Abstract Quercetin (QCT) is an abundant plant polyphenol with demonstrated efficacy in several diseases including colon cancer. Herein we have developed polymeric nanoparticles (NPs) of QCT based on the pH-sensitive polymer Eudragit® S100 to achieve colon pH-specific drug release following oral administration. NPs were prepared by the nanoprecipitation technique and showed a mean diameter of 66.8 nm and a partially negative surface charge of −5.2 mV. NPs contained on average 2.2% w/w QCT at an encapsulation efficiency of 41.8%. IR spectroscopy and differential scanning calorimetry (DSC) both revealed the presence of intermolecular interactions, most likely H-bonding, between QCT and Eudragit® S100, which likely contributed to drug loading. DSC also indicated that the drug was present in the NPs in an amorphous state, which was further confirmed by X-ray diffraction. In vitro release testing showed a delay in drug release in acidic pH, but complete release within 24 h at pH 7.2. A cytotoxicity assay was performed on CT26 murine colon carcinoma cells, where QCT-loaded NPs displayed significantly higher potency (IC50 = 0.8 μM) than free QCT (IC50 = 65.1 μM). Our findings present a promising nanomedicine for colon-targeted delivery of QCT in diseases such as colon cancer.
pH-sensitive polymeric nanoparticles of quercetin as a potential colon cancer-targeted nanomedicine
Suhair Sunoqrot,Lujain Abujamous
Published 2019 in Journal of Drug Delivery Science and Technology
ABSTRACT
PUBLICATION RECORD
- Publication year
2019
- Venue
Journal of Drug Delivery Science and Technology
- Publication date
2019-08-01
- Fields of study
Medicine, Materials Science, Chemistry
- Identifiers
- External record
- Source metadata
Semantic Scholar
CITATION MAP
EXTRACTION MAP
CLAIMS
- No claims are published for this paper.
CONCEPTS
- No concepts are published for this paper.
REFERENCES
Showing 1-41 of 41 references · Page 1 of 1
CITED BY
Showing 1-64 of 64 citing papers · Page 1 of 1