Isolation of glia from Alzheimer's mice reveals inflammation and dysfunction.

No abstract is available for this paper.

• Publication year

  2014

• Venue

  Neurobiology of Aging

• Publication date

  2014-12-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.neurobiolaging.2014.06.004PMID 25002035
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Acute isolation and transcriptome characterization of cortical astrocytes and microglia from young and aged mice.

  2014influential reference
• Involvement of Aquaporin 4 in Astrocyte Function and Neuropsychiatric Disorders

  2014influential reference
• Microglia: Scapegoat, Saboteur, or Something Else?

  2013cited by this paper
• IFN-γ Production by Amyloid β–Specific Th1 Cells Promotes Microglial Activation and Increases Plaque Burden in a Mouse Model of Alzheimer’s Disease

  2013cited by this paper
• Chronic exposure of astrocytes to interferon-α reveals molecular changes related to Aicardi-Goutieres syndrome.

  2013cited by this paper
• Animal systems in the development of treatments for Alzheimer's disease: challenges, methods, and implications.

  2013cited by this paper
• Microglia, seen from the CX3CR1 angle

  2013cited by this paper
• Integrated systems approach identifies genetic nodes and networks in late-onset Alzheimer's disease.

  2013cited by this paper
• A star is born: new insights into the mechanism of astrogenesis

  2013cited by this paper
• Cortical beta amyloid protein triggers an immune response, but no synaptic changes in the APPswe/PS1dE9 Alzheimer's disease mouse model.

  2013cited by this paper
• Reactive glia show increased immunoproteasome activity in Alzheimer's disease.

  2013influential reference
• Reactive astrocytes give neurons less support: implications for Alzheimer's disease.

  2012cited by this paper
• Mice, men and the relatives: cross-species studies underpin innate immunity

  2012cited by this paper
• Microglia in Alzheimer Brain: A Neuropathological Perspective

  2012cited by this paper
• Low-density lipoprotein receptor overexpression enhances the rate of brain-to-blood Aβ clearance in a mouse model of β-amyloidosis

  2012cited by this paper
• Genomic Analysis of Reactive Astrogliosis

  2012influential reference
• Differential cell proliferation in the cortex of the appsweps1de9 alzheimer's disease mouse model

  2012influential reference
• Innate immunity in the central nervous system.

  2012cited by this paper
• Reversal of autophagy dysfunction in the TgCRND8 mouse model of Alzheimer's disease ameliorates amyloid pathologies and memory deficits.

  2011cited by this paper
• P3‐157: A novel microRNA interaction relevant to alzheimer's disease pathogenesis and drug target discovery: miR‐346 induces expression of amyloid precursor protein

  2011cited by this paper
• Disturbed Neurotransmitter Transporter Expression in Alzheimer’s Disease Brain

  2011cited by this paper
• Microglial cystatin F expression is a sensitive indicator for ongoing demyelination with concurrent remyelination

  2011cited by this paper
• Physiology of microglia.

  2011cited by this paper
• Biochemical and behavioral characterization of the double transgenic mouse model (APPswe/PS1dE9) of Alzheimer’s disease

  2011cited by this paper
• Intensity-based analysis of dual-color gene expression data as an alternative to ratio-based analysis to enhance reproducibility

  2010influential reference
• Microglia in neurodegenerative disease

  2010cited by this paper
• Divergence of human and mouse brain transcriptome highlights Alzheimer disease pathways

  2010influential reference
• Concerted changes in transcripts in the prefrontal cortex precede neuropathology in Alzheimer's disease.

  2010influential reference
• Jagged1 regulates the activation of astrocytes via modulation of NFκB and JAK/STAT/SOCS pathways

  2009cited by this paper
• Committed neuronal precursors confer astrocytic potential on residual neural precursor cells.

  2009cited by this paper
• Molecular dissection of reactive astrogliosis and glial scar formation.

  2009cited by this paper
• A top-NOTCH way to make astrocytes.

  2009cited by this paper
• Cognitive Decline in Alzheimer's Disease Is Associated with Selective Changes in Calcineurin/NFAT Signaling

  2009cited by this paper
• Astrocytes: biology and pathology

  2009cited by this paper
• ApoE promotes the proteolytic degradation of Abeta.

  2008cited by this paper
• The astrocyte odyssey.

  2008cited by this paper
• Microglial Dysfunction and Defective β-Amyloid Clearance Pathways in Aging Alzheimer's Disease Mice

  2008cited by this paper
• Cystatin F is a cathepsin C-directed protease inhibitor regulated by proteolysis

  2008cited by this paper
• WGCNA: an R package for weighted correlation network analysis

  2008cited by this paper
• Glutamate-glutamine cycling in Alzheimer's disease.

  2007cited by this paper
• Notch regulates cell fate and dendrite morphology of newborn neurons in the postnatal dentate gyrus

  2007cited by this paper
• Astrocyte dysfunction in neurological disorders: a molecular perspective

  2006cited by this paper
• Factor correction as a tool to eliminate between-session variation in replicate experiments: application to molecular biology and retrovirology

  2006cited by this paper
• Resting Microglial Cells Are Highly Dynamic Surveillants of Brain Parenchyma in Vivo

  2005cited by this paper
• Astrocytes, from brain glue to communication elements: the revolution continues

  2005cited by this paper
• Dynamic Complexity of the Microglial Activation Response in Transgenic Models of Amyloid Deposition: Implications for Alzheimer Therapeutics

  2005cited by this paper
• Neuropathological stageing of Alzheimer-related changes

  2004cited by this paper
• APP processing and amyloid deposition in mice haplo-insufficient for presenilin 1.

  2004cited by this paper
• A comparison of normalization methods for high density oligonucleotide array data based on variance and bias

  2003cited by this paper
• Genesis: cluster analysis of microarray data

  2002cited by this paper
• Alzheimer's disease: genes, proteins, and therapy.

  2001cited by this paper
• Sequence of Aβ‐Protein Deposition in the Human Medial Temporal Lobe

  2000cited by this paper
• Sequence of Abeta-protein deposition in the human medial temporal lobe.

  2000cited by this paper
• Astrocytes regulate microglial phagocytosis of senile plaque cores of Alzheimer's disease.

  1998cited by this paper
• Relationship of microglia and astrocytes to amyloid deposits of Alzheimer disease.

  1989cited by this paper
• Patterns of gliosis in alzheimer's disease and aging cerebrum

  1989cited by this paper

• Ozone and PM2.5 co-exposure induced neurodegenerative alterations in mice: Implication of mitochondrial dysfunction in glial cells.

  2025cites this paper
• Potential beneficial effects of PD-1/PD-L1 blockade in Alzheimer’s disease: A systematic review and meta-analysis of preclinical and clinical studies

  2025cites this paper
• The role of microglia in the prion-like transmission of protein aggregates in neurodegeneration

  2025cites this paper
• Relationship between Alzheimer's Disease and Type 2 Diabetes: Critical Review On Cellular and Molecular Common Pathogenic Mechanisms.

  2025cites this paper
• TREM2 deficiency aggravates neuroinflammatory response and cognitive impairment via disease-associated microglia in Parkinson's disease models.

  2025cites this paper
• Extracellular Vesicles and Purinergic Signaling in Alzheimer’s Disease—Joining Forces for Novel Therapeutic Approach

  2025cites this paper
• regionalpcs improve discovery of DNA methylation associations with complex traits

  2025cites this paper
• Do microglia metabolize fructose in Alzheimer’s disease?

  2025cites this paper
• Mechanisms of ubiquitin-independent proteasomal degradation and their roles in age-related neurodegenerative disease

  2025cites this paper
• The Role of Glial Fibrillary Acidic Protein in the Neuropathology of Alzheimer’s Disease and Its Potential as a Blood Biomarker for Early Diagnosis and Progression

  2025cites this paper
• Mechanistic Role of Astrocytic Rac1 Protein in Alzheimer's Disease.

  2025cites this paper
• The uptake of β-amyloid by various brain cells exhibits heterogeneity and correlates with the CD14 expression.

  2025cites this paper
• STING–IFN–CH25H lipid axis links innate immune activation to tau pathology

  2025cites this paper
• Divergent CNS–Peripheral Signaling Reflects Astrocyte Dysfunction and Contributes to Insulin Resistance in Early Aβ Pathology

  2025cites this paper
• Stem cells therapy in neurodegenerative and neuroimmune diseases: current status of treatments and future prospects.

  2025cites this paper
• Co-regulation of microglial subgroups in Alzheimer’s amyloid pathology: Implications for diagnosis and drug development

  2025cites this paper
• New insight into the role of altered brain cholesterol metabolism in the pathogenesis of AD: a unifying cholesterol hypothesis and new therapeutic approach for AD.

  2025cites this paper
• Amyloid-β induces lipid droplet-mediated microglial dysfunction via the enzyme DGAT2 in Alzheimer's disease.

  2025cites this paper
• Inactivation of the PHD3-FOXO3 axis blunts the type I interferon response in microglia and ameliorates Alzheimer’s disease progression

  2025cites this paper
• Design, Current States, and Challenges of Nanomaterials in Anti-Neuroinflammation: A Perspective on Alzheimer's Disease.

  2025cites this paper
• pTDP-43 levels correlate with cell type–specific molecular alterations in the prefrontal cortex of C9orf72 ALS/FTD patients

  2025cites this paper
• Targeting Inflammation in Alzheimer’s Disease: Insights Into Pathophysiology and Therapeutic Avenues-A Comprehensive Review

  2025cites this paper
• Region-specific and age-related differences in astrocytes in the human brain.

  2024cites this paper
• A drug cocktail of rapamycin, acarbose, and phenylbutyrate enhances resilience to features of early-stage Alzheimer’s disease in aging mice

  2024cites this paper
• The multifaceted role of quaking protein in neuropsychiatric disorders and tumor progression

  2024cites this paper
• PRDM16-DT: A Brain and Astrocyte-Specific lncRNA Implicated in Alzheimer’s Disease

  2024cites this paper
• Alzheimer’s Disease, Obesity, and Type 2 Diabetes: Focus on Common Neuroglial Dysfunctions (Critical Review and New Data on Human Brain and Models)

  2024cites this paper
• Impact of aquaporin-4 and CD11c + microglia in the development of ependymal cells in the aqueduct: inferences to hydrocephalus

  2024cites this paper
• Distinct origin and region-dependent contribution of stromal fibroblasts to fibrosis following traumatic injury in mice

  2024cites this paper
• snCED-seq: high-fidelity cryogenic enzymatic dissociation of nuclei for single-nucleus RNA-seq of FFPE tissues

  2024cites this paper
• PRDM16-DT is a novel lncRNA that regulates astrocyte function in Alzheimer’s disease

  2024cites this paper
• Therapeutic potential of exercise-hormone irisin in Alzheimer’s disease

  2024cites this paper
• regionalpcs: improved discovery of DNA methylation associations with complex traits

  2024cites this paper
• Alternating hemiplegia of childhood associated mutations in Atp1a3 reveal diverse neurological alterations in mice

  2024influential citation
• Astrocyte transcriptomic changes along the spatiotemporal progression of Alzheimer’s disease

  2024cites this paper
• Microglia mitochondrial complex I deficiency during development induces glial dysfunction and early lethality

  2024cites this paper
• Microglial modulation as a therapeutic strategy in Alzheimer's disease: Focus on microglial preconditioning approaches

  2024cites this paper
• Hippocampal astrocytes induce sex-dimorphic effects on memory

  2024cites this paper
• A lifetime perspective on risk factors for cognitive decline with a special focus on early events

  2024cites this paper
• The PHD3-FOXO3 axis modulates the interferon type I response in microglia aggravating Alzheimer’s disease progression

  2024cites this paper
• Absence of Aquaporin-4 (AQP4) Prolongs the Presence of a CD11c+ Microglial Population during Postnatal Corpus Callosum Development

  2024cites this paper
• Genetic deletion of astrocytic calcineurin B1 prevents cognitive impairment and neuropathology development in acute and chronic mouse models of Alzheimer's disease

  2024cites this paper
• Alzheimer’s disease risk allele of PICALM causes detrimental lipid droplets in microglia

  2024cites this paper
• Histone deacetylase inhibition mitigates cognitive deficits and astrocyte dysfunction induced by amyloid‐β (Aβ) oligomers

  2024cites this paper
• Astrocytes in Amyloid Generation and Alcohol Metabolism: Implications of Alcohol Use in Neurological Disorder(s)

  2024cites this paper
• Chromosome X-wide association study in case control studies of pathologically confirmed Alzheimer’s disease in a European population

  2024cites this paper
• Pharmaceutical-mediated neuroimmune modulation in psychiatric/psychological adverse events.

  2024cites this paper
• The Role of Glia in Wilson’s Disease: Clinical, Neuroimaging, Neuropathological and Molecular Perspectives

  2024cites this paper
• High-Resolution Characterization of Human Brain Cortex with High-Fidelity Spatial Transcriptomic Slides (HiFi-Slides)

  2023cites this paper
• Novel insights into brain lipid metabolism in Alzheimer's disease: Oligodendrocytes and white matter abnormalities

  2023cites this paper
• Amyloid β Induces Lipid Droplet-Mediated Microglial Dysfunction in Alzheimer’s Disease

  2023cites this paper
• RT-DOb, a switch gene for the gene pair {Csf1r, Milr1}, can influence the onset of Alzheimer’s disease by regulating communication between mast cell and microglia

  2023cites this paper
• Microglia in Alzheimer’s disease: pathogenesis, mechanisms, and therapeutic potentials

  2023cites this paper
• Reduced levels of NGF shift astrocytes toward a neurotoxic phenotype

  2023cites this paper
• Reactive astrogliosis in the era of single-cell transcriptomics

  2023cites this paper
• Radial stem astrocytes (aka neural stem cells): Identity, development, physio‐pathology, and therapeutic potential

  2023cites this paper
• Cellular cholesterol loss by DHCR24 knockdown leads to Aβ production by changing APP intracellular localization

  2023cites this paper
• Experimental hepatic encephalopathy causes early but sustained glial transcriptional changes

  2023cites this paper
• Neuronal APOE4 removal protects against tau-mediated gliosis, neurodegeneration and myelin deficits

  2023cites this paper
• Beyond the amyloid cascade: An update of Alzheimer's disease pathophysiology.

  2023cites this paper
• Human hippocampal astrocytes: Computational dissection of their transcriptome, sexual differences and exosomes across ageing and mild‐cognitive impairment

  2023cites this paper
• Molecular and metabolic heterogeneity of astrocytes and microglia.

  2023cites this paper
• Single nucleus multiome analysis of the prefrontal cortex from C9orf72 ALS/FTD patients illuminates pathways affected during disease progression

  2023cites this paper
• pTDP-43 levels correlate with cell type specific molecular alterations in the prefrontal cortex of C9orf72 ALS/FTD patients

  2023cites this paper
• APOE4-promoted gliosis and degeneration in tauopathy are ameliorated by pharmacological inhibition of HMGB1 release

  2023cites this paper
• Free complement and complement containing extracellular vesicles as potential biomarkers for neuroinflammatory and neurodegenerative disorders

  2023cites this paper
• Sex and APOE Genotype Alter the Basal and Induced Inflammatory States of Primary Astrocytes from Humanized Targeted Replacement Mice

  2023cites this paper
• Correction: Retinal cholesterol metabolism is perturbated in response to experimental glaucoma in the rat

  2023cites this paper
• Microglia and Astrocytes in Amyotrophic Lateral Sclerosis: Disease-Associated States, Pathological Roles, and Therapeutic Potential

  2023cites this paper
• Transcriptomics Meta-Analysis Reveals Phagosome and Innate Immune System Dysfunction as Potential Mechanisms in the Cortex of Alzheimer’s Disease Mouse Strains

  2023cites this paper
• Optogenetics in Alzheimer’s Disease: Focus on Astrocytes

  2023cites this paper
• Identification of methylation-regulated genes modulating microglial phagocytosis in hyperhomocysteinemia-exacerbated Alzheimer’s disease

  2023cites this paper
• Lysosomal acidification dysfunction in microglia: an emerging pathogenic mechanism of neuroinflammation and neurodegeneration

  2023cites this paper
• Rescue of Alzheimer’s disease phenotype in a mouse model by transplantation of wild-type hematopoietic stem and progenitor cells

  2023cites this paper
• Region-Specific Homeostatic Identity of Astrocytes Is Essential for Defining Their Response to Pathological Insults

  2023cites this paper
• Sex-dependent factors of alcohol and neuroimmune mechanisms

  2023cites this paper
• Chemogenetic manipulation of astrocyte activity at the synapse— a gateway to manage brain disease

  2023cites this paper
• Region-specific homeostatic identity of astrocytes is essential for defining their reactive phenotypes following pathological insults

  2023cites this paper
• Metallothionein I/II Expression and Metal Ion Levels in Correlation with Amyloid Beta Deposits in the Aged Feline Brain

  2023cites this paper
• Neuroinflammation: The Abused Concept

  2023cites this paper
• Human Alzheimer’s disease reactive astrocytes exhibit a loss of homeostastic gene expression

  2023cites this paper
• Quantifying Glial-Glial Interactions In Drosophila Using Automated Image Analysis

  2023cites this paper
• Proteomics for comprehensive characterization of extracellular vesicles in neurodegenerative disease.

  2022cites this paper
• Therapeutic Potential of Astrocyte Transplantation

  2022cites this paper
• Excessive local host-graft connectivity in aging and amyloid-loaded brain

  2022cites this paper
• The Role of Astrocytes in Synapse Loss in Alzheimer's Disease: A Systematic Review

  2022cites this paper
• A Dichotomous Role for FABP7 in Sleep and Alzheimer’s Disease Pathogenesis: A Hypothesis

  2022cites this paper
• Overexpression of UCP4 in astrocytic mitochondria prevents multilevel dysfunctions in a mouse model of Alzheimer’s disease

  2022cites this paper
• APOE modulates microglial immunometabolism in response to age, amyloid pathology, and inflammatory challenge

  2022cites this paper
• TGF-β as a Key Modulator of Astrocyte Reactivity: Disease Relevance and Therapeutic Implications

  2022cites this paper
• DHCR24 Knockdown Induces Tau Hyperphosphorylation at Thr181, Ser199, Ser262, and Ser396 Sites via Activation of the Lipid Raft-Dependent Ras/MEK/ERK Signaling Pathway in C8D1A Astrocytes

  2022cites this paper
• Intracerebral Hemorrhage: The Effects of Aging on Brain Injury

  2022cites this paper
• Applications of single‐cell multi‐omics sequencing in deep understanding of brain diseases

  2022cites this paper
• Alzheimer's disease is an inherent, natural part of human brain aging: an integrated perspective.

  2022cites this paper
• Retinal cholesterol metabolism is perturbated in response to experimental glaucoma in the rat

  2022cites this paper
• Calcium signaling in individual APP/PS1 mouse dentate gyrus astrocytes increases ex vivo with Aβ pathology and age without affecting astrocyte network activity

  2022cites this paper
• Impact of APOE ε3 and ε4 genotypes on plasma proteome signatures in Alzheimer’s disease

  2022cites this paper
• Good, bad, and neglectful: Astrocyte changes in neurodegenerative disease

  2022cites this paper
• Profiling Microglia in a Mouse Model of Machado–Joseph Disease

  2022cites this paper
• The role of DHCR24 in the pathogenesis of AD: re-cognition of the relationship between cholesterol and AD pathogenesis

  2022cites this paper