Neuroprotective FK506 does not alter in vivo nitric oxide production during ischemia and early reperfusion in rats.

No abstract is available for this paper.

• Publication year

  1999

• Venue

  Stroke

• Publication date

  1999-06-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1161/01.STR.30.6.1279PMID 10356112
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Mitochondria in Neurodegeneration: Bioenergetic Function in Cell Life and Death

  1999cited by this paper
• Estrogen-mediated neuroprotection after experimental stroke in male rats.

  1998cited by this paper
• Amelioration by cyclosporin A of brain damage in transient forebrain ischemia in the rat.

  1998cited by this paper
• Potent δ1-Receptor Ligand 4-Phenyl-1-(4-Phenyl) Piperidine (PPBP), Modulates Basal and N-methyl-D-aspartate-Evoked Nitric Oxide Production In Vivo: 604

  1998cited by this paper
• Gender-linked brain injury in experimental stroke.

  1998cited by this paper
• Cyclosporin A, But Not FK 506, Protects Mitochondria and Neurons against Hypoglycemic Damage and Implicates the Mitochondrial Permeability Transition in Cell Death

  1998cited by this paper
• Potent sigma1-receptor ligand 4-phenyl-1-(4-phenylbutyl) piperidine modulates basal and N-methyl-D-aspartate-evoked nitric oxide production in vivo.

  1998cited by this paper
• Cytosolic Redistribution of Cytochrome C after Transient Focal Cerebral Ischemia in Rats

  1998cited by this paper
• Neurotrophic actions of nonimmunosuppressive analogues of immunosuppressive drugs FK506, rapamycin and cyclosporin A

  1997cited by this paper
• The immunosuppressant drug FK506 ameliorates secondary mitochondrial dysfunction following transient focal cerebral ischemia in the rat.

  1997cited by this paper
• Calcineurin Inhibitor, FK506, Prevents Reduction in the Binding Capacity of Cyclic AMP-Dependent Protein Kinase in Ischemic Gerbil Brain

  1997cited by this paper
• Characterization of ionotropic glutamate receptor-mediated nitric oxide production in vivo in rats.

  1997cited by this paper
• Tacrolimus (FK506) ameliorates skilled motor deficits produced by middle cerebral artery occlusion in rats.

  1996cited by this paper
• Resistance to neurotoxicity in cortical cultures from neuronal nitric oxide synthase-deficient mice

  1996cited by this paper
• Effect of immunosuppressant FK506 on ischemia-induced degeneration of hippocampal neurons in gerbils.

  1996cited by this paper
• PPBP [4-phenyl-1-(4-phenylbutyl) piperidine] decreases brain injury after transient focal ischemia in rats.

  1996cited by this paper
• The immunosuppressant FK506 ameliorates ischaemic damage in the rat brain.

  1996cited by this paper
• Neuroprotective effect of FK506, an immunosuppressant, on transient global ischemia in gerbil.

  1996cited by this paper
• The mitochondrial permeability transition.

  1995cited by this paper
• Immunophilin FK506 binding protein associated with inositol 1,4,5-trisphosphate receptor modulates calcium flux.

  1995cited by this paper
• Inhibitory effect of cyclosporin A and FK506 on nitric oxide production by cultured macrophages. Evidence of a direct effect on nitric oxide synthase activity.

  1995cited by this paper
• Calcineurin functions in Ca(2+)-activated cell death in mammalian cells

  1995cited by this paper
• Adenosine modulates N-methyl-D-aspartate-stimulated hippocampal nitric oxide production in vivo.

  1995cited by this paper
• In vivo production of nitric oxide correlates with NMDA-induced cerebral hyperemia in newborn sheep.

  1995cited by this paper
• Tyrosine Phosphorylation and Activation of Mitogen‐ Activated Protein Kinase in the Rat Brain Following Transient Cerebral Ischemia

  1994cited by this paper
• Expression of the neural form of nitric oxide synthase by CA1 hippocampal neurons and other central nervous system neurons.

  1994cited by this paper
• Effects of cerebral ischemia in mice deficient in neuronal nitric oxide synthase.

  1994cited by this paper
• Nitric oxide activation of poly(ADP-ribose) synthetase in neurotoxicity.

  1994cited by this paper
• Stabilization of calcium release channel (ryanodine receptor) function by FK506-binding protein.

  1994cited by this paper
• The immunophilins, FK506 binding protein and cyclophilin, are discretely localized in the brain: relationship to calcineurin.

  1994cited by this paper
• Immunophilins mediate the neuroprotective effects of FK506 in focal cerebral ischaemia

  1994cited by this paper
• Effect of Brain Edema on Infarct Volume in a Focal Cerebral Ischemia Model in Rats

  1993cited by this paper
• Immunosuppressant FK506 enhances phosphorylation of nitric oxide synthase and protects against glutamate neurotoxicity.

  1993cited by this paper
• Protective Effect of FK506 on Ischemia/Reperfusion‐Induced Myocardial Damage in Canine Heart

  1993cited by this paper
• Mechanisms of nitric oxide-mediated neurotoxicity in primary brain cultures

  1993cited by this paper
• Time Course of the Translocation and Inhibition of Protein kinase C During Complete Cerebral Ischemia in the Rat

  1993cited by this paper
• Sodium‐Dependent Antiporters in Choroid Plexus Epithelial Cultures from Rabbit

  1993cited by this paper
• Quantitative Examination of Tissue Concentration Profiles Associated with Microdialysis

  1992cited by this paper
• High brain densities of the immunophilin FKBP colocalized with calcineurin

  1992cited by this paper
• FK 506 ameliorates the hepatic injury associated with ischemia and reperfusion in rats

  1991cited by this paper
• Further evidence that cyclosporin A protects mitochondria from calcium overload by inhibiting a matrix peptidyl-prolyl cis-trans isomerase. Implications for the immunosuppressive and toxic effects of cyclosporin.

  1991cited by this paper
• Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes.

  1991cited by this paper
• Localization of nitric oxide synthase indicating a neural role for nitric oxide

  1990cited by this paper
• The Effect of Local Infusion of Adenosine and Adenosine Analogues on Local Cerebral Blood Flow

  1989cited by this paper
• The immunosuppressant FK506 selectively inhibits expression of early T cell activation genes.

  1989cited by this paper
• Elevation of the Extracellular Concentrations of Glutamate and Aspartate in Rat Hippocampus During Transient Cerebral Ischemia Monitored by Intracerebral Microdialysis

  1984cited by this paper
• Glutamate: A Neurotransmitter in Mammalian Brain

  1984cited by this paper
• The Rat Brain in Stereotaxic Coordinates

  1983cited by this paper
• Journal of Cerebral Blood Flow and Metabolism Characterization of Metabotropic Glutamate Receptor­ Mediated Nitric Oxide Production in Vivo

  year unknowncited by this paper

• Fabrication of highly concentrated collagens using cooled urea/HAc as novel binary solvent

  2019cites this paper
• Non-invasive evaluation of neuroprotective drug candidates for cerebral infarction by PET imaging of mitochondrial complex-I activity

  2016cites this paper
• Posterior Reversible Encephalopathy Syndrome After Transplantation: a Review

  2016cites this paper
• EGb761 Co-administrated with FK506 Offer no More Neuroprotective Efficacy than EGb761 Alone during Focal Cerebral Ischemia and Reperfusion Monitored by Microdialysis Coupled with Microbore Liquid Chromatography

  2015cites this paper
• CALCINEURIN-MEDIATED SIGNALING IN ISCHEMIC PRECONDITIONING AND NEURONAL CELL DEATH

  2014cites this paper
• Treatment of cerebral ischemia‐reperfusion injury with PEGylated liposomes encapsulating FK506

  2013cites this paper
• Neurotrophic Factors as Novel Therapeutic Targets

  2011cites this paper
• Ginsenoside Rd in Experimental Stroke: Superior Neuroprotective Efficacy with a Wide Therapeutic Window

  2011cites this paper
• The calcineurin inhibitor, FK506, does not alter glutamate transport in the ischaemic mouse retina.

  2010cites this paper
• Possible nitric oxide modulation in protective effect of FK-506 against 3-nitropropionic acid-induced behavioral, oxidative, neurochemical, and mitochondrial alterations in rat brain

  2010cites this paper
• Neuroprotective action of FK-506 (tacrolimus) after seizures induced with pilocarpine: quantitative and topographic elemental analysis of brain tissue

  2010cites this paper
• Injections of vehicle, but not cyclosporin A or tacrolimus (FK506), afford neuroprotection following injury in the developing rat brain.

  2007cites this paper
• Neuroprotective effects of tacrolimus (FK506) in a model of ischemic cortical cell cultures: role of glutamate uptake and FK506 binding protein 12 kDa.

  2006cites this paper
• Inhibition of arachidonic acid release by cytosolic phospholipase A2 is involved in the antiapoptotic effect of FK506 and cyclosporin a on astrocytes exposed to simulated ischemia in vitro.

  2006cites this paper
• Effectiveness of FK506 on lipid peroxidation in the spinal cord following experimental traumatic injury

  2005cites this paper
• A novel mechanism of FK506‐mediated neuroprotection: Downregulation of cytokine expression in glial cells

  2005influential citation
• Systematic review and metaanalysis of the efficacy of FK 506 in experimental stroke

  2005cites this paper
• Systematic Review and Metaanalysis of the Efficacy of FK506 in Experimental Stroke

  2005cites this paper
• Comparison of continuous and discontinuous FK506 administration on autograft or allograft repair of sciatic nerve resection

  2004cites this paper
• FK506 abrogates delayed neuronal death via suppression of nitric oxide production in rats.

  2004cites this paper
• FK506 prevents mitochondrial-dependent apoptotic cell death induced by 3-nitropropionic acid in rat primary cortical cultures.

  2004cites this paper
• Ginkgo biloba Extract (EGb761) and FK506 Preserve Energy Metabolites in the Striatum during Focal Cerebral Ischemia and Reperfusion in Gerbils Monitored by Microdialysis

  2004cites this paper
• Molecular mechanisms of neuroprotective action of immunosuppressants ‐ facts and hypotheses

  2004cites this paper
• Neuroprotective effects of an immunosuppressant agent on diffusion/perfusion mismatch in transient focal ischemia

  2004cites this paper
• Nitric oxide and its role in ischaemic brain injury.

  2004cites this paper
• Nitric oxide reactivity and toxicity in brain tissue in vitro

  2004cites this paper
• FK506 reduces infarct volume due to permanent focal cerebral ischemia by maintaining BAD turnover and inhibiting cytochrome c release.

  2004cites this paper
• Chapter 6 – Statins and Reduction of Stroke: Cholesterol-Lowering versus Pleiotropic Effects

  2004cites this paper
• Protective Effect of Cyclosporin A on Glial Activation and White Matter Alterations Induced by Chronic Cerebral Hypoperfusion

  2003cites this paper
• Introduction: Immunosuppressants as Neuroprotective Agents

  2003cites this paper
• FK506 is neuroprotective in a model of antiretroviral toxic neuropathy

  2003cites this paper
• Possible antioxidant and neuroprotective mechanisms of FK506 in attenuating haloperidol-induced orofacial dyskinesia.

  2003cites this paper
• Recommendations for Advancing Development of Acute Stroke Therapies: Stroke Therapy Academic Industry Roundtable 3

  2003cites this paper
• Expression of FKBP12 after brain ischemia

  2003cites this paper
• The Role of Immunophilins in Focal Cerebral Ischemia

  2003cites this paper
• Immunosuppressant Analogs in Neuroprotection

  2003influential citation
• Nitric-oxide-synthase-mediated cyclic guanosine monophosphate production in neonatal rat cerebellar prisms is resistant to calcineurin inhibition.

  2002cites this paper
• [Immunophilins: neuroprotective agents and promoters of neural regeneration].

  2002cites this paper
• Axonal regeneration after cold preservation of nerve allografts and immunosuppression with tacrolimus in mice.

  2002cites this paper
• Decreased lung ischemia-reperfusion injury in rats after preoperative administration of cyclosporine and tacrolimus.

  2002cites this paper
• Neuroimmunophilin Ligand V-10,367 is Neuroprotective after 24-Hour Delayed Administration in a Mouse Model of Diffuse Traumatic Brain Injury

  2002cites this paper
• Calcineurin as a multifunctional regulator.

  2002cites this paper
• The effects of rapamycin in murine peripheral nerve isografts and allografts.

  2002cites this paper
• Statins and stroke: evidence for cholesterol-independent effects.

  2002cites this paper
• Dynamics of nitric oxide during simulated ischaemia‐reperfusion in rat striatal slices measured using an intrinsic biosensor, soluble guanylyl cyclase

  2002cites this paper
• Cerebral Ischemia: Pathophysiology and Neuroprotection

  2002cites this paper
• Neuroimmunophilin ligands exert neuroregeneration and neuroprotection in midbrain dopaminergic neurons

  2001cites this paper
• Nitro-aspirin (NCX4016) reduces brain damage induced by focal cerebral ischemia in the rat.

  2001cites this paper
• Neuroimmunophilins: Novel neuroprotective and neuroregenerative targets

  2001cites this paper
• Neuroprotective Effect of s1-Receptor Ligand 4-Phenyl-1-(4-Phenylbutyl) Piperidine (PPBP) Is Linked to Reduced Neuronal Nitric Oxide Production

  2001cites this paper
• Neuroprotective effect of σ1-receptor ligand 4-phenyl-1-(4-phenylbutyl) piperidine (PPBP) is linked to reduced neuronal nitric oxide production

  2001cites this paper
• Effects of MK-801, dantrolene, and FK506 on convulsive seizures and brain nitric oxide production in seizure-susceptible EL mice.

  2001cites this paper
• Neuroprotective Effect of s 1 -Receptor Ligand 4-Phenyl-1-(4-Phenylbutyl) Piperidine (PPBP) Is Linked to Reduced Neuronal Nitric Oxide Production

  2001cites this paper
• SEA0400, a novel and selective inhibitor of the Na+-Ca2+ exchanger, attenuates reperfusion injury in the in vitro and in vivo cerebral ischemic models.

  2001cites this paper
• Effect of FK-506 on inflammation and behavioral outcome following intracerebral hemorrhage in rat.

  2001cites this paper
• Neuroprotective effect of sigma(1)-receptor ligand 4-phenyl-1-(4-phenylbutyl) piperidine (PPBP) is linked to reduced neuronal nitric oxide production.

  2001cites this paper
• The neuroprotective actions of FK506 binding protein ligands: neuronal survival is triggered by de novo RNA synthesis, but is independent of inhibition of JNK and calcineurin.

  2001cites this paper
• The Effects of FK506 on Neurologic and Histopathologic Outcome After Transient Spinal Cord Ischemia Induced by Aortic Cross-Clamping in Rats

  2001influential citation
• Resveratrol reduction of infarct size in Long-Evans rats subjected to focal cerebral ischemia.

  2001cites this paper
• FK506 promotes adenosine release from endothelial cells via inhibition of adenosine kinase.

  2001cites this paper
• Neuroimmunophilin ligands: evaluation of their therapeutic potential for the treatment of neurological disorders

  2000cites this paper
• Role of calcium in neuronal cell injury: which subcellular compartment is involved?

  2000cites this paper
• Subacute But Not Acute Generation of Nitric Oxide in Focal Cerebral Ischemia

  2000cites this paper
• Brain ischemia and reperfusion: molecular mechanisms of neuronal injury.

  2000cites this paper
• Nitric Oxide and Cerebral Ischemia

  2000cites this paper
• Ischemic cell death in brain neurons.

  1999cites this paper