NTF2 mediates nuclear import of Ran

No abstract is available for this paper.

• Publication year

  1998

• Venue

  EMBO Journal

• Publication date

  1998-11-16

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1093/emboj/17.22.6587PMID 9822603PMCID PMC1171005
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Functions of the GTPase Ran in RNA export from the nucleus.

  1998influential reference
• Transport of macromolecules between the nucleus and the cytoplasm.

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• Import and export of the nuclear protein import receptor transportin by a mechanism independent of GTP hydrolysis.

  1998cited by this paper
• Structural basis for molecular recognition between nuclear transport factor 2 (NTF2) and the GDP-bound form of the Ras-family GTPase Ran.

  1998cited by this paper
• Transport into and out of the cell nucleus

  1998cited by this paper
• Importin β, transportin, RanBP5 and RanBP7 mediate nuclear import of ribosomal proteins in mammalian cells

  1998influential reference
• Nucleocytoplasmic transport: the soluble phase.

  1998influential reference
• Identification of a tRNA-specific nuclear export receptor.

  1998cited by this paper
• Identification of a nuclear export receptor for tRNA.

  1998cited by this paper
• The nuclear import factor p10 regulates the functional size of the nuclear pore complex during oogenesis.

  1998influential reference
• A distinct nuclear import pathway used by ribosomal proteins.

  1997cited by this paper
• A Novel Class of RanGTP Binding Proteins

  1997cited by this paper
• RanBP2 associates with Ubc9p and a modified form of RanGAP1.

  1997cited by this paper
• Molecular interactions between the importin alpha/beta heterodimer and proteins involved in vertebrate nuclear protein import.

  1997cited by this paper
• Disassembly of RanGTP-Karyopherin β Complex, an Intermediate in Nuclear Protein Import*

  1997cited by this paper
• RanBP1 is crucial for the release of RanGTP from importin β‐related nuclear transport factors

  1997cited by this paper
• Export of importin alpha from the nucleus is mediated by a specific nuclear transport factor.

  1997cited by this paper
• Nuclear import of hnRNP A 1 is mediated by a novel cellular cofactor related to karyopherin-β

  1997cited by this paper
• High Levels of the GTPase Ran/TC4 Relieve the Requirement for Nuclear Protein Transport Factor 2*

  1997cited by this paper
• Ran-binding Protein 1 (RanBP1) Forms a Ternary Complex with Ran and Karyopherin β and Reduces Ran GTPase-activating Protein (RanGAP) Inhibition by Karyopherin β*

  1997cited by this paper
• Nuclear import of hnRNP A1 is mediated by a novel cellular cofactor related to karyopherin-beta.

  1997cited by this paper
• Nuclear protein import is decreased by engineered mutants of nuclear transport factor 2 (NTF2) that do not bind GDP-Ran.

  1997cited by this paper
• Requirement of guanosine triphosphate-bound ran for signal-mediated nuclear protein export.

  1997cited by this paper
• Yrb4p, a yeast Ran–GTP‐binding protein involved in import of ribosomal protein L25 into the nucleus

  1997cited by this paper
• The asymmetric distribution of the constituents of the Ran system is essential for transport into and out of the nucleus

  1997cited by this paper
• Dominant‐negative mutants of importin‐β block multiple pathways of import and export through the nuclear pore complex

  1997cited by this paper
• The human homologue of yeast CRM1 is in a dynamic subcomplex with CAN/Nup214 and a novel nuclear pore component Nup88

  1997cited by this paper
• Molecular interactions between the importin α/β heterodimer and proteins involved in vertebrate nuclear protein import

  1997cited by this paper
• CRM1 is an export receptor for leucine-rich nuclear export signals.

  1997cited by this paper
• Interaction between the small GTPase Ran/Gsp1p and Ntf2p is required for nuclear transport

  1997cited by this paper
• A small ubiquitin-related polypeptide involved in targeting RanGAP1 to nuclear pore complex protein RanBP2.

  1997cited by this paper
• Ran-unassisted Nuclear Migration of a 97-kD Component of Nuclear Pore–targeting Complex

  1997cited by this paper
• Transportin-mediated Nuclear Import of Heterogeneous Nuclear RNP Proteins

  1997cited by this paper
• Characterization of the nuclear protein import mechanism using Ran mutants with altered nucleotide binding specificities.

  1996cited by this paper
• A novel ubiquitin-like modification modulates the partitioning of the Ran-GTPase-activating protein RanGAP1 between the cytosol and the nuclear pore complex

  1996cited by this paper
• Importin provides a link between nuclear protein import and U snRNA export.

  1996cited by this paper
• Identification of different roles for RanGDP and RanGTP in nuclear protein import.

  1996cited by this paper
• A nuclear export signal is essential for the cytosolic localization of the Ran binding protein, RanBP1

  1996cited by this paper
• RAN/TC4 mutants identify a common requirement for snRNP and protein import into the nucleus

  1996cited by this paper
• RanBP1 stabilizes the interaction of Ran with p97 nuclear protein import

  1996cited by this paper
• Nucleotide-specific interaction of Ran/TC4 with nuclear transport factors NTF2 and p97.

  1996influential reference
• Separate binding sites on nuclear transport factor 2 (NTF2) for GDP-Ran and the phenylalanine-rich repeat regions of nucleoporins p62 and Nsp1p.

  1996cited by this paper
• Crystallization and preliminary X-ray diffraction analysis of nuclear transport factor 2.

  1996cited by this paper
• The NTF2 Gene Encodes an Essential, Highly Conserved Protein That Functions in Nuclear Transport in Vivo*

  1996influential reference
• Role of the Nuclear Transport Factor p10 in Nuclear Import

  1996influential reference
• Human RanGTPase activating protein RanGAP1 is a homolog of yeast RNA1p involved in messenger RNA processing and transport

  1995cited by this paper
• Co‐activation of RanGTPase and inhibition of GTP dissociation by Ran‐GTP binding protein RanBP1.

  1995cited by this paper
• Crystal structure of the nuclear Ras-related protein Ran in its GDP-bound form

  1995cited by this paper
• Identification of NTF2, a cytosolic factor for nuclear import that interacts with nuclear pore complex protein p62

  1995influential reference
• Protein import into nuclei: association and dissociation reactions involving transport substrate, transport factors, and nucleoporins.

  1995cited by this paper
• RNA1 Encodes a GTPase-activating Protein Specific for Gsp1p, the Ran/TC4 Homologue of Saccharomyces cerevisiae(*)

  1995cited by this paper
• Human RanGTPase-activating protein RanGAP1 is a homologue of yeast Rna1p involved in mRNA processing and transport.

  1995cited by this paper
• Mutants in a yeast Ran binding protein are defective in nuclear transport.

  1995influential reference
• Interaction of the nuclear GTP-binding protein Ran with its regulatory proteins RCC1 and RanGAP1.

  1995influential reference
• The C Terminus of the Nuclear RAN/TC4 GTPase Stabilizes the GDP-bound State and Mediates Interactions with RCC1, RAN-GAP, and HTF9A/RANBP1 (*)

  1995cited by this paper
• RanGAP1 induces GTPase activity of nuclear Ras-related Ran.

  1994cited by this paper
• Purification of a Ran-interacting protein that is required for protein import into the nucleus.

  1994influential reference
• A functional homologue of the RNA1 gene product in Schizosaccharomyces pombe: purification, biochemical characterization, and identification of a leucine-rich repeat motif.

  1993cited by this paper
• Ran/TC4: a small nuclear GTP-binding protein that regulates DNA synthesis

  1993cited by this paper
• Characterization of proteins that interact with the cell-cycle regulatory protein Ran/TC4

  1993influential reference
• Inhibition of nuclear protein import by nonhydrolyzable analogues of GTP and identification of the small GTPase Ran/TC4 as an essential transport factor [published erratum appears in J Cell Biol 1994 Jan;124(1-2):217]

  1993cited by this paper
• The GTP-binding protein Ran/TC4 is required for protein import into the nucleus

  1993cited by this paper
• CSE1 and CSE2, two new genes required for accurate mitotic chromosome segregation in Saccharomyces cerevisiae

  1993cited by this paper
• Mitotic regulator protein RCC1 is complexed with a nuclear ras-related polypeptide.

  1991cited by this paper
• Catalysis of guanine nucleotide exchange on Ran by the mitotic regulator RCC1

  1991influential reference
• The yeast RNA1 gene product necessary for RNA processing is located in the cytosol and apparently excluded from the nucleus

  1990influential reference
• Facilitated nuclear transport of histone H1 and other small nucleophilic proteins.

  1990cited by this paper
• Nuclear protein import in permeabilized mammalian cells requires soluble cytoplasmic factors

  1990cited by this paper
• The RCC1 protein, a regulator for the onset of chromosome condensation locates in the nucleus and binds to DNA

  1989influential reference
• Movement of a karyophilic protein through the nuclear pores of oocytes

  1984cited by this paper
• tRNA transport from the nucleus in a eukaryotic cell: carrier-mediated translocation process.

  1983cited by this paper
• The Cell Nucleus

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