The tyrosine kinase encoded by the MET proto-oncogene is activated by autophosphorylation

No abstract is available for this paper.

• Publication year

  1991

• Venue

  Molecular and Cellular Biology

• Publication date

  1991-04-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1128/mcb.11.4.1793-1803.1991PMID 2005882PMCID PMC359847
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Analysis of mutant forms of the c-src gene product containing a phenylalanine substitution for tyrosine 416.

  1990cited by this paper
• Protein kinase-c activation inhibits tyrosine phosphorylation of the c-met protein.

  1990cited by this paper
• Signal transduction by receptors with tyrosine kinase activity.

  1990cited by this paper
• Biosynthesis of the protein encoded by the c-met proto-oncogene.

  1989cited by this paper
• Tyrosine kinase receptor indistinguishable from the c-met protein

  1989cited by this paper
• Substrate phosphorylation catalyzed by the insulin receptor tyrosine kinase. Kinetic correlation to autophosphorylation of specific sites in the beta subunit.

  1989cited by this paper
• Relationship of site-specific beta subunit tyrosine autophosphorylation to insulin activation of the insulin receptor (tyrosine) protein kinase activity.

  1988cited by this paper
• Characterization of the TPR-MET oncogene p65 and the MET protooncogene p140 protein-tyrosine kinases.

  1988cited by this paper
• Growth factor receptor tyrosine kinases.

  1988cited by this paper
• p145, a protein with associated tyrosine kinase activity in a human gastric carcinoma cell line

  1988cited by this paper
• Kinetic parameters of the protein tyrosine kinase activity of EGF‐receptor mutants with individually altered autophosphorylation sites.

  1988cited by this paper
• The protein kinase family: conserved features and deduced phylogeny of the catalytic domains.

  1988cited by this paper
• Tryptic activation of the insulin receptor. Proteolytic truncation of the alpha-subunit releases the beta-subunit from inhibitory control.

  1988cited by this paper
• Truncation of the human EGF receptor leads to differential transforming potentials in primary avian fibroblasts and erythroblasts.

  1988cited by this paper
• Biological activities of EGF‐receptor mutants with individually altered autophosphorylation sites.

  1988cited by this paper
• Signal transduction by allosteric receptor oligomerization.

  1988cited by this paper
• Alteration of epidermal growth factor receptor activity by mutation of its primary carboxyl-terminal site of tyrosine self-phosphorylation.

  1988cited by this paper
• Evidence for autocrine activation of a tyrosine kinase in a human gastric carcinoma cell line

  1988cited by this paper
• Characterization of the mouse met proto-oncogene.

  1988cited by this paper
• Structure of the met protein and variation of met protein kinase activity among human tumour cell lines.

  1988cited by this paper
• Enzymatic activation of Fujinami sarcoma virus gag‐fps transforming proteins by autophosphorylation at tyrosine.

  1987cited by this paper
• A thousand and one protein kinases.

  1987cited by this paper
• Tyrosine phosphorylation regulates the biochemical and biological properties of pp60c-src.

  1987cited by this paper
• Sequence of MET protooncogene cDNA has features characteristic of the tyrosine kinase family of growth-factor receptors.

  1987cited by this paper
• Cell transformation by pp60c-src mutated in the carboxy-terminal regulatory domain.

  1987cited by this paper
• Insulin stimulation of the insulin receptor kinase can occur in the complete absence of beta subunit autophosphorylation.

  1987cited by this paper
• Activation and suppression of pp60c-src transforming ability by mutation of its primary sites of tyrosine phosphorylation.

  1987cited by this paper
• Tyrosine phosphorylation of insulin receptor beta subunit activates the receptor tyrosine kinase in intact H-35 hepatoma cells.

  1986cited by this paper
• Immunological detection of proteins phosphorylated at tyrosine in cells stimulated by growth factors or transformed by retroviral-oncogene-coded tyrosine kinases.

  1986cited by this paper
• Replacement of insulin receptor tyrosine residues 1162 and 1163 compromises insulin-stimulated kinase activity and uptake of 2-deoxyglucose.

  1986cited by this paper
• Phosphotyrosine antibodies identify the p210c-abl tyrosine kinase and proteins phosphorylated on tyrosine in human chronic myelogenous leukemia cells

  1986cited by this paper
• Insulin activation of insulin receptor tyrosine kinase in intact rat adipocytes. An in vitro system to measure histone kinase activity of insulin receptors activated in vivo.

  1986cited by this paper
• A lysine in the ATP‐binding site of P130gag‐fps is essential for protein‐tyrosine kinase activity.

  1986cited by this paper
• The activated human met gene encodes a protein tyrosine kinase

  1986cited by this paper
• Autophosphorylation of the insulin receptor in vitro. Designation of phosphorylation sites and correlation with receptor kinase activation.

  1986cited by this paper
• Mechanism of met oncogene activation.

  1986cited by this paper
• Self-phosphorylation enhances the protein-tyrosine kinase activity of the epidermal growth factor receptor.

  1985cited by this paper
• Autophosphorylation and protein kinase C phosphorylation of the epidermal growth factor receptor. Effect on tyrosine kinase activity and ligand binding affinity.

  1985cited by this paper
• The human met oncogene is related to the tyrosine kinase oncogenes

  1985cited by this paper
• Activation of the pp60c‐src kinase by middle T antigen binding or by dephosphorylation.

  1985cited by this paper
• Protein-tyrosine kinases.

  1985cited by this paper
• Kinetic properties and sites of autophosphorylation of the partially purified insulin receptor from hepatoma cells.

  1984cited by this paper
• Close similarity of epidermal growth factor receptor and v-erb-B oncogene protein sequences

  1984cited by this paper
• 42,000-molecular weight EGF receptor has protein kinase activity

  1984cited by this paper
• Tyrosine phosphorylation of the insulin receptor beta subunit activates the receptor-associated tyrosine kinase activity.

  1984cited by this paper
• Molecular cloning of a new transforming gene from a chemically transformed human cell line

  1984cited by this paper
• Immunoaffinity purification of the epidermal growth factor receptor. Stoichiometry of binding and kinetics of self-phosphorylation.

  1984cited by this paper
• Detection of phosphotyrosine‐containing proteins in the detergent‐insoluble fraction of RSV‐transformed fibroblasts by azobenzene phosphonate antibodies.

  1984cited by this paper
• Detection and quantification of phosphotyrosine in proteins.

  1983cited by this paper
• Characterization and use of monoclonal antibodies for isolation of phosphotyrosyl proteins from retrovirus-transformed cells and growth factor-stimulated cells

  1983cited by this paper
• The kinetics of tyrosine phosphorylation by the purified epidermal growth factor receptor kinase of A-431 cells.

  1983cited by this paper
• Phosphorylation activates the insulin receptor tyrosine protein kinase.

  1983cited by this paper
• Characterization of the Rous sarcoma virus transforming gene product.

  1983cited by this paper
• "Western blotting": electrophoretic transfer of proteins from sodium dodecyl sulfate--polyacrylamide gels to unmodified nitrocellulose and radiographic detection with antibody and radioiodinated protein A.

  1981cited by this paper
• Evaluation of the regrowth assay method as an in vitro drug sensitivity test and its application to cultured humah gastric cancer cell lines

  1979cited by this paper
• Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications.

  1979cited by this paper
• Isolation of phosphorylated peptides and proteins on ion exchange papers.

  1978cited by this paper
• Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

  1970cited by this paper
• Self-phosphorylation Enhances the Protein-tyrosine Kinase Activity of the Epidermal Growth Factor Receptor *

  year unknowncited by this paper

• Tyrosine-Mediated Static and Dynamic Quenching of a Receptor Tyrosine Kinase Biosensor Reveals Inhibitor Binding Modes and Kinase Conformations.

  2025cites this paper
• Conserved regulatory motifs in the juxtamembrane domain and kinase N-lobe revealed through deep mutational scanning of the MET receptor tyrosine kinase domain

  2024cites this paper
• MET receptor tyrosine kinase promotes the generation of functional synapses in adult cortical circuits

  2024cites this paper
• Reduced expression of phosphorylated ataxia-telangiectasia mutated gene is related to poor prognosis and gemcitabine chemoresistance in pancreatic cancer

  2023cites this paper
• Conserved regulatory motifs in the juxtamembrane domain and kinase N-lobe revealed through deep mutational scanning of the MET receptor tyrosine kinase domain

  2023cites this paper
• Reduced HGF/MET Signaling May Contribute to the Synaptic Pathology in an Alzheimer's Disease Mouse Model

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• Growth Factor Receptor

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• Control of cortical synapse development and plasticity by MET receptor tyrosine kinase, a genetic risk factor for autism

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• Time-delimited signaling of MET receptor tyrosine kinase regulates cortical circuit development and critical period plasticity

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• Qualitative and semi-quantitative analysis of signal transduction networks

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• Understanding c-MET signalling in squamous cell carcinoma of the head & neck.

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• Regulation of the MET oncogene: molecular mechanisms.

  2016cites this paper
• The autism associated MET receptor tyrosine kinase engages early neuronal growth mechanism and controls glutamatergic circuits development in the forebrain

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• Promise and challenges on the horizon of MET-targeted cancer therapeutics.

  2015cites this paper
• cMET in triple-negative breast cancer: is it a therapeutic target for this subset of breast cancer patients?

  2014cites this paper
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• Role of Met Axis in Head and Neck Cancer

  2013cites this paper
• growth factor, in Hodgkin disease Expression of the c-met proto-oncogene and its ligand, hepatocyte

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  2012cites this paper
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  2011cites this paper
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  2011cites this paper
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  2011cites this paper
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• Biochemical basis for the functional switch that regulates hepatocyte growth factor receptor tyrosine kinase activation.

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  2005cites this paper
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  2005cites this paper
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  2005cites this paper
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  2005cites this paper
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  2004cites this paper
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  2004cites this paper
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  2004cites this paper
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