutic Targeting

  2021cites this paper
• Title: Quantification of vascular networks in photoacoustic mesoscopy

  2021cites this paper
• Physical Forces and Transient Nuclear Envelope Rupture during Metastasis: The Key for Success?

  2021cites this paper
• Quantification of vascular networks in photoacoustic mesoscopy

  2021cites this paper
• Single-Cell Atlas of Lineage States, Tumor Microenvironment, and Subtype-Specific Expression Programs in Gastric Cancer

  2021cites this paper
• Hypoxia Pathway Proteins and Their Impact on the Blood Vasculature

  2021cites this paper
• The Application of and Strategy for Gold Nanoparticles in Cancer Immunotherapy

  2021cites this paper
• Dynamic Contrast Enhanced MRI and Intravoxel Incoherent Motion to Identify Molecular Subtypes of Breast Cancer with Different Vascular Normalization Gene Expression

  2021cites this paper
• Biology of Pericytes – Recent Advances: Role of Pericytes in Brain Metastasis

  2021cites this paper
• Drug delivery nanocarriers and recent advances ventured to improve therapeutic efficacy against osteosarcoma: an overview

  2021cites this paper
• Hyperthermia can alter tumor physiology and improve chemo- and radio-therapy efficacy.

  2020cites this paper
• Autophagy as a Mechanism for Anti-Angiogenic Therapy Resistance.

  2020cites this paper
• Quantitative assessment and clinical relevance of VEGFRs-positive tumor cells in refractory brain tumors.

  2020cites this paper
• Hyperthermia and smart drug delivery systems for solid tumor therapy.

  2020cites this paper
• Overcoming the biological barriers in the tumor microenvironment for improving drug delivery and efficacy.

  2020cites this paper
• Prostaglandin E2 breaks down pericyte–endothelial cell interaction via EP1 and EP4-dependent downregulation of pericyte N-cadherin, connexin-43, and R-Ras

  2020cites this paper
• Nano-therapeutics for modulating the tumour microenvironment: Design, development, and clinical translation.

  2020cites this paper
• Signalling, Metabolic Pathways and Iron Homeostasis in Endothelial Cells in Health, Atherosclerosis and Alzheimer’s Disease

  2020cites this paper
• Endothelial-Tumor Cell Interaction in Brain and CNS Malignancies

  2020cites this paper
• The cerebral microvasculature: Basic and clinical perspectives on stroke and glioma

  2020cites this paper
• Hypo-fractionation radiotherapy normalizes tumor vasculature in non-small cell lung cancer xenografts through the p-STAT3/HIF-1 alpha signaling pathway

  2020cites this paper
• Pericytes Relationship with Cancer Stem Cells in the Colon

  2020cites this paper
• The application of nanoparticles in cancer immunotherapy: Targeting tumor microenvironment

  2020cites this paper
• Sarcoma Tumor Microenvironment.

  2020cites this paper
• Predictive Value of Diminished Serum PDGF-BB after Curative Resection of Hepatocellular Cancer

  2019cites this paper
• Pericytes in Microvessels: From “Mural” Function to Brain and Retina Regeneration

  2019cites this paper
• Modulation of pericytes by a fusion protein comprising of a PDGFRβ-antagonistic affibody and TNFα induces tumor vessel normalization and improves chemotherapy.

  2019cites this paper
• Pericytes in Sarcomas and Other Mesenchymal Tumors.

  2019cites this paper
• Pericytes and Neurovascular Function in the Healthy and Diseased Brain

  2019cites this paper
• Vascular Disrupting Agents in cancer treatment: Cardiovascular toxicity and implications for co-administration with other cancer chemotherapeutics.

  2019cites this paper
• Angiogenic role of miR-20a in breast cancer

  2018cites this paper
• Spatiotemporal endothelial cell – pericyte association in tumors as shown by high resolution 4D intravital imaging

  2018cites this paper
• Basic Components of Vascular Connective Tissue and Extracellular Matrix.

  2018cites this paper
• The critical role of tumor microenvironment in cancer evolution and metastasis

  2018cites this paper
• Overcoming obstacles in the tumor microenvironment: Recent advancements in nanoparticle delivery for cancer theranostics.

  2018cites this paper
• Glioblastoma niches: from the concept to the phenotypical reality

  2018cites this paper
• Harnessing Tumor Microenvironment for Nanoparticle‐Mediated Radiotherapy

  2018cites this paper
• Characterization of the tumor cell microenvironment

  2018cites this paper
• Stromal contributions to the carcinogenic process

  2017cites this paper
• Immunotherapeutic Targeting of Tumor-Associated Blood Vessels.

  2017cites this paper
• Inhibition of Lysyl Oxidases Impairs Migration and Angiogenic Properties of Tumor-Associated Pericytes

  2017cites this paper
• Tumour progression and metastasis

  2016cites this paper
• Microenvironment and microvascular wall modulate cancer cell progression

  2016cites this paper
• Brain mesenchymal stem cells: physiology and pathological implications

  2016cites this paper
• Quantitative Perfusion and Permeability Biomarkers in Brain Cancer from Tomographic CT and MR Images

  2016cites this paper
• Immune Regulation by Pericytes: Modulating Innate and Adaptive Immunity

  2016cites this paper
• Adaptation to antiangiogenic therapy in neurological tumors

  2015cites this paper
• Predictive tissue biomarkers for bevacizumab-containing therapy in metastatic colorectal cancer: an update

  2015cites this paper
• Microvascular disturbance with decreased pericyte coverage is prominent in the ventral horn of patients with amyotrophic lateral sclerosis

  2015cites this paper
• Combined Effects of Pericytes in the Tumor Microenvironment

  2015cites this paper
• Targeting Notch Signaling with a Notch2/Notch3 Antagonist (Tarextumab) Inhibits Tumor Growth and Decreases Tumor-Initiating Cell Frequency

  2015cites this paper
• Selective eradication of tumor vascular pericytes by peptide-conjugated nanoparticles for antiangiogenic therapy of melanoma lung metastasis.

  2014cites this paper
• Angiogenesis is increased in advanced haemophilic joint disease and characterised by normal pericyte coverage

  2014cites this paper
• Convergence of Nanotechnology and Cancer Prevention: Are We There Yet?

  2014cites this paper
• The role of hypoxia in pulmonary vascular diseases: a perspective.

  2013cites this paper
• Lipopolysaccharide Activates Toll-like Receptor 4 (TLR4)-mediated NF-κB Signaling Pathway and Proinflammatory Response in Human Pericytes*

  2013cites this paper
• Chemomechanics at cell-cell and cell-matrix interfaces critical to angiogenesis

  2013cites this paper
• Ablative Hypofractionated Radiotherapy Normalizes Tumor Vasculature in Lewis Lung Carcinoma Mice Model

  2013cites this paper
• Preoperative pathological diagnosis of lung cancer: is it always necessary?

  2012cites this paper