Experimental design for the optimization of lipid nanoparticles.

No abstract is available for this paper.

• Publication year

  2009

• Venue

  Journal of Pharmacy and Science

• Publication date

  2009-05-01

• Fields of study

  Medicine, Materials Science, Chemistry, Engineering

• Identifiers
  DOI 10.1002/jps.21549PMID 18781636
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Preparation and characterization of stearic acid nanostructured lipid carriers by solvent diffusion method in an aqueous system.

  2005cited by this paper
• Solvent injection as a new approach for manufacturing lipid nanoparticles--evaluation of the method and process parameters.

  2003cited by this paper
• Crystal Growth Technology

  2003cited by this paper
• Preparation of solid lipid nanoparticles with clobetasol propionate by a novel solvent diffusion method in aqueous system and physicochemical characterization.

  2002cited by this paper
• Solid lipid nanoparticles: production, characterization and applications.

  2001cited by this paper
• Solid lipid nanoparticles (SLN) for controlled drug delivery - a review of the state of the art.

  2000cited by this paper
• Pharmaceutical Experimental Design

  2000cited by this paper
• Effect of light and temperature on zeta potential and physical stability in solid lipid nanoparticle (SLN) dispersions

  1998cited by this paper
• Peptide-loaded solid lipid nanoparticles (SLN): Influence of production parameters

  1997cited by this paper
• Application of central composite designs to the preparation of polycaprolactone nanoparticles by solvent displacement.

  1996cited by this paper
• Investigations on solid lipid nanoparticles prepared by precipitation in o/w emulsions

  1996cited by this paper
• Preparation of Poly(D,L-Lactide/Glycolide) Nanoparticles of Controlled Particle Size Distribution: Application of Experimental Designs

  1992cited by this paper
• Statistics for experimenters : an introduction to design, data analysis, and model building

  1979cited by this paper

• NLCs based in situ gelling systems for ocular delivery of drug cargo against bacterial conjunctivitis

  2026cites this paper
• Cotton Fabric Coated with Ag/ZnO/SiO2 for Methyl Orange Degradation and Bacterial Suppression in Water Treatment

  2025cites this paper
• QbD assisted formulation, optimization and characterization of psoralen phytosome prepared through thin film hydration method

  2025cites this paper
• Green-synthesized silver–copper nanocomposites from Sargassum latifolium: antibacterial, anticancer, and in silico pharmacokinetic evaluation

  2025influential citation
• Ball-milling-assisted extraction and niosomal delivery of lycopene from Gac fruit for enhanced physicochemical properties, drug delivery, anti-inflammatory, and collagen stimulation

  2025cites this paper
• Design, development, and preclinical evaluation of pirfenidone-loaded nanostructured lipid carriers for pulmonary delivery

  2025cites this paper
• Nanoemulsion Technology in Oral Drug Delivery: A Path to Enhanced Solubility and Bioavailability.

  2025cites this paper
• “Design, Evaluation and Optimization of Novel Topical Drug Delivery System of Antifungal Agent”

  2025cites this paper
• Preparing a Phytosome for Promoting Delivery Efficiency and Biological Activities of Methyl Jasmonate-Treated Dendropanax morbifera Adventitious Root Extract (DMARE)

  2024cites this paper
• High payload dexamethasone palmitate-loaded solid lipid nanoparticles for enhanced anti-inflammatory effects in acute skin inflammation model

  2024influential citation
• Enhanced efficacy of β-carotene loaded solid lipid nanoparticles optimized and developed via central composite design on breast cancer cell lines

  2024cites this paper
• Back to Nature: Development and Optimization of Bioinspired Nanocarriers for Potential Breast Cancer Treatment

  2024cites this paper
• Optimization of Prebiotic Exopolysaccharide production from Probiotic Lactobacillus brevis using Taguchi Experimental Design

  2024cites this paper
• High drug loading solid lipid nanoparticles, nanostructured lipid carriers and nanoemulsions for the dual drug delivery of the HIV drugs darunavir and ritonavir

  2023cites this paper
• Potential of nanostructured lipid carriers in oral delivery of the poorly soluble drugs

  2023cites this paper
• Optimization of Enterocin Production from Probiotic Enterococcus faecium Using Taguchi Experimental Design

  2023cites this paper
• Etoposide‐Entrapped Progesterone‐Cationic Lipid Nanoaggregates as Selective Therapeutics against Etoposide‐Resistant Colorectal Cancer Cells

  2023cites this paper
• Digestion of lipid excipients and lipid-based nanocarriers by pancreatic lipase and pancreatin.

  2022cites this paper
• In Vitro Evaluation of Curcumin- and Quercetin-Loaded Nanoemulsions for Intranasal Administration: Effect of Surface Charge and Viscosity

  2022cites this paper
• Horseshoe lamination mixer (HLM) sets new standards in the production of monodisperse lipid nanoparticles.

  2022cites this paper
• Silymarin loaded solid lipid nanoparticles for oral delivery: Development, characterization and cytotoxic effect on breast cancer cells

  2022cites this paper
• Solid Lipid Nanoparticles

  2022cites this paper
• Goodbye fouling: a unique coaxial lamination mixer (CLM) enabled by two-photon polymerization for the stable production of monodisperse drug carrier nanoparticles.

  2021cites this paper
• Formulation, optimization, and in vitro characterization of omega-3-rich binary lipid carriers for curcumin delivery: in vitro evaluation of sustained release and its potential antioxidant behavior

  2021cites this paper
• Preparation, physicochemical and biopharmaceutical characterization of oxcarbazepine-loaded nanostructured lipid carriers as potential antiepileptic devices

  2021cites this paper
• Optimizing the Size of Drug-Loaded Nanoparticles Using Design of Experiments

  2021cites this paper
• Quality-by-Design Approach Development, Characterization, and In Vitro Release Mechanism Elucidation of Nanostructured Lipid Carriers for Quetiapine Fumarate Oral Delivery

  2021cites this paper
• Taguchi design Analysis for optimization of probiotics cholesterol assimilation

  2021cites this paper
• Development and Evaluation of 1′-Acetoxychavicol Acetate (ACA)-Loaded Nanostructured Lipid Carriers for Prostate Cancer Therapy

  2021cites this paper
• Optimizing the Design of Blood–Brain Barrier-Penetrating Polymer-Lipid-Hybrid Nanoparticles for Delivering Anticancer Drugs to Glioblastoma

  2021cites this paper
• Preparation of 9Z-β-Carotene and 9Z-β-Carotene High-Loaded Nanostructured Lipid Carriers: Characterization and Storage Stability.

  2020cites this paper
• Assessment of the antidiabetic potentiality of glyburide loaded glyceryl monostearate solid lipid nanoparticles

  2020cites this paper
• Development of Pomegranate Extract-Loaded Solid Lipid Nanoparticles: Quality by Design Approach to Screen the Variables Affecting the Quality Attributes and Characterization

  2020cites this paper
• Nanostructured lipid carriers accumulate in atherosclerotic plaques of ApoE-/- mice.

  2020cites this paper
• Nanostructured lipid carriers-mediated brain delivery of carbamazepine for improved in vivo anticonvulsant and anxiolytic activity.

  2020cites this paper
• Co-encapsulation of Docetaxel and Thymoquinone in mPEG-DSPE-Vitamin E TPGS-Lipid nanocapsules for breast cancer therapy: Formulation Optimization and Implications on cellular and in vivo toxicity.

  2020cites this paper
• Cordyceps militaris Fungus Extracts-Mediated Nanoemulsion for Improvement Antioxidant, Antimicrobial, and Anti-Inflammatory Activities

  2020cites this paper
• ArtinM Grafted Phospholipid Nanoparticles for Enhancing Antibiotic Cellular Uptake Against Intracellular Infection

  2020cites this paper
• Solid Lipid Nanoparticle: A Novel Drug Delivery in Pharmaceutical Science

  2020cites this paper
• Optimization of nanostructured lipid carriers: understanding the types, designs, and parameters in the process of formulations

  2020cites this paper
• Preparation of Solid Lipid Nanoparticles and Nanostructured Lipid Carriers for Drug Delivery and the Effects of Preparation Parameters of Solvent Injection Method

  2020influential citation
• Optimization of the Synthetic Parameters of Lipid Polymer Hybrid Nanoparticles Dual Loaded with Darunavir and Ritonavir for the Treatment of HIV.

  2020cites this paper
• Factorial Experimental Design for Optimization of Zinc Oxide Nanoparticles Production

  2020cites this paper
• Lattice structures and phase behavior of amphiphilic monoglycerol monolayers.

  2019cites this paper
• Fabrication of long-acting insulin formulation based on poly (3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) nanoparticles: preparation, optimization, characterization, and in vitro evaluation

  2019cites this paper
• In vitro characterization and in vivo performance of mefenamic acid-sodium diethyldithiocarbamate based liposomes

  2019cites this paper
• Resveratrol loaded functionalized nanostructured lipid carriers for breast cancer targeting: Systematic development, characterization and pharmacokinetic evaluation.

  2019cites this paper
• Simvastatin‐loaded solid lipid nanoparticles for enhanced anti‐hyperlipidemic activity in hyperlipidemia animal model

  2019cites this paper
• Formulation design, characterization, and in vitro and in vivo evaluation of nanostructured lipid carriers containing a bile salt for oral delivery of gypenosides

  2019cites this paper
• Retinoic acid-loaded solid lipid nanoparticles surrounded by chitosan film support diabetic wound healing in in vivo study.

  2019cites this paper
• Kinetic Study of ß-Carotene Degradation in Nanostructured Lipid Carriers

  2019cites this paper
• Application of quality by design principles in the development and evaluation of semisolid drug carrier systems for the transdermal delivery of lidocaine

  2018cites this paper
• A CENTRAL COMPOSITE DESIGN APPROACH FOR QUANTIFYING LIPID NANOPARTICLES USING UV-TRANSMITTANCE

  2018influential citation
• Astaxanthin-Loaded Nanostructured Lipid Carriers for Preservation of Antioxidant Activity

  2018cites this paper
• Armamentarium of nanoscaled lipid drug delivery systems customized for oral administration: In silico docking patronage, absorption phenomenon, preclinical status, clinical status and future prospects.

  2018cites this paper
• Mesoscopic characterization of amphiphilic monoglycerol monolayers.

  2018cites this paper
• Preparation and investigation of indirubin‐loaded SLN nanoparticles and their anti‐cancer effects on human glioblastoma U87MG cells

  2018cites this paper
• Study on the In-vitro Release Kinetics of Olmesartan-loaded Optimized Solid Lipid Nanoparticles

  2018cites this paper
• Lipid-drug conjugates: a potential nanocarrier system for oral drug delivery applications

  2018cites this paper
• Fatty acid conjugated pyridinium cationic amphiphiles as antibacterial agents and self-assembling nano carriers.

  2018cites this paper
• Optimization of mixed surfactants-based β-carotene nanoemulsions using response surface methodology: An ultrasonic homogenization approach.

  2018cites this paper
• Rosuvastatin calcium-loaded Solid Lipid Nanoparticles (SLN) using design of experiment approach for oral delivery

  2017cites this paper
• PAST AND PRESENT SCENARIO OF SOLID LIPID NANOPARTICLES:A LITERATURE REVIEW

  2017cites this paper
• Loteprednol Etabonate Nanoparticles: Optimization via Box-Behnken Design Response Surface Methodology and Physicochemical Characterization.

  2017cites this paper
• Lipid Based nanoformulation of lycopene improves oral delivery: formulation optimization, ex vivo assessment and its efficacy against breast cancer

  2017influential citation
• Formulation development and characterization of curcumin loaded solid lipid nanoparticles for improved aqueous solubility and bioavailability

  2017cites this paper
• Physicochemical characterization of chitosan-hyaluronan-coated solid lipid nanoparticles for the targeted delivery of paclitaxel: a proof-of-concept study in breast cancer cells.

  2017cites this paper
• Preparation, characterization, and optimization of altretamine-loaded solid lipid nanoparticles using Box-Behnken design and response surface methodology

  2016cites this paper
• Potential advantages of a novel chitosan-N-acetylcysteine surface modified nanostructured lipid carrier on the performance of ophthalmic delivery of curcumin

  2016cites this paper
• Nanostructured Lipid Carriers: A Novel Platform for Chemotherapeutics.

  2016cites this paper
• Stability study of sodium colistimethate-loaded lipid nanoparticles

  2016influential citation
• Optimization of ciprofloxacin complex loaded PLGA nanoparticles for pulmonary treatment of cystic fibrosis infections: Design of experiments approach.

  2016cites this paper
• Application of Response Surface Methodology for the Technological Improvement of Solid Lipid Nanoparticles.

  2016cites this paper
• Pulmonary delivery of antibiotic-loaded lipid nanoparticles for the treatment of Pseudomonas aeruginosa infections associated with cystic fibrosis

  2016cites this paper
• Shea butter solid nanoparticles for curcumin encapsulation: Influence of nanoparticles size on drug loading

  2016cites this paper
• Optimization of protein loaded PLGA nanoparticle manufacturing parameters following a quality-by-design approach

  2016cites this paper
• Lipid Nanoparticle Formulations for Enhanced Antituberculosis Therapy

  2016cites this paper
• Design of chitosan-based nanoparticles functionalized with gallic acid.

  2016cites this paper
• ORAL DRUG DELIVERY OF EFAVIRENZ BY SOLID LIPID NANOPARTICLES

  2016cites this paper
• Enhanced oral bioavailability of insulin-loaded solid lipid nanoparticles: pharmacokinetic bioavailability of insulin-loaded solid lipid nanoparticles in diabetic rats

  2015influential citation
• Solid lipid nanoparticles for cancer therapy

  2015cites this paper
• Formulation of enrofloxacin SLNs and its pharmacokinetics in emu (Dromaius novaehollandiae) birds

  2015cites this paper
• Mono layer Characteristics of 1-Monostearoyl-rac-glycerol at the Air-Water Interface

  2015cites this paper
• Experimental Design for the Optimization of Nanoscale Solid Lipid Particles Containing Rasagiline Mesylate

  2015cites this paper
• Solid lipid nanoparticles for cancer therapy

  2015cites this paper
• Effect of Techniques in Preparing VCO Nanoparticles

  2015cites this paper
• Reinvestigating nanoprecipitation via Box–Behnken design: a systematic approach

  2015cites this paper
• Formulation, characterization and evaluation of paclitaxel loaded solid lipid nanoparticles prepared by temperature modulated solidification technique

  2015cites this paper
• FORMULATION AND EVALUATION OF SILIBININ LOADED SOLID LIPID NANOPARTICLES FOR PERORAL USE TARGETING LOWER PART OF GASTROINTESTINAL TRACT

  2014cites this paper
• Improved brain delivery of vincristine using dextran sulfate complex solid lipid nanoparticles: optimization and in vivo evaluation.

  2014cites this paper
• Nano-proniosomes enhancing the transdermal delivery of mefenamic acid

  2014cites this paper
• Characterization and Evaluation of 5-Fluorouracil-Loaded Solid Lipid Nanoparticles Prepared via a Temperature-Modulated Solidification Technique

  2014cites this paper
• Physico-chemical characterisation, cytotoxic activity, and biocompatibility studies of tamoxifen-loaded solid lipid nanoparticles prepared via a temperature-modulated solidification method

  2014cites this paper
• Quantitative, Qualitative and In Vitro Evaluation of Solid Lipid Nanoparticles Containing 5-Fluorouracil

  2014cites this paper
• Preparation, characterization and optimization of sildenafil citrate loaded PLGA nanoparticles by statistical factorial design

  2013cites this paper
• Microemulsion extrusion technique: a new method to produce lipid nanoparticles

  2013cites this paper
• Development of Ciprofloxacin HCl-Based Solid Lipid Nanoparticles Using Ouzo Effect: An Experimental Optimization and Comparative Study

  2013cites this paper
• Optimized dispersion of ZnO nanoparticles and antimicrobial activity against foodborne pathogens and spoilage microorganisms

  2013cites this paper
• The Pharmacokinetics of Chelerythrine Solution and Chelerythrine Liposomes after Oral Administration to Rats

  2013cites this paper
• Solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs): recent advances in drug delivery

  2013influential citation