BONE MARROW AS SOURCE OF CELLS IN REACTIONS OF CELLULAR HYPERSENSITIVITY

Splenectomy or thymectomy of adult Lewis rats following sensitization with tubercle bacilli did not affect their ability to develop delayed skin lesions upon skin testing with PPD. The presence of the thymus also had no significant effect on reactivity of the recipients in passive transfer experiments. The passive transfer of tuberculin hypersensitivity with sensitized lymph node cells to thymectomized, irradiated recipients depended on the simultaneous or prior injection of normal bone marrow cells. When lymph node cell transfer was performed shortly after irradiation and injection of marrow, high doses of marrow cells (3.5–4.0 x 108 were required to permit eliciting reactions of reasonable intensity. If, however, periods of 7–10 days elapsed between the injection of bone marrow and sensitized lymph node cells, lower doses of marrow were sufficient for comparable reactions. Normal thymus, spleen, lymph node, or peritoneal exudate cells, even at high doses could not be substituted for the bone marrow in producing good tuberculin reactions.

• Publication year

  1968

• Venue

  Journal of Experimental Medicine

• Publication date

  1968-11-30

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1084/JEM.128.6.1425PMID 4880000PMCID 2138576
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The mononuclear-cell infiltrate in allergic contact dermatitis. 2. Selective accumulation of cells from the bone marrow.

  2009cited by this paper
• BONE MARROW AS SOURCE OF CELLS IN REACTIONS OF CELLULAR HYPERSENSITIVITY

  1968cited by this paper
• The mononuclear-cell infiltrate in allergic contact dermatitis. 1. Participation of thymic cells.

  1967cited by this paper
• Role of the Thymus in Tolerance

  1967cited by this paper
• Delayed Hypersensitivity: Bone Marrow as the Source of Cells in Delayed Skin Reactions

  1967cited by this paper
• THE ORIGIN AND TURNOVER OF MONONUCLEAR CELLS IN PERITONEAL EXUDATES IN RATS

  1966cited by this paper
• Homograft target cells: contact destruction in vitro by immune macrophages.

  1966cited by this paper
• Interrelationships of myeloid and lymphoid cells: studies with chromosome-marked cells transfused into lethally irradiated mice

  1966cited by this paper
• ROLE OF THE THYMUS IN TOLERANCE

  1965cited by this paper
• THE ORIGIN OF MACROPHAGES FROM BONE MARROW IN THE RAT.

  1965cited by this paper
• Tuberculin Hypersensitivity: Studies with Radioactive Antigen and Mononuclear Cells

  1963cited by this paper
• Radioautographic study of cellular mechanisms in delayed hypersensitivity. I. Delayed reactions to tuberculin and purified proteins in the rat and guinea-pig.

  1963cited by this paper
• Studies on the specificity of the cellular infiltrate of delayed hypersensitivity reactions.

  1963cited by this paper
• STUDIES ON THE SPECIFICITY OF THE CELLULAR INFILTRATE IN DELAYED HYPERSENSITIVITY REACTIONS.

  1963cited by this paper
• SPECIFICITY OF PASSIVELY TRANSFERRED DELAYED HYPERSENSITIVITY

  1963cited by this paper
• The passive transfer of delayed hypersensitivity in guinea pigs by the transfusion of isotopically-labelled lymphoid cells.

  1962cited by this paper
• PASSIVE TRANSFER OF TUBERCULIN SENSITIVITY BY TRITIATED THYMIDINE-LABELED LYMPHOID CELLS

  1961cited by this paper
• The histology of the tuberculin reaction and its modification by cortisone.

  1951cited by this paper

• Macrophages As Effectors Of Cell-Mediated Immunity

  2020cites this paper
• Pillars Article: Peculiar Immunobiology of Bone Marrow Allografts: I. Graft Rejection by Irradiated Responder Mice. J Exp Med. 1971. 134: 83-102.

  2015cites this paper
• Effect of irradiation on established delayed hypersensitivity. Suppression of skin reactions, recovery and the effect of cell transfer.

  2009cites this paper
• DADA-17-68-C-8124, by Grant AI-07809 from the United States-Japan Cooperative Medical Science Program administered by the National Institute of Allergy and Infectious Diseases, and in part by Grant AM-11038 from the National Institute of Arthritis and Metabolic Dis-

  2003cites this paper
• Effects of total body irradiation and cyclosporin a on the lethality of toxic shock syndrome toxin-1 in a rabbit model of toxic shock syndrome.

  2003cites this paper
• Passive Transfer of Tuberculin HypersensiHvity with Lymph Node Cdls.--TeehnJques

  2003cites this paper
• Culture Medium , Hormones , and Growth Factors

  2003cites this paper
• Plaque-Forming Ability of the Different Rabbit Lymphoid Tissues and the Optimal Conditions for the Induction of Primed Bone Marrow In Vivo and of Hemolytic Plaques In Vitro

  2003cites this paper
• Passive Transfer of Tuberculin HypersensiHvity with Lymph Node Cdls.--TeehnJques

  2003cites this paper
• Parental Strain Thymus and Bone Marrow Cells Do Not Interact to Produce Splenomegaly in Unirradiated LAF 1 Hosts

  2003cites this paper
• ALVIN VOLKMAN AND

  2003cites this paper
• β-Estradiol Suppresses T Cell-Mediated Delayed-Type Hypersensitivity through Suppression of Antigen-Presenting Cell Function and Th1 Induction

  2000cites this paper
• Transfer of the inflammatory disease of HLA-B27 transgenic rats by bone marrow engraftment

  1993cites this paper
• Pathogenic and non-pathogenic T lymphocytes specific for the encephalitogenic epitope of myelin basic protein: functional characteristics and vaccination properties.

  1993cites this paper
• A comparison of regulatory cells in spinal fluid and blood in patients with multiple sclerosis and other neurologic diseases

  1990cites this paper
• The role of lymphotoxin in inflammation.

  1988cites this paper
• Involvement of Antigen-Specific T Cell Factors in Regulation of Separate Steps in the Delayed-Type Hypersensitivity Cascade

  1987cites this paper
• Human monoclonal antibody by an established human-human hybridoma.

  1987cites this paper
• The absence of delayed-type hypersensitivity reactivity in a syngeneic murine tumour system.

  1987cites this paper
• Experimental allergic encephalomyelitis in the absence of a classical delayed-type hypersensitivity reaction. Severe paralytic disease correlates with the presence of interleukin 2 receptor-positive cells infiltrating the central nervous system

  1987cites this paper
• The mechanism of inhibition of experimental allergic encephalomyelitis in the rat by monoclonal antibody against CD4.

  1986cites this paper
• Local transfer of delayed-type hypersensitivity after Salmonella infection in mice

  1985cites this paper
• The cellular response to Listeria monocytogenes is mediated by a heterogeneous population of immunospecific T cells.

  1984cites this paper
• A selective culture system for generating terminal deoxynucleotidyl transferase-positive (TdT+) lymphoid precursor cells in vitro. I. Description of the culture system

  1984cites this paper
• Allergic contact dermatitis in children.

  1984cites this paper
• Immunopathology of Delayed Hypersensitivity

  1983cites this paper
• Delayed-type hypersensitivity: activation of mast cells by antigen-specific T-cell factors initiates the cascade of cellular interactions.

  1983cites this paper
• Intracellular parasites and phagocytic cells: cell biology and pathophysiology.

  1982cites this paper
• Localization of leucocytes in sites of delayed-type hypersensitivity and in lymph nodes: dependence on vasoactive amines.

  1982cites this paper
• The role of cell-mediated immunity in bacterial infections.

  1981cites this paper
• Delayed expulsion of the nematode Nippostrongylus brasiliensis from rats on a low protein diet: the role of a bone marrow derived component.

  1981cites this paper
• The immunology of leprosy: speculations on the leprosy spectrum.

  1981cites this paper
• Histamine inhibition of the in vitro induction of cytotoxic T-cell responses.

  1980cites this paper
• Contemporary Topics in Immunobiology

  1980cites this paper
• Mechanisms of hypersensitivity: cellular interactions. Basophil arrival and function in tissue hypersensitivity reactions.

  1979cites this paper
• Binding of bacterial lipopolysaccharide to histocompatibility-2-complex proteins of mouse lymphocytes.

  1979cites this paper
• The collaboration of T-cell subsets in the mitogenic stimulation of purified B-cell subpopulations.

  1979cites this paper
• Ultrastructural findings in the mouse exocrine pancreas during graft-versus host reaction.

  1978cites this paper
• Irradiation potentiation of cellular transfer of EAE: time course and locus of effect in irradiated recipient Lewis rats.

  1978cites this paper
• Regulation of delayed-type hypersensitivity reactions by cyclophosphamide-sensitive T cells.

  1978cites this paper
• Site of action of serum factors that block delayed-type hypersensitivity in mice

  1978cites this paper
• Impaired chemotactic responsiveness of macrophages from gnotobiotic rats

  1978cites this paper
• Regulation of the Immune Response

  1978cites this paper
• Tumor-growth suppression in vivo: cooperation between immune lymphoid cells sensitized in vitro and nonimmune bone marrow cells.

  1978cites this paper
• Characterization of macrophage cytotoxicity factor (MCF).

  1977cites this paper
• Mononuclear phagocyte. Development, structure, function, and involvement in immune response.

  1977cites this paper
• Induction in B2/B2 chickens of immunity to transplantable carcinogen-induced fibrosarcomas mediated by T-cell monocyte cooperation: role of delayed hypersensitivity to unrelated antigens.

  1977cites this paper
• Isolation and characterization of membrane receptors for pokeweed mitogens from mouse lymphocytes.

  1977cites this paper
• Acute inflammation. A review.

  1977cites this paper
• ADCC effector cells in a murine adenocarcinoma. I. Evidence for blood‐borne bone‐marrow‐derived monocytes

  1977cites this paper
• Passive transfer of systemic tumor immunity with cells generated in vitro by a secondary immune response to a syngeneic rat gross virus-induced lymphoma.

  1977cites this paper
• Metabolism and Functions of Monocytes and Macrophages

  1977cites this paper
• The lymphoreticular response to a transplanted adenovirus 12‐induced tumour of CBA mice

  1976cites this paper
• [Regulation mechanisms of the activity of T lymphocytes : applications to infective and tumoral pathology. II. -- BCG and immuno-stimulation (author's transl)].

  1976cites this paper
• Graft-versus-Host reactions: a review.

  1976cites this paper
• 18 – Induction of Macrophage-Mediated Cytotoxicity

  1976cites this paper
• Listeria cell wall fraction: a B cell adjuvant.

  1976cites this paper
• Secretory function of mononuclear phagocytes: a review.

  1976cites this paper
• DISSEMINATED SYSTEMIC EXPRESSION OF THE “LOCAL” POPLITEAL LYMPH NODE ASSAY IN RATS

  1976cites this paper
• Das Monozyten-Makrophagen-System

  1976cites this paper
• [Rheumatoid polyarthritis: increase of M cells in blood mononuclear subpopulations].

  1976cites this paper
• Small lymphocyte and transitional cell populations of the bone marrow; their role in the mediation of immune and hemopoietic progenitor cell functions.

  1976cites this paper
• Immunocompetent cells in resistance to bacterial infections

  1976cites this paper
• [Immunobiology of tuberculosis].

  1976cites this paper
• Studies on the pathogenesis of experimental autoimmune renal tubulointerstitial disease in guinea pigs.1 II. passive transfer of renal lesions by anti-tubular basement membrane autoantibody and nonimmune bone marrow cells to leukocyte-depleted recipients.

  1976cites this paper
• Type IV reactions in the skin.

  1976cites this paper
• Migration of lymphoblasts to the small intestine. II. Divergent migration of mesenteric and peripheral immunoblasts to sites of inflammation in the mouse.

  1976cites this paper
• Immunocompetent cells in resistance to bacterial infections.

  1976cites this paper
• Purification and biological activities of pokeweek (Phytolacca americana) mitogens.

  1976cites this paper
• Selective macrophage cytotoxicity of carrageenan in vivo.

  1975cites this paper
• BCG immunopotentiation of an antitumor response: evidence for a cell-mediated mechanism.

  1975cites this paper
• Mononuclear phagocyte proliferation, maturation and function.

  1975cites this paper
• LYMPHOKINES IN RHEUMATOID SYNOVITIS

  1975cites this paper
• Requirement for a bone marrow-derived component in the expression of cell-mediated antibacterial immunity

  1975cites this paper
• Requirement for vasoactive amines for production of delayed-type hypersensitvity skin reactions

  1975cites this paper
• Studies on the pathogenesis of experimental autoimmune renal tubulointerstitial disease in guinea pigs. 1. Inhibition of tissue injury in leukocyte-depleted passive transfer recipients.

  1975cites this paper
• Enhancement of host defense mechanisms by pharmacological agents.

  1975cites this paper
• Hyporeactivity to tuberculin in germ-free mice.

  1975cites this paper
• Role for cell-mediated immunity in the resistance of mice to subcutaneous herpes simplex virus infection

  1975cites this paper
• The monocyte disorder with herpes zoster.

  1974cites this paper
• Antigenic competition: a review of nonspecific antigen-induced suppression.

  1974cites this paper
• Requirement for bone marrow-derived cells in resistance to Listeria.

  1974cites this paper
• T Cell Response to Viral and Bacterial Infection

  1974cites this paper
• Localization of non-immune radioactively labelled cells in the lesions of contact sensitivity in mice.

  1974cites this paper
• Vaccines and cell-mediated immunity

  1974cites this paper
• Passive Transfer of Delayed Hypersensitivity to Blastomyces dermatitidis Between Mice

  1974cites this paper
• The "Three R's" of Delayed Hypersensitivity

  1974cites this paper
• Pathogenesis of Rinderpest Virus Infection in Rabbits II. Effect of Rinderpest Virus on the Immune Functions of Rabbits

  1974cites this paper
• Anti-tumour Activity of Aprotinin

  1974cites this paper
• The Metabolism and Physiology of the Mononuclear Phagocytes

  1974cites this paper
• Vaccines and cell-mediated immunity.

  1974cites this paper
• THE CYTOKINETICS OF MONOCYTOSIS IN ACUTE SALMONELLA INFECTION IN THE RAT

  1974cites this paper
• Stimulatory and inhibitory effects of graft-versus-host reactions on contact sensitivity in mice.

  1974cites this paper
• Immune responses in elderly cuti-negative subjects and the effect of levamisole.

  1973cites this paper
• Immunologic defenses against cancer.

  1973cites this paper
• Lymphoid cells in carcinoma of the breast. Failure of response to phytohaemagglutinin in vitro.

  1973cites this paper
• T‐Cell Cytotoxicity and Amplification of the Cytotoxic Reaction by Macrophages

  1973cites this paper
• Bone marrow origin of nonsensitized effector cells in skin allograft rejection.

  1973cites this paper
• Immunologic models used for the study of rheumatoid arthritis.

  1973cites this paper
• Lymphocyte mediators and cellular hypersensitivity.

  1973cites this paper