Genetic Architecture of Hsp90-Dependent Drug Resistance

ABSTRACT Hsp90 potentiates the evolution of azole resistance in the model yeast Saccharomyces cerevisiae and the opportunistic pathogen Candida albicans via calcineurin. Here, we explored effectors downstream of calcineurin regulating this Hsp90-dependent trait. Using S. cerevisiae erg3 mutants as a model, we determined that both Crz1 and Hph1 modulate azole resistance.

• Publication year

  2006

• Venue

  Eukaryotic Cell

• Publication date

  2006-10-20

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1128/EC.00274-06PMID 17056742PMCID PMC1694807
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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