CELLS INVOLVED IN THE IMMUNE RESPONSE

Bone marrow cells obtained from rabbits of one allotype were injected into irradiated rabbits of a different allotype. The recipients were also injected with sheep red blood cells, and their spleen cells were tested for plaque-forming capacity 7 days later. Spleen cells of all recipients gave large numbers of plaques as did spleen cells incubated with antiserum, directed toward donor allotype. However, incubation of the recipient spleen cells with antiserum directed toward recipient allotype completely suppressed plaque formation. These results demonstrate that antibody-formation in irradiated recipients of transferred lymphoid cells is a property of the recipient animal and that the antibody-forming cell is relatively irradiation-resistant. It was also demonstrated that only viable normal bone marrow cells are capable of transferring antibody-forming capacity to irradiated recipient rabbits. Neither sonicates nor heat-killed preparations of normal rabbit bone marrow cells possessed this capacity.

• Publication year

  1969

• Venue

  Journal of Experimental Medicine

• Publication date

  1969-06-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1084/JEM.129.6.1261PMID 4890861PMCID 2138661
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• CELLS INVOLVED IN THE IMMUNE RESPONSE

  1969cited by this paper
• Cells involved in the immune response. V. The migration of antigen-reactive immunocompetent cells out of the bone marrow following antigen administration.

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  1969cited by this paper
• CELLS INVOLVED IN THE IMMUNE RESPONSE

  1968cited by this paper
• Lymphocytes and Immunoglobulins

  1968cited by this paper
• BONE MARROW AS SOURCE OF CELLS IN REACTIONS OF CELLULAR HYPERSENSITIVITY

  1968cited by this paper
• Cells involved in the immune response. I. The response of normal rabbit bone marrow cells to antigens in vitro.

  1968cited by this paper
• THE ORIGIN AND KINETICS OF MONONUCLEAR PHAGOCYTES

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• STUDIES ON RABBIT LYMPHOCYTES IN VITRO

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• A THREE-CELL INTERACTION REQUIRED FOR THE INDUCTION OF THE PRIMARY IMMUNE RESPONSE in vitro.

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• CELL TO CELL INTERACTION IN THE IMMUNE RESPONSE

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• Cells involved in the immune response. 3. Responsiveness in antigens of a lymphocyte-rich fraction of normal rabbit bone marrow.

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• Immunological activity of thymus and thoracic-duct lymphocytes.

  1968influential reference
• The macrophage in allograft immunity. II. Passive transfer with immune macrophages.

  1968cited by this paper
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• CELL TO CELL INTERACTION IN THE IMMUNE RESPONSE

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• CELLS AS ANTIGEN CARRIERS AND AS IMMUNOGLOBULIN PRODUCERS

  1967cited by this paper
• Cellular immunity.

  1967cited by this paper
• PRIMARY STIMULATION AND MEASUREMENT OF ANTIBODY PRODUCTION TO SHEEP RED BLOOD CELLS IN VITRO

  1967cited by this paper
• In vitro demonstration of suppressive antibody in mouse antisera vs. allogeneic spleen cells.

  1967cited by this paper
• Role of macrophages in antibody production. Immune response to sheep red blood cells.

  1967cited by this paper
• Studies on the radiosensitive phase of the primary antibody response in rabbits. I. The role of the macrophage.

  1967cited by this paper
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  1967cited by this paper
• Suppression of transferred allogeneic spleen cells in the mouse: active induction and passive transfer by antiserum.

  1967cited by this paper
• The role of macrophages in the induction of antibody in x-irradiated animals.

  1967cited by this paper
• Immunoglobulin allotypes of experimental animals.

  1967cited by this paper
• THE FAILURE OF THYMUS‐DERIVED CELLS TO PRODUCE ANTIBODY

  1967cited by this paper
• Allotypic Specificity and Hemolytic Capacity of Antibodies Produced by Single Cells (Part 1 of 2)

  1967influential reference
• Detection of immune response against synthetic polymers of amino acids employing the plaque-forming cell system. I. Reaction with sheep erythrocytes coated with polymer.

  1967cited by this paper
• Antibody formation initiated in vitro. 3. Antibody formation and allotypic specificity directed by ribonucleic acid from peritoneal exudate cells.

  1966cited by this paper
• Immunocompetence of transferred thymus-marrow cell combinations.

  1966cited by this paper
• THE ORIGIN AND TURNOVER OF MONONUCLEAR CELLS IN PERITONEAL EXUDATES IN RATS

  1966cited by this paper
• Immunoglobulin M Allotypes of the Rabbit: Identification of a Second Specificity

  1966cited by this paper
• STUDIES ON RABBIT LYMPHOCYTES IN VITRO

  1965cited by this paper
• STUDIES ON RABBIT LYMPHOCYTES IN VITRO

  1965cited by this paper
• Facilitation of immune hemolysis by an interaction between red cell-sensitizing antibody and gamma-globulin allotype antibody.

  1965cited by this paper
• ANTIBODY FORMATION INITIATED IN VITRO

  1963cited by this paper
• Plaque Formation in Agar by Single Antibody-Producing Cells

  1963cited by this paper
• IMMUNOCHEMICAL IDENTIFICATION AND GENETICS OF RABBIT GAMMA-GLOBULIN ALLOTYPES.

  1963cited by this paper
• A Notation for Allotypy

  1962cited by this paper
• Heredity of Rabbit Gamma-Globulin Iso-Antigens

  1962cited by this paper
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  1961cited by this paper
• ALLOTYPY OF RABBIT SERUM PROTEINS

  1960cited by this paper
• ALLOTYPY OF RABBIT SERUM PROTEINS

  1960cited by this paper
• Two antigenically different gamma-globulins in domestic rabbits revealed by isoprecipitins.

  1959cited by this paper
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  1959cited by this paper
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  1959cited by this paper
• STUDIES ON THE TRANSFER OF LYMPH NODE CELLS

  1958cited by this paper
• Differences in the antigenic components of sera of individual rabbits as shown by induced isoprecipitins.

  1958cited by this paper
• Transfer of Lymph Node Cells to Recipient Rabbits Pre-Injected with Blood Leucocytes of Donors.†

  1957cited by this paper
• [The allotype of certain blood protein antigens].

  1956cited by this paper
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  1956cited by this paper
• STUDIES ON THE TRANSFER OF LYMPH NODE CELLS

  1956cited by this paper
• STUDIES ON THE TRANSFER OF LYMPH NODE CELLS

  1954cited by this paper
• Cells Involved in the Immune Response Iv. the Response of Nop.~al and I~xo~m Rabbit Bone Ma~ow and Lymphoid Tissue Ly~fphocytes to Antigens in Vitro*

  year unknowncited by this paper

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  1976cites this paper
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  1975cites this paper
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  1975cites this paper
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  1972cites this paper
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  1971cites this paper
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  1971cites this paper
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  1971cites this paper
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  1969cites this paper
• CELLS INVOLVED IN THE IMMUNE RESPONSE

  1969cites this paper
• CELLS INVOLVED IN THE IMMUNE RESPONSE

  1969cites this paper
• CELLS INVOLVED IN THE IMMUNE RESPONSE

  1969cites this paper
• CELLS INVOLVED IN THE IMMUNE RESPONSE

  1969cites this paper