Modulation of Fronto-Cortical Activity by Modafinil: A Functional Imaging and Fos Study in the Rat

No abstract is available for this paper.

• Publication year

  2012

• Venue

  Neuropsychopharmacology

• Publication date

  2012-02-01

• Fields of study

  Medicine, Psychology

• Identifiers
  DOI 10.1038/npp.2011.260PMID 22048464PMCID PMC3260987
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Modafinil reverses phencyclidine-induced deficits in cognitive flexibility, cerebral metabolism, and functional brain connectivity.

  2012cited by this paper
• Approved and Investigational Uses of Modafinil

  2012cited by this paper
• Functional Magnetic Resonance Imaging Reveals Different Neural Substrates for the Effects of Orexin-1 and Orexin-2 Receptor Antagonists

  2011influential reference
• The likelihood of cognitive enhancement.

  2011cited by this paper
• Disruption of Frontal Theta Coherence by Δ9-Tetrahydrocannabinol is Associated with Positive Psychotic Symptoms

  2011cited by this paper
• Functional and pharmacological MRI in understanding brain function at a systems level.

  2011cited by this paper
• Behavioral evaluation of modafinil and the abuse-related effects of cocaine in rhesus monkeys.

  2010cited by this paper
• Antagonism at serotonin 5-HT2A receptors modulates functional activity of frontohippocampal circuit

  2010influential reference
• Functional connectivity in the rat brain: a complex network approach.

  2010cited by this paper
• Brain penetration of local anaesthetics in the rat: Implications for experimental neuroscience.

  2010cited by this paper
• Modafinil and methylphenidate for neuroenhancement in healthy individuals: A systematic review.

  2010cited by this paper
• The psychostimulant modafinil facilitates water maze performance and augments synaptic potentiation in dentate gyrus.

  2010cited by this paper
• Halothane-induced Hypnosis Is Not Accompanied by Inactivation of Orexinergic Output in Rodents

  2009cited by this paper
• Effects of modafinil on dopamine and dopamine transporters in the male human brain: clinical implications.

  2009cited by this paper
• Modafinil for clozapine-treated schizophrenia patients: a double-blind, placebo-controlled pilot trial.

  2009cited by this paper
• Community structure in networks of functional connectivity: Resolving functional organization in the rat brain with pharmacological MRI

  2009cited by this paper
• How high-resolution basal-state functional imaging can guide the development of new pharmacotherapies for schizophrenia.

  2009cited by this paper
• Armodafinil promotes wakefulness and activates Fos in rat brain.

  2009influential reference
• Glutamate and the neural basis of the subjective effects of ketamine: a pharmaco-magnetic resonance imaging study.

  2008cited by this paper
• Drug-anaesthetic interaction in phMRI: the case of the psychotomimetic agent phencyclidine.

  2008influential reference
• Brain–computer interface in paralysis

  2008cited by this paper
• Cerebral blood flow changes in man by wake‐promoting drug, modafinil: a randomized double blind study

  2008cited by this paper
• Rapid eye movement (REM) sleep homeostatic regulatory processes in the rat: changes in the sleep-wake stages and electroencephalographic power spectra.

  2008cited by this paper
• Modafinil: A Review of Neurochemical Actions and Effects on Cognition

  2008influential reference
• Pharmacological stimulation of NMDA receptors via co-agonist site suppresses fMRI response to phencyclidine in the rat

  2008influential reference
• Dopaminergic D1 and D2 Receptors Are Essential for the Arousal Effect of Modafinil

  2008cited by this paper
• Differential Effects of Antipsychotic and Glutamatergic Agents on the phMRI Response to Phencyclidine

  2008influential reference
• Functional connectivity in the pharmacologically activated brain: Resolving networks of correlated responses to d‐amphetamine

  2007cited by this paper
• In vivo mapping of functional connectivity in neurotransmitter systems using pharmacological MRI

  2007cited by this paper
• Low-resolution brain electromagnetic tomography (LORETA) identifies brain regions linked to psychometric performance under modafinil in narcolepsy.

  2007cited by this paper
• Study-level wavelet cluster analysis and data-driven signal models in pharmacological MRI.

  2007influential reference
• A multimodality investigation of cerebral hemodynamics and autoregulation in pharmacological MRI.

  2007cited by this paper
• A randomized, double-blind, placebo-controlled trial of modafinil for negative symptoms in schizophrenia.

  2007cited by this paper
• Modafinil enhances extracellular levels of dopamine in the nucleus accumbens and increases wakefulness in rats.

  2007cited by this paper
• Euphorigenic and abusive properties of modafinil.

  2006cited by this paper
• Interactions among the medial prefrontal cortex, hippocampus and midline thalamus in emotional and cognitive processing in the rat.

  2006cited by this paper
• Functional magnetic resonance imaging and c-Fos mapping in rats following an anorectic dose of m-chlorophenylpiperazine

  2006cited by this paper
• Neural Substrates of Psychostimulant-Induced Arousal

  2006cited by this paper
• Region-Specific Effects of Nicotine on Brain Activity: A Pharmacological MRI Study in the Drug-Naïve Rat

  2006cited by this paper
• A multimodality investigation of cerebral haemodynamics and autoregulation in phMRI

  2006cited by this paper
• Dissociable Roles for the Nucleus Accumbens Core and Shell in Regulating Set Shifting

  2006cited by this paper
• Impact of modafinil on prefrontal executive function in schizophrenia.

  2006cited by this paper
• Modafinil Occupies Dopamine and Norepinephrine Transporters in Vivo and Modulates the Transporters and Trace Amine Activity in Vitro

  2006cited by this paper
• A stereotaxic MRI template set for the rat brain with tissue class distribution maps and co-registered anatomical atlas: Application to pharmacological MRI

  2006influential reference
• Cerebral Cortex doi:10.1093/cercor/bhl073 Thalamic--Prefrontal Cortical--Ventral Striatal Circuitry Mediates Dissociable Components of Strategy Set Shifting

  2006cited by this paper
• Modafinil activates cortical and subcortical sites in the sleep-deprived state.

  2006cited by this paper
• Reinforcing effects of modafinil: influence of dose and behavioral demands following drug administration

  2005cited by this paper
• Electrocorticographic and deep intracerebral EEG recording in mice using a telemetry system.

  2005cited by this paper
• Continuous noninvasive monitoring of transcutaneous blood gases for a stable and persistent BOLD contrast in fMRI studies in the rat

  2005cited by this paper
• Modafinil modulates anterior cingulate function in chronic schizophrenia.

  2005cited by this paper
• Modafinil more effectively induces wakefulness in orexin-null mice than in wild-type littermates.

  2005cited by this paper
• Prefrontal executive and cognitive functions in rodents: neural and neurochemical substrates.

  2004cited by this paper
• Imaging correlates of brain function in monkeys and rats isolates a hippocampal subregion differentially vulnerable to aging.

  2004cited by this paper
• EEG-tomographic studies with LORETA on vigilance differences between narcolepsy patients and controls and subsequent double-blind, placebo-controlled studies with modafinil

  2004cited by this paper
• Sleep neurobiology for the clinician.

  2004cited by this paper
• Advances in functional and structural MR image analysis and implementation as FSL.

  2004influential reference
• Human pharmacological MRI.

  2004cited by this paper
• Effects of modafinil on cognitive and meta‐cognitive performance

  2004cited by this paper
• Testing the validity of c-fos expression profiling to aid the therapeutic classification of psychoactive drugs

  2004cited by this paper
• Expression of the c-Fos Gene in Spinal Cord and Brain Cells in Rats Subjected to Stress in Conditions of Exposure to Various Types of Halothane Anesthesia

  2004cited by this paper
• Modafinil: preclinical, clinical, and post-marketing surveillance--a review of abuse liability issues.

  2004cited by this paper
• Enhancement of learning processes following an acute modafinil injection in mice.

  2003cited by this paper
• Functional MRI using intravascular contrast agents: detrending of the relative cerebrovascular (rCBV) time course.

  2003cited by this paper
• Comparison of electroencephalogram activity and auditory evoked responses during isoflurane and halothane anaesthesia in the rat.

  2003influential reference
• Do rats have a prefrontal cortex?

  2003cited by this paper
• Effects of Subanesthetic Doses of Ketamine on Regional Cerebral Blood Flow, Oxygen Consumption, and Blood Volume in Humans

  2003cited by this paper
• Perceptual Attentional Set-Shifting Is Impaired in Rats with Neurotoxic Lesions of Posterior Parietal Cortex

  2003cited by this paper
• Effect of volatile anesthetics on interhemispheric EEG cross-approximate entropy in the rat.

  2002cited by this paper
• The Neurobiology of Sleep: Genetics, cellular physiology and subcortical networks

  2002cited by this paper
• Research report Motivational views of reinforcement: implications for understanding the behavioral functions of nucleus accumbens dopamine

  2002cited by this paper
• Differential enhancement of dialysate serotonin levels in distinct brain regions of the awake rat by modafinil: Possible relevance for wakefulness and depression

  2002cited by this paper
• Cognitive enhancing effects of modafinil in healthy volunteers

  2002cited by this paper
• Neurophysiological investigation of the basis of the fMRI signal

  2001cited by this paper
• Variations in extracellular monoamines in the prefrontal cortex and medial hypothalamus after modafinil administration: a microdialysis study in rats

  2001cited by this paper
• Dopaminergic Role in Stimulant-Induced Wakefulness

  2001cited by this paper
• First evidence of a delay-dependent working memory-enhancing effect of modafinil in mice

  2001cited by this paper
• Maintaining alertness and performance during sleep deprivation: modafinil versus caffeine

  2001cited by this paper
• An evaluation of the abuse potential of modafinil using methylphenidate as a reference

  2000cited by this paper
• Hypothalamic Arousal Regions Are Activated during Modafinil-Induced Wakefulness

  2000influential reference
• Effects of amphetamine and modafinil on the sleep/wake cycle during experimental hypersomnia induced by sleep deprivation in the cat

  2000cited by this paper
• Amphetamine-induced activation of forebrain EEG is prevented by noradrenergic β-receptor blockade in the halothane-anesthetized rat

  2000cited by this paper
• On the functional significance of c-fos induction during the sleep-waking cycle.

  2000cited by this paper
• Cerebrovascular dynamics of autoregulation and hypoperfusion. An MRI study of CBF and changes in total and microvascular cerebral blood volume during hemorrhagic hypotension.

  1999cited by this paper
• Comparison of brain metabolic activity patterns induced by ketamine, MK-801 and amphetamine in rats: support for NMDA receptor involvement in responses to subanesthetic dose of ketamine.

  1999cited by this paper
• A Double‐Blind, Placebo‐Controlled, Ascending‐Dose Evaluation of the Pharmacokinetics and Tolerability of Modafinil Tablets in Healthy Male Volunteers

  1999cited by this paper
• Erratum to: Modafinil: a review of its pharmacology and clinical efficacy in the management of narcolepsy

  1998cited by this paper
• Brain regional substrates for the actions of the novel wake-promoting agent modafinil in the rat: comparison with amphetamine.

  1998influential reference
• Modafinil

  1998cited by this paper
• Dynamic functional imaging of relative cerebral blood volume during rat forepaw stimulation

  1998influential reference
• Nicotine-induced limbic cortical activation in the human brain: a functional MRI study.

  1998cited by this paper
• Inducibility of c‐Fos protein in visuo‐motor system and limbic structures after acute and repeated administration of nicotine in the rat

  1998cited by this paper
• Sleep and arousal: thalamocortical mechanisms.

  1997cited by this paper
• Nitrous oxide or halothane, or both, fail to suppress c-fos expression in rat spinal cord dorsal horn neurones after subcutaneous formalin.

  1996cited by this paper
• Potential brain neuronal targets for amphetamine-, methylphenidate-, and modafinil-induced wakefulness, evidenced by c-fos immunocytochemistry in the cat.

  1996cited by this paper
• Evaluation of the cocaine-like discriminative stimulus effects and reinforcing effects of modafinil

  1996cited by this paper
• Arousal--Revisiting the Reticular Activating System

  1996cited by this paper
• ネコ脳のアンフェタミン,メチルフェニデート,モダフィニルの覚醒作用における標的ニューロンのc‐fos免疫組織化学による検索

  1996cited by this paper
• Modafinil, d‐amphetamine and placebo during 64 hours of sustained mental work. I. Effects on mood, fatigue, cognitive performance and body temperature

  1995cited by this paper
• Mr contrast due to intravascular magnetic susceptibility perturbations

  1995influential reference
• Analysis of functional MRI time‐series

  1994cited by this paper

• Modafinil-Induced Hyperkinetic Movements in Post-Stroke Patients: A Case Series.

  2025cites this paper
• Modafinil, an atypical CNS stimulant?

  2024cites this paper
• Anti-Diabetic Drugs Inhibit Bulimia Induced Obesity.

  2023cites this paper
• “Less is more”: A dose-response account of intranasal oxytocin pharmacodynamics in the human brain

  2021cites this paper
• Neurophysiological and Neurochemical Effects of the Putative Cognitive Enhancer (S)-CE-123 on Mesocorticolimbic Dopamine System

  2020cites this paper
• Whole-brain signatures of functional connectivity after bidirectional modulation of the dopaminergic system in mice.

  2020cites this paper
• Modafinil reduces choice impulsivity while increasing motor activity in preadolescent rats treated prenatally with alcohol.

  2020cites this paper
• Combinatorial Targeting of Distributed Forebrain Networks Reverses Noise Hypersensitivity in a Model of Autism Spectrum Disorder.

  2019cites this paper
• The effects of single‐dose injections of modafinil and methamphetamine on epigenetic and functional markers in the mouse medial prefrontal cortex: potential role of dopamine receptors

  2019cites this paper
• Modafinil for people with schizophrenia or related disorders.

  2019cites this paper
• Acute and repeated intranasal oxytocin differentially modulate brain-wide functional connectivity

  2019cites this paper
• phMRI, neurochemical and behavioral responses to psychostimulants distinguishing genetically selected alcohol‐preferring from genetically heterogenous rats

  2018cites this paper
• Oscillatory brain states govern spontaneous fMRI network dynamics

  2018cites this paper
• Cortico-Amygdala-Striatal Activation by Modafinil/Flecainide Combination

  2018influential citation
• Repeated methamphetamine and modafinil induce differential cognitive effects and specific histone acetylation and DNA methylation profiles in the mouse medial prefrontal cortex

  2017cites this paper
• Emotion stimulus processing in narcolepsy with cataplexy

  2017cites this paper
• Intranasal Oxytocin and Vasopressin Modulate Divergent Brainwide Functional Substrates

  2017cites this paper
• MAM-E17 rat model impairments on a novel continuous performance task: effects of potential cognitive enhancing drugs

  2017cites this paper
• Brainwide mapping of endogenous serotonergic transmission via chemogenetic-fMRI

  2017cites this paper
• Mapping the Connectional Architecture of the Rodent Brain with fMRI

  2017cites this paper
• Histamine H3 Receptor Antagonist Prevents Memory Deficits and Synaptic Plasticity Disruption Following Isoflurane Exposure

  2017cites this paper
• Cognitive enhancers versus addictive psychostimulants: The good and bad side of dopamine on prefrontal cortical circuits.

  2016cites this paper
• Quand le cerveau succombe aux addictions: Facteurs de vulnérabilité, implication des circuits cortico-striataux et développement d’une technique de neuromodulation pour favoriser le sevrage

  2016cites this paper
• Impact of Astroglial Connexins on Modafinil Pharmacological Properties.

  2016cites this paper
• Table of Contents Belief Behind the Scars : The Role of Entity Beliefs About Emotion in Non-Suicidal Self-Injury 4

  2015cites this paper
• Limbic thalamus and state-dependent behavior: The paraventricular nucleus of the thalamic midline as a node in circadian timing and sleep/wake-regulatory networks.

  2015cites this paper
• Prenatal Exposure to Methylphenidate Affects the Dopamine System and the Reactivity to Natural Reward in Adulthood in Rats

  2015cites this paper
• Pharmacological imaging as a tool to visualise dopaminergic neurotoxicity.

  2014cites this paper
• Modafinil improves methamphetamine-induced object recognition deficits and restores prefrontal cortex ERK signaling in mice.

  2014cites this paper
• Distributed BOLD and CBV-weighted resting-state networks in the mouse brain

  2014cites this paper
• Modafinil augments oscillatory power in middle frequencies during rule selection.

  2014cites this paper
• Duration of activity and mode of action of modafinil: Studies on sleep and wakefulness in humans

  2014cites this paper
• Gabapentin‐induced pharmacodynamic effects in the spinal nerve ligation model of neuropathic pain

  2014cites this paper
• Differential Effects of Environment-Induced Changes in Body Temperature on Modafinil’s Actions Against Methamphetamine-Induced Striatal Toxicity in Mice

  2014cites this paper
• The psychostimulant modafinil enhances gap junctional communication in cortical astrocytes.

  2013cites this paper
• Modafinil effects on cognition and emotion in schizophrenia and its neurochemical modulation in the brain.

  2013influential citation
• Reduced limbic metabolism and fronto-cortical volume in rats vulnerable to alcohol addiction

  2013cites this paper
• Roles of Adrenergic α1 and Dopamine D1 and D2 Receptors in the Mediation of the Desynchronization Effects of Modafinil in a Mouse EEG Synchronization Model

  2013cites this paper
• Cognitive impairment : quantification and possibilities for pharmacological treatment

  2013cites this paper
• Differential Effect of Orexin-1 and CRF-1 Antagonism on Stress Circuits: a fMRI Study in the Rat with the Pharmacological Stressor Yohimbine

  2013cites this paper
• Central functional response to the novel peptide cannabinoid, hemopressin.

  2013cites this paper
• Addiction-related gene regulation: risks of exposure to cognitive enhancers vs. other psychostimulants.

  2013cites this paper
• The neurobiology of modafinil as an enhancer of cognitive performance and a potential treatment for substance use disorders

  2013cites this paper