HOXA10 is a critical regulator for hematopoietic stem cells and erythroid/megakaryocyte development.

No abstract is available for this paper.

• Publication year

  2007

• Venue

  Blood

• Publication date

  2007-05-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1182/BLOOD-2006-10-054676PMID 17234739
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• National Center for Biotechnology Information

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• Hoxb4-deficient mice undergo normal hematopoietic development but exhibit a mild proliferation defect in hematopoietic stem cells.

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• High-level ectopic HOXB4 expression confers a profound in vivo competitive growth advantage on human cord blood CD34+ cells, but impairs lymphomyeloid differentiation.

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• A role for Wnt signalling in self-renewal of haematopoietic stem cells

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• Enforced adenoviral vector-mediated expression of HOXB4 in human umbilical cord blood CD34+ cells promotes myeloid differentiation but not proliferation.

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• Identification of the haematopoietic stem cell niche and control of the niche size

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• Reduced Proliferative Capacity of Hematopoietic Stem Cells Deficient in Hoxb3 and Hoxb4

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• The Wnt Signaling Inhibitor Dickkopf-1 Is Required for Reentry into the Cell Cycle of Human Adult Stem Cells from Bone Marrow*

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• Complementary Signaling through flt3 and Interleukin-7 Receptor α Is Indispensable for Fetal and Adult B Cell Genesis

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• SHP1 Protein-tyrosine Phosphatase Regulates HoxA10 DNA Binding and Transcriptional Repression Activity in Undifferentiated Myeloid Cells*

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• Proliferation of primitive myeloid progenitors can be reversibly induced by HOXA10.

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• Overexpression of HOXA10 perturbs human lymphomyelopoiesis in vitro and in vivo.

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• Tyrosine Phosphorylation of HoxA10 Decreases DNA Binding and Transcriptional Repression during Interferon γ-induced Differentiation of Myeloid Leukemia Cell Lines*

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• p21 is a transcriptional target of HOXA10 in differentiating myelomonocytic cells.

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• Interleukin-3 supports expansion of long-term multilineage repopulating activity after multiple stem cell divisions in vitro.

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• Pluripotent, cytokine-dependent, hematopoietic stem cells are immortalized by constitutive Notch1 signaling

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• Notch1-induced delay of human hematopoietic progenitor cell differentiation is associated with altered cell cycle kinetics.

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• Generalized lacZ expression with the ROSA26 Cre reporter strain

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• Constitutive HOXA5 expression inhibits erythropoiesis and increases myelopoiesis from human hematopoietic progenitors.

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• Cbfa2 is required for the formation of intra-aortic hematopoietic clusters.

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• HOXA9 Forms Triple Complexes with PBX2 and MEIS1 in Myeloid Cells

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• A lineage‐selective knockout establishes the critical role of transcription factor GATA‐1 in megakaryocyte growth and platelet development

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• Overexpression of HOXA10 in murine hematopoietic cells perturbs both myeloid and lymphoid differentiation and leads to acute myeloid leukemia

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• Effects of HOX homeobox genes in blood cell differentiation

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• Mice bearing a targeted interruption of the homeobox gene HOXA9 have defects in myeloid, erythroid, and lymphoid hematopoiesis.

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