The endocrine role between β cells and intra-islet endothelial cells.

No abstract is available for this paper.

• Publication year

  2014

• Venue

  Endocrine journal

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1507/ENDOCRJ.EJ14-0045PMID 24681780
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The β-Cell/EC Axis: How Do Islet Cells Talk to Each Other?

  2013cited by this paper
• Dipeptidyl Peptidase IV Inhibition Activates CREB and Improves Islet Vascularization through VEGF-A/VEGFR-2 Signaling Pathway

  2013cited by this paper
• Altered Islet Morphology but Normal Islet Secretory Function In Vitro in a Mouse Model with Microvascular Alterations in the Pancreas

  2013cited by this paper
• FOXO1 mediates the autocrine effect of endothelin-1 on endothelial cell survival.

  2012cited by this paper
• Enhanced expression of VEGF-A in β cells increases endothelial cell number but impairs islet morphogenesis and β cell proliferation.

  2012cited by this paper
• Heparan sulfate and heparanase play key roles in mouse β cell survival and autoimmune diabetes.

  2012cited by this paper
• VEGF signaling inside vascular endothelial cells and beyond.

  2012cited by this paper
• CCN2/Connective Tissue Growth Factor Is Essential for Pericyte Adhesion and Endothelial Basement Membrane Formation during Angiogenesis

  2012cited by this paper
• Donor Islet Endothelial Cells in Pancreatic Islet Revascularization

  2011cited by this paper
• The thrombospondins.

  2011cited by this paper
• Type 1 diabetes: etiology, immunology, and therapeutic strategies.

  2011cited by this paper
• Thrombospondin-1: An Islet Endothelial Cell Signal of Importance for β-Cell Function

  2011cited by this paper
• Integrin {alpha}3, but not {beta}1, regulates islet cell survival and function via PI3K/Akt signaling pathways.

  2011cited by this paper
• Endothelial Cells in Co-culture Enhance Embryonic Stem Cell Differentiation to Pancreatic Progenitors and Insulin-Producing Cells through BMP Signaling

  2011cited by this paper
• Islet Graft Survival and Function: Concomitant Culture and Transplantation With Vascular Endothelial Cells in Diabetic Rats

  2011cited by this paper
• Glucose and inflammation control islet vascular density and beta-cell function in NOD mice: control of islet vasculature and vascular endothelial growth factor by glucose.

  2011cited by this paper
• Improving Islet Engraftment by Gene Therapy

  2011cited by this paper
• The therapeutic role of endothelial progenitor cells in Type 1 diabetes mellitus.

  2011cited by this paper
• Conditional β1‐integrin‐deficient mice display impaired pancreatic β cell function

  2011cited by this paper
• Connective tissue growth factor acts within both endothelial cells and β cells to promote proliferation of developing β cells

  2011cited by this paper
• Endothelial cells promote pancreatic stem cell activation during islet regeneration in mice.

  2011cited by this paper
• The role of blood vessels, endothelial cells, and vascular pericytes in insulin secretion and peripheral insulin action.

  2010cited by this paper
• 'Giving and taking': endothelial and beta-cells in the islets of Langerhans.

  2010cited by this paper
• The effect of extracellular matrix components on the preservation of human islet function in vitro.

  2010cited by this paper
• MR imaging of pancreatic islets: tracking isolation, transplantation and function.

  2010influential reference
• Connective tissue growth factor (CTGF) inactivation leads to defects in islet cell lineage allocation and beta-cell proliferation during embryogenesis.

  2009cited by this paper
• The interaction of Thrombospondins with extracellular matrix proteins

  2009cited by this paper
• β1 integrin/FAK/ERK signalling pathway is essential for human fetal islet cell differentiation and survival

  2009cited by this paper
• Endothelial cells in pancreatic islet development and function

  2009cited by this paper
• Regulated laminin‐332 expression in human islets of Langerhans

  2009cited by this paper
• The Met tyrosine kinase receptor in development and cancer

  2008cited by this paper
• Magic-Factor 1, a Partial Agonist of Met, Induces Muscle Hypertrophy by Protecting Myogenic Progenitors from Apoptosis

  2008cited by this paper
• Improved Vascular Engraftment and Graft Function After Inhibition of the Angiostatic Factor Thrombospondin-1 in Mouse Pancreatic Islets

  2008cited by this paper
• Blood vessels of human islets of Langerhans are surrounded by a double basement membrane

  2008cited by this paper
• Unique basement membrane structure of human pancreatic islets: implications for β‐cell growth and differentiation

  2008cited by this paper
• Angiopoietin-1 Production in Islets Improves Islet Engraftment and Protects Islets From Cytokine-Induced Apoptosis

  2007cited by this paper
• Protein Kinase C-ζ Activation Markedly Enhances β-Cell Proliferation

  2007cited by this paper
• Protein kinase C-zeta activation markedly enhances beta-cell proliferation: an essential role in growth factor mediated beta-cell mitogenesis.

  2007cited by this paper
• Structure and Function of Basement Membranes

  2007cited by this paper
• Elevation of vascular endothelial growth factor production and its effect on revascularization and function of graft islets in diabetic rats.

  2007cited by this paper
• Improving islet transplantation by gene delivery of hepatocyte growth factor (HGF) and its downstream target, protein kinase B (PKB)/Akt

  2007cited by this paper
• The pancreatic islet endothelial cell: emerging roles in islet function and disease.

  2006influential reference
• VEGF-dependent plasticity of fenestrated capillaries in the normal adult microvasculature.

  2006cited by this paper
• Signaling and Functions of Angiopoietin-1 in Vascular Protection

  2006cited by this paper
• The vascular basement membrane: a niche for insulin gene expression and Beta cell proliferation.

  2006cited by this paper
• Pancreatic Islet Production of Vascular Endothelial Growth Factor-A Is Essential for Islet Vascularization, Revascularization, and Function

  2006cited by this paper
• Islet endothelial cells and pancreatic beta-cell proliferation: studies in vitro and during pregnancy in adult rats.

  2006cited by this paper
• Conditional Expression of Smad7 in Pancreatic β Cells Disrupts TGF-β Signaling and Induces Reversible Diabetes Mellitus

  2006cited by this paper
• Hepatocyte growth factor gene therapy for islet transplantation

  2004cited by this paper
• Microvascular development: learning from pancreatic islets

  2004cited by this paper
• Regulation of Human β-Cell Adhesion, Motility, and Insulin Secretion by Collagen IV and Its Receptor α1β1*

  2004cited by this paper
• Vascular Endothelial Growth Factor and Angiogenesis

  2004cited by this paper
• Regulation of human beta-cell adhesion, motility, and insulin secretion by collagen IV and its receptor alpha1beta1.

  2004cited by this paper
• ERK and MMPs sequentially regulate distinct stages of epithelial tubule development.

  2004cited by this paper
• Knockout of insulin and IGF-1 receptors on vascular endothelial cells protects against retinal neovascularization.

  2003cited by this paper
• Fibronectin at a glance

  2002cited by this paper
• Regulation of laminin 1-induced pancreatic beta-cell differentiation by alpha6 integrin and alpha-dystroglycan.

  2001cited by this paper
• Regulation of Laminin 1-Induced Pancreatic β-Cell Differentiation by α6 Integrin and α-Dystroglycan

  2001cited by this paper
• Transgenic overexpression of hepatocyte growth factor in the beta-cell markedly improves islet function and islet transplant outcomes in mice.

  2001cited by this paper
• High glucose levels enhance TGF-beta1-thrombospondin-1 pathway in cultured human mesangial cells via mechanisms dependent on glucose-induced PKC activation.

  2001cited by this paper
• The cell biology of thrombospondin-1.

  2000cited by this paper
• Hepatocyte Growth Factor Overexpression in the Islet of Transgenic Mice Increases Beta Cell Proliferation, Enhances Islet Mass, and Induces Mild Hypoglycemia*

  2000cited by this paper
• Regulation of endothelial constitutive nitric oxide synthase gene expression in endothelial cells and in vivo : a specific vascular action of insulin.

  2000cited by this paper
• Endothelin-1 (ET-1)-potentiated insulin secretion: involvement of protein kinase C and the ET(A) receptor subtype.

  2000cited by this paper
• Hepatocyte growth factor is essential for amelioration of hyperglycemia in streptozotocin-induced diabetic mice receiving a marginal mass of intrahepatic islet grafts.

  1999cited by this paper
• Laminin-1 promotes differentiation of fetal mouse pancreatic beta-cells.

  1999cited by this paper
• Maintenance of beta-cell function and survival following islet isolation requires re-establishment of the islet-matrix relationship.

  1999cited by this paper
• Hypoxia induces vascular endothelial growth factor gene and protein expression in cultured rat islet cells.

  1998cited by this paper
• Thrombospondin-1 is a major activator of TGF-beta1 in vivo.

  1998cited by this paper
• Thrombospondin-1 Is a Major Activator of TGF-β1 In Vivo

  1998cited by this paper
• Evidence for a Role of Rho-like GTPases and Stress-activated Protein Kinase/c-Jun N-terminal Kinase (SAPK/JNK) in Transforming Growth Factor β-mediated Signaling*

  1997cited by this paper
• CD36 Mediates the In Vitro Inhibitory Effects of Thrombospondin-1 on Endothelial Cells

  1997cited by this paper
• Endogenous Insulin Modulates Circulating Endothelin-1 Concentrations in Humans

  1996cited by this paper
• Mechanisms of the Glycaemic Effects of Sulfonylureas

  1996cited by this paper
• A role for hepatocyte growth factor/scatter factor in fetal mesenchyme-induced pancreatic beta-cell growth.

  1996cited by this paper
• Endothelin-1 stimulates insulin secretion by direct action on the islets of Langerhans in mice

  1996cited by this paper
• The Role of Cell Adhesion Molecules in the Development of IDDM: Implications for Pathogenesis and Therapy

  1996cited by this paper
• Ontogeny of hepatocyte growth factor and c-met/hgf receptor in rat pancreas.

  1996cited by this paper
• Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice

  1995cited by this paper
• Hepatocyte growth factor/scatter factor modulates cell motility, proliferation, and proteoglycan synthesis of chondrocytes

  1995cited by this paper
• Insulin Stimulates Production and Secretion of Endothelin From Bovine Endothelial Cells

  1993cited by this paper
• The met oncogene: from detection by transfection to transmembrane receptor for hepatocyte growth factor.

  1992cited by this paper
• The Role of Basement Membranes in Vascular Development

  1990cited by this paper
• A novel potent vasoconstrictor peptide produced by vascular endothelial cells

  1988cited by this paper

• Generation of vascularized pancreatic progenitors through co-differentiation of endoderm and mesoderm from human pluripotent stem cells

  2024cites this paper
• Single-cell transcriptome analysis reveals the regulatory functions of islet exocrine cells after short-time obesogenic diet

  2024cites this paper
• An update on pancreatic regeneration mechanisms: Searching for paths to a cure for type 2 diabetes

  2023cites this paper
• Challenges and opportunities in the islet transplantation microenvironment: a comprehensive summary of inflammatory cytokine, immune cells, and vascular endothelial cells

  2023cites this paper
• Crosstalk Communications Between Islets Cells and Insulin Target Tissue: The Hidden Face of Iceberg

  2022cites this paper
• Development of scaffold-free vascularized pancreatic beta-islets in vitro models by the anchoring of cell lines to a bioligand-functionalized gelatine substrate

  2022cites this paper
• Bioengineering the Vascularized Endocrine Pancreas: A Fine-Tuned Interplay Between Vascularization, Extracellular-Matrix-Based Scaffold Architecture, and Insulin-Producing Cells

  2022cites this paper
• An Overview of Engineered Hydrogel-Based Biomaterials for Improved β-Cell Survival and Insulin Secretion

  2021cites this paper
• The functional importance of the cellular and extracellular composition of the islets of Langerhans

  2021cites this paper
• miR-320a induces pancreatic β cells dysfunction in diabetes by inhibiting MafF

  2021cites this paper
• CD47 and thrombospondin-1 regulation of mitochondria, metabolism, and diabetes.

  2021cites this paper
• The Role of Pancreatic Alpha Cells and Endothelial Cells in the Reduction of Oxidative Stress in Pseudoislets

  2021cites this paper
• The simpler, the better: tissue vascularization using the body's own resources.

  2021cites this paper
• A New Hypothetical Model for Pancreatic Development Based on Change in the Cell Division Orientation.

  2021cites this paper
• Liver to Pancreas Transdifferentiation

  2019cites this paper
• The role of the vasculature niche on insulin-producing cells generated by transdifferentiation of adult human liver cells

  2019cites this paper
• Pancreatic Blood Flow with Special Emphasis on Blood Perfusion of the Islets of Langerhans.

  2019cites this paper
• Bone Marrow Mesenchymal Stem Cells as a New Therapeutic Approach for Diabetes Mellitus

  2019cites this paper
• Analysis of Gene Expression Differences between Different Pancreatic Cells

  2019cites this paper
• Pivotal micro factors associated with endothelial cells

  2019cites this paper
• Quercetin improves endothelial function in diabetic rats through inhibition of endoplasmic reticulum stress‐mediated oxidative stress

  2018cites this paper
• Specific storage of glycoconjugates with terminal &agr;-galactosyl moieties in the exocrine pancreas of Fabry disease patients with blood group B

  2018influential citation
• Toxicity to the Insulin-Secreting β-Cell

  2018cites this paper
• The Good , the Bad , and the Ugly – role of the pancreas , endothelium , and adipose tissue axis in the management of pancreatic β-cell failure in obesity-related type 2 diabetes

  2018cites this paper
• Pseudo-hemorrhagic region formation in pancreatic neuroendocrine tumors is a result of blood vessel dilation followed by endothelial cell detachment

  2018cites this paper
• Kinetics of pancreatic tissue proliferation in a polymeric platform in mice.

  2017cites this paper
• Intra-islet endothelial cell and β-cell crosstalk: Implication for islet cell transplantation

  2017cites this paper
• Applied Developmental Biology: Making Human Pancreatic Beta Cells for Diabetics.

  2016cites this paper
• Pancreas of C57 black mice after long-term space flight (Bion-M1 Space Mission).

  2015cites this paper
• Role of C-Kit Receptor Tyrosine Kinase on INS-1 Cell VEGF-A Expression in Vitro

  2014cites this paper