The met oncogene: from detection by transfection to transmembrane receptor for hepatocyte growth factor.

No abstract is available for this paper.

• Publication year

  1992

• Venue

  Oncogene

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine

• Identifiers
  PMID 1531516
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• A broad-spectrum human lung fibroblast-derived mitogen is a variant of hepatocyte growth factor.

  1991cited by this paper
• Alternative splicing generates isoforms of the met receptor tyrosine kinase which undergo differential processing

  1991cited by this paper
• Hepatocyte growth factor (HGF) stimulates the tyrosine kinase activity of the receptor encoded by the proto-oncogene c-MET.

  1991cited by this paper
• Identification of the hepatocyte growth factor receptor as the c-met proto-oncogene product.

  1991cited by this paper
• c-met is amplified but not mutated in a cell line with an activated met tyrosine kinase.

  1991cited by this paper
• The tyrosine kinase encoded by the MET proto-oncogene is activated by autophosphorylation

  1991cited by this paper
• Analysis by pulsed field gel electrophoresis reveals complex rearrangements in two MET alleles in a chemically-treated human cell line, MNNG-HOS.

  1990cited by this paper
• TPR-MET oncogenic rearrangement: detection by polymerase chain reaction amplification of the transcript and expression in human tumor cell lines.

  1990cited by this paper
• Analysis of the transgenome of MET transfectant cell lines reveals that MET activation is accompanied by an interstitial insertion

  1990cited by this paper
• Protein kinase-c activation inhibits tyrosine phosphorylation of the c-met protein.

  1990cited by this paper
• Structure, tissue-specific expression, and transforming activity of the mouse met protooncogene.

  1990cited by this paper
• Hepatocytes and scatter factor

  1990cited by this paper
• Identity of a tumor cytotoxic factor from human fibroblasts and hepatocyte growth factor.

  1990cited by this paper
• Biosynthesis of the protein encoded by the c-met proto-oncogene.

  1989cited by this paper
• Molecular cloning and expression of human hepatocyte growth factor

  1989cited by this paper
• Purification of scatter factor, a fibroblast-derived basic protein that modulates epithelial interactions and movement.

  1989cited by this paper
• Molecular cloning and sequence analysis of cDNA for human hepatocyte growth factor.

  1989cited by this paper
• Purification and characterization of a newly identified growth factor specific for epithelial cells.

  1989cited by this paper
• Tyrosine kinase receptor indistinguishable from the c-met protein

  1989cited by this paper
• Characterization of the TPR-MET oncogene p65 and the MET protooncogene p140 protein-tyrosine kinases.

  1988cited by this paper
• tpr homologues activate met and raf.

  1988cited by this paper
• Two rearranged MET alleles in MNNG-HOS cells reveal the orientation of MET on chromosome 7 to other markers tightly linked to the cystic fibrosis locus.

  1988cited by this paper
• Characterization of the mouse met proto-oncogene.

  1988cited by this paper
• p145, a protein with associated tyrosine kinase activity in a human gastric carcinoma cell line

  1988cited by this paper
• Characterization of the rearranged tpr-met oncogene breakpoint

  1987cited by this paper
• Sequence of MET protooncogene cDNA has features characteristic of the tyrosine kinase family of growth-factor receptors.

  1987cited by this paper
• Rat c-raf oncogene activation by a rearrangement that produces a fused protein

  1987cited by this paper
• Primary structure of the met protein tyrosine kinase domain.

  1987cited by this paper
• A candidate for the cystic fibrosis locus isolated by selection for methylation-free islands

  1987cited by this paper
• Scatter factor is a fibroblast-derived modulator of epithelial cell mobility

  1987cited by this paper
• Amplification and overexpression of the met gene in spontaneously transformed NIH3T3 mouse fibroblasts.

  1986cited by this paper
• A human oncogene formed by the fusion of truncated tropomyosin and protein tyrosine kinase sequences

  1986cited by this paper
• Activation of the met oncogene in the human MNNG-HOS cell line involves a chromosomal rearrangement.

  1986cited by this paper
• Chromosome mediated gene transfer of six DNA markers linked to the cystic fibrosis locus on human chromosome seven.

  1986cited by this paper
• The met oncogene: a new member of the tyrosine kinase family and a marker for cystic fibrosis.

  1986cited by this paper
• The activated human met gene encodes a protein tyrosine kinase

  1986cited by this paper
• Mechanism of met oncogene activation.

  1986cited by this paper
• The human met oncogene is related to the tyrosine kinase oncogenes

  1985cited by this paper
• Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes

  1985cited by this paper
• A closely linked genetic marker for cystic fibrosis

  1985cited by this paper
• An alteration of the human c-abl protein in K562 leukemia cells unmasks associated tyrosine kinase activity.

  1984cited by this paper
• Characterization of human transforming genes from chemically transformed, teratocarcinoma, and pancreatic carcinoma cell lines.

  1984cited by this paper
• Molecular cloning of a new transforming gene from a chemically transformed human cell line

  1984cited by this paper
• Transformation of human cells in culture by N-methyl-N′-nitro-N-nitrosoguanidine

  1975cited by this paper
• Transformation of human osteosarcoma cells by a chemical carcinogen.

  1975cited by this paper

• Unique characteristics of autoantibodies targeting MET in patients with breast and lung cancer

  2025cites this paper
• Computational investigation of hepatocyte growth factor receptor-ligand interactions for the identification of novel therapeutic inhibitors

  2025cites this paper
• FOXP2 confers oncogenic effects in prostate cancer

  2023cites this paper
• Huaier Inhibits Cancer Progression Correlated with the Mutated EGFR and Other Receptor Tyrosine Kinases (c-MET/erbB-2) by Down-Regulation of Multiple Signal Transduction Pathways

  2021influential citation
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  2021cites this paper
• Huaier Compensates Impaired Signal Transfer Inter/Intra Neurons in Central and Peripheral Nervous Systems

  2021cites this paper
• Lipocalin-2 Inhibits Osteosarcoma Cell Metastasis by Suppressing MET Expression via the MEK–ERK Pathway

  2021cites this paper
• Targeted Therapies in Cholangiocarcinoma: Emerging Evidence from Clinical Trials

  2019cites this paper
• Extracellular Matrix Influencing HGF/c-MET Signaling Pathway: Impact on Cancer Progression

  2018cites this paper
• LncRNA FLVCR1‐AS1 acts as miR‐513c sponge to modulate cancer cell proliferation, migration, and invasion in hepatocellular carcinoma

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• Intracellular Pathways Associated with the Etiology of Autism

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• Characterization of a Mouse Model of Emphysema Induced by Multiple Instillations of Low-Dose Elastase

  2016cites this paper
• Prognostic impact of tumor MET expression among patients with stage IV gastric cancer: a Danish cohort study.

  2016cites this paper
• Signal transduction in Acute Myeloid Leukemia - Implications for Novel Therapeutic Concepts.

  2015cites this paper
• Identification of biomarkers for development of NF1-associated malignant peripheral nerve sheath tumours

  2015cites this paper
• Genetics of Bladder Malignant Tumors in Childhood

  2015cites this paper
• The endocrine role between β cells and intra-islet endothelial cells.

  2014cites this paper
• Application perspectives of localization microscopy in virology

  2014cites this paper
• Targeting C-Met/VEGF in Castration Resistant Prostate Cancer

  2014cites this paper
• Targeted therapies in metastatic esophageal cancer: advances over the past decade.

  2014cites this paper
• Avaliação da via de sinalização HGF/C-MET em neoplasias benignas e malignas de glândulas salivares

  2014cites this paper
• Quantitative analysis of individual hepatocyte growth factor receptor clusters in influenza A virus infected human epithelial cells using localization microscopy.

  2014cites this paper
• Somatic Genome Alterations in Human Lung Cancers

  2014cites this paper
• Dysregulated microRNAs in non-cirrhotic hepatocellular carcinoma

  2013cites this paper
• Landmarks in non‐hormonal pharmacological therapies for castration‐resistant prostate cancer

  2012cites this paper
• The Expression Pattern of Von Hippel-Lindau Tumor Suppressor Protein, MET Proto-oncogene, and TFE3 Transcription Factor Oncoprotein in Renal Cell Carcinoma in Upper Egypt

  2011cites this paper
• Immunohistochemical expressions of fatty acid synthase and phosphorylated c-Met in thyroid carcinomas of follicular origin.

  2011cites this paper
• UNIFORMED SERVICES UNIVERSITY OF THE HEALTH SCIENCE F. EDWARD HEBERT SCHOOL OF MEDICINE GRADUATE PROGRAMS IN THE BIOMEDICAL SCIENCES AND PUBLIC HEALTH

  2010cites this paper
• Heparanase Plays a Dual Role in Driving Hepatocyte Growth Factor (HGF) Signaling by Enhancing HGF Expression and Activity*♦

  2010cites this paper
• Dose variation of hepatocyte growth factor and its effects on an animal model of TPN-induced liver injury.

  2010cites this paper
• ASSOCIATION FOR ACADEMIC SURGERY Dose Variation of Hepatocyte Growth Factor and its Effects on an Animal Model of TPN-Induced Liver Injury

  2010cites this paper
• Transcriptional regulation of the hepatocyte growth factor gene by pyrrolidine dithiocarbamate

  2008cites this paper
• Hepatocyte Growth Factor/Scatter Factor and Prostate Cancer Metastasis

  2008cites this paper
• Role of non-receptor and receptor tyrosine kinases (TKs) in the antitumor action of α-difluoromethylornithine (DFMO) in breast cancer cells

  2008cites this paper
• Metastasis of prostate cancer

  2007cites this paper
• The molecular and clinical impact of hepatocyte growth factor, its receptor, activators, and inhibitors in wound healing

  2006cites this paper
• The molecular and clinical impact of hepatocyte growth factor, its receptor, activators, and inhibitors in wound healing.

  2006cites this paper
• Overexpression of c-met in oral SCC promotes hepatocyte growth factor-induced disruption of cadherin junctions and invasion.

  2004cites this paper
• Targeting Protein Kinases for Tumor Therapy

  2001cites this paper
• Enhancement of retrovirus-mediated gene transfer to rat liver in vivo by infusion of hepatocyte growth factor and triiodothyronine.

  2000cites this paper
• Friendship in Childhood and Adulthood: Lessons across the Life Span

  2000cites this paper
• Hepatocyte growth factor upregulates E1AF that induces oral squamous cell carcinoma cell invasion by activating matrix metalloproteinase genes.

  2000cites this paper
• Enhanced wear performance of highly crosslinked UHMWPE for artificial joints.

  2000cites this paper
• Regulation of keratinocyte integrins by scatter factor.

  2000cites this paper
• Met-HGF/SF mediates growth arrest and differentiation in T47D breast cancer cells.

  1999cites this paper
• Presence and tyrosine phosphorylation of c-met receptor in human sperm.

  1999cites this paper
• A src-related kinase in the brush border membranes of gastrointestinal cells is regulated by c-met.

  1999cites this paper
• Serum hepatocyte growth factor as an index of extensive catabolism of patients awaiting liver transplantation

  1999cites this paper
• Hair cycle-dependent expression of hepatocyte growth factor (HGF) activator, other proteinases, and proteinase inhibitors correlates with the expression of HGF in rat hair follicles.

  1999cites this paper
• Inherited carcinomas of the kidney.

  1998cites this paper
• Activation of the urokinase plasminogen activator/urokinase plasminogen activator receptor system and redistribution of E-cadherin are associated with hepatocyte growth factor-induced motility of pancreas tumor cells overexpressing Met.

  1998cites this paper
• C-met proto-oncogene expression in benign and malignant human renal tissues.

  1997cites this paper
• Growth factor receptor tyrosine kinases

  1997cites this paper
• Hepatocyte growth factor/scatter factor, a cytokine playing multiple and converse roles.

  1997cites this paper
• Expression of HGF, Its Receptor c-met, c-myc, and Albumin in Cirrhotic and Neoplastic Human Liver Tissue

  1997cites this paper
• Plasma carnitine kinetics during orthotopic liver transplantation.

  1997cites this paper
• Immunodetection of c-met-oncogene's protein product in renal cell neoplasia.

  1997cites this paper
• Clinical significance of serum hepatocyte growth factor in orthotopic liver transplantation.

  1996cites this paper
• The relation between reactive oxygen species and cytokines in andrological patients with or without male accessory gland infection.

  1996cites this paper
• The receptor encoded by the human C-MET oncogene is expressed in testicular tissue and on human spermatozoa.

  1996cites this paper
• Hepatocyte growth factor is a potent mitogen for normal human pancreas cells in vitro.

  1995cites this paper
• Growth factor regulation of integrin-mediated cell motility

  1995cites this paper
• c-met proto-oncogene expression in benign and malignant human prostate tissues.

  1995cites this paper
• Hepatocyte growth factor and its receptor (c-MET) in prostatic carcinoma.

  1995cites this paper
• Overexpression and amplification of the met/HGF receptor gene during the progression of colorectal cancer.

  1995cites this paper
• Phosphorylation of serine 985 negatively regulates the hepatocyte growth factor receptor kinase.

  1994cites this paper
• Tyrosines1234-1235 are critical for activation of the tyrosine kinase encoded by the MET proto-oncogene (HGF receptor).

  1994cites this paper
• Molecular and cellular basis of cancer invasion and metastasis: Implications for treatment

  1994cites this paper
• Ras mutations in methylclofenapate-induced B6C3F1 and C57BL/10J mouse liver tumours.

  1994cites this paper
• Hepatocyte growth factor stimulates invasion across reconstituted basement membranes by a new human small intestinal cell line

  1994cites this paper
• Hepatocyte growth factor/scatter factor, liver regeneration and cancer metastasis

  1993cites this paper
• A novel putative receptor protein tyrosine kinase of the met family.

  1993cites this paper
• Hepatocyte growth factor: another ubiquitous cytokine.

  1993cites this paper
• Phorbol ester-induced scattering of HT-29 human intestinal cancer cells is associated with down-modulation of E-cadherin.

  1993cites this paper
• Hepatocyte growth factor--how do I know thee? Let me count the ways.

  1992cites this paper
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