Evidence for the involvement of proline-directed serine/threonine phosphorylation in sperm capacitation.

No abstract is available for this paper.

• Publication year

  2006

• Venue

  Molecular human reproduction

• Publication date

  2006-12-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1093/MOLEHR/GAL085PMID 17050774
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The "soluble" adenylyl cyclase in sperm mediates multiple signaling events required for fertilization.

  2005cited by this paper
• Protein tyrosine phosphorylation, hyperactivation and progesterone-induced acrosome reaction are enhanced in IVF media: an effect that is not associated with an increase in protein kinase A activation.

  2005cited by this paper
• Reactive Oxygen Species and Protein Kinases Modulate the Level of Phospho-MEK-Like Proteins During Human Sperm Capacitation1

  2005cited by this paper
• Isolation and Proteomic Analysis of Mouse Sperm Detergent-Resistant Membrane Fractions: Evidence for Dissociation of Lipid Rafts During Capacitation1

  2005cited by this paper
• Pinning down cell signaling, cancer and Alzheimer's disease.

  2004cited by this paper
• Mice deficient for soluble adenylyl cyclase are infertile because of a severe sperm-motility defect.

  2004cited by this paper
• Reorganization of Lipid Rafts During Capacitation of Human Sperm1

  2004cited by this paper
• Sperm-specific protein kinase A catalytic subunit Calpha2 orchestrates cAMP signaling for male fertility.

  2004cited by this paper
• Phosphorylation of the Arginine-X-X-(Serine/Threonine) motif in human sperm proteins during capacitation: modulation and protein kinase A dependency.

  2004cited by this paper
• Expression analysis of the human testis-specific serine/threonine kinase (TSSK) homologues. A TSSK member is present in the equatorial segment of human sperm.

  2004cited by this paper
• Inhibitors of phosphoinositide 3-kinase, LY294002 and wortmannin, affect sperm capacitation and associated phosphorylation of proteins differently: Ca2+-dependent divergences.

  2004cited by this paper
• Cholesterol Efflux Alters Lipid Raft Stability and Distribution During Capacitation of Boar Spermatozoa1

  2004cited by this paper
• Rapid PKA‐catalysed phosphorylation of boar sperm proteins induced by the capacitating agent bicarbonate

  2004cited by this paper
• Phosphoproteome Analysis of Capacitated Human Sperm

  2003cited by this paper
• Pregnancies after ICSI using sperm with abnormal head-tail junction from two brothers: case report.

  2003cited by this paper
• Different signal transduction pathways are involved during human sperm capacitation induced by biological and pharmacological agents.

  2002cited by this paper
• Pinning down proline-directed phosphorylation signaling.

  2002cited by this paper
• The extracellular signal-regulated kinase (ERK) pathway is involved in human sperm function and modulated by the superoxide anion.

  2002influential reference
• Evolution of protein kinase signaling from yeast to man.

  2002cited by this paper
• Capacitation‐associated changes in protein tyrosine phosphorylation, hyperactivation and acrosome reaction in hamster spermatozoa

  2001cited by this paper
• Identification of mouse trp homologs and lipid rafts from spermatogenic cells and sperm

  2001cited by this paper
• Dual regulation of the T‐type Ca2+ current by serum albumin and β‐estradiol in mammalian spermatogenic cells

  2000cited by this paper
• Cholesterol efflux-mediated signal transduction in mammalian sperm: cholesterol release signals an increase in protein tyrosine phosphorylation during mouse sperm capacitation.

  1999cited by this paper
• Roles of bicarbonate, cAMP, and protein tyrosine phosphorylation on capacitation and the spontaneous acrosome reaction of hamster sperm.

  1999cited by this paper
• Effect of methyl‐β‐cyclodextrin on the acrosomal responsiveness of human sperm

  1999cited by this paper
• Regulation of human sperm capacitation by a cholesterol efflux-stimulated signal transduction pathway leading to protein kinase A-mediated up-regulation of protein tyrosine phosphorylation.

  1999cited by this paper
• Effect of methyl-beta-cyclodextrin on the acrosomal responsiveness of human sperm.

  1999cited by this paper
• Cholesterol Efflux-mediated Signal Transduction in Mammalian Sperm

  1999cited by this paper
• Role of cholesterol in sperm capacitation.

  1998cited by this paper
• Cyclodextrin removes cholesterol from mouse sperm and induces capacitation in a protein-free medium.

  1998cited by this paper
• Extracellular signal-regulated kinases modulate capacitation of human spermatozoa.

  1998cited by this paper
• Regulation of protein tyrosine phosphorylation in boar sperm through a cAMP‐dependent pathway

  1998cited by this paper
• Signaling through scaffold, anchoring, and adaptor proteins.

  1997cited by this paper
• Major proteins of bovine seminal plasma modulate sperm capacitation by high-density lipoprotein.

  1997cited by this paper
• Regulation of protein tyrosine phosphorylation during bovine sperm capacitation by a cyclic adenosine 3'5'-monophosphate-dependent pathway.

  1997cited by this paper
• Sequence-specific and phosphorylation-dependent proline isomerization: a potential mitotic regulatory mechanism.

  1997cited by this paper
• Sperm motility development in the epididymis is associated with decreased glycogen synthase kinase-3 and protein phosphatase 1 activity.

  1996cited by this paper
• Unesterified cholesterol content of human sperm regulates the response of the acrosome to the agonist, progesterone.

  1996cited by this paper
• Cyclic adenosine 3',5'monophosphate-dependent regulation of protein tyrosine phosphorylation in relation to human sperm capacitation and motility.

  1996cited by this paper
• Effect of cholesterol and other sterols on human sperm acrosomal responsiveness

  1996cited by this paper
• Capacitation of mouse spermatozoa. II. Protein tyrosine phosphorylation and capacitation are regulated by a cAMP-dependent pathway.

  1995cited by this paper
• Capacitation of mouse spermatozoa. I. Correlation between the capacitation state and protein tyrosine phosphorylation.

  1995cited by this paper
• Ultrastructural localization of protein kinase C in human sperm.

  1995cited by this paper
• Roles of heterotrimeric and monomeric G proteins in sperm-induced activation of mouse eggs.

  1994cited by this paper
• Role of protein kinase C in the acrosome reaction of mammalian spermatozoa.

  1992cited by this paper
• Purification and characterization of polyamine-stimulated protein kinase (casein kinase II) from bovine spermatozoa.

  1991cited by this paper
• Casein kinase I in bovine sperm: purification and characterization.

  1991cited by this paper
• Protein kinase C is present in human sperm: possible role in flagellar motility.

  1990cited by this paper
• Changes in the distribution of intramembranous particles and filipin-reactive membrane sterols during in vitro capacitation of golden hamster spermatozoa.

  1989cited by this paper
• A molecular membrane model of sperm capacitation and the acrosome reaction of mammalian spermatozoa

  1985cited by this paper
• Albumin-mediated changes in sperm sterol content during capacitation.

  1985cited by this paper
• Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

  1970cited by this paper
• Observations on the penetration of the sperm in the mammalian egg.

  1951cited by this paper
• Fertilizing Capacity of Spermatozoa deposited into the Fallopian Tubes

  1951cited by this paper

• Spatiotemporal translation of sperm acrosome associated proteins during early capacitation modulates sperm fertilizing ability

  2025cites this paper
• Does the Type of Semen Affect the Phosphoproteome of Turkey (Meleagris gallopavo) Spermatozoa?

  2025cites this paper
• Revisiting the Injury Mechanism of Goat Sperm Caused by the Cryopreservation Process from a Perspective of Sperm Metabolite Profiles

  2024cites this paper
• Rapid characterization of adeno-associated virus (AAV) capsid proteins using microchip ZipChip CE-MS

  2023cites this paper
• Naringin regulates intestinal microorganisms and serum metabolites to promote spermatogenesis.

  2023cites this paper
• Characterization of two novel ammonia transporters, HIAT1α and HIAT1β, in the American Horseshoe Crab, Limulus polyphemus.

  2022cites this paper
• Inhibition of human sperm function by an antibody against apolipoprotein A1: A protein located in human spermatozoa

  2022cites this paper
• Influence of the Season and Region Factor on Phosphoproteome of Stallion Epididymal Sperm

  2021cites this paper
• "In vitro" capacitation and further progesterone-induced acrosome exocytosis are linked to specific changes in the expression and location of threonine phosphorylation of boar spermatozoa.

  2019cites this paper
• Compartmentalization of the proteasome-interacting proteins during sperm capacitation

  2019cites this paper
• Molecular Basis of Human Sperm Capacitation

  2018cites this paper
• Sperm capacitation is associated with phosphorylation of the testis-specific radial spoke protein Rsph6a†

  2018cites this paper
• PrESOgenesis: A two-layer multi-label predictor for identifying fertility-related proteins using support vector machine and pseudo amino acid composition approach

  2018cites this paper
• TSSK6 is required for γH2AX formation and the histone-to-protamine transition during spermiogenesis

  2017cites this paper
• Bacteriospermia and porcine reproduction: effects on sperm quality and fertility potential of boar spermatozoa

  2016cites this paper
• Oviductal epithelial cells selected boar sperm according to their functional characteristics

  2016cites this paper
• A Mouse Model for Dietary Xenosialitis

  2016cites this paper
• Effect of Pseudomonas aeruginosa on sperm capacitation and protein phosphorylation of boar spermatozoa.

  2016cites this paper
• An In Vitro Evaluation of Biochemical Processes Involved in Lead-Induced Changes on Ram Spermatozoa.

  2016cites this paper
• Sperm Capacitation associated increase in Tyrosine Phosphorylation: kinetic of the increase and novel members involved in the process.

  2016influential citation
• Tyrosine phosphorylation of dihydrolipoamide dehydrogenase as a potential cadmium target and its inhibitory role in regulating mouse sperm motility.

  2016cites this paper
• Factors and pathways involved in capacitation: how are they regulated?

  2016cites this paper
• Second messengers, steroids and signaling cascades: Crosstalk in sperm development and function.

  2015cites this paper
• Dynamic Changes in Equatorial Segment Protein 1 (SPESP1) Glycosylation During Mouse Spermiogenesis1

  2015cites this paper
• CDs in Artificial Fertilization of Animals

  2015cites this paper
• Importancia de la evaluación del estrés oxidativo en el semen humano Importance of the assessment of oxidative stress in human semen

  2015cites this paper
• Embryotrophic Potential Of Novel And Candidate Oviductal Fluid Proteins Of Buffalo

  2014cites this paper
• The Increase in Phosphorylation Levels of Serine Residues of Protein HSP70 during Holding Time at 17°C Is Concomitant with a Higher Cryotolerance of Boar Spermatozoa

  2014cites this paper
• [Cloning and expression of Tssk1 & Tssk2 in mice and the presence & localization of them in mature sperm].

  2013influential citation
• esticular phosphoproteome in perfluorododecanoic acid-exposed ats

  2013cites this paper
• Testicular phosphoproteome in perfluorododecanoic acid-exposed rats.

  2013cites this paper
• Amphibian Oocytes Release Heat Shock Protein A During Spawning: Evidence for a Role in Fertilization1

  2012cites this paper
• Modulation of mammalian sperm motility is crucial to fertilization

  2012influential citation
• 'In vitro' capacitation and further 'in vitro' progesterone-induced acrosome exocytosis are linked to specific changes in the expression and acrosome location of protein phosphorylation in serine residues of boar spermatozoa.

  2012cites this paper
• Sperm phosphoproteomics: historical perspectives and current methodologies

  2012cites this paper
• Amphibian Oocytes Release Heat Shock Protein A During Spawning: Evidence for a Role

  2012cites this paper
• Sperm Capacitation as an Oxidative Event

  2012cites this paper
• A Novel Epidermal Growth Factor-Dependent Extracellular Signal-Regulated MAP Kinase Cascade Involved in Sperm Functionality in Sheep1

  2012cites this paper
• Two Distinct Ca 2+ Signaling Pathways Modulate Sperm Flagellar Beating Patterns in Mice Short title: Ca 2+ signals modulate hyperactivation Summary sentence: Two distinct Ca 2+ signaling pathways alter the symmetry of mouse sperm

  2011cites this paper
• Calcium channels in the development, maturation, and function of spermatozoa.

  2011cites this paper
• Two Distinct Ca2+ Signaling Pathways Modulate Sperm Flagellar Beating Patterns in Mice1

  2011cites this paper
• Ion channels, phosphorylation and mammalian sperm capacitation.

  2011cites this paper
• Markers of human sperm functions in the ICSI era.

  2011cites this paper
• Glucose and fructose as functional modulators of overall dog, but not boar sperm function.

  2011cites this paper
• Expression and localization of five members of the testis-specific serine kinase (Tssk) family in mouse and human sperm and testis.

  2011cites this paper
• Reactive oxygen and nitrogen species in normal physiological processes

  2010cites this paper
• The “switching on” of mammalian spermatozoa: Molecular events involved in promotion and regulation of capacitation

  2010cites this paper
• Elucidation of the signaling pathways that underpin capacitation‐associated surface phosphotyrosine expression in mouse spermatozoa

  2010cites this paper
• Proteins from human oviductal tissue-conditioned medium modulate sperm capacitation.

  2010cites this paper
• Analysis of CAPZA3 localization reveals temporally discrete events during the acrosome reaction

  2010cites this paper
• Testicular Expression of Adora3i2 in Adora3 Knockout Mice Reveals a Role of Mouse A3Ri2 and Human A3Ri3 Adenosine Receptors in Sperm*

  2010cites this paper
• The role of Mitogen activated protein kinase (MAPK) in sperm functions.

  2010cites this paper
• Tssk6 is required for Izumo relocalization and gamete fusion in the mouse

  2009cites this paper
• Localization of Low-Density Detergent-Resistant Membrane Proteins in Intact and Acrosome-Reacted Mouse Sperm

  2009cites this paper
• Dinàmica de la motilitat, la fosforil·lació de proteïnes i l'activitat mitocondrial de l'espermatozoide porcí durant la capacitació i reacció acrosòmica "in vitro"

  2009cites this paper
• Use of differential isotopic labeling and mass spectrometry to analyze capacitation-associated changes in the phosphorylation status of mouse sperm proteins.

  2009cites this paper
• Molecular Mechanism for Human Sperm Chemotaxis Mediated by Progesterone

  2009cites this paper
• Molecular markers of human sperm functions.

  2009cites this paper
• Cholesterol and desmosterol in two sperm populations separated on Sil-Select gradient.

  2009cites this paper
• Changes in content and localization of proteins phosphorylated at tyrosine, serine and threonine residues during ram sperm capacitation and acrosome reaction.

  2009influential citation
• threonine residues during ram sperm capacitation and acrosome reaction

  2009cites this paper
• Phosphorylation of Mouse Sperm Axoneme Central Apparatus Protein SPAG16L by a Testis-Specific Kinase, TSSK21

  2008cites this paper
• Biochemical and structural characterization of apolipoprotein A-I binding protein, a novel phosphoprotein with a potential role in sperm capacitation.

  2008influential citation
• Sperm activation: role of reactive oxygen species and kinases.

  2008cites this paper
• PACSIN2 regulates cell adhesion during gastrulation in Xenopus laevis.

  2008cites this paper
• Mitogen activated protein kinases (MAPKs) as regulators of spermatogenesis and spermatozoa functions.

  2008cites this paper
• Identification of proteins undergoing tyrosine phosphorylation during mouse sperm capacitation.

  2008cites this paper
• Characterization of a novel, testis‐specific equine serine/threonine kinase

  2008cites this paper
• TSKS concentrates in spermatid centrioles during flagellogenesis.

  2008cites this paper
• Current Concepts of Molecular Events During Bovine and Porcine Spermatozoa Capacitation

  2007cites this paper