Rosuvastatin Decreases Caveolin-1 and Improves Nitric Oxide–Dependent Heart Rate and Blood Pressure Variability in Apolipoprotein E−/− Mice In Vivo

No abstract is available for this paper.

• Publication year

  2003

• Venue

  Circulation

• Publication date

  2003-05-20

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1161/01.CIR.0000065601.83526.3EPMID 12719275
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Cellular Antioxidant Effects of Atorvastatin In Vitro and In Vivo

  2002cited by this paper
• Blood pressure variability and organ damage in a general population: results from the PAMELA study (Pressioni Arteriose Monitorate E Loro Associazioni).

  2002cited by this paper
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  2002cited by this paper
• HMG-CoA reductase inhibitors improve heart rate variability in patients with a previous myocardial infarction.

  2002cited by this paper
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  2002cited by this paper
• Long-term telemetric measurement of cardiovascular parameters in awake mice: a physiological genomics tool.

  2001cited by this paper
• Post-translational control of endothelial nitric oxide synthase: why isn't calcium/calmodulin enough?

  2001cited by this paper
• Heart rate variability after long-term treatment with atorvastatin in hypercholesterolaemic patients with or without coronary artery disease.

  2001cited by this paper
• Hsp90 and Caveolin Are Key Targets for the Proangiogenic Nitric Oxide–Mediated Effects of Statins

  2001cited by this paper
• Hydroxy-Methylglutaryl–Coenzyme A Reductase Inhibition Promotes Endothelial Nitric Oxide Synthase Activation Through a Decrease in Caveolin Abundance

  2001cited by this paper
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  2001cited by this paper
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  2001cited by this paper
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  2001cited by this paper
• Caveolin-1 null mice are viable but show evidence of hyperproliferative and vascular abnormalities.

  2001cited by this paper
• Role of Nitric Oxide in Buffering Short-Term Blood Pressure Fluctuations.

  2000cited by this paper
• Use of statins and blood pressure control in treated hypertensive patients with hypercholesterolemia.

  2000cited by this paper
• Blood pressure control in eNOS knock-out mice: comparison with other species under NO blockade.

  2000cited by this paper
• Direct vascular effects of HMG-CoA reductase inhibitors.

  2000cited by this paper
• Autonomic cardiovascular control in conscious mice.

  2000cited by this paper
• Enhanced blood pressure variability in eNOS knockout mice.

  1999cited by this paper
• Distinct and combined vascular effects of ACE blockade and HMG-CoA reductase inhibition in hypertensive subjects.

  1999cited by this paper
• Hypercholesterolemia decreases nitric oxide production by promoting the interaction of caveolin and endothelial nitric oxide synthase.

  1999cited by this paper
• Impaired atrial M(2)-cholinoceptor function in obesity-related hypertension.

  1999cited by this paper
• Hypertension and endothelial dysfunction in apolipoprotein E knockout mice.

  1999cited by this paper
• Oxidized Low Density Lipoprotein Displaces Endothelial Nitric-oxide Synthase (eNOS) from Plasmalemmal Caveolae and Impairs eNOS Activation*

  1999cited by this paper
• Heart rate variability and progression of coronary atherosclerosis.

  1999cited by this paper
• [Hypotensive effect of an inhibitor of cholesterol synthesis (fluvastatin). A pilot study].

  1998cited by this paper
• Endothelin ETA receptor blockade restores NO-mediated endothelial function and inhibits atherosclerosis in apolipoprotein E-deficient mice.

  1998cited by this paper
• The Endothelial Nitric-oxide Synthase-Caveolin Regulatory Cycle*

  1998cited by this paper
• Prevention of cardiovascular events and death with pravastatin in patients with coronary heart disease and a broad range of initial cholesterol levels.

  1998cited by this paper
• Two sterol regulatory element-like sequences mediate up-regulation of caveolin gene transcription in response to low density lipoprotein free cholesterol.

  1997cited by this paper
• Circadian rhythms of cardiovascular functions are modulated by the baroreflex and the autonomic nervous system in the rat.

  1997cited by this paper
• Atherosclerosis, vascular remodeling, and impairment of endothelium-dependent relaxation in genetically altered hyperlipidemic mice.

  1997cited by this paper
• Direct vascular effects of HMG-CoA reductase inhibitors.

  1997cited by this paper
• Elevated blood pressures in mice lacking endothelial nitric oxide synthase.

  1996cited by this paper
• The effect of pravastatin on coronary events after myocardial infarction in patients with average cholesterol levels. Cholesterol and Recurrent Events Trial investigators.

  1996cited by this paper
• Oxidized Low-density Lipoprotein Decreases the Expression of Endothelial Nitric Oxide Synthase (*)

  1995cited by this paper
• A cellular mechanism for nitric oxide-mediated cholinergic control of mammalian heart rate

  1995cited by this paper
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  1995cited by this paper
• Hypertension in mice lacking the gene for endothelial nitric oxide synthase

  1995cited by this paper
• Essential role for nitric oxide in neurogenic inflammation in rat cutaneous microcirculation. Evidence for an endothelium-independent mechanism.

  1995cited by this paper
• Blood pressure variability and organ damage.

  1994cited by this paper
• Control of cardiac muscle cell function by an endogenous nitric oxide signaling system.

  1993cited by this paper

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  2025cites this paper
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  2025cites this paper
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  2025cites this paper
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  2025cites this paper
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  2025cites this paper
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  2025cites this paper
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  2024cites this paper
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  2024cites this paper
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  2024cites this paper
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  2024influential citation
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  2024cites this paper
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  2023influential citation
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  2022cites this paper
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  2021cites this paper
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  2020cites this paper
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  2020cites this paper
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  2020cites this paper
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  2020cites this paper
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  2020cites this paper
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  2020cites this paper
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  2020cites this paper
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  2020cites this paper
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  2019cites this paper
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  2019cites this paper
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  2019cites this paper
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  2019cites this paper
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  2019cites this paper
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  2019cites this paper
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  2018cites this paper
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  2018cites this paper
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  2018cites this paper
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  2018cites this paper
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  2017cites this paper
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  2017cites this paper
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  2017cites this paper
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  2017cites this paper
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  2017cites this paper
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  2017cites this paper
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  2017cites this paper
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  2017cites this paper
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  2017cites this paper
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  2017cites this paper
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  2016cites this paper
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  2016cites this paper
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  2016cites this paper
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  2016cites this paper
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  2015cites this paper
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  2015influential citation
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  2015cites this paper
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  2015cites this paper
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  2015cites this paper
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  2015cites this paper
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  2015cites this paper
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  2014cites this paper
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  2014cites this paper
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  2014cites this paper
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  2014cites this paper
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  2014cites this paper
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  2014cites this paper
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  2014cites this paper
• Low-Density Lipoprotein-Cholesterol-Induced Endothelial Dysfunction and Oxidative Stress: The Role of Statins

  2014influential citation
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  2014cites this paper
• Statins as Regulators of Redox State in the Vascular Endothelium: Beyond Lipid Lowering

  2014cites this paper
• Догоспитальный этап медицинской помощи больным с острым коронарным синдромом с подъемом сегмента ST

  2013cites this paper
• The involvement of modified lipids in vascular injury and disease

  2013cites this paper
• Statins and vein graft failure in coronary bypass surgery.

  2012cites this paper
• Reduction in life-threatening ventricular tachyarrhythmias in statin-treated patients with nonischemic cardiomyopathy enrolled in the MADIT-CRT (Multicenter Automatic Defibrillator Implantation Trial with Cardiac Resynchronization Therapy).

  2012cites this paper
• Simvastatin reduces endothelial NOS: caveolin-1 ratio but not the phosphorylation status of eNOS in vivo.

  2012cites this paper
• Cardiovascular Autonomic Imbalance and Baroreflex Dysfunction in the Apolipoprotein E-deficient Mouse

  2012cites this paper
• Cardiac and vascular phenotypes in the apolipoprotein E-deficient mouse

  2012influential citation
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  2012cites this paper
• Caveolin-1-eNOS/Hsp70 interactions mediate rosuvastatin antifibrotic effects in neonatal obstructive nephropathy.

  2012cites this paper
• Regulation of eNOS in caveolae.

  2012cites this paper
• Non-antiarrhythmic Therapies for Cardiac Arrhythmias

  2012cites this paper
• Cholesterol-Lowering Drugs Inhibit Lectin-Like Oxidized Low-Density Lipoprotein-1 Receptor Function by Membrane Raft Disruption

  2012cites this paper
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  2012cites this paper
• Caveolae, caveolin, and cavins: Potential targets for the treatment of cardiac disease

  2012influential citation
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  2012influential citation
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  2012cites this paper
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  2012cites this paper
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  2012cites this paper
• Regulation of Cell Signaling and Function by Endothelial Caveolins: Implications in Disease

  2012cites this paper
• Mechanisms of statin treatment in cerebral vasospasm.

  2011cites this paper
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  2011cites this paper
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  2011cites this paper
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  2011cites this paper
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  2011cites this paper
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  2011influential citation
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  2011cites this paper
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  2011cites this paper
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  2010cites this paper
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  2010cites this paper
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  2010cites this paper
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  2010cites this paper
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  2010cites this paper
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  2009cites this paper