Efferent Protection from Acoustic Injury Is Mediated via α9 Nicotinic Acetylcholine Receptors on Outer Hair Cells

No abstract is available for this paper.

• Publication year

  2002

• Venue

  Journal of Neuroscience

• Publication date

  2002-12-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1523/JNEUROSCI.22-24-10838.2002PMID 12486177PMCID PMC6758430
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The relationship between opsin overexpression and photoreceptor degeneration.

  2001cited by this paper
• α10: A determinant of nicotinic cholinergic receptor function in mammalian vestibular and cochlear mechanosensory hair cells

  2001cited by this paper
• Nicotinic receptor function: new perspectives from knockout mice.

  2000cited by this paper
• Acoustic injury in mice: 129/SvEv is exceptionally resistant to noise-induced hearing loss.

  2000cited by this paper
• Telomere length measurements using digital fluorescence microscopy.

  1999cited by this paper
• Nicotinic receptors in the brain: correlating physiology with function.

  1999cited by this paper
• Role of a 9 Nicotinic ACh Receptor Subunits in the Development and Function of Cochlear Efferent

  1999influential reference
• Visualization of alpha9 acetylcholine receptor expression in hair cells of transgenic mice containing a modified bacterial artificial chromosome.

  1999influential reference
• Developmental expression of α9 acetylcholine receptor mRNA in the rat cochlea and vestibular inner ear

  1998cited by this paper
• Differential expression of the α9 nicotinic acetylcholine receptor subunit in neonatal and adult cochlear hair cells

  1998cited by this paper
• Differential expression of the alpha 9 nicotinic acetylcholine receptor subunit in neonatal and adult cochlear hair cells.

  1998cited by this paper
• Unique Postsynaptic Signaling at the Hair Cell Efferent Synapse Permits Calcium to Evoke Changes on Two Time Scales

  1997cited by this paper
• Conditioning-related protection from acoustic injury: effects of chronic deefferentation and sham surgery.

  1997cited by this paper
• The effect of efferent stimulation on basilar membrane displacement in the basal turn of the guinea pig cochlea

  1996influential reference
• Medial efferent inhibition produces the largest equivalent attenuations at moderate to high sound levels in cat auditory-nerve fibers.

  1996cited by this paper
• Efferent-mediated protection from acoustic overexposure: relation to slow effects of olivocochlear stimulation.

  1995cited by this paper
• Chronic cochlear de-efferentation and susceptibility to permanent acoustic injury.

  1995cited by this paper
• Alpha 9: an acetylcholine receptor with novel pharmacological properties expressed in rat cochlear hair cells.

  1994cited by this paper
• α9: An acetylcholine receptor with novel pharmacological properties expressed in rat cochlear hair cells

  1994cited by this paper
• Neurotransmitters and neuromodulators of the mammalian cochlea.

  1993cited by this paper
• The active cochlea

  1992cited by this paper
• Cholinergic inhibition of short (outer) hair cells of the chick's cochlea

  1992cited by this paper
• Direct measurement of the action of acetylcholine on isolated outer hair cells of the guinea pig cochlea

  1991cited by this paper
• Afferent and efferent innervation of the cat cochlea: Quantitative analysis with light and electron microscopy

  1990cited by this paper
• Effect of electrical stimulation of the crossed olivocochlear bundle on temporary threshold shifts in auditory sensitivity. II. Dependence on the level of temporary threshold shifts.

  1988cited by this paper
• Masked cochlear whole-nerve response intensity functions altered by electrical stimulation of the crossed olivocochlear bundle.

  1988cited by this paper
• Physiology of cochlear efferent and afferent neurons: direct comparisons in the same animal.

  1988cited by this paper
• Effect of electrical stimulation of the crossed olivocochlear bundle on temporary threshold shifts in auditory sensitivity. I. Dependence on electrical stimulation parameters.

  1988influential reference
• Neurobiology of hearing: The cochlea

  1987cited by this paper
• Otoacoustic emissions, travelling waves and cochlear mechanisms.

  1986cited by this paper
• Neurobiology of hearing : the cochlea

  1986cited by this paper
• The Auditory psychobiology of the mouse

  1983cited by this paper
• Effects of electric stimulation of the crossed olivocochlear bundle on single auditory-nerve fibers in the cat.

  1970cited by this paper
• Variations in the effects of electric stimulation of the crossed olivocochlear bundle on cat single auditory-nerve-fiber responses to tone bursts.

  1970cited by this paper

• Impaired development of the medial olivocochlear system in a KCNQ4-deficient mouse model

  2026cites this paper
• LOUDNESS HYPERACUSIS: MECHANISMS OF LOUDNESS PERCEPTION AND THEIR BREAKDOWN

  2025cites this paper
• The Medial Olivocochlear Efferent Pathway Potentiates Cochlear Amplification in Response to Hearing Loss

  2025cites this paper
• Virally mediated enhancement of efferent inhibition reduces acoustic trauma in wild-type murine cochleas

  2025cites this paper
• Lateral olivocochlear neurons modulate cochlear responses to noise exposure

  2025cites this paper
• Strengthening Medial Olivocochlear Feedback Reduces the Developmental Impact of Early Noise Exposure

  2025cites this paper
• Medial olivocochlear efferent modulation of cochlear micromechanics requires P2X4 expression in outer hair cells

  2025cites this paper
• A Review of Calcitonin Gene-Related Peptide and Its Implications for Vestibular Disorders

  2024cites this paper
• The quantification and mRNA expression levels of cochlear synapses in C57BL/6j mice following repeated exposure to noise

  2024cites this paper
• Virally-Mediated Enhancement of Efferent Inhibition Reduces Acoustic Trauma in Wild Type Murine Cochleas

  2024cites this paper
• Engineering olivocochlear inhibition to reduce acoustic trauma

  2023cites this paper
• Abnormal outer hair cell efferent innervation in Hoxb1-dependent sensorineural hearing loss

  2023cites this paper
• Efferent Activity Controls Hair Cell Response to Mechanical Overstimulation

  2022cites this paper
• Noise-induced hearing loss vulnerability in type III intermediate filament peripherin gene knockout mice

  2022cites this paper
• The α9α10 nicotinic acetylcholine receptor: a compelling drug target for hearing loss?

  2022influential citation
• The mammalian efferent vestibular system utilizes cholinergic mechanisms to excite primary vestibular afferents

  2021cites this paper
• C1ql1 is expressed in adult outer hair cells of the cochlea in a tonotopic gradient

  2021cites this paper
• The comprehensive audiological evaluation in young violinists: the medial olivocochlear system, high frequency thresholds, and the auditory figure ground test

  2021cites this paper
• Perspectives on Human Hearing Loss, Cochlear Regeneration, and the Potential for Hearing Restoration Therapies

  2020cites this paper
• Preventing presbycusis in mice with enhanced medial olivocochlear feedback

  2020cites this paper
• Functional Postnatal Maturation of the Medial Olivocochlear Efferent–Outer Hair Cell Synapse

  2020cites this paper
• Age-related hearing loss pertaining to potassium ion channels in the cochlea and auditory pathway

  2020cites this paper
• The immune response after noise damage in the cochlea is characterized by a heterogeneous mix of adaptive and innate immune cells

  2020cites this paper
• A review of efferent cholinergic synaptic transmission in the vestibular periphery and its functional implications.

  2019cites this paper
• Hidden Hearing Loss: A Disorder with Multiple Etiologies and Mechanisms.

  2019cites this paper
• Cholinergic Hypofunction in Presbycusis-Related Tinnitus With Cognitive Function Impairment: Emerging Hypotheses

  2018cites this paper
• CDK2 inhibitors as candidate therapeutics for cisplatin- and noise-induced hearing loss

  2018influential citation
• The Effect of Activating the Medial Olivocochlear Fibers on Cochlear Distortions in Humans

  2018cites this paper
• Enhancement of the Medial Olivocochlear System Prevents Hidden Hearing Loss

  2018cites this paper
• Anatomical studies of the olivocochlear collaterals system

  2018cites this paper
• Immunohistochemical expression of the nicotinic acetylcholine receptor (nAChR) subunits in the human placenta, and effects of cigarette smoking and preeclampsia.

  2018cites this paper
• Paraflocculus plays a role in salicylate‐induced tinnitus

  2017cites this paper
• Carbaryl‐induced ototoxicity in rat postnatal cochlear organotypic cultures

  2017cites this paper
• Reflex Modification Audiometry Reveals Dual Roles for Olivocochlear Neurotransmission

  2017cites this paper
• Cellular and Molecular Underpinnings of Neuronal Assembly in the Central Auditory System during Mouse Development

  2017cites this paper
• Intermittent hypercapnic hypoxia effects on the nicotinic acetylcholine receptors in the developing piglet hippocampus and brainstem

  2017cites this paper
• An Observational Study on the Clinical Efficacy of Neramexane in Subjective Tinnitus in a Phase 2 Clinical Trial in a Hispanic Cohort in Laredo, Texas

  2017cites this paper
• Generation and Characterization of α9 and α10 Nicotinic Acetylcholine Receptor Subunit Knockout Mice on a C57BL/6J Background

  2017cites this paper
• Behavioral Studies of the Olivocochlear Efferent System

  2016cites this paper
• α9α10 Acetylcholine receptors: structure and functions

  2016cites this paper
• Preserved Vestibular Function in Mice with Loss of α-9 Subunit of the α-9/10 Nicotinic Acetylcholine Receptor (α-9/10 nAChR)

  2016cites this paper
• Univerzita Karlova v Praze 1. lékařská fakulta Autoreferát disertační práce Role of Islet 1, BDNF and nanoparticles in development, function and regeneration of the auditory system. Úloha Islet1, BDNF a nanočástic ve vývoji, funkci a regeneraci sluchového systému. MUDr

  2016cites this paper
• TEN BK Channels in the Vertebrate Inner Ear

  2016cites this paper
• Differential effects of Cdh23(753A) on auditory and vestibular functional aging in C57BL/6J mice.

  2016influential citation
• BK Channels in the Vertebrate Inner Ear.

  2016cites this paper
• Cochlear efferents in developing adult and pathological conditions

  2015cites this paper
• Chronic Conductive Hearing Loss Leads

  2015cites this paper
• Chronic Conductive Hearing Loss Leads to Cochlear Degeneration

  2015cites this paper
• Characterisation of cello : an ENU-induced mouse model of early-onset hearing loss

  2015cites this paper
• THE EFFECT OF TINNITUS AND PRESBYCUSIS ON CONTRALATERAL SUPPRESSION OF OTOACOUSTIC EMISSIONS

  2015cites this paper
• Postnatal nicotine effects on the expression of nicotinic acetylcholine receptors in the developing piglet hippocampus and brainstem

  2015cites this paper
• New treatment options for hearing loss

  2015cites this paper
• Acoustic input and efferent activity regulate the expression of molecules involved in cochlear micromechanics

  2015cites this paper
• throughout the cochlea evidence for combined action of BK and SK2 channels Olivocochlear suppression of outer hair cells in vivo

  2015cites this paper
• Caractérisation d'une mutation humaine du transporteur vésiculaire du glutamate de type 3 (VGLUT3) : VGLUT3-p.A211V dans le système nerveux central de souris

  2015cites this paper
• How can the auditory efferent system protect our ears from noise-induced hearing loss? Let us count the ways

  2015cites this paper
• Deterioration of the Medial Olivocochlear Efferent System Accelerates Age-Related Hearing Loss in Pax2-Isl1 Transgenic Mice

  2015cites this paper
• Functional Development of the Vestibular System

  2014cites this paper
• A case of tinnitus induced by chlorpromazine in a pediatric patient

  2014cites this paper
• A review of hyperacusis and future directions: part I. Definitions and manifestations.

  2014cites this paper
• Vulnerability to Acoustic Trauma in the Normal Hearing Ear With Contralateral Hearing Loss

  2014cites this paper
• Efferent Feedback Slows Cochlear Aging

  2014cites this paper
• Loss of α-Calcitonin Gene-Related Peptide (αCGRP) Reduces the Efficacy of the Vestibulo-ocular Reflex (VOR)

  2014cites this paper
• Cigarette smoking during pregnancy regulates the expression of specific nicotinic acetylcholine receptor (nAChR) subunits in the human placenta.

  2014cites this paper
• &agr;‐Conotoxin RgIA protects against the development of nerve injury‐induced chronic pain and prevents both neuronal and glial derangement

  2014cites this paper
• Otoacoustic-emission-based medial-olivocochlear reflex assays for humans.

  2014cites this paper
• The protein expression of the nicotinic acetylcholine receptors in the human placenta, and effects of cigarette smoking and pre-eclampsia.

  2014cites this paper
• Short-term plasticity and modulation of synaptic transmission at mammalian inhibitory cholinergic olivocochlear synapses

  2014cites this paper
• Alternative splice isoforms of small conductance calcium-activated SK2 channels differ in molecular interactions and surface levels

  2014cites this paper
• Prestin Regulation and Function in Residual Outer Hair Cells after Noise-Induced Hearing Loss

  2013cites this paper
• Expression, pharmacological and physiological properties of nicotinic acetylcholine receptors

  2013cites this paper
• Hox genes and region‐specific sensorimotor circuit formation in the hindbrain and spinal cord

  2013cites this paper
• Functional Expression of Human α9* Nicotinic Acetylcholine Receptors in X. laevis Oocytes Is Dependent on the α9 Subunit 5′ UTR

  2013cites this paper
• Olivocochlear suppression of outer hair cells in vivo: evidence for combined action of BK and SK2 channels throughout the cochlea.

  2013cites this paper
• Maturation of the human medial efferent reflex revisited.

  2013cites this paper
• Inner ear symptoms and disease: Pathophysiological understanding and therapeutic options

  2013cites this paper
• Assembly of the Auditory Circuitry by a Hox Genetic Network in the Mouse Brainstem

  2013influential citation
• Positive modulation of the α9α10 nicotinic cholinergic receptor by ascorbic acid

  2013cites this paper
• The Cochlea and the Auditory Nerve as a Primary Source of Tinnitus

  2012cites this paper
• Sound-Evoked Olivocochlear Activation in Unanesthetized Mice

  2012cites this paper
• DopaminergicSignalingintheCochlea:ReceptorExpression PatternsandDeletionPhenotypes

  2012cites this paper
• Efferent synapses return to inner hair cells in the aging cochlea.

  2012cites this paper
• Dopaminergic Signaling in the Cochlea: Receptor Expression Patterns and Deletion Phenotypes

  2012cites this paper
• The efferent medial olivocochlear-hair cell synapse.

  2012cites this paper
• The cochlea as an independent neuroendocrine organ: expression and possible roles of a local hypothalamic-pituitary-adrenal axis-equivalent signaling system.

  2012cites this paper
• Molecular biology of hearing

  2012cites this paper
• An unheard benefit of phosphodiesterase inhibition

  2012cites this paper
• Position-dependent patterning of spontaneous action potentials in immature cochlear inner hair cells

  2011cites this paper
• Functional assembly of mammalian cochlear hair cells

  2011influential citation
• Modulation of hair cell efferents.

  2011cites this paper
• Patterns of olivocochlear axonal branches.

  2011cites this paper
• α-Synuclein deficiency and efferent nerve degeneration in the mouse cochlea: a possible cause of early-onset presbycusis.

  2011cites this paper
• The Cochlear CRF Signaling Systems and their Mechanisms of Action in Modulating Cochlear Sensitivity and Protection Against Trauma

  2011cites this paper
• Investigating the contributions of TRPP2 and α7 nAChR to mouse auditory function utilising various genetic approaches

  2011cites this paper
• Radicals Attack the Ear The Toll: A Loss of Hearing

  2011cites this paper
• Cholinergic Inhibition of Hair Cells

  2011cites this paper
• Mice Lacking Adrenergic Signaling Have Normal Cochlear Responses and Normal Resistance to Acoustic Injury but Enhanced Susceptibility to Middle-Ear Infection

  2010cites this paper
• The Efferent System or Olivocochlear Function Bundle – Fine Regulator and Protector of Hearing Perception

  2010cites this paper
• MuscarinicSignalingintheCochlea:Presynapticand PostsynapticEffectsonEfferentFeedbackandAfferent Excitability

  2010cites this paper
• Muscarinic Signaling in the Cochlea: Presynaptic and Postsynaptic Effects on Efferent Feedback and Afferent Excitability

  2010influential citation