Potential role of the glial water channel aquaporin-4 in epilepsy.

No abstract is available for this paper.

• Publication year

  2007

• Venue

  Neuron Glia Biology

• Publication date

  2007-11-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1017/S1740925X08000112PMID 18634561
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Aquaporin-4 independent Kir4.1 K+ channel function in brain glial cells.

  2008influential reference
• Intracerebral VEGF injection highly upregulates AQP4 mRNA and protein in the perivascular space and glia limitans externa.

  2008cited by this paper
• Vascular endothelial growth factor is up-regulated after status epilepticus and protects against seizure-induced neuronal loss in hippocampus.

  2008cited by this paper
• Selective stimulation of astrocyte calcium in situ does not affect neuronal excitatory synaptic activity.

  2007cited by this paper
• Evidence against Functional Interaction between Aquaporin-4 Water Channels and Kir4.1 Potassium Channels in Retinal Müller Cells*

  2007influential reference
• Conditional Knock-Out of Kir4.1 Leads to Glial Membrane Depolarization, Inhibition of Potassium and Glutamate Uptake, and Enhanced Short-Term Synaptic Potentiation

  2007influential reference
• Effects of agrin on the expression and distribution of the water channel protein aquaporin‐4 and volume regulation in cultured astrocytes

  2007cited by this paper
• Fever, febrile seizures and epilepsy.

  2007cited by this paper
• Angiogenesis is associated with blood-brain barrier permeability in temporal lobe epilepsy.

  2007cited by this paper
• Astrocyte control of the cerebrovasculature

  2007cited by this paper
• Effects of Potassium Concentration on Firing Patterns of Low‐Calcium Epileptiform Activity in Anesthetized Rat Hippocampus: Inducing of Persistent Spike Activity

  2006cited by this paper
• Increased seizure duration and slowed potassium kinetics in mice lacking aquaporin‐4 water channels

  2006influential reference
• Astrocyte dysfunction in neurological disorders: a molecular perspective

  2006cited by this paper
• Lack of the Kir4.1 channel subunit abolishes K+ buffering properties of astrocytes in the ventral respiratory group: impact on extracellular K+ regulation.

  2006influential reference
• Functional changes in astroglial cells in epilepsy

  2006cited by this paper
• Coexisting Muscular Dystrophies and Epilepsy in Children

  2006cited by this paper
• Assembly of a perivascular astrocyte protein scaffold at the mammalian blood–brain barrier is dependent on α‐syntrophin

  2006cited by this paper
• Effect of water deprivation on aquaporin 4 (AQP4) mRNA expression in chickens (Gallus domesticus).

  2005cited by this paper
• Astrocytes and NG2‐glia: what's in a name?

  2005cited by this paper
• Noninvasive early detection of brain edema in mice by near‐infrared light scattering

  2005cited by this paper
• K+ waves in brain cortex visualized using a long-wavelength K+-sensing fluorescent indicator

  2005influential reference
• Furosemide and mannitol suppression of epileptic activity in the human brain.

  2005cited by this paper
• Brain Inflammation in Epilepsy: Experimental and Clinical Evidence

  2005cited by this paper
• Enhanced macromolecular diffusion in brain extracellular space in mouse models of vasogenic edema measured by cortical surface photobleaching

  2005cited by this paper
• Regulation of Brain Water: Is there a Role for Aquaporins in Epilepsy?

  2005cited by this paper
• An astrocytic basis of epilepsy

  2005cited by this paper
• Loss of perivascular aquaporin 4 may underlie deficient water and K+ homeostasis in the human epileptogenic hippocampus.

  2005influential reference
• New facets of the neuropathology and molecular profile of human temporal lobe epilepsy.

  2005cited by this paper
• Astrocytes, from brain glue to communication elements: the revolution continues

  2005cited by this paper
• More than just water channels: unexpected cellular roles of aquaporins

  2005cited by this paper
• Synaptic transmission onto hippocampal glial cells with hGFAP promoter activity

  2005cited by this paper
• Sevenfold-reduced osmotic water permeability in primary astrocyte cultures from AQP-4-deficient mice, measured by a fluorescence quenching method.

  2004cited by this paper
• Seizure susceptibility to various convulsant stimuli in dystrophin-deficient mdx mice.

  2004cited by this paper
• Vascular endothelial growth factor (VEGF) in seizures: a double-edged sword.

  2004cited by this paper
• Aquaporin-4 is increased in the sclerotic hippocampus in human temporal lobe epilepsy

  2004influential reference
• INTO WATER TRANSPORT AND EDEMA IN THE ENTRAL NERVOUS SYSTEM FROM PHENOTYPE ANALYSIS OF QUAPORIN-4 NULL MICE

  2004cited by this paper
• New insights into water transport and edema in the central nervous system from phenotype analysis of aquaporin-4 null mice.

  2004cited by this paper
• Potassium buffering in the central nervous system.

  2004influential reference
• Aquaporin-4 in the central nervous system: cellular and subcellular distribution and coexpression with KIR4.1.

  2004influential reference
• Distinct types of astroglial cells in the hippocampus differ in gap junction coupling

  2004cited by this paper
• The Potassium Channel Kir4.1 Associates with the Dystrophin-Glycoprotein Complex via α-Syntrophin in Glia*

  2004influential reference
• Expression of aquaporin water channels in mouse spinal cord.

  2004cited by this paper
• The neurobiology of antiepileptic drugs

  2004cited by this paper
• In vivo expression of aquaporin‐4 by reactive microglia

  2004cited by this paper
• Increased seizure duration in mice lacking aquaporin-4 water channels.

  2004influential reference
• Glial modulation of synaptic transmission in the hippocampus

  2004cited by this paper
• Febrile seizures and mechanisms of epileptogenesis: insights from an animal model.

  2004cited by this paper
• Stimulus and Potassium-Induced Epileptiform Activity in the Human Dentate Gyrus from Patients with and without Hippocampal Sclerosis

  2004cited by this paper
• Aquaporin‐4 facilitates reabsorption of excess fluid in vasogenic brain edema

  2004cited by this paper
• The neurobiology of glia in the context of water and ion homeostasis.

  2004cited by this paper
• XPRESSION OF AQUAPORIN WATER CHANNELS IN MOUSE SPINAL ORD

  2004cited by this paper
• Increased seizure threshold in mice lacking aquaporin-4 water channels

  2004influential reference
• In Vivo Measurement of Brain Extracellular Space Diffusion by Cortical Surface Photobleaching

  2004influential reference
• Aquaporin 1 and aquaporin 4 expression in human brain after subarachnoid hemorrhage and in peritumoral tissue.

  2003cited by this paper
• An α-syntrophin-dependent pool of AQP4 in astroglial end-feet confers bidirectional water flow between blood and brain

  2003influential reference
• The molecular basis of water transport in the brain

  2003cited by this paper
• Segregated Expression of AMPA-Type Glutamate Receptors and Glutamate Transporters Defines Distinct Astrocyte Populations in the Mouse Hippocampus

  2003cited by this paper
• Delayed K+ clearance associated with aquaporin-4 mislocalization: Phenotypic defects in brains of α-syntrophin-null mice

  2003influential reference
• New roles for astrocytes (stars at last).

  2003cited by this paper
• Time course of inner ear degeneration and deafness in mice lacking the Kir4.1 potassium channel subunit.

  2003influential reference
• New insights into neuron-glia communication.

  2002cited by this paper
• Delayed onset of brain edema and mislocalization of aquaporin-4 in dystrophin-null transgenic mice

  2002influential reference
• Aquaporins in Brain: Distribution, Physiology, and Pathophysiology

  2002cited by this paper
• Optical measurement of swelling and water transport in spinal cord slices from aquaporin null mice.

  2002cited by this paper
• KCNJ10 (Kir4.1) potassium channel knockout abolishes endocochlear potential.

  2002cited by this paper
• Aquaporin-4 expression is increased in oedematous human brain tumours

  2002cited by this paper
• Glial membrane channels and receptors in epilepsy: impact for generation and spread of seizure activity.

  2002influential reference
• Mildly abnormal retinal function in transgenic mice without Müller cell aquaporin-4 water channels.

  2002cited by this paper
• Physiological importance of aquaporin water channels

  2002cited by this paper
• Ion Regulation in the Brain: Implications for Pathophysiology

  2002influential reference
• Kir4.1 Potassium Channel Subunit Is Crucial for Oligodendrocyte Development and In Vivo Myelination

  2001influential reference
• Syntrophin-dependent expression and localization of Aquaporin-4 water channel protein

  2001cited by this paper
• Aquaporin‐4 deficiency in skeletal muscle and brain of dystrophic mdx mice

  2001cited by this paper
• Impaired Hearing in Mice Lacking Aquaporin-4 Water Channels*

  2001influential reference
• A Novel Role of Vasopressin in the Brain: Modulation of Activity-Dependent Water Flux in the Neocortex

  2001cited by this paper
• Directed spatial potassium redistribution in rat neocortex

  2000cited by this paper
• Astrocytes in the hippocampus of patients with temporal lobe epilepsy display changes in potassium conductances

  2000cited by this paper
• Alterations of Glial Cell Function in Temporal Lobe Epilepsy

  2000cited by this paper
• Effects of barium on stimulus‐induced rises of [K+]o in human epileptic non‐sclerotic and sclerotic hippocampal area CA1

  2000cited by this paper
• Presence of aquaporin-4 and muscarinic receptors in astrocytes and ependymal cells in rat brain: a clue to a common function?

  2000cited by this paper
• Genetic Inactivation of an Inwardly Rectifying Potassium Channel (Kir4.1 Subunit) in Mice: Phenotypic Impact in Retina

  2000influential reference
• Aquaporin-4 deletion in mice reduces brain edema after acute water intoxication and ischemic stroke

  2000cited by this paper
• Astrocytic regulation of the recovery of extracellular potassium after seizures in vivo

  1999cited by this paper
• Anterior temporal abnormality in temporal lobe epilepsy

  1999cited by this paper
• Differential upregulation of aquaporin-4 mRNA expression in reactive astrocytes after brain injury: potential role in brain edema.

  1999cited by this paper
• Molecular neuropathology of human mesial temporal lobe epilepsy.

  1999cited by this paper
• Diffusion mapping applied to mesial temporal lobe epilepsy

  1999cited by this paper
• Direct immunogold labeling of aquaporin-4 in square arrays of astrocyte and ependymocyte plasma membranes in rat brain and spinal cord.

  1998cited by this paper
• Osmolarity, ionic flux, and changes in brain excitability.

  1998influential reference
• Generation and phenotype of a transgenic knockout mouse lacking the mercurial-insensitive water channel aquaporin-4.

  1997influential reference
• Specialized Membrane Domains for Water Transport in Glial Cells: High-Resolution Immunogold Cytochemistry of Aquaporin-4 in Rat Brain

  1997influential reference
• The Extracellular Space in the CNS: Its Regulation, Volume and Geometry in Normal and Pathological Neuronal Function

  1997cited by this paper
• Absence of orthogonal arrays in kidney, brain and muscle from transgenic knockout mice lacking water channel aquaporin-4.

  1997cited by this paper
• The Mercurial Insensitive Water Channel (AQP-4) Forms Orthogonal Arrays in Stably Transfected Chinese Hamster Ovary Cells (*)

  1996cited by this paper
• Influence of osmolality on seizure amplitude and propagation in the rat dentate gyrus.

  1996influential reference
• cDNA Cloning, Gene Organization, and Chromosomal Localization of a Human Mercurial Insensitive Water Channel

  1995cited by this paper
• Localization of MIWC and GLIP water channel homologs in neuromuscular, epithelial and glandular tissues.

  1995cited by this paper
• Hypotonic exposure enhances synaptic transmission and triggers spreading depression in rat hippocampal tissue slices.

  1995cited by this paper
• Molecular cloning of a mercurial-insensitive water channel expressed in selected water-transporting tissues.

  1994cited by this paper
• Molecular characterization of an aquaporin cDNA from brain: candidate osmoreceptor and regulator of water balance.

  1994cited by this paper

• Disrupted astrocyte-neuron signaling reshapes brain activity in epilepsy and Alzheimer's disease.

  2025cites this paper
• Aquaporine-4 inhibition attenuates Pentylentetrazole-induced behavioral seizures and cognitive impairments in kindled rats.

  2024cites this paper
• Exploring multi-omics strategies for herbal treatment of drug-resistant epilepsy: a comprehensive review

  2024cites this paper
• Spinal astrocyte dysfunction drives motor neuron loss in late-onset spinal muscular atrophy

  2023cites this paper
• Chapter 41 Epilepsy *

  2022cites this paper
• Astrocyte Glutamate Uptake and Signaling as Novel Targets for Antiepileptogenic Therapy

  2020cites this paper
• Aquaporin regulation in metabolic organs.

  2020cites this paper
• bulunan Aquaporin 4 ve Aquaporin 2 kanallarının gen ekspresyonları Gene expressions of the Aquaporin 4 and Aquaporin 2 channels in the kidney in experimental epilepsy model

  2018cites this paper
• Nuclear Receptor Regulation of Aquaglyceroporins in Metabolic Organs

  2018cites this paper
• Acetazolamide Suppresses Multi-Drug Resistance-Related Protein 1 and P-Glycoprotein Expression by Inhibiting Aquaporins Expression in a Mesial Temporal Epilepsy Rat Model

  2017cites this paper
• A research update on the potential roles of aquaporin 4 in neuroinflammation

  2016cites this paper
• Types of Epilepsy

  2016cites this paper
• Therapeutic Targets and Future Directions

  2016cites this paper
• Role of astrocytes in epilepsy.

  2015cites this paper
• NADPH oxidase activation and 4-hydroxy-2-nonenal/aquaporin-4 adducts as possible new players in oxidative neuronal damage presents in drug-resistant epilepsy.

  2015cites this paper
• Tonicity-responsive enhancer binding protein haplodeficiency attenuates seizure severity and NF-κB-mediated neuroinflammation in kainic acid-induced seizures

  2014cites this paper
• The epilepsies: complex challenges needing complex solutions.

  2013cites this paper
• Glial cells as primary therapeutic targets for epilepsy.

  2013influential citation
• Aquaporin-4 water channels and synaptic plasticity in the hippocampus.

  2013influential citation
• Neuron-astrocyte signaling and epilepsy.

  2013cites this paper
• Glial cell changes in epilepsy: overview of the clinical problem and therapeutic opportunities.

  2013cites this paper
• Decreased expression of the glial water channel aquaporin-4 in the intrahippocampal kainic acid model of epileptogenesis.

  2012cites this paper
• Altered Water Diffusivity in Mouse AQP4-/- Brain During Development Using Diffusion Tensor Imaging

  2012cites this paper
• Cellular bases of focal and generalized epilepsies.

  2012cites this paper
• Different Aquaporin-4 Expression in Glioblastoma Multiforme Patients with and without Seizures

  2012cites this paper
• Laminar-specific and developmental expression of aquaporin-4 in the mouse hippocampus.

  2011cites this paper
• Impairment of Select Forms of Spatial Memory and Neurotrophin-Dependent Synaptic Plasticity by Deletion of Glial Aquaporin-4

  2011cites this paper
• Novel mechanisms of drug delivery

  2010cites this paper
• Expression von Aquaporin 4 und Aquaporin 9 in glialen und neuronalen Zellkulturen des Mesencephalons und des Striatums der Maus

  2010cites this paper
• Acuaporinas y edema cerebral

  2009cites this paper
• Mechanism of aquaporin-4's fast and highly selective water conduction and proton exclusion.

  2009cites this paper
• Immunhistochemische Untersuchungen zur Blut-Hirn-Schranke im RG2-Gliom der Ratte

  2009cites this paper
• Cerebrovascular (Patho)Physiology in Preeclampsia/Eclampsia

  2009cites this paper
• AEG-1 expression in invasive ductal and lobular breast cancers and its relationship with prognostic parameters

  2009cites this paper
• AQP4, Aquaporin 4

  2008cites this paper
• RAIN VOLUME REGULATION: OSMOLYTES AND AQUAPORIN ERSPECTIVES

  year unknowncites this paper