How ATR turns on: TopBP1 goes on ATRIP with ATR.

No abstract is available for this paper.

• Publication year

  2008

• Venue

  Genes & Development

• Publication date

  2008-06-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1101/gad.1685108PMID 18519633PMCID PMC2732414
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• TopBP1 activates ATR through ATRIP and a PIKK regulatory domain.

  2008influential reference
• The Rad9-Hus1-Rad1 (9-1-1) clamp activates checkpoint signaling via TopBP1.

  2007cited by this paper
• Tel2 regulates the stability of PI3K-related protein kinases.

  2007cited by this paper
• The Rad9-Hus1-Rad1 Checkpoint Clamp Regulates Interaction of TopBP1 with ATR*

  2007cited by this paper
• The DNA damage response: ten years after.

  2007cited by this paper
• Tel2 Is Required for Activation of the Mrc1-mediated Replication Checkpoint*

  2007cited by this paper
• Ataxia-telangiectasia Mutated (ATM)-dependent Activation of ATR Occurs through Phosphorylation of TopBP1 by ATM*

  2007cited by this paper
• Phosphorylation of Xenopus Rad1 and Hus1 defines a readout for ATR activation that is independent of Claspin and the Rad9 carboxy terminus.

  2006influential reference
• TopBP1 activates the ATR-ATRIP complex.

  2006cited by this paper
• Three-dimensional structure of the human DNA-PKcs/Ku70/Ku80 complex assembled on DNA and its implications for DNA DSB repair.

  2006cited by this paper
• The FATC Domains of PIKK Proteins Are Functionally Equivalent and Participate in the Tip60-dependent Activation of DNA-PKcs and ATM*

  2006cited by this paper
• ATRIP Oligomerization Is Required for ATR-dependent Checkpoint Signaling*

  2005cited by this paper
• ATRIP binding to replication protein A-single-stranded DNA promotes ATR-ATRIP localization but is dispensable for Chk1 phosphorylation.

  2005cited by this paper
• Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage

  2005cited by this paper
• A role for the Tip60 histone acetyltransferase in the acetylation and activation of ATM.

  2005cited by this paper
• Chk1 activation requires Rad9 S/TQ-site phosphorylation to promote association with C-terminal BRCT domains of Rad4TOPBP1.

  2004cited by this paper
• Replication protein A-mediated recruitment and activation of Rad17 complexes

  2003cited by this paper
• GbetaL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR.

  2003cited by this paper
• Sensing DNA Damage Through ATRIP Recognition of RPA-ssDNA Complexes

  2003cited by this paper
• Genetic and physical interactions between DPB11 and DDC1 in the yeast DNA damage response pathway.

  2002cited by this paper
• A DNA Damage-Regulated BRCT-Containing Protein, TopBP1, Is Required for Cell Survival

  2002cited by this paper
• ATR and ATRIP: Partners in Checkpoint Signaling

  2001cited by this paper
• ATR disruption leads to chromosomal fragmentation and early embryonic lethality.

  2000cited by this paper
• Dpb11, which interacts with DNA polymerase II(epsilon) in Saccharomyces cerevisiae, has a dual role in S-phase progression and at a cell cycle checkpoint.

  1995cited by this paper
• Fission yeast cut5+, required for S phase onset and M phase restraint, is identical to the radiation-damage repair gene rad4+.

  1993cited by this paper

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  2024cites this paper
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  2023cites this paper
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  2021cites this paper
• ATM and ATR Activation Through Crosstalk Between DNA Damage Response Pathways

  2021cites this paper
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  2021cites this paper
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  2020cites this paper
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  2020cites this paper
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  2020cites this paper
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  2019cites this paper
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  2019cites this paper
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  2019cites this paper
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  2018cites this paper
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  2018cites this paper
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  2018cites this paper
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  2017cites this paper
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  2017cites this paper
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  2017cites this paper
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  2017cites this paper
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  2016influential citation
• The Fanconi Anemia Pathway and Interstrand Cross-Link Repair

  2016cites this paper
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  2015cites this paper
• Maintain Genomic Stability: Multitask of DNA Replication Proteins

  2015cites this paper
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  2015cites this paper
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  2015cites this paper
• Identification of Proteins Involved in the Maintenance of Genome Stability

  2015cites this paper
• Protein-protein interactions underlying damage checkpointactivation in S. pombe

  2014cites this paper
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  2014cites this paper
• TopBP1: A BRCT-scaffold protein functioning in multiple cellular pathways.

  2014cites this paper
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  2014cites this paper
• Polymerase alpha components associate with telomeres to mediate overhang processing

  2014cites this paper
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  2014cites this paper
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  2014cites this paper
• Chromatin: receiver and quarterback for cellular signals.

  2013cites this paper
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  2013cites this paper
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  2013cites this paper
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  2013cites this paper
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  2013cites this paper
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  2013cites this paper
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  2013cites this paper
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  2013cites this paper
• ATR-ATRIP kinase complex triggers activation of the Fanconi anemia DNA repair pathway.

  2012influential citation
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  2012cites this paper
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  2012cites this paper
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  2012cites this paper
• Characterization of checkpoint adaptation in human fibroblastic glioma cells and an analysis of protein phosphatase inhibitors

  2012influential citation
• Recognition, signaling, and repair of DNA double-strand breaks produced by ionizing radiation in mammalian cells: the molecular choreography.

  2012cites this paper
• c-Jun N-terminal kinase–mediated Rad18 phosphorylation facilitates Polη recruitment to stalled replication forks

  2012cites this paper
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  2011cites this paper
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  2011cites this paper
• TopBP1 in DNA Damage Response

  2011cites this paper
• A positive role for c-Abl in Atm and Atr activation in DNA damage response

  2011cites this paper
• Proapoptotic Bid mediates the Atr-directed DNA damage response to replicative stress

  2011cites this paper
• Pro-apoptotic bid facilitates atr function following replicative stress

  2011cites this paper
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  2011cites this paper
• ERK1 and ERK2 kinases activate hydroxyurea-induced S-phase checkpoint in MCF7 cells by mediating ATR activation.

  2011cites this paper
• Genomic Instability and Breast Cancer

  2011cites this paper
• Shelterin complex and associated factors at human telomeres

  2011cites this paper
• Mechanistic and biological aspects of helicase action on damaged DNA

  2010cites this paper
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  2010cites this paper
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  2010cites this paper
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  2010cites this paper
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  2010cites this paper
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  2010cites this paper
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  2010cites this paper
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  2010cites this paper
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  2010influential citation
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  2009cites this paper
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  2009cites this paper
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  2009cites this paper
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  2009cites this paper
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  2009cites this paper
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  2008cites this paper