Conditional Rhythmicity of Ventral Spinal Interneurons Defined by Expression of the Hb9 Homeodomain Protein

No abstract is available for this paper.

• Publication year

  2005

• Venue

  Journal of Neuroscience

• Publication date

  2005-06-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1523/JNEUROSCI.0274-05.2005PMID 15958737PMCID PMC6724883
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Localization of spinal neurons activated during locomotion using the c-fos immunohistochemical method.

  2005cited by this paper
• Locomotor-like rhythms in a genetically distinct cluster of interneurons in the mammalian spinal cord.

  2005cited by this paper
• Peripheral axotomy induces depletion of the vesicular glutamate transporter VGLUT1 in central terminals of myelinated afferent fibres in the rat spinal cord.

  2004cited by this paper
• Pax6 and Engrailed 1 Regulate Two Distinct Aspects of Renshaw Cell Development

  2004cited by this paper
• Transmission in a locomotor-related group Ib pathway from hindlimb extensor muscles in the cat

  2004cited by this paper
• Engrailed-1 Expression Marks a Primitive Class of Inhibitory Spinal Interneuron

  2004cited by this paper
• Primitive Roles for Inhibitory Interneurons in Developing Frog Spinal Cord

  2004cited by this paper
• Genetic identification of spinal interneurons that coordinate left-right locomotor activity necessary for walking movements.

  2004cited by this paper
• Low micromolar concentrations of 4-aminopyridine facilitate fictive locomotion expressed by the rat spinal cord in vitro.

  2004cited by this paper
• Differential contribution of pacemaker properties to the generation of respiratory rhythms during normoxia and hypoxia.

  2004cited by this paper
• Lumbar commissural interneurons with reticulospinal inputs in the cat: Morphology and discharge patterns during fictive locomotion

  2004cited by this paper
• Role of EphA4 and EphrinB3 in Local Neuronal Circuits That Control Walking

  2003cited by this paper
• Neuronal Basis of Crossed Actions from the Reticular Formation on Feline Hindlimb Motoneurons

  2003cited by this paper
• Functional identification of interneurons responsible for left-right coordination of hindlimbs in mammals.

  2003cited by this paper
• The expression of vesicular glutamate transporters VGLUT1 and VGLUT2 in neurochemically defined axonal populations in the rat spinal cord with emphasis on the dorsal horn

  2003cited by this paper
• Cellular localization of three vesicular glutamate transporter mRNAs and proteins in rat spinal cord and dorsal root ganglia

  2003cited by this paper
• Networks of inhibitory and excitatory commissural interneurons mediating crossed reticulospinal actions

  2003cited by this paper
• Regulation of motor neuron pool sorting by differential expression of type II cadherins.

  2002cited by this paper
• Basis of Changes in Left–Right Coordination of Rhythmic Motor Activity during Development in the Rat Spinal Cord

  2002cited by this paper
• Directed differentiation of embryonic stem cells into motor neurons.

  2002cited by this paper
• Gap junctions and motor behavior.

  2002cited by this paper
• DrosophilaHB9 Is Expressed in a Subset of Motoneurons and Interneurons, Where It Regulates Gene Expression and Axon Pathfinding

  2002influential reference
• The formation of sensorimotor circuits.

  2002cited by this paper
• Firing Properties of Identified Interneuron Populations in the Mammalian Hindlimb Central Pattern Generator

  2002cited by this paper
• Drosophila homeodomain protein dHb9 directs neuronal fate via crossrepressive and cell-nonautonomous mechanisms.

  2002cited by this paper
• Control of interneuron fate in the developing spinal cord by the progenitor homeodomain protein Dbx1.

  2001cited by this paper
• Spinal cholinergic neurons activated during locomotion: localization and electrophysiological characterization.

  2000cited by this paper
• Activation of Locomotion in Adult Chronic Spinal Rats Is Achieved by Transplantation of Embryonic Raphe Cells Reinnervating a Precise Lumbar Level

  2000cited by this paper
• Neuronal patterning: Making stripes in the spinal cord.

  2000cited by this paper
• A Homeodomain Protein Code Specifies Progenitor Cell Identity and Neuronal Fate in the Ventral Neural Tube

  2000cited by this paper
• An olfactory sensory map in the fly brain.

  2000cited by this paper
• Initiating or Blocking Locomotion in Spinal Cats by Applying Noradrenergic Drugs to Restricted Lumbar Spinal Segments

  2000cited by this paper
• Characterization of calcium currents in functionally mature mouse spinal motoneurons

  2000influential reference
• Diffuse distribution of sulforhodamine‐labeled neurons during serotonin‐evoked locomotion in the neonatal rat thoracolumbar spinal cord

  2000cited by this paper
• Neuronal specification in the spinal cord: inductive signals and transcriptional codes

  2000cited by this paper
• A homeodomain protein code specifies progenitor cell identity and neuronal fate in the ventral neural tube.

  2000cited by this paper
• An in vitro functionally mature mouse spinal cord preparation for the study of spinal motor networks.

  1999cited by this paper
• The homeodomain transcription factors Islet 1 and HB9 are expressed in adult alpha and gamma motoneurons identified by selective retrograde tracing

  1999cited by this paper
• Regulation of the rebound depolarization and spontaneous firing patterns of deep nuclear neurons in slices of rat cerebellum.

  1999cited by this paper
• Requirement for the homeobox gene Hb9 in the consolidation of motor neuron identity.

  1999cited by this paper
• Active suppression of interneuron programs within developing motor neurons revealed by analysis of homeodomain factor HB9.

  1999influential reference
• A sonic hedgehog-independent, retinoid-activated pathway of neurogenesis in the ventral spinal cord.

  1999cited by this paper
• Analysis of the Central Pattern Generator for Swimming in the Mollusk Clione a

  1998cited by this paper
• Inducible and constitutive transcription factors in the mammalian nervous system: control of gene expression by Jun, Fos and Krox, and CREB/ATF proteins.

  1998cited by this paper
• NMDA receptor-mediated oscillatory activity in the neonatal rat spinal cord is serotonin dependent.

  1998cited by this paper
• Specification of motor neuron identity by the MNR2 homeodomain protein.

  1998cited by this paper
• Extracellular K+ induces locomotor-like patterns in the rat spinal cord in vitro: comparison with NMDA or 5-HT induced activity.

  1998cited by this paper
• Distribution of Central Pattern Generators for Rhythmic Motor Outputs in the Spinal Cord of Limbed Vertebrates a

  1998cited by this paper
• Dorsal-ventral patterning during neural induction in Xenopus: assessment of spinal cord regionalization with xHB9, a marker for the motor neuron region.

  1997influential reference
• Synchronous Bursting Can Arise from Mutual Excitation, Even When Individual Cells are not Endogenous Bursters

  1997cited by this paper
• Pax6 controls progenitor cell identity and neuronal fate in response to graded Shh signaling.

  1997cited by this paper
• Low-voltage-activated calcium channels in the lamprey locomotor network: simulation and experiment.

  1997cited by this paper
• Regional distribution of the locomotor pattern-generating network in the neonatal rat spinal cord.

  1997cited by this paper
• Queer current and pacemaker: the hyperpolarization-activated cation current in neurons.

  1996cited by this paper
• The synaptic drive from the spinal locomotor network to motoneurons in the newborn rat

  1996cited by this paper
• Plateau properties in mammalian spinal interneurons during transmitter-induced locomotor activity.

  1996cited by this paper
• Requirement for LIM homeobox gene Isl1 in motor neuron generation reveals a motor neuron-dependent step in interneuron differentiation.

  1996cited by this paper
• Distribution of Networks Generating and Coordinating Locomotor Activity in the Neonatal Rat Spinal Cord In Vitro: A Lesion Study

  1996cited by this paper
• Properties of networks controlling locomotion and significance of voltage dependency of NMDA channels: stimulation study of rhythm generation sustained by positive feedback.

  1995cited by this paper
• Dopamine modulation of two subthreshold currents produces phase shifts in activity of an identified motoneuron.

  1995cited by this paper
• Cytochemical characteristics of cat spinal neurons activated during fictive locomotion.

  1995cited by this paper
• Electrical coupling and intrinsic neuronal oscillations in Rana temporaria spinal cord.

  1994cited by this paper
• Sulphorhodamine‐labelled cells in the neonatal rat spinal cord following chemically induced locomotor activity in vitro.

  1994cited by this paper
• A comparison of motor patterns induced by N-methyl-D-aspartate, acetylcholine and serotonin in the in vitro neonatal rat spinal cord.

  1994cited by this paper
• TTX-resistant NMDA receptor-mediated voltage oscillations in mammalian lumbar motoneurons.

  1994influential reference
• Electrical coupling and intrinsic neuronal oscillations in Rana temporaria spinal cord.

  1994cited by this paper
• Early stages of motor neuron differentiation revealed by expression of homeobox gene Islet-1.

  1992cited by this paper
• Interneuronal relay in spinal pathways from proprioceptors.

  1992cited by this paper
• Induction of fos expression by activity in the spinal rhythm generator for scratching.

  1992cited by this paper
• A generic intron increases gene expression in transgenic mice

  1991cited by this paper
• Characterization and Function of Spinal Excitatory Interneurons with Commissural Projections in Xenopus laevis embryos

  1990cited by this paper
• Labelling neurons with fluorescent dyes administered via intravenous, subcutaneous or intraperitoneal route.

  1990cited by this paper
• Mutual Re‐excitation with Post‐Inhibitory Rebound: A Simulation Study on the Mechanisms for Locomotor Rhythm Generation in the Spinal Cord of Xenopus Embryos

  1990influential reference
• Emerging principles governing the operation of neural networks.

  1989cited by this paper
• Identification of excitatory interneurons contributing to generation of locomotion in lamprey: structure, pharmacology, and function.

  1989cited by this paper
• A mechanism for production of phase shifts in a pattern generator.

  1984cited by this paper
• A low voltage-activated, fully inactivating Ca channel in vertebrate sensory neurones

  1984cited by this paper
• Motor-pattern production: interaction of chemical and electrical synapses.

  1981cited by this paper
• [Impulse activity of interneurons of the lumbar portion of the spinal cord during the late long discharges in the motor nerves of immobilized thalamic cats].

  1979cited by this paper
• Pattern generation in the lobster (Panulirus) stomatogastric ganglion

  1979cited by this paper
• Impulse activity of interneurons of the lumbar portion of the spinal cord during the late long discharges in the motor nerves of immobilized thalamic cats

  1979cited by this paper
• Cells of origin of propriospinal fibers and of fibers ascending to supraspinal levels. A HRP study in cat and rhesus monkey.

  1978cited by this paper
• Motor Pattern Production in Reciprocally Inhibitory Neurons Exhibiting Postinhibitory Rebound

  1974influential reference
• A structural analysis of spinal interneurons and Renshaw cells.

  1969cited by this paper
• The intrinsic factors in the act of progression in the mammal

  1911cited by this paper

• Focus on the excitatory and inhibitory neurotransmission imbalance in amyotrophic lateral sclerosis: a harmful disease player or a potential therapeutic opportunity?

  2026cites this paper
• Neuro293: A REST-knockout HEK-293 cell line enables the expression of neuron-restricted genes for the high-throughput testing of human neurobiology and the biochemistry of neuronal proteins

  2025cites this paper
• Multimodal sensory control of motor performance by glycinergic interneurons of the mouse spinal cord deep dorsal horn.

  2024cites this paper
• Contribution of the neuron-specific ATP1A3 to embryonic spinal circuit emergence

  2024cites this paper
• Sparse Firing in a Hybrid Central Pattern Generator for Spinal Motor Circuits

  2024cites this paper
• Rare phenomena of central rhythm and pattern generation in a case of complete spinal cord injury

  2023cites this paper
• Multimodal sensory control of motor performance by glycinergic interneurons of the spinal cord deep dorsal horn

  2023cites this paper
• Astrocytic Kir4.1 channels regulate locomotion by orchestrating neuronal rhythmicity in the spinal network

  2023cites this paper
• Interrelationships between spinal sympathetic preganglionic neurons, autonomic systems and electrical synapses formed by connexin36-containing gap junctions.

  2023cites this paper
• The alpha2 nicotinic acetylcholine receptor, a subunit with unique and selective expression in inhibitory interneurons associated with principal cells.

  2023cites this paper
• Spinal cords: Symphonies of interneurons across species

  2023cites this paper
• Localization of rhythm generating components of the mammalian locomotor CPG.

  2023cites this paper
• Distinguishing subtypes of spinal locomotor neurons to inform circuit function and dysfunction.

  2023cites this paper
• Long-Term Cultures of Spinal Cord Interneurons

  2022cites this paper
• Astrocytes regulate locomotion by orchestrating neuronal rhythmicity in the spinal network via potassium clearance

  2022cites this paper
• On the organization of connexin36 expression in electrically coupled cholinergic V0c neurons (partition cells) in the spinal cord and their C-terminal innervation of motoneurons.

  2022cites this paper
• Transcription Factor Hb9 Is Expressed in Glial Cell Lineages in the Developing Mouse Spinal Cord

  2022cites this paper
• Identification of adult spinal Shox2 neuronal subpopulations based on unbiased computational clustering of electrophysiological properties

  2022cites this paper
• Motoneuronal Regulation of Central Pattern Generator and Network Function.

  2022cites this paper
• Elimination of glutamatergic transmission from Hb9 interneurons does not impact treadmill locomotion

  2021cites this paper
• Spinal Cord Injury Alters Spinal Shox2 Interneurons by Enhancing Excitatory Synaptic Input and Serotonergic Modulation While Maintaining Intrinsic Properties in Mouse

  2021cites this paper
• Experimental Model Systems for Understanding Human Axonal Injury Responses

  2021cites this paper
• Maturation of persistent and hyperpolarization-activated inward currents shapes the differential activation of motoneuron subtypes during postnatal development

  2021cites this paper
• Control of spinal motor neuron terminal differentiation through sustained Hoxc8 gene activity

  2021cites this paper
• Upper motor neurons are a target for gene therapy and UCHL1 is necessary and sufficient to improve cellular integrity of diseased upper motor neurons

  2021cites this paper
• Role of DSCAM in the Development of Neural Control of Movement and Locomotion

  2021cites this paper
• Upper motor neurons are a target for gene therapy and UCHL1 is necessary and sufficient to improve cellular integrity of diseased upper motor neurons

  2021cites this paper
• Recent Insights into the Rhythmogenic Core of the Locomotor CPG

  2021influential citation
• Differential dopamine modulation of spinal reflex amplitudes is associated with the presence or absence of the autonomic nervous system.

  2020cites this paper
• It takes two to tango: M-current swings with the persistent sodium current to set the speed of locomotion

  2020cites this paper
• Using mouse genetics to study the developing spinal locomotor circuit

  2020cites this paper
• Dynamics of episodic and continuous rhythmic activities from a developing central pattern generator

  2020cites this paper
• The M-current works in tandem with the persistent sodium current to set the speed of locomotion

  2020cites this paper
• Modulation of respiratory network activity by forelimb and hindlimb locomotor generators.

  2020cites this paper
• Contributions of h- and Na+/K+ Pump Currents to the Generation of Episodic and Continuous Rhythmic Activities

  2020cites this paper
• Multiple Rhythm-Generating Circuits Act in Tandem with Pacemaker Properties to Control the Start and Speed of Locomotion.

  2020cites this paper
• Neural Interactions in Developing Rhythmogenic Spinal Networks: Insights From Computational Modeling

  2020cites this paper
• Spinal motoneuron firing properties mature from rostral to caudal during postnatal development of the mouse

  2020cites this paper
• Candidate interneurons mediating the resetting of the locomotor rhythm by extensor group I afferents in the cat.

  2020cites this paper
• Developmental stage‐dependent switching in the neuromodulation of vertebrate locomotor central pattern generator networks

  2019cites this paper
• Stimulation of Single, Possible CHX10 Hindbrain Neurons Turns Swimming On and Off in Young Xenopus Tadpoles

  2019cites this paper
• Sp1-regulated expression of p11 contributes to motor neuron degeneration by membrane insertion of TASK1

  2019cites this paper
• Developmental Expression of Mutant PFN1 in Motor Neurons Impacts Neuronal Growth and Motor Performance of Young and Adult Mice

  2019cites this paper
• Central pattern generators in the brainstem and spinal cord: an overview of basic principles, similarities and differences

  2019cites this paper
• The rhythm section: An update on spinal interneurons setting the beat for mammalian locomotion.

  2019cites this paper
• Rôle de DSCAM dans le développement du circuit locomoteur spinal

  2018influential citation
• Walking with perturbations: a guide for biped humans and robots

  2018cites this paper
• Sub-populations of Spinal V3 Interneurons Form Focal Modules of Layered Pre-motor Microcircuits

  2018cites this paper
• TJ-positive neurons implication in Drosophila larva locomotor behaviour

  2018cites this paper
• Interneuron diversity and function in the zebrafish locomotor circuits

  2018cites this paper
• Spinal Shox2 interneuron interconnectivity related to function and development

  2018influential citation
• Decoupling of timescales reveals sparse convergent CPG network in the adult spinal cord

  2018cites this paper
• Characterization of Dmrt3-Derived Neurons Suggest a Role within Locomotor Circuits

  2018cites this paper
• Orexinergic Modulation of Spinal Motor Activity in the Neonatal Mouse Spinal Cord

  2018cites this paper
• Delineating the Diversity of Spinal Interneurons in Locomotor Circuits

  2017cites this paper
• Diversity of molecularly defined spinal interneurons engaged in mammalian locomotor pattern generation.

  2017cites this paper
• Identifying Vertebrate Brain Prototypes in Deuterostomes

  2017cites this paper
• Neurons versus Networks: The Interplay between Individual Neurons and Neural Networks in Cognitive Functions

  2017cites this paper
• Spinal Hb9::Cre-derived excitatory interneurons contribute to rhythm generation in the mouse

  2017cites this paper
• Dopamine Pumping Up Spinal Locomotor Network Function

  2017cites this paper
• CHARACTERIZATION OF HB9 INTERNEURONS: BEHAVIOUR AND ANATOMY

  2017influential citation
• PTEN as a therapeutic target for the promotion of cell survival in cell models of amyotrophic lateral sclerosis

  2017cites this paper
• Serotonin controls initiation of locomotion and afferent modulation of coordination via 5‐HT7 receptors in adult rats

  2017cites this paper
• Regulation of axon guidance receptor expression and activity during neuronal morphogenesis

  2016cites this paper
• AAV9-mediated central nervous system–targeted gene delivery via cisterna magna route in mice

  2016cites this paper
• Nonreciprocal mechanisms in up- and downregulation of spinal motoneuron excitability by modulators of KCNQ/Kv7 channels.

  2016cites this paper
• Sensory Activation of Command Cells for Locomotion and Modulatory Mechanisms: Lessons from Lampreys

  2016cites this paper
• Loci impacting polymorphic gait in the Tennessee Walking Horse.

  2016cites this paper
• Modeling ALS with motor neurons derived from human induced pluripotent stem cells

  2016cites this paper
• Coordination antéropostérieure pendant la locomotion chez le chat adulte intact et suite à une lésion partielle de la moelle épinière

  2016cites this paper
• VGLUT 2 is required for central respiratory rhythm generation but not for locomotor central pattern generation Abbreviated title : The role of VGLUT 2 in respiration

  2016cites this paper
• From the Department of Neuroscience Karolinska Institutet │Stockholm – Sweden MOLECULAR CODING AND PHYSIOLOGICAL ROLES OF EXCITATORY NEURONS IN MOTOR CONTROL

  2016cites this paper
• Central Pattern Generators: Mechanisms of Operation and Their Role in Controlling Automatic Movements

  2016cites this paper
• Decoding the organization of spinal circuits that control locomotion

  2016cites this paper
• Connectivity and Regional Distribution of Constituent Cells of the Mammalian Locomotor Central Pattern Generator

  2016cites this paper
• Generator for Locomotion and Regulates the Locomotor Rhythm The Persistent Sodium Current Generates Pacemaker Activities in the Central Pattern

  2015cites this paper
• Assembly and function of spinal circuits for motor control.

  2015cites this paper
• locomotor-like activity in neonatal mice Low-threshold calcium currents contribute to

  2015cites this paper
• Four Subpopulations in the Intermediolateral Nucleus Preganglionic Neurons of Neonatal Mice: Evidence of Heterogeneity of Membrane Properties in Sympathetic

  2015cites this paper
• Sensory-evoked perturbations of locomotor activity by sparse sensory input: a computational study.

  2015cites this paper
• Oscillations in Hb9-Expressing Interneurons Sensory Modulation of Locomotor-Like Membrane

  2015cites this paper
• Serotonergic System and Gait: Dorsal Raphe Nucleus as a Control System for Gait

  2015cites this paper
• Descending Command Neurons in the Brainstem that Halt Locomotion.

  2015cites this paper
• Neuromodulation of spinal networks in embryonic and larval zebrafish

  2015cites this paper
• Molecular and cellular development of spinal cord locomotor circuitry

  2015cites this paper
• neonatal mouse spinal cord Functional characterization of dI6 interneurons in the

  2015cites this paper
• Locomotor Pattern Generation in Neonatal Rats Contribution of Persistent Sodium Current to

  2015cites this paper
• [Central Pattern Generators: Mechanisms of the Activity and Their Role in the Control of "Automatic" Movements].

  2015cites this paper
• Sensory and Motor Systems Organization of the Mammalian Locomotor CPG: Review of Computational Model and Circuit Architectures Based on Genetically Identified Spinal Interneurons

  2015cites this paper
• The development and neuromodulation of motor control systems in pro-metamorphic Xenopus laevis frog tadpoles

  2014cites this paper
• Motor Neuron-Specific Restoration of SMN in Two SMA Mouse Models: Insights into the Role of Motor Neurons in Spinal Muscular Atrophy

  2014cites this paper
• Neuronal Networks of Movement Slc 10 a 4 as a Modulator & Dmrt 3 as a Gait

  2014cites this paper
• Spinal inhibitory circuits and their role in motor neuron degeneration.

  2014cites this paper
• The homeodomain transcription factor Hb9 controls axon guidance in Drosophila through the regulation of Robo receptors.

  2014cites this paper
• Directed midbrain and spinal cord neurogenesis from pluripotent stem cells to model development and disease in a dish

  2014cites this paper
• Dopamine: a parallel pathway for the modulation of spinal locomotor networks

  2014cites this paper
• Physiopathologie de la sclérose latérale amyotropique : implication des systèmes neuromodulateurs dans les réseaux moteurs spinaux

  2014cites this paper
• Locomotor Pattern Generation in the Rodent Spinal Cord

  2014cites this paper
• The Brain and Spinal Cord Networks Controlling Locomotion

  2014cites this paper
• Preclinical evidence supporting the clinical development of central pattern generator-modulating therapies for chronic spinal cord-injured patients

  2014cites this paper