Growth factor-induced phosphoinositide 3-OH kinase/Akt phosphorylation in smooth muscle cells: induction of cell proliferation and inhibition of cell death.

No abstract is available for this paper.

• Publication year

  2000

• Venue

  Cardiovascular Research

• Publication date

  2000-10-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/S0008-6363(00)00152-8PMID 11033117
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The Survival Function of the Bcr-Abl Oncogene Is Mediated by Bad-Dependent and -Independent Pathways: Roles for Phosphatidylinositol 3-Kinase and Raf

  2000cited by this paper
• Reentry into the Cell Cycle of Contact-inhibited Vascular Endothelial Cells by a Phosphatase Inhibitor

  2000cited by this paper
• Roles of Phosphatidylinositol 3-Kinase and Mitogen-Activated Protein Kinase Pathways in Stimulation of Vascular Smooth Muscle Cell Migration and Deoxyriboncleic Acid Synthesis by Insulin-Like Growth Factor-I1.

  1999cited by this paper
• Platelet-derived growth factor-BB (PDGF-BB) regulation of migration and focal adhesion kinase phosphorylation in rabbit aortic vascular smooth muscle cells: roles of phosphatidylinositol 3-kinase and mitogen-activated protein kinases.

  1999cited by this paper
• Insulin-like Growth Factor-I Induces bcl-2 Promoter through the Transcription Factor cAMP-Response Element-binding Protein*

  1999cited by this paper
• Phosphatidylinositol 3-kinase is required for growth factor-induced amino acid uptake by vascular smooth muscle cells.

  1999cited by this paper
• Multiple Signaling Pathways of the Insulin-Like Growth Factor 1 Receptor in Protection from Apoptosis

  1999cited by this paper
• PTEN tumour suppressor is linked to the cell cycle control through the retinoblastoma protein

  1999cited by this paper
• Changes in the Balance of Phosphoinositide 3-Kinase/Protein Kinase B (Akt) and the Mitogen-activated Protein Kinases (ERK/p38MAPK) Determine a Phenotype of Visceral and Vascular Smooth Muscle Cells

  1999cited by this paper
• Multiple Ras Effector Pathways Contribute to G1Cell Cycle Progression*

  1999cited by this paper
• PTEN suppresses breast cancer cell growth by phosphatase activity-dependent G1 arrest followed by cell death.

  1999cited by this paper
• Regulation of vascular smooth muscle cell apoptosis. Modulation of bad by a phosphatidylinositol 3-kinase-dependent pathway.

  1999cited by this paper
• Roles of phosphatidylinositol 3-kinase and mitogen-activated protein kinase pathways in stimulation of vascular smooth muscle cell migration and deoxyriboncleic acid synthesis by insulin-like growth factor-I.

  1999cited by this paper
• Phosphorylation and regulation of Raf by Akt (protein kinase B).

  1999cited by this paper
• Platelet-derived growth factor-BB, insulin-like growth factor-I, and phorbol ester activate different signaling pathways for stimulation of vascular smooth muscle cell migration.

  1998cited by this paper
• Angiotensin blockade inhibits activation of mitogen-activated protein kinases in rat balloon-injured artery.

  1998cited by this paper
• SIGNAL TRANSDUCTION: Lipid-Regulated Kinases: Some Common Themes at Last

  1998cited by this paper
• Cyclin D Expression Is Controlled Post-transcriptionally via a Phosphatidylinositol 3-Kinase/Akt-dependent Pathway*

  1998cited by this paper
• Protein kinase B kinases that mediate phosphatidylinositol 3,4,5-trisphosphate-dependent activation of protein kinase B.

  1998cited by this paper
• Fluid shear stress stimulates phosphorylation of Akt in human endothelial cells: involvement in suppression of apoptosis.

  1998cited by this paper
• Glycogen synthase kinase-3beta regulates cyclin D1 proteolysis and subcellular localization.

  1998cited by this paper
• Growth factors and mitogen-activated protein kinases.

  1998cited by this paper
• Dissociation of cytokine-induced phosphorylation of Bad and activation of PKB/akt: involvement of MEK upstream of Bad phosphorylation.

  1998cited by this paper
• Regulation of cell death protease caspase-9 by phosphorylation.

  1998cited by this paper
• PI3K: downstream AKTion blocks apoptosis.

  1997cited by this paper
• Protein Kinase C-ζ Mediates Angiotensin II Activation of ERK1/2 in Vascular Smooth Muscle Cells*

  1997cited by this paper
• A specific product of phosphatidylinositol 3-kinase directly activates the protein kinase Akt through its pleckstrin homology domain

  1997cited by this paper
• Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt.

  1997cited by this paper
• Insulin-like Growth Factor 1 Inhibits Apoptosis Using the Phosphatidylinositol 3′-Kinase and Mitogen-activated Protein Kinase Pathways*

  1997cited by this paper
• Protein kinase C-zeta mediates angiotensin II activation of ERK1/2 in vascular smooth muscle cells.

  1997cited by this paper
• Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery.

  1997cited by this paper
• Antiapoptotic signalling by the insulin-like growth factor I receptor, phosphatidylinositol 3-kinase, and Akt

  1997cited by this paper
• Matrix adhesion and Ras transformation both activate a phosphoinositide 3‐OH kinase and protein kinase B/Akt cellular survival pathway

  1997cited by this paper
• Transformation of hematopoietic cells by BCR/ABL requires activation of a PI‐3k/Akt‐dependent pathway

  1997cited by this paper
• The PI 3-kinase/Akt signaling pathway delivers an anti-apoptotic signal.

  1997cited by this paper
• Regulation of Neuronal Survival by the Serine-Threonine Protein Kinase Akt

  1997cited by this paper
• Shear stress inhibits H2O2-induced apoptosis of human endothelial cells by modulation of the glutathione redox cycle and nitric oxide synthase.

  1997cited by this paper
• Signal-transducing protein phosphorylation cascades mediated by Ras/Rho proteins in the mammalian cell: the potential for multiplex signalling.

  1996cited by this paper
• Activation and phosphorylation of a pleckstrin homology domain containing protein kinase (RAC-PK/PKB) promoted by serum and protein phosphatase inhibitors.

  1996cited by this paper
• Angiotensin II signal transduction and the mitogen-activated protein kinase pathway.

  1995cited by this paper
• Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

  1995cited by this paper
• Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction

  1995cited by this paper
• Apoptosis participates in cellularity regulation during rat aortic intimal thickening.

  1995cited by this paper
• Insulin regulates expression of c-fos and c-jun and suppresses apoptosis of lens epithelial cells.

  1995cited by this paper
• The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase.

  1995cited by this paper
• Apoptosis in human atherosclerosis and restenosis.

  1995cited by this paper
• Apoptosis of human vascular smooth muscle cells derived from normal vessels and coronary atherosclerotic plaques.

  1995cited by this paper
• Endothelins stimulate mitogen-activated protein kinase cascade through either ETA or ETB.

  1994cited by this paper
• The pathogenesis of atherosclerosis: a perspective for the 1990s

  1993cited by this paper
• The myocardial vasculature during ischemia and reperfusion: a target for injury and protection.

  1993cited by this paper
• Direct transfer of transforming growth factor beta 1 gene into arteries stimulates fibrocellular hyperplasia.

  1993cited by this paper
• Vascular smooth muscle cell hypertrophy vs. hyperplasia. Autocrine transforming growth factor-beta 1 expression determines growth response to angiotensin II.

  1992cited by this paper
• Arterial response to mechanical injury: balloon catheter de-endothelialization.

  1992cited by this paper
• Active oxygen species stimulate vascular smooth muscle cell growth and proto-oncogene expression.

  1992cited by this paper
• Platelet-derived growth factor promotes smooth muscle migration and intimal thickening in a rat model of balloon angioplasty.

  1992cited by this paper
• Role of basic fibroblast growth factor in vascular lesion formation.

  1991cited by this paper
• Time course of smooth muscle cell proliferation in the intima and media of arteries following experimental angioplasty.

  1990cited by this paper
• Kinetics of cellular proliferation after arterial injury. V. Role of acute distension in the induction of smooth muscle proliferation.

  1989cited by this paper
• Regulation of Smooth Muscle Cell Growth in Injured Artery

  1989cited by this paper
• Treatment of Hypertension and Ischemic Heart Disease

  1989cited by this paper
• Insulin-stimulated MAP-2 kinase phosphorylates and activates ribosomal protein S6 kinase II

  1988cited by this paper
• Production of platelet-derived growth factor-like molecules by cultured arterial smooth muscle cells accompanies proliferation after arterial injury.

  1986cited by this paper
• Actin expression in smooth muscle cells of rat aortic intimal thickening, human atheromatous plaque, and cultured rat aortic media.

  1984cited by this paper
• Cardiovascular Research

  1966cited by this paper

• Far-infrared irradiation attenuates platelet-derived growth factor-stimulated vascular smooth muscle cell migration through protein phosphatase 2A-mediated Akt inhibition.

  2025cites this paper
• Stress Granules in Atherosclerosis: Insights and Therapeutic Opportunities.

  2024cites this paper
• Inhibition of human glioblastoma multiforme cells by 10,11-dehydrocurvularin through the MMP-2 and PI3K/AKT signaling pathways.

  2022cites this paper
• Molecular Mechanisms of Danhong Injection in Treatment of Pulmonary Fibrosis Based on Network Pharmacology and Experimental Validation

  2021cites this paper
• Beneficial effect of walnuts on vascular tone is associated with Akt signalling, voltage-dependent calcium channel LTCC and ATP-sensitive potassium channel Kv1.2

  2020cites this paper
• The relationship between estrogen-induced phenotypic transformation and proliferation of vascular smooth muscle and hypertensive intracerebral hemorrhage

  2020cites this paper
• A low dose of simvastatin enhanced the therapeutic efficacy of mesenchymal stem cell (MSC) transplantation in skin wound healing in diabetic mice associated with increases in pAkt, SDF-1, and angiogenesis

  2019cites this paper
• Cellular Effects of Butyrate on Vascular Smooth Muscle Cells are Mediated through Disparate Actions on Dual Targets, Histone Deacetylase (HDAC) Activity and PI3K/Akt Signaling Network

  2019cites this paper
• hPMSC transplantation restoring ovarian function in premature ovarian failure mice is associated with change of Th17/Tc17 and Th17/Treg cell ratios through the PI3K/Akt signal pathway

  2018cites this paper
• Angiotensin II type 1 receptor-associated protein regulates carotid intimal hyperplasia through controlling apoptosis of vascular smooth muscle cells.

  2018cites this paper
• The Role of the Mammalian Target of Rapamycin (mTOR) in Pulmonary Fibrosis

  2018cites this paper
• Drug repurposing and therapeutic anti-microRNA predictions for inhibition of oxidized low-density lipoprotein-induced vascular smooth muscle cell-associated diseases

  2017cites this paper
• Hypoxia in Mesenchymal Stem Cell Hypoxia in Mesenchymal Stem Cell

  2017cites this paper
• Ketamine, a Clinically Used Anesthetic, Inhibits Vascular Smooth Muscle Cell Proliferation via PP2A-Activated PI3K/Akt/ERK Inhibition

  2017cites this paper
• Agastache rugosa Kuntze extract, containing the active component rosmarinic acid, prevents atherosclerosis through up-regulation of the cyclin-dependent kinase inhibitors p21WAF1/CIP1 and p27KIP1

  2017cites this paper
• Wedelolactone, a plant coumarin, prevents vascular smooth muscle cell proliferation and injury‐induced neointimal hyperplasia through Akt and AMPK signaling

  2017cites this paper
• Hypoxia in Mesenchymal Stem Cell

  2017cites this paper
• Effect of the PI3K/AKT signaling pathway on hypoxia-induced proliferation and differentiation of bone marrow-derived mesenchymal stem cells

  2016cites this paper
• Rheumatic involvement of the cleft mitral valve

  2016cites this paper
• Identify potential drugs for cardiovascular diseases caused by stress-induced genes in vascular smooth muscle cells

  2016cites this paper
• Antiproliferative Activity of Hinokitiol, a Tropolone Derivative, Is Mediated via the Inductions of p-JNK and p-PLCγ1 Signaling in PDGF-BB-Stimulated Vascular Smooth Muscle Cells

  2015cites this paper
• The Protective Effect of Bee Venom on Fibrosis Causing Inflammatory Diseases

  2015cites this paper
• fibroblast proliferation hypoxia-induced pulmonary artery adventitial mammalian target of rapamycin is necessary for Activation of phosphatidylinositol 3-kinase, Akt, and

  2015cites this paper
• The Effects Of Environmental Pollutants On Adipogenesis In The 3T3-L1 Model

  2015cites this paper
• Protective effects of the polyphenols (+)-episesamin and sesamin against PDGF-BB-induced activation of vascular smooth muscle cells are mediated by induction of haem oxygenase-1 and inhibition of mitogenic signalling

  2015cites this paper
• Effects of Nigella sativa L. seed oil on intima–media thickness and Bax and Caspase 3 expression in diabetic rat aorta

  2015cites this paper
• Apelin induces vascular smooth muscle cells migration via a PI3K/Akt/FoxO3a/MMP-2 pathway.

  2015cites this paper
• The lignan (+)‐episesamin interferes with TNF‐α‐induced activation of VSMC via diminished activation of NF‐ĸB, ERK1/2 and AKT and decreased activity of gelatinases

  2015cites this paper
• Hypoxia‐induced proliferation in mesenchymal stem cells and angiotensin II‐mediated PI3K/AKT pathway

  2015cites this paper
• Murrayafoline A Induces a G0/G1-Phase Arrest in Platelet-Derived Growth Factor-Stimulated Vascular Smooth Muscle Cells

  2015cites this paper
• Apamin inhibits PDGF-BB-induced vascular smooth muscle cell proliferation and migration through suppressions of activated Akt and Erk signaling pathway.

  2015cites this paper
• Current siRNA targets in atherosclerosis and aortic aneurysm.

  2014cites this paper
• Expression of mammalian target of rapamycin in atherosclerotic plaques is decreased under diabetic conditions: a mechanism for rapamycin resistance.

  2014cites this paper
• 15-oxo-Eicosatetraenoic acid prevents serum deprivation-induced apoptosis of pulmonary arterial smooth muscle cells by activating pro-survival pathway.

  2014cites this paper
• Chlamydia pneumoniae Infection Promotes Vascular Smooth Muscle Cell Migration through a Toll-Like Receptor 2-Related Signaling Pathway

  2013cites this paper
• Denbinobin induces human glioblastoma multiforme cell apoptosis through the IKKα-Akt-FKHR signaling cascade.

  2013cites this paper
• Camptothecin inhibits platelet-derived growth factor-BB-induced proliferation of rat aortic vascular smooth muscle cells through inhibition of PI3K/Akt signaling pathway.

  2013cites this paper
• 20(S)-protopanaxadiol triggers mitochondrial-mediated apoptosis in human lung adenocarcinoma A549 cells via inhibiting the PI3K/Akt signaling pathway.

  2013cites this paper
• Chlamydia pneumoniae infection promotes vascular smooth muscle 1 cell migration through Toll-like receptor 2-related signaling 2 pathway 3 4

  2013cites this paper
• Potential targets for prevention of colorectal cancer: a focus on PI3K/Akt/mTOR and Wnt pathways.

  2013cites this paper
• In vitro models for investigating keratinocyte responses to ultraviolet B radiation

  2013cites this paper
• Tocotrienols target PI3K/Akt signaling in anti-breast cancer therapy.

  2013cites this paper
• proliferationpulmonary artery adventitial fibroblast mammalian target of rapamycin is necessary for Activation of phosphatidylinositol 3-kinase, Akt, and

  2013cites this paper
• Piperlongumine inhibits atherosclerotic plaque formation and vascular smooth muscle cell proliferation by suppressing PDGF receptor signaling.

  2012cites this paper
• Melittin has an inhibitory effect on TNF-α-induced migration of human aortic smooth muscle cells by blocking the MMP-9 expression.

  2012cites this paper
• Zerumbone suppresses IKKα, Akt, and FOXO1 activation, resulting in apoptosis of GBM 8401 cells

  2012cites this paper
• Clitocybin B inhibits rat aortic smooth muscle cell proliferation through suppressing PDGF-Rβ phosphorylation.

  2012cites this paper
• CIAPIN1 siRNA inhibits proliferation, migration and promotes apoptosis of VSMCs by regulating Bcl-2 and Bax.

  2012cites this paper
• Hydroxytyrosol induces vascular smooth muscle cells apoptosis through NO production and PP2A activation with subsequent inactivation of Akt.

  2011cites this paper
• Inhibitory effects of docetaxel on platelet-derived growth factor (PDGF)-BB-induced proliferation of vascular smooth muscle cells through blocking PDGF-receptor β phosphorylation.

  2011cites this paper
• Tangeretin, a citrus flavonoid, inhibits PGDF-BB-induced proliferation and migration of aortic smooth muscle cells by blocking AKT activation.

  2011cites this paper
• Ellagic acid prevents rat colon carcinogenesis induced by 1, 2 dimethyl hydrazine through inhibition of AKT-phosphoinositide-3 kinase pathway.

  2011influential citation
• Islet Endothelium: Role in Type 1 Diabetes and in Coxsackievirus Infections

  2011cites this paper
• Perspectives of Cell Therapy in Type 1 Diabetes

  2011cites this paper
• Effects of electroacupuncture at Quchi point on vascular smooth muscle cells apoptosis of two kidney one clip hypertensive rates (2K1C-RHR) in carotid artery

  2011cites this paper
• DHEA and Vascular Health and Functions

  2011cites this paper
• Hydroxytyrosol Induces Vascular Smooth Muscle Cells Apoptosis through NO Production and PP2A Activation with Subsequent Inactivation of Akt

  2011cites this paper
• Erythropoietin Increases Expression and Function of Vascular Copper- and Zinc-Containing Superoxide Dismutase

  2010cites this paper
• Myricetin inhibits Akt survival signaling and induces Bad‐mediated apoptosis in a low dose ultraviolet (UV)‐B‐irradiated HaCaT human immortalized keratinocytes

  2010cites this paper
• Denbinobin induces apoptosis in human lung adenocarcinoma cells via Akt inactivation, Bad activation, and mitochondrial dysfunction.

  2008cites this paper
• Akt Regulates the Survival of Vascular Smooth Muscle Cells via Inhibition of FoxO3a and GSK3*

  2008cites this paper
• Hyperglycemia induces apoptosis of human pancreatic islet endothelial cells: effects of pravastatin on the Akt survival pathway.

  2008cites this paper
• Antiproliferative and Apoptotic Effects of Tocotrienols on Normal and Neoplastic Mammary Epithelial Cells

  2008cites this paper
• Akt activation prevents Apop-1-induced death of cells.

  2008cites this paper
• JM91, a newly synthesized indoledione derivative, inhibits rat aortic vascular smooth muscle cells proliferation and cell cycle progression through inhibition of ERK1/2 and Akt activations.

  2008cites this paper
• Pathogenic Mediators of Vessel Sclerosis: Regulation of Vascular Smooth Muscle Cell Proliferation by Growth Factors, the Extracellular Matrix, and the Endothelium

  2008cites this paper
• Abnormalities of insulin-like growth factor-I signaling and impaired cell proliferation in osteoblasts from subjects with osteoporosis.

  2008cites this paper
• Beneficial Effect of Atorvastatin on Left Ventricular Remodeling in Spontaneously Hypertensive Rats

  2007cites this paper
• EGF receptor activity modulates apoptosis induced by inhibition of the proteasome of vascular smooth muscle cells.

  2007cites this paper
• La diabetes mellitus tipo 2 como enfermedad cardiovascular

  2007cites this paper
• Efectos pleiotrópicos de telmisartán en el paciente diabético

  2007cites this paper
• Insulin causes a transient induction of proliferation via activation of the PI3-kinase pathway in airway smooth muscle cells.

  2007cites this paper
• Human antimicrobial peptide LL-37 is present in atherosclerotic plaques and induces death of vascular smooth muscle cells: a laboratory study

  2006cites this paper
• Osteoprotegerin: a pathological role in human abdominal aortic aneurysm

  2006cites this paper
• Melittin Inhibits Vascular Smooth Muscle Cell Proliferation through Induction of Apoptosis via Suppression of Nuclear Factor-κB and Akt Activation and Enhancement of Apoptotic Protein Expression

  2006influential citation
• Down-regulation of Manganese-Superoxide Dismutase through Phosphorylation of FOXO3a by Akt in Explanted Vascular Smooth Muscle Cells from Old Rats*

  2006cites this paper
• Insulin Signaling in Arteries Prevents Smooth Muscle Apoptosis

  2005cites this paper
• The Role of Reactive Oxygen Species in Insulin Signaling in the Vasculature

  2005cites this paper
• Activation of phosphatidylinositol 3-kinase, Akt, and mammalian target of rapamycin is necessary for hypoxia-induced pulmonary artery adventitial fibroblast proliferation.

  2005cites this paper
• Sustained orbital shear stress stimulates smooth muscle cell proliferation via the extracellular signal-regulated protein kinase 1/2 pathway.

  2005cites this paper
• Systematic Evaluation of Anti-apoptotic Growth Factor Signaling in Vascular Smooth Muscle Cells

  2005cites this paper
• Insulin signaling in arteries prevents smooth muscle apoptosis.

  2005cites this paper
• Aging alters vascular mechanotransduction: pressure-induced regulation of p70S6k in the rat aorta.

  2005cites this paper
• On How Insulin May Influence Ageing and Become Atherogenic throughout the Insulin-Like Growth Factor-1 Receptor Pathway: In vitro Studies with Human Vascular Smooth Muscle Cells

  2005cites this paper
• Native and oxidized low density lipoproteins oppositely modulate the effects of insulin-like growth factor I on VSMC

  2004cites this paper
• Dose-Dependent Effects of Platelet-Derived Growth Factor-B on Glial Tumorigenesis

  2004cites this paper
• Native and oxidized low density lipoproteins oppositely modulate the effects of insulin-like growth factor I on VSMC.

  2004cites this paper
• Inhibition of cell cycle progression and migration of vascular smooth muscle cells by prostaglandin D2 synthase: resistance in diabetic Goto-Kakizaki rats.

  2004cites this paper
• Induction of gicerin/CD146 in the rat carotid artery after balloon injury.

  2004cites this paper
• Dual role of SRC homology domain 2-containing inositol phosphatase 2 in the regulation of platelet-derived growth factor and insulin-like growth factor I signaling in rat vascular smooth muscle cells.

  2003cites this paper
• Prostaglandin D2 Synthase Inhibits the Exaggerated Growth Phenotype of Spontaneously Hypertensive Rat Vascular Smooth Muscle Cells*

  2003cites this paper
• Akt Controls Vascular Smooth Muscle Cell Proliferation In Vitro and In Vivo by Delaying G1/S Exit

  2003cites this paper
• Platelet-derived Growth Factor-BB-mediated Activation of Akt Suppresses Smooth Muscle-specific Gene Expression through Inhibition of Mitogen-activated Protein Kinase and Redistribution of Serum Response Factor*

  2003cites this paper
• A proatherogenic role for cGMP-dependent protein kinase in vascular smooth muscle cells

  2003cites this paper
• Oscillatory shear stress increases smooth muscle cell proliferation and Akt phosphorylation.

  2003cites this paper
• Insulin Stimulates Glucose Transport Via Nitric Oxide/Cyclic GMP Pathway in Human Vascular Smooth Muscle Cells

  2003cites this paper
• IGF-I but not insulin inhibits apoptosis at a low concentration in vascular smooth muscle cells.

  2003influential citation
• Resveratrol Attenuates Vascular Smooth Muscle Cell Hypertrophy and Hyperplasia

  2003cites this paper
• Age-dependent decline of in vitro migration (basal and stimulated by IGF-1 or insulin) of human vascular smooth muscle cells.

  2003cites this paper
• Results Insulin Stimulates Glucose Transport and a Rapid Increase of GLUT 4 at the Cell Surface in hVSMCs : Both Are

  2003cites this paper