Comparative Study of Hypolipidemic Profile of Resinoids of Commiphora mukul/Commiphora wightii from Different Geographical Locations

The antihyperlipidemic activity of resinoids of guggul (Commiphora mukul/Commiphora wightii), belonging to family Burseraceae (Genus: Commiphora), collected from different parts of India (Gujarat, Madhya Pradesh and Rajasthan), was studied on cholesterol-rich high fat diet-induced model of hyperlipidemia in rats. The resinoids of these exudates were prepared in ethyl acetate and ethyl alcohol. The physicochemical characterization of these resinoids was carried out to determine their appearance, %yield, %moisture, %ash, acid value (mg/KOH/g), saponification value (mg/KOH/g), ester value and iodine value (g/g). Antihyperlipidemic study was carried out on all resinoids in high fat diet induced model of hyperlipidemia in Wistar albino rats. The result demonstrated that the resinoids of exudates of Commiphora wightii and Commiphora mukul, collected from Gujarat and extracted in ethyl acetate, and the resinoids of exudates of Commiphora mukul, collected from Madhya Pradesh and extracted in ethyl acetate, possessed significantly higher antihyperlipidemic activity compared with other resinoids, which may be due to regional/geographical variations.

• Publication year

  2012

• Venue

  Indian Journal of Pharmaceutical Sciences

• Publication date

  2012-09-01

• Fields of study

  Medicine, Environmental Science

• Identifiers
  DOI 10.4103/0250-474X.108417PMID 23716870PMCID 3660868
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Evaluation of Anti-inflammatory and Antioxidant Activities of Stem Bark of Toddalia asiatica (L.) Lam. using Different Experimental Models

  2012cited by this paper
• Antihyperlipidemic Activity of Rimonabant on High Cholesterol Diet Induced Hyperlipidemia in Rats

  2011cited by this paper
• Guggul : An Excellent Herbal Panacea

  2011cited by this paper
• Anti-peroxidative and anti-hyperlipidemic nature of Ulva lactuca crude polysaccharide on D-galactosamine induced hepatitis in rats.

  2008cited by this paper
• The cholesterol lowering property of coriander seeds (Coriandrum sativum): mechanism of action.

  2008cited by this paper
• Gugulipid, an extract of Commiphora whighitii with lipid-lowering properties, has protective effects against streptozotocin-induced memory deficits in mice.

  2007cited by this paper
• Ayurvedic and collateral herbal treatments for hyperlipidemia: a systematic review of randomized controlled trials and quasi-experimental designs.

  2007cited by this paper
• Therapeutic effects of guggul and its constituent guggulsterone: cardiovascular benefits.

  2007cited by this paper
• Chemistry and pharmacological profile of guggul⎯A review

  2006cited by this paper
• Guggul for hyperlipidemia: a review by the Natural Standard Research Collaboration.

  2005cited by this paper
• Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) final report.

  2002cited by this paper
• Evaluation of serum cholesterol and triglyceride levels in 1-6-year-old Saudi children.

  2001cited by this paper
• In vivo radioprotection by ocimum flavonoids: survival of mice.

  1999cited by this paper
• Hypolipidemic and antioxidant effects of commiphora mukul as an adjunct to dietary therapy in patients with hypercholesterolemia

  1994cited by this paper
• Plasma triglyceride and high density lipoprotein cholesterol as predictors of ischaemic heart disease in British men

  1992cited by this paper
• Effect of chemically different calcium antagonists on lipid profile in rats fed on a high fat diet.

  1992cited by this paper
• Inhibitory effect of green tea polyphenol and morin on the oxidative modification of low density lipoprotein

  1992cited by this paper
• Official methods of analysis of the Association of Official Analytical Chemists

  1990cited by this paper
• Effect of Commiphora mukul (gum guggulu) in patients of hyperlipidemia with special reference to HDL-cholesterol.

  1988cited by this paper
• Effects of Commiphora Mukul (Guggul) in experimentally induced hyperlipemia and atherosclerosis.

  1981cited by this paper
• Effect of guggulu (Commiphora mukul--Engl.) on serum lipids in obese, hypercholesterolemic and hyperlipemic cases.

  1978cited by this paper
• The Wealth of India. Raw Materials

  1978cited by this paper
• Effect of some fractions of Commiphora mukul on various serum lipid levels in hypercholesterolemic chicks and their effectiveness in myocardial infarction in rats.

  1973cited by this paper
• Chemistry of Ayurvedic crude drugs—I : Guggulu (resin from Commiphora mukul)—1: Steroidal constituents

  1972cited by this paper
• Antiarthritic and anti-inflammatory activity of gum guggul (Balsamodendron mukul Hook).

  1960cited by this paper

• Oleo Gum Resin Extracts of Commiphora wightii negatively impact the activity of Recombinant Human Lipoprotein Lipase

  2025cites this paper
• Review of ethnomedicinal uses and phytopharmacology of herbs for the treatment of Alzheimer's disease

  2024cites this paper
• The role of pharmacological interventions in managing hyperlipidemia: A closer look at different drugs

  2024cites this paper
• Commiphora mukul (Hook. ex Stocks) Engl.: Historical records, application rules, phytochemistry, pharmacology, clinical research, and adverse reaction.

  2023cites this paper
• Ethnopharmacologically important highly subsidized Indian medicinal plants: Systematic review on their traditional uses, phytochemistry, pharmacology, quality control, conservation status and future prospective.

  2023cites this paper
• Hypolipidemic Activity of Medicinal Plants: An Overview

  2022cites this paper
• Pharmacokinetic and pharmacodynamic interaction of Rosuvastatin calcium with guggulipid extract in rats

  2021cites this paper
• Effects of containers and duration of storage on the guggulsterone and volatile oils content of guggul

  2020cites this paper
• Commiphora wightii (Arn.) Bhandari/C. mukul (Hook. ex Stocks) Engl. (Burseraceae)

  2020cites this paper
• Diversity and Antimicrobial Activity of Plant Associated Bacteria from Selected Medicinal Plants in Kutch, Dhinodhar Hill, Gujarat

  2018cites this paper
• Anti-depressant Activity of Commiphora mukul

  2016cites this paper
• Antiulcer Effect of Commiphora molmol Engl . ( Burceraceae ) Oleo-gum-resin and its Interaction with Ranitidine , as Demonstrated by Histological Studies

  2016cites this paper
• Effects of Balsamodendron mukul Gum Resin Extract on Articular Cartilage in Papain-induced Osteoarthritis.

  2016cites this paper
• Standardization of Commiphora Abyssinica Engl. Gum Resin From Kajiado, Kenya

  2016cites this paper
• Interaction Between Myrrh and Glibenclamide on Organ Damage in Diabetic Rats, a Morphological Study

  2016cites this paper
• Evaluation of the composition, physico-chemical characteristics, surfactant and anti-microbial potential of commiphora abyssinica gum resin

  2015influential citation
• Time Tested Safe and Effect Oriented Drugs in Unani Medicine for Dyslipidemia-A Review

  2015cites this paper
• Antimicrobial activity of Commiphora wightii gum (Guggul gum) extract against gram positive and gram negative bacteria

  2015cites this paper
• Alleviation of Abiotic Stress in Medicinal Plants by PGPR

  2015cites this paper
• Biotechnological Approaches to Medicinal Plants of Aravalli Hills: Conservation and Scientific Validation of Biological Activities

  2014cites this paper
• Antihyperlipidemic activity of the medicinal plants among Kadazan and Dusun communities in Sabah, Malaysia: a review

  2014cites this paper
• EFFECT OF BALSAMODENDRON MUKUL GUM RESIN EXTRACT ON PAIN RESPONSE IN OSTEOARTHRITIC RATS

  2014cites this paper