Increasing incidence of adenocarcinoma of the gastric cardia and adjacent sites.

Data in a regional cancer registry covering a population of 5 million and with an efficiency of registration of over 95% have been used to examine incidence trends in oesophageal and gastric carcinoma. In the West Midlands Region of the UK, during the period 1962 to 1981 the age standardised incidence of gastric carcinoma decreased by 20%. However, an analysis by both histological type and detailed site reveals that while the incidence of distal lesions is diminishing, the incidence of adenocarcinoma of the oesophagus and cardia is increasing. The proximal and distal lesions also exhibit marked differences in social class distribution and sex ratio. The results strongly suggest that the aetiological factors involved for cardia and adjoining sites are different from those for pyloric antrum.

• Publication year

  1990

• Venue

  British Journal of Cancer

• Publication date

  1990-09-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1038/bjc.1990.314PMID 2206952PMCID 1971432
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Epidemiological characteristics of adenocarcinoma of the gastric cardia and distal stomach in the United States, 1973-1982.

  1988cited by this paper
• The Einstein sign: the clinical picture of acute cholecystitis caused by ruptured abdominal aortic aneurysm.

  1984cited by this paper
• Changing aspects of gastric adenocarcinoma.

  1984cited by this paper
• [Comparison of pulmonary, laryngeal, esophageal and stomach cancer in Denmark, 1943-1977].

  1983cited by this paper
• [Comparison of pulmonary, laryngeal, esophageal and stomach cancer in Denmark, 1943-1977].

  1983cited by this paper
• Cancer Handbook of Epidemiology and Prognosis

  1974cited by this paper
• Cancer Incidence in Five Continents

  1970cited by this paper
• Cancer of the stomach.

  1951influential reference
• Cancer of the Oesophagus

  1942cited by this paper

• Association between hot beverage intake and gastric cancer risk: a prospective cohort study from the UK Biobank.

  2025cites this paper
• Human Epidermal Growth Factor Receptor 2 [HER‐2/neu] Amplification and Microsatellite Stable Status in Gastric and Gastroesophageal Adenocarcinoma: Assessing Frequency and Prognostic Implications at the Cancer Institute of Iran

  2025cites this paper
• Clinical Outcomes According to Surgical Strategies in Proximal Early Gastric Cancer: A Systematic Review and Network Meta-Analysis

  2025cites this paper
• Trends in the Incidence and Location of Gastric Cancers: A Single Center Experience

  2024cites this paper
• Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

  2024cites this paper
• Advancements in Understanding Gastric Cancer: A Comprehensive Review

  2023cites this paper
• Current management of gastric adenocarcinoma: a narrative review

  2023cites this paper
• Cell‐free DNA integrity correlates with lymph node metastasis and predicts short‐term postoperative recurrence in patients with proximal gastric carcinoma after curative gastrectomy

  2023cites this paper
• The effect of demographic features on survival in patients with gastric cancer

  2022cites this paper
• Mide kanserli hastaların demografik özelliklerinin sağ kalıma etkisi

  2022cites this paper
• Gastric Carcinoma and its Common Imaging Mimickers

  2022cites this paper
• Recent advances in immune-based approaches for the treatment of esophagogastric cancer

  2021cites this paper
• Is surgery the best treatment for elderly gastric cancer patients?

  2021cites this paper
• Chronic atrophic gastritis and intestinal metaplasia induced by high-salt and N-methyl-N'-nitro-N-nitrosoguanidine intake in rats

  2021cites this paper
• Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries

  2021cites this paper
• Gastric cancer: Epidemiology, risk factors and prevention strategies

  2020cites this paper
• Consensus statement of the Hellenic and Cypriot Gastric Cancer Study Group on the diagnosis, staging and management of gastric cancer

  2020cites this paper
• 146-Article Text-893-2-15-20200706- copy editing-PROOFREAD.cdr

  2020cites this paper
• Gastric Cancer: Where Are We Heading?

  2020cites this paper
• Photodynamic diagnostics of early gastric cancer: Complexity measures of gastric microcirculation and new model of metastatic adenocarcinoma of rat stomach

  2019cites this paper
• Density of CD 8-positive tumor-infiltrating T-lymphocytes is an independent prognostic factor in adenocarcinoma of the esophagogastric junction

  2019cites this paper
• Effect of body-mass index on the risk of gastric cancer: A population-based cohort study in A Japanese population.

  2019cites this paper
• Clinicopathological Features and Increased Expression of Toll-Like Receptor 4 of Gastric Cardia Cancer in a High-Risk Chinese Population

  2018cites this paper
• Epidemiology of gastric cancer and risk factors

  2018cites this paper
• Factores predictores del grado de regresión tumoral en los tumores gástricos localmente avanzados

  2018cites this paper
• Prognostic Role of Primary Tumor Location in Non-Metastatic Gastric Cancer: A Systematic Review and Meta-Analysis of 50 Studies

  2017cites this paper
• Evaluation of Pattern of HER2 neu Overexpression in Primary Gastric Carcinoma by Immunohistochemistry

  2017cites this paper
• Expression and Significance of Cyclophilin J in Primary Gastric Adenocarcinoma.

  2017cites this paper
• Helicobacter pylori genotypes determine risk of non-cardia gastric cancer and intestinal- or diffuse-type GC in Ardabil: A very high-risk area in Northwestern Iran.

  2017cites this paper
• Randomized controlled trial of S-1 maintenance therapy in metastatic esophagogastric cancer – the multinational MATEO study

  2017cites this paper
• A Coral Like Papillary Mass in the Gastric Cardia.

  2017cites this paper
• [Survival of Gastric Cancer in Western Honduras Pilot study: 2002-2012].

  2017cites this paper
• Intraoperatively Testing the Anastomotic Integrity of Esophagojejunostomy Using Methylene Blue

  2017cites this paper
• Chapter 47 – Gastric/GE Junction Cancer

  2016cites this paper
• Laparoscopic Proximal Gastrectomy with Double-Tract Reconstruction by Intracorporeal Anastomosis with Linear Staplers.

  2016cites this paper
• Gastric Cancer, Version 3.2016; Clinical Practice Guidelines in Oncology

  2016cites this paper
• Expression of CDX2 in gastric cardia adenocarcinoma and its correlation with H. pylori and cell proliferation

  2016influential citation
• Fluctuating Risk Factors and Epidemiology

  2016cites this paper
• Gastric Cancer, Version 3.2016, NCCN Clinical Practice Guidelines in Oncology.

  2016cites this paper
• Approach to Gastric Cancers

  2016cites this paper
• The Role of Hereditary and Environmental Factors in Gastrointestinal Cancers

  2016cites this paper
• Comparisons Between Different Procedures of No. 10 Lymphadenectomy for Gastric Cancer Patients With Total Gastrectomy

  2015cites this paper
• Robert H. Lurie Comprehensive Cancer Center of Northwestern University

  2015cites this paper
• Overview: The Changing Nature of Esophageal Cancer*

  2015cites this paper
• The socioeconomic profile of a Barrett’s oesophagus cohort assessed by the 2010 Index of Multiple Deprivation

  2015cites this paper
• Intrathoracic esophagojejunostomy using OrVil™ for gastric adenocarcinoma involving the esophagus.

  2014cites this paper
• Development of gastric cancer and its prevention.

  2014cites this paper
• Infection and esophageal cancer

  2014cites this paper
• Critical role of spatial interaction between CD8+ and Foxp3+ cells in human gastric cancer: the distance matters

  2014cites this paper
• Efficacy and Safety of Trastuzumab-based Therapy in Combination with Different Chemotherapeutic Regimens in Advanced Esophagogastric Cancer – a Single Cancer-center Experience

  2014cites this paper
• Inpatient survival after gastrectomy for gastric cancer in the 21st century.

  2014cites this paper
• A morphologic and immunohistochemical analysis of gastric adenocarcinoma with regard to the presence of E-cadherin and localisation of β-catenin staining

  2014cites this paper
• Gastric Cancer: Descriptive Epidemiology, Risk Factors, Screening, and Prevention

  2014cites this paper
• NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines

  2014cites this paper
• Principles of Palliative/Best Supportive Care

  2014cites this paper
• Survival Benefit and Safety of No. 10 Lymphadenectomy for Gastric Cancer Patients With Total Gastrectomy

  2014cites this paper
• When It Comes to Gastric Cancer, There Is More to It Than H. pylori!

  2014cites this paper
• MicroRNA-645, up-regulated in human adencarcinoma of gastric esophageal junction, inhibits apoptosis by targeting tumor suppressor IFIT2

  2014influential citation
• The changing role of the pathologist in the management of Barrett's oesophagus

  2014cites this paper
• Clinicopathological characteristics and prognosis of gastric cancer with malignant ascites

  2014cites this paper
• Inequality in outcome for oesophago-gastric cancer in England : is there an association with gastroscopy rates in general practice populations?

  2013cites this paper
• An investigation of the relationship between patient physiology, inflammatory response and outcome in patients with oesophageal and gastric cancer

  2013cites this paper
• Dietary phytoestrogens and esophageal cancer

  2013cites this paper
• Cancer Bone Marrow Micrometastases and Markers of Angiogenesis in Esophageal

  2013cites this paper
• Clinicopathological features and outcomes of patients with gastric cancer: a single-center experience.

  2013cites this paper
• Epidemiology and risk factors for oesophageal adenocarcinoma.

  2013cites this paper
• Clinicopathological features and localization of gastric cancers and their effects on survival in Turkey.

  2013cites this paper
• Incidence and survival of oesophageal and gastric cancer in England between 1998 and 2007, a population-based study

  2012cites this paper
• Gastric/GE Junction Cancer

  2012cites this paper
• Transthoracic Resection versus Non-Transthoracic Resection for Gastroesophageal Junction Cancer: A Meta-Analysis

  2012cites this paper
• Descriptive epidemiology of gastric adenocarcinoma in the State of Texas by ethnicity: Hispanic versus White non-Hispanic

  2012cites this paper
• A global assessment of the oesophageal adenocarcinoma epidemic

  2012cites this paper
• Esophageal Cancer: Associated Factors with Special Reference to the Kashmir Valley

  2012cites this paper
• Evaluation of dietary and life-style habits of patients with gastric cancer: a case-control study in Turkey.

  2012cites this paper
• iArc monogrAphs on the evAluAtion oF cArcinogenic risks to humAns

  2012cites this paper
• Barrett’s Adenocarcinomas are Frequently Underdiagnosed as “High Grade Intraepithelial Neoplasia”

  2012cites this paper
• Epidemiology of Adenocarcinoma of Esophagogastric Junction

  2012cites this paper
• Laparoscopy-assisted Proximal Gastrectomy with Sentinel Node Mapping for Early Gastric Cancer

  2011cites this paper
• Gastric cancer: prevention, risk factors and treatment

  2011cites this paper
• A Population-Based Analysis of Esophageal and Gastric Cardia Adenocarcinomas in Ontario, Canada: Incidence, Risk Factors, and Regional Variation

  2011cites this paper
• Correlation of overall survival with gene expression profiles in a prospective study of resectable esophageal cancer.

  2011cites this paper
• Stomach cancer.

  2011cites this paper
• Inflammation in gastric adenocarcinoma of the cardia: how do EBV infection, Her2 amplification and cancer progression influence tumor-infiltrating lymphocytes?

  2011cites this paper
• Epidemiology and etiology of gastric cancer

  2011cites this paper
• Epidemiology of adenocarcinoma of the esophagus, gastric cardia, and upper gastric third.

  2010cites this paper
• Trends in incidence, management, and survival of gastric and cardia carcinomas in the area of Finistere (France) between 1984 and 2003

  2010cites this paper
• Presentation and Survival of Operable Esophageal Cancer in Patients 55 Years of Age and Below

  2010cites this paper
• Dating the Rise of Esophageal Adenocarcinoma: Analysis of Connecticut Tumor Registry Data, 1940–2007

  2010cites this paper
• Reverse Double-Stapling End-to-End Esophagogastrostomy in Proximal Gastrectomy

  2010cites this paper
• Epidemiology of gastric cancer in Jos University Teaching Hospital Jos a 20 year review of cases.

  2010cites this paper
• Gastric cancer.

  2010cites this paper
• Phase II study of mitomycin, ifosfamide and cisplatin in adenocarcinoma of the oesophagus

  2009cites this paper
• Effectiveness and safety of splenectomy for gastric carcinoma: a meta-analysis.

  2009cites this paper
• INFEeTION WlTH HELICOBACTER PYLORI

  2009cites this paper
• The possibility of performing a limited resection and a lymphadenectomy for proximal gastric carcinoma based on sentinel node navigation

  2009cites this paper
• Changing incidence of gastric and oesophageal cancer subtypes in central Switzerland between 1982 and 2007

  2009cites this paper
• The effect of economic deprivation on oesophageal and gastric cancer in a UK cancer network

  2009cites this paper
• Gastric cancer.

  2009influential citation
• Macroscopic extent of gastric mucosal atrophy: increased risk factor for esophageal squamous cell carcinoma in Japan

  2009cites this paper
• Gastric cancer: the correlation between the clinicopathological factors and patients' survival (I).

  2009cites this paper