Two serine phosphorylation sites in the C‐terminus of Rad9 are critical for 9‐1‐1 binding to TopBP1 and activation of the DNA damage checkpoint response in HeLa cells

No abstract is available for this paper.

• Publication year

  2012

• Venue

  Genes to Cells

• Publication date

  2012-10-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1111/j.1365-2443.2012.01630.xPMID 22925454
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Structure and function of the Rad9-binding region of the DNA-damage checkpoint adaptor TopBP1

  2010cited by this paper
• Casein kinase 2‐dependent phosphorylation of human Rad9 mediates the interaction between human Rad9‐Hus1‐Rad1 complex and TopBP1

  2010cited by this paper
• TopBP1 activates ATR through ATRIP and a PIKK regulatory domain.

  2008cited by this paper
• ATR: an essential regulator of genome integrity

  2008cited by this paper
• How ATR turns on: TopBP1 goes on ATRIP with ATR.

  2008cited by this paper
• DNA damage sensor protein hRad9, a novel molecular target for lung cancer treatment.

  2008cited by this paper
• The Rad9-Hus1-Rad1 (9-1-1) clamp activates checkpoint signaling via TopBP1.

  2007cited by this paper
• Cdc25 and Wee1: analogous opposites?

  2007cited by this paper
• The Rad9-Hus1-Rad1 Checkpoint Clamp Regulates Interaction of TopBP1 with ATR*

  2007cited by this paper
• ATRIP associates with replication protein A-coated ssDNA through multiple interactions.

  2006cited by this paper
• TopBP1 activates the ATR-ATRIP complex.

  2006cited by this paper
• Checkpoint responses to replication fork barriers.

  2005cited by this paper
• Functional uncoupling of MCM helicase and DNA polymerase activities activates the ATR-dependent checkpoint.

  2005cited by this paper
• Initiating cellular stress responses.

  2004cited by this paper
• Replication protein A-mediated recruitment and activation of Rad17 complexes

  2003cited by this paper
• A Role for the Phosphorylation of hRad9 in Checkpoint Signaling*

  2003cited by this paper
• Sensing DNA Damage Through ATRIP Recognition of RPA-ssDNA Complexes

  2003cited by this paper
• Phosphorylation of Human Rad9 Is Required for Genotoxin-activated Checkpoint Signaling*

  2003cited by this paper
• Clamp and clamp loader structures of the human checkpoint protein complexes, Rad9‐1‐1 and Rad17‐RFC

  2002cited by this paper
• Structures of the Human Rad17-Replication Factor C and Checkpoint Rad 9-1-1 Complexes Visualized by Glycerol Spray/Low Voltage Microscopy*

  2002cited by this paper
• ATR and ATRIP: Partners in Checkpoint Signaling

  2001cited by this paper
• BRCT Domain-containing Protein TopBP1 Functions in DNA Replication and Damage Response*

  2001cited by this paper
• Cell cycle checkpoint signaling through the ATM and ATR kinases.

  2001cited by this paper
• The human G2 checkpoint control protein hRAD9 is a nuclear phosphoprotein that forms complexes with hRAD1 and hHUS1.

  1999cited by this paper
• Human Homologs of Schizosaccharomyces pombe Rad1, Hus1, and Rad9 Form a DNA Damage-responsive Protein Complex*

  1999cited by this paper
• Replication Protein A

  1997influential reference

• Structural basis for intra- and intermolecular interactions on RAD9 subunit of 9-1-1 checkpoint clamp implies functional 9-1-1 regulation by RHINO

  2024cites this paper
• Investigation of the Possible Role of RAD9 in Post-Diapaused Embryonic Development of the Brine Shrimp Artemia sinica

  2019cites this paper
• The relationship of CDK18 expression in breast cancer to clinicopathological parameters and therapeutic response

  2018cites this paper
• Response of alternative splice isoforms of OsRad9 gene from Oryza sativa to environmental stress

  2017cites this paper
• Functions of Multiple Clamp and Clamp-Loader Complexes in Eukaryotic DNA Replication.

  2017cites this paper
• Multiple regulatory roles of Rad9 C-tail in DNA damage responses

  2017cites this paper
• Human CDK18 promotes replication stress signaling and genome stability

  2016cites this paper
• Centrosome cohesion: functions of C-NAP1

  2016cites this paper
• The Rad9.M50 Variant of the DNA Damage Checkpoint Protein Rad9 Regulates the MAP Kinase pathway in the Response to Heat Stress

  2016cites this paper
• Intramolecular Binding of the Rad9 C Terminus in the Checkpoint Clamp Rad9-Hus1-Rad1 Is Closely Linked with Its DNA Binding*

  2015cites this paper
• Interaction between Rad9-Hus1-Rad1 and TopBP1 activates ATR-ATRIP and promotes TopBP1 recruitment to sites of UV-damage.

  2014cites this paper
• Protein-protein interactions underlying damage checkpointactivation in S. pombe

  2014cites this paper
• The interaction between Rad9 and Tousled-like kinase 1 in the cell cycle and the DNA damage response

  2013cites this paper
• Tousled-Like Kinase-Dependent Phosphorylation of Rad9 Plays a Role in Cell Cycle Progression and G2/M Checkpoint Exit

  2013influential citation
• Author Index

  2012cites this paper