A SEROLOGIC RECAPITULATION OF PAST EXPERIENCES WITH INFLUENZA A; ANTIBODY RESPONSE TO MONOVALENT VACCINE

The results of the present study provide a striking demonstration of antibody orientation produced by the dominant antigens of the strains of influenza virus encountered at childhood. The homologous and heterologous antibody response to monovalent vaccines containing swine, PR8, FM1, or Cuppett viruses show that the antibody-forming mechanisms of children born after 1943 are oriented to strains of influenza A-prime; of recruits to strains of influenza A; and of persons over 30 years of age to a strain of swine influenza. It was shown that antibody response to heterotypic viruses appears to provide a serologic index of the amount of experience each of the segments of the general population studied have had with antigenic variants of influenza virus. Finally it was demonstrated that the antibody response of humans to strains of influenza A or influenza A-prime is remarkably uniform for isolates of each antigenic type.

• Publication year

  1956

• Venue

  Journal of Experimental Medicine

• Publication date

  1956-07-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1084/JEM.104.1.85PMID 13332182PMCID 2136633
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• Antibody responses to influenza A and influenza A-prime isolates are remarkably uniform within each antigenic type.

  Confidence 0.93

  박진우 (dztg5apj7m) extraction뀨 (7c402c1b98) reviewB (s683577b42) reviewKiller Whale (322360f1c1) review
• Antibody responses to heterotypic viruses provide a serologic index of prior experience with antigenic variants of influenza virus in the studied population.

  Confidence 0.95

  박진우 (dztg5apj7m) extraction뀨 (7c402c1b98) reviewB (s683577b42) reviewKiller Whale (322360f1c1) review
• Monovalent vaccines containing swine, PR8, FM1, or Cuppett viruses elicited age-dependent antibody orientations: children born after 1943 toward influenza A-prime, recruits toward influenza A, and people over 30 years of age toward swine influenza.

  Confidence 0.98

  박진우 (dztg5apj7m) extraction뀨 (7c402c1b98) reviewB (s683577b42) reviewKiller Whale (322360f1c1) review

• antibody orientation

  immunological phenomenon

  The age-linked tendency of antibody-forming responses to favor particular influenza antigenic types.

  Aliases: orientation of antibody response

  박진우 (dztg5apj7m) extraction뀨 (7c402c1b98) reviewB (s683577b42) reviewKiller Whale (322360f1c1) review
• heterotypic viruses

  virus strains, test antigens

  Influenza virus strains that are antigenically different from the strain used for comparison or vaccination.

  Aliases: heterotypic virus

  박진우 (dztg5apj7m) extraction뀨 (7c402c1b98) reviewB (s683577b42) reviewKiller Whale (322360f1c1) review
• influenza a

  virus strain, antigenic type

  An influenza antigenic type distinguished in the cohort comparisons of antibody response.

  Aliases: A

  박진우 (dztg5apj7m) extraction뀨 (7c402c1b98) reviewB (s683577b42) reviewKiller Whale (322360f1c1) review
• influenza a-prime

  virus strain, antigenic type

  An influenza antigenic type distinguished in the cohort comparisons of antibody response.

  Aliases: A-prime

  박진우 (dztg5apj7m) extraction뀨 (7c402c1b98) reviewB (s683577b42) reviewKiller Whale (322360f1c1) review
• monovalent vaccine

  vaccine

  A vaccine formulation containing a single influenza virus strain and used here to test antibody response patterns.

  Aliases: monovalent vaccines

  박진우 (dztg5apj7m) extraction뀨 (7c402c1b98) reviewB (s683577b42) reviewKiller Whale (322360f1c1) review
• serologic index

  measurement concept

  A serologic measure used here as a proxy for prior experience with influenza antigenic variants.

  Aliases: serological index

  박진우 (dztg5apj7m) extraction뀨 (7c402c1b98) reviewB (s683577b42) reviewKiller Whale (322360f1c1) review
• swine influenza

  virus strain, antigenic type

  A swine-origin influenza antigenic type used in the vaccine comparisons.

  박진우 (dztg5apj7m) extraction뀨 (7c402c1b98) reviewB (s683577b42) reviewKiller Whale (322360f1c1) review
• uniform antibody response

  observation

  The consistency of antibody responses across isolates belonging to the same influenza antigenic type.

  Aliases: remarkably uniform

  박진우 (dztg5apj7m) extraction뀨 (7c402c1b98) reviewB (s683577b42) reviewKiller Whale (322360f1c1) review

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