Dentate Gyrus NMDA Receptors Mediate Rapid Pattern Separation in the Hippocampal Network

No abstract is available for this paper.

• Publication year

  2007

• Venue

  Science

• Publication date

  2007-07-06

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1126/SCIENCE.1140263PMID 17556551
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Hippocampal remapping and grid realignment in entorhinal cortex

  2007cited by this paper
• Pattern Separation in the Dentate Gyrus and CA3 of the Hippocampus

  2007cited by this paper
• The role of the dorsal CA3 hippocampal subregion in spatial working memory and pattern separation.

  2006cited by this paper
• Fast rate coding in hippocampal CA3 cell ensembles

  2006cited by this paper
• CA3 NMDA receptors are crucial for rapid and automatic representation of context memory

  2006cited by this paper
• Attractor Dynamics in the Hippocampal Representation of the Local Environment

  2005cited by this paper
• Independent Codes for Spatial and Episodic Memory in Hippocampal Neuronal Ensembles

  2005cited by this paper
• Leptin receptor signaling in POMC neurons is required for normal body weight homeostasis.

  2004cited by this paper
• Distinct Ensemble Codes in Hippocampal Areas CA3 and CA1

  2004cited by this paper
• Comparison of population coherence of place cells in hippocampal subfields CA1 and CA3

  2004cited by this paper
• The medial temporal lobe.

  2004cited by this paper
• Putting Fear in Its Place: Remapping of Hippocampal Place Cells during Fear Conditioning

  2004cited by this paper
• Hippocampal CA3 NMDA receptors are crucial for memory acquisition of one-time experience.

  2003cited by this paper
• The human hippocampus and spatial and episodic memory.

  2002cited by this paper
• Long-term plasticity in hippocampal place-cell representation of environmental geometry

  2002cited by this paper
• Requirement for Hippocampal CA3 NMDA Receptors in Associative Memory Recall

  2002cited by this paper
• Place fields of rat hippocampal pyramidal cells and spatial learning in the watermaze

  2001cited by this paper
• Dissociating hippocampal subregions: A double dissociation between dentate gyrus and CA1

  2001cited by this paper
• Temporally structured replay of awake hippocampal ensemble activity during rapid eye movement sleep.

  2001cited by this paper
• CA1-specific N-methyl-d-aspartate receptor knockout mice are deficient in solving a nonspatial transverse patterning task

  2001cited by this paper
• Memory and the Medial Temporal Lobe: Patient H. M.

  2000cited by this paper
• Loss of recent memory after bilateral hippocampal lesions. 1957.

  2000cited by this paper
• Formation of temporal memory requires NMDA receptors within CA1 pyramidal neurons.

  2000cited by this paper
• Generalized lacZ expression with the ROSA26 Cre reporter strain

  1999cited by this paper
• Reactivation of neuronal ensembles in hippocampal dentate gyrus during sleep after spatial experience

  1998cited by this paper
• Impaired hippocampal representation of space in CA1-specific NMDAR1 knockout mice.

  1996cited by this paper
• The essential role of hippocampal CA1 NMDA receptor-dependent synaptic plasticity in spatial memory.

  1996cited by this paper
• Considerations arising from a complementary learning systems perspective on hippocampus and neocortex

  1996cited by this paper
• Latest Homo erectus of Java: Potential Contemporaneity with Homo sapiens in Southeast Asia

  1996cited by this paper
• Replay of Neuronal Firing Sequences in Rat Hippocampus During Sleep Following Spatial Experience

  1996cited by this paper
• Hippocampal conjunctive encoding, storage, and recall: Avoiding a trade‐off

  1994cited by this paper
• Dynamics of the hippocampal ensemble code for space.

  1993cited by this paper
• On the role of the hippocampus in learning and memory in the rat.

  1993cited by this paper
• J Neuropsychiatry Clin Neurosci

  1992cited by this paper
• Naloxone and Pavlovian fear conditioning

  1981cited by this paper
• Simple memory: a theory for archicortex.

  1971cited by this paper
• The hippocampus as a spatial map. Preliminary evidence from unit activity in the freely-moving rat.

  1971cited by this paper

• Increased dendritic inhibition of dentate gyrus granule cells in a mouse model of Down syndrome

  2026cites this paper
• Protocol to build open-source Discrimin8 maze to study discrimination of reward-context associations in mice during open-field foraging.

  2026cites this paper
• Developmental reprogramming in melanocortin neurons modulates diet-induced obesity in mice.

  2026cites this paper
• Transient DREADD Manipulation of the Dorsal Dentate Gyrus in Rats Impairs Initial Learning of Place‐Outcome Associations

  2025influential citation
• Capturing dynamic neuronal responses to dominant and subordinate social hierarchy members with catFISH.

  2025cites this paper
• Dentate gyrus drives pattern separation in proximal CA3 during rate, but not global, remapping

  2025cites this paper
• Septin 3 regulates memory and L-LTP-dependent extension of endoplasmic reticulum into spines.

  2025cites this paper
• Effective computations for hippocampal place cell phenomena in sparse untrained random networks

  2025cites this paper
• Systemic Glucose Homeostasis Requires Pancreatic but Not Neuronal ATP-sensitive Potassium Channels

  2025cites this paper
• The dentate gyrus provides flexibility for efficient spatial navigation

  2025cites this paper
• Separate orexigenic hippocampal ensembles shape dietary choice by enhancing contextual memory and motivation

  2025cites this paper
• On a new content indeterminacy problem in neuroscience

  2025cites this paper
• Neuronal Network Activation Induced by Forniceal Deep Brain Stimulation in Mice

  2025cites this paper
• Passive immunization against amyloid peptide restores pattern separation deficits in early stage of amyloid pathology but not in normal aging

  2025cites this paper
• Adult hippocampal neurogenesis and temporal lobe epilepsy: A potential key to understanding cognitive deficit.

  2025cites this paper
• Cognitive enrichment improves spatial memory and alters hippocampal synaptic connectivity in a mouse model for early-life stress

  2025cites this paper
• Unpredictable stress boosts perceptual learning and alters glucocorticoid and norepinephrine receptors in rats’ dorsal hippocampus

  2025cites this paper
• Cortical glutamatergic and GABAergic inputs support learning-driven hippocampal stability.

  2025cites this paper
• Cellular and circuit features distinguish mouse dentate gyrus semilunar granule cells and granule cells activated during contextual memory formation

  2025cites this paper
• The Signalled Licking/Avoidance of Punishment (SLAP) Paradigm in Rats: Capacity for Insight Between Goal Conditioning and Signalling Contingencies

  2025cites this paper
• Human Adipose-Stem-Cell-Derived Small Extracellular Vesicles Modulate Behavior and Glial Cells in Young and Aged Mice Following TBI

  2025cites this paper
• Degeneracy Explains Diversity in Interneuronal Regulation of Pattern Separation in Heterogeneous Dentate Gyrus Networks

  2025cites this paper
• Pharmacological reduction of reverse-translated hippocampal hyperactivity in mouse: relevance for psychosis

  2025cites this paper
• Neural mechanisms of cognitive generalization across species: From hippocampus to cortex

  2025cites this paper
• GPR45 modulates Gαs at primary cilia of the paraventricular hypothalamus to control food intake.

  2025cites this paper
• Memory processing by hippocampal adult-born neurons.

  2025cites this paper
• Time-dependent fear memory generalization triggered by phosphodiesterase 5 inhibition during reconsolidation.

  2025cites this paper
• Impaired spatial coding of the hippocampus in a dentate gyrus hypoplasia mouse model

  2025cites this paper
• Neotenic expansion of adult-born dentate granule cells reconfigures GABAergic inhibition to enhance social memory consolidation

  2025cites this paper
• Dynamic memory enqrams: Unveiling the celular mechanisms of memory encoding, consolidation, generalizaton, and updating in the brain

  2025cites this paper
• Early impairment in dentate pattern separation in a rodent model of temporal lobe epilepsy

  2025cites this paper
• Hippocampal subfields and psychotic symptoms: Functional connectivity insights from pediatric bipolar disorder.

  2025cites this paper
• DKK2 contributes to context discrimination and adult hippocampal neurogenesis by suppressing Wnt/PCP signaling.

  2025cites this paper
• Cognitive enrichment improves spatial memory and alters hippocampal synaptic connectivity in a mouse model for early-life stress

  2025cites this paper
• Ketamine administration during adolescence impairs synaptic integration and inhibitory synaptic transmission in the adult dentate gyrus.

  2025cites this paper
• The relevance of context in memory tasks influences the magnitude of hippocampal remapping

  2025cites this paper
• Dentate gyrus norepinephrine ramping facilitates aversive contextual processing

  2025cites this paper
• fMRI signals of pattern separation in the neocortex and hippocampus to non-meaningful objects and their spatial location

  2025cites this paper
• Neotenic expansion of adult-born dentate granule cells reconfigures GABAergic inhibition to enhance social memory consolidation

  2025cites this paper
• Sex-dependent Schizophrenia and Drug Reward Behavioral Phenotypes in Metabotropic Glutamate 5 Receptor Heterozygous and Homozygous Mice.

  2025cites this paper
• Exercise Benefits Dentate Gyrus Function: Bridging from Animal Models to Human High-Resolution Functional MRI of Pattern Separation.

  2025cites this paper
• Inhibiting aberrant seizure-induced neurogenesis by temozolomide improves cognitive impairments associated with long-term amygdala kindling

  2025cites this paper
• Dynamics of evoked responses in hippocampal pathways are encoded by the duration of vigilance states

  2025cites this paper
• Adult Neurogenesis, Context Encoding, and Pattern Separation: A Pathway for Treating Overgeneralization.

  2024cites this paper
• Dorsoventral Heterogeneity of Synaptic Connectivity in Hippocampal CA3 Pyramidal Neurons

  2024cites this paper
• Dominant activities of fear engram cells in the dorsal dentate gyrus underlie fear generalization in mice

  2024cites this paper
• Protocol for electrophysiological measurements of circadian changes in excitability in dentate granule cells from adult mice

  2024cites this paper
• Retrieval of contextual memory can be predicted by CA3 remapping and is differentially influenced by NMDAR activity in rat hippocampus subregions

  2024cites this paper
• The heterogeneous population of granule cells contributes to pattern separation of the dentate gyrus neural network

  2024cites this paper
• N-Methyl-D-Aspartate Receptor-Antibody Encephalitis Impairs Maintenance of Attention to Items in Working Memory

  2024cites this paper
• The mirage of big-data phrenology

  2024cites this paper
• Maladaptation of dentate gyrus mossy cells mediates contextual discrimination deficit after traumatic stress.

  2024cites this paper
• Histamine H1 receptors in dentate gyrus-projecting cholinergic neurons of the medial septum suppress contextual fear retrieval in mice

  2024cites this paper
• Ion-channel degeneracy and heterogeneities in the emergence of signature physiological characteristics of dentate gyrus granule cells

  2024cites this paper
• Differential effects of bilateral hippocampal CA3 damage on the implicit learning and recognition of complex event sequences

  2024cites this paper
• Treadmill Running Regulates Adult Neurogenesis, Spatial and Non-spatial Learning, Parvalbumin Neuron Activity by ErbB4 Signaling

  2024cites this paper
• Somatostatin and the pathophysiology of Alzheimer's disease.

  2024cites this paper
• Subfield-specific interneuron circuits govern the hippocampal response to novelty in male mice

  2024cites this paper
• Mechanisms and postulations of engram cells

  2024cites this paper
• Silencing dentate newborn neurons alters excitatory/inhibitory balance and impairs behavioral inhibition and flexibility

  2024cites this paper
• Retinoic acid modulation of granule cell activity and spatial discrimination in the adult hippocampus

  2024cites this paper
• Hippocampal Engrams and Contextual Memory.

  2024cites this paper
• Overlapping and distinct phenotypic profiles in Alzheimer’s disease and late onset epilepsy: a biologically-based approach

  2024cites this paper
• Neurotrophin-3 from the dentate gyrus supports postsynaptic sites of mossy fiber-CA3 synapses and hippocampus-dependent cognitive functions

  2024influential citation
• Cellular and circuit features distinguish dentate gyrus semilunar granule cells and granule cells activated during contextual memory formation

  2024cites this paper
• Behavioral Analysis of NMDAR Function in Rodents: Tests of Long-Term Spatial Memory.

  2024cites this paper
• Dentate Gyrus Norepinephrine Ramping Facilitates Aversive Contextual Processing

  2024influential citation
• Stochastic neuropeptide signals compete to calibrate the rate of satiation

  2024cites this paper
• The m5C reader protein Ybx1 promotes axon growth by regulating local translation in axons.

  2024cites this paper
• Schizophrenia pathology reverse-translated into mouse shows hippocampal hyperactivity, psychosis behaviors and hyper-synchronous events

  2024cites this paper
• Prefrontal multistimulus integration within a dedicated disambiguation circuit guides interleaving contingency judgment learning.

  2024cites this paper
• Ablation of PC1/3 in POMC-Expressing Tissues but Not in Immune Cells Induces Sepsis Hypersensitivity

  2024cites this paper
• Causally Probing the Role of the Hippocampus in Fear Discrimination: A Precision Functional Mapping-Guided, Transcranial Magnetic Stimulation Study in Participants With Posttraumatic Stress Symptoms.

  2024cites this paper
• Memory circuits in dementia: The engram, hippocampal neurogenesis and Alzheimer’s disease

  2024cites this paper
• Dopamine D2 receptors in mossy cells reduce excitatory transmission and are essential for hippocampal function

  2023cites this paper
• Infection-induced epilepsy is caused by increased expression of chondroitin sulfate proteoglycans in hippocampus and amygdala

  2023cites this paper
• Towards Preclinical Validation of Arbaclofen (R-baclofen) Treatment for 16p11.2 Deletion Syndrome

  2023cites this paper
• Hippocampal area CA2: interneuron disfunction during pathological states

  2023cites this paper
• Altered expression of synaptic proteins and adhesion molecules in the hippocampus and cortex following the onset of diabetes in nonobese diabetic mice

  2023cites this paper
• Synchronized LFP rhythmicity in the social brain reflects the context of social encounters

  2023cites this paper
• Behavioral, molecular and neuronal mechanisms involved in recognition memory retrieval under degraded spatial cues in the rat hippocampus

  2023cites this paper
• Partial EC outputs by degraded cues are amplified in hippocampal CA3 circuits for retrieving stored patterns

  2023cites this paper
• Hypothalamic Supramammillary Nucleus Selectively Excites Hippocampal CA3 Interneurons to Suppress CA3 Pyramidal Neuron Activity

  2023cites this paper
• Dissecting cell‐type‐specific pathways in medial entorhinal cortical‐hippocampal network for episodic memory

  2023cites this paper
• Dentate Neurogenesis Modulates Dorsal Hippocampal Excitation/Inhibition Balance Crucial for Cognitive Flexibility

  2023cites this paper
• Traumatic brain injury-induced fear generalization in mice involves hippocampal memory trace dysfunction and is alleviated by (R,S)-ketamine

  2023cites this paper
• Knockdown of adenosine A2A receptors in hippocampal neurons prevents post-TBI fear memory retrieval.

  2023cites this paper
• Dorsal raphe serotonergic neurons preferentially reactivate dorsal dentate gyrus cell ensembles associated with positive experience.

  2023cites this paper
• Genetic architecture of hippocampus subfields volumes in Alzheimer’s disease

  2023cites this paper
• The Pathological Effects of Circulating Hydrophobic Bile Acids in Alzheimer’s Disease

  2023cites this paper
• Early Deficits in Dentate Circuit and Behavioral Pattern Separation after Concussive Brain Injury

  2023cites this paper
• Mapping the spatial transcriptomic signature of the hippocampus during memory consolidation

  2023cites this paper
• High-Fat-Sugar Diet is Associated with Impaired Hippocampus-Dependent Memory in Humans.

  2023cites this paper
• Absence of VGLUT3 Expression Leads to Impaired Fear Memory in Mice

  2023cites this paper
• Robust and consistent measures of pattern separation based on information theory and demonstrated in the dentate gyrus

  2023cites this paper
• Synaptic plasticity at the dentate gyrus granule cell to somatostatin-expressing interneuron synapses supports object location memory

  2023cites this paper
• Dopamine D2 receptors in hilar mossy cells regulate excitatory transmission and hippocampal function

  2023cites this paper
• Senktide blocks aberrant RTN3 interactome to retard memory decline and tau pathology in social isolated Alzheimer’s disease mice

  2023cites this paper
• Hippocampal Engrams Generate Variable Behavioral Responses and Brain-Wide Network States

  2023cites this paper
• Behavioral status modulates CA2 influence on hippocampal network dynamics

  2023cites this paper