High antigen levels induce an exhausted phenotype in a chronic infection without impairing T cell expansion and survival

Using recombinant antigen variant-expressing chronic LCMV strains, Zehn and colleagues showed that amount rather than antigen strength is a key determinant of inducing a chronic infection phenotype in T cells.

• Publication year

  2016

• Venue

  Journal of Experimental Medicine

• Publication date

  2016-08-22

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1084/jem.20150598PMID 27455951PMCID 4995073
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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