FK506 prevents mitochondrial-dependent apoptotic cell death induced by 3-nitropropionic acid in rat primary cortical cultures.

No abstract is available for this paper.

• Publication year

  2004

• Venue

  Neurobiology of Disease

• Publication date

  2004-12-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/J.NBD.2004.07.002PMID 15571979
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Methods of Enzymatic Analysis

  2019cited by this paper
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  2004influential reference
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  2003cited by this paper
• Calcineurin controls the expression of numerous genes in cerebellar granule cells.

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  2003cited by this paper
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  2003influential reference
• Role of calcineurin in calcium-mediated hypoxic injury to white matter.

  2003cited by this paper
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• 3-Nitropropionic acid induces cell death and mitochondrial dysfunction in rat corticostriatal slice cultures.

  2002influential reference
• The mechanisms of neuronal death produced by mitochondrial toxin 3-nitropropionic acid: the roles of N-methyl-D-aspartate glutamate receptors and mitochondrial calcium overload.

  2002cited by this paper
• Acute and chronic alterations in calcium homeostasis in 3-nitropropionic acid-treated human NT2-N neurons.

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  2000cited by this paper
• Tauroursodeoxycholic Acid Partially Prevents Apoptosis Induced by 3‐Nitropropionic Acid

  2000cited by this paper
• Mitochondria as the central control point of apoptosis.

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  1999influential reference
• Neuroprotective FK506 does not alter in vivo nitric oxide production during ischemia and early reperfusion in rats.

  1999cited by this paper
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  1999cited by this paper
• Ca2+-induced apoptosis through calcineurin dephosphorylation of BAD.

  1999cited by this paper
• Immunophilins in the Nervous System Review

  1998cited by this paper
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  1998cited by this paper
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  1998cited by this paper
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  1998cited by this paper
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  1996cited by this paper
• The role of the cyclic AMP-responsive element binding protein (CREB) in hypoxic-ischemic brain damage and repair.

  1996cited by this paper
• Calcineurin and mitochondrial function in glutamate‐induced neuronal cell death

  1996influential reference
• Induction of bcl-2 expression by phosphorylated CREB proteins during B-cell activation and rescue from apoptosis

  1996cited by this paper
• 3-Nitropropionic acid induces apoptosis in cultured striatal and cortical neurons.

  1995cited by this paper
• X-ray structure of calcineurin inhibited by the immunophilin-immunosuppressant FKBP12-FK506 complex.

  1995influential reference
• Brain-Derived Neurotrophic Factor Protects against Ischemic Cell Damage in Rat Hippocampus

  1994cited by this paper
• Increased production of the TrkB protein tyrosine kinase receptor after brain insults.

  1993cited by this paper
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  1993cited by this paper
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  1991influential reference
• Comparative specificity and kinetic studies on porcine calpain I and calpain II with naturally occurring peptides and synthetic fluorogenic substrates.

  1984cited by this paper
• Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays.

  1983cited by this paper
• Inactivation of succinate dehydrogenase by 3-nitropropionate.

  1979cited by this paper
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  1977influential reference
• UV-Assay with Pyruvate and NADH

  1974cited by this paper

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