LRP4 serves as a coreceptor of agrin.

No abstract is available for this paper.

• Publication year

  2008

• Venue

  Neuron

• Publication date

  2008-10-23

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.neuron.2008.10.006PMID 18957220PMCID PMC2743173
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Muscle-Specific Receptor Tyrosine Kinase Endocytosis in Acetylcholine Receptor Clustering in Response to Agrin

  2008cited by this paper
• Retrograde regulation of motoneuron differentiation by muscle β-catenin

  2008cited by this paper
• Further Observations in Congenital Myasthenic Syndromes

  2008cited by this paper
• β-catenin in reverse action

  2008cited by this paper
• MuSK controls where motor axons grow and form synapses

  2008cited by this paper
• The Ig1/2 Domain of MuSK Binds to Muscle Surface and Is Involved in Acetylcholine Receptor Clustering

  2008cited by this paper
• Caprin-2 enhances canonical Wnt signaling through regulating LRP5/6 phosphorylation

  2008cited by this paper
• A role for LRP4 in neuronal cell viability is related to apoE-binding.

  2007cited by this paper
• The Frizzled family of unconventional G-protein-coupled receptors.

  2007cited by this paper
• Wnt signaling positions neuromuscular connectivity by inhibiting synapse formation in C. elegans.

  2007cited by this paper
• β-Catenin Regulates Acetylcholine Receptor Clustering in Muscle Cells through Interaction with Rapsyn

  2007cited by this paper
• LDL-receptor-related protein 4 is crucial for formation of the neuromuscular junction

  2006cited by this paper
• The Muscle Protein Dok-7 Is Essential for Neuromuscular Synaptogenesis

  2006cited by this paper
• Mutations in the gene encoding the low-density lipoprotein receptor LRP4 cause abnormal limb development in the mouse.

  2006cited by this paper
• Synapse disassembly and formation of new synapses in postnatal muscle upon conditional inactivation of MuSK.

  2006cited by this paper
• Casein kinase 2-dependent serine phosphorylation of MuSK regulates acetylcholine receptor aggregation at the neuromuscular junction.

  2006cited by this paper
• Dishevelled: a mobile scaffold catalyzing development.

  2006cited by this paper
• Interaction of LDL receptor‐related protein 4 (LRP4) with postsynaptic scaffold proteins via its C‐terminal PDZ domain‐binding motif, and its regulation by Ca2+/calmodulin‐dependent protein kinase II

  2006cited by this paper
• Wnt/beta-catenin signaling in development and disease.

  2006cited by this paper
• Expression of low density lipoprotein receptor-related protein 4 (Lrp4) gene in the mouse germ cells.

  2006cited by this paper
• Wnt signaling: complexity at the surface

  2006cited by this paper
• The synaptic muscle‐specific kinase (MuSK) complex: New partners, new functions

  2005cited by this paper
• Abnormal development of the apical ectodermal ridge and polysyndactyly in Megf7-deficient mice.

  2005cited by this paper
• Neuromuscular junction autoimmune disease: muscle specific kinase antibodies and treatments for myasthenia gravis

  2005cited by this paper
• Wingless Signaling at Synapses Is Through Cleavage and Nuclear Import of Receptor DFrizzled2

  2005cited by this paper
• Signalling in neural development: WNTS in the vertebrate nervous system: from patterning to neuronal connectivity

  2005cited by this paper
• LDL receptor-related proteins 5 and 6 in Wnt/β-catenin signaling: Arrows point the way

  2004cited by this paper
• Regulation of acetylcholine receptor clustering by the tumor suppressor APC

  2003cited by this paper
• Aberrant Patterning of Neuromuscular Synapses in Choline Acetyltransferase-Deficient Mice

  2003cited by this paper
• Implication of geranylgeranyltransferase I in synapse formation.

  2003cited by this paper
• Postsynaptic requirement for Abl kinases in assembly of the neuromuscular junction

  2003cited by this paper
• Cooperative Regulation by Rac and Rho of Agrin-induced Acetylcholine Receptor Clustering in Muscle Cells*

  2003cited by this paper
• The Drosophila Wnt, wingless, provides an essential signal for pre- and postsynaptic differentiation.

  2002cited by this paper
• Lipoprotein receptors in the nervous system.

  2002cited by this paper
• Agrin regulates neuronal responses to excitatory neurotransmitters in vitro and in vivo.

  2002cited by this paper
• Regulation of AChR clustering by Dishevelled interacting with MuSK and PAK1.

  2002cited by this paper
• Induction, assembly, maturation and maintenance of a postsynaptic apparatus

  2001cited by this paper
• Patterning of muscle acetylcholine receptor gene expression in the absence of motor innervation.

  2001cited by this paper
• Novel mechanism of Wnt signalling inhibition mediated by Dickkopf-1 interaction with LRP6/Arrow

  2001cited by this paper
• Agrin-induced Activation of Acetylcholine Receptor-bound Src Family Kinases Requires Rapsyn and Correlates with Acetylcholine Receptor Clustering*

  2001cited by this paper
• Effects of Purified Recombinant Neural and Muscle Agrin on Skeletal Muscle Fibers in Vivo

  2001cited by this paper
• LDL-receptor-related protein 6 is a receptor for Dickkopf proteins

  2001cited by this paper
• Src-Class Kinases Act within the Agrin/MuSK Pathway to Regulate Acetylcholine Receptor Phosphorylation, Cytoskeletal Anchoring, and Clustering

  2001cited by this paper
• Head inducer Dickkopf-1 is a ligand for Wnt coreceptor LRP6.

  2001cited by this paper
• Distinct roles of nerve and muscle in postsynaptic differentiation of the neuromuscular synapse

  2001cited by this paper
• Dissection of receptor folding and ligand-binding property with functional minireceptors of LDL receptor-related protein.

  2001cited by this paper
• An adaptive coding model of neural function in prefrontal cortex

  2001cited by this paper
• Axonal remodeling and synaptic differentiation in the cerebellum is regulated by WNT-7a signaling.

  2000cited by this paper
• LDL-receptor-related proteins in Wnt signal transduction

  2000cited by this paper
• The juxtamembrane region of MuSK has a critical role in agrin‐mediated signaling

  2000cited by this paper
• Agrin-Induced Acetylcholine Receptor Clustering Is Mediated by the Small Guanosine Triphosphatases Rac and Cdc42

  2000cited by this paper
• Agrin Controls Synaptic Differentiation in Hippocampal Neurons

  2000cited by this paper
• Cloning and characterization of muscle-specific kinase in chicken.

  2000cited by this paper
• Alkaline phosphatase fusion proteins for molecular characterization and cloning of receptors and their ligands.

  2000cited by this paper
• Distinct Domains of Musk Mediate Its Abilities to Induce and to Associate with Postsynaptic Specializations

  1999cited by this paper
• Abnormal synapse formation in agrin-depleted hippocampal neurons.

  1999cited by this paper
• Development of the vertebrate neuromuscular junction.

  1999cited by this paper
• Identification of high-molecular-weight proteins with multiple EGF-like motifs by motif-trap screening.

  1998cited by this paper
• Kinase domain of the muscle-specific receptor tyrosine kinase (MuSK) is sufficient for phosphorylation but not clustering of acetylcholine receptors: required role for the MuSK ectodomain?

  1997cited by this paper
• Induction by agrin of ectopic and functional postsynaptic-like membrane in innervated muscle.

  1997cited by this paper
• Association of muscle‐specific kinase MuSK with the acetylcholine receptor in mammalian muscle

  1997cited by this paper
• Expression of agrin in the developing and adult rat brain.

  1997cited by this paper
• Alternative RNA splicing that determines agrin activity regulates binding to heparin and alpha-dystroglycan.

  1996cited by this paper
• Agrin binding to alpha-dystroglycan. Domains of agrin necessary to induce acetylcholine receptor clustering are overlapping but not identical to the alpha-dystroglycan-binding region.

  1996cited by this paper
• Induction of Acetylcholine Receptor Gene Expression by ARIA Requires Activation of Mitogen-activated Protein Kinase*

  1996cited by this paper
• Agrin acts via a MuSK receptor complex.

  1996cited by this paper
• Defective neuromuscular synaptogenesis in agrin-deficient mutant mice.

  1996cited by this paper
• Alternative splicing of agrin alters its binding to heparin, dystroglycan, and the putative agrin receptor.

  1996cited by this paper
• Agrin is synthesized by retinal cells and colocalizes with gephyrin [corrected].

  1996cited by this paper
• The receptor tyrosine kinase MuSK is required for neuromuscular junction formation in vivo.

  1996cited by this paper
• The receptor tyrosine kinase MuSK is required for neuromuscular junction formation and is a functional receptor for agrin.

  1996cited by this paper
• Agrin-induced acetylcholine receptor clustering in mammalian muscle requires tyrosine phosphorylation

  1996cited by this paper
• Acetylcholine receptor-aggregating activity of agrin isoforms and mapping of the active site

  1995cited by this paper
• Receptor tyrosine kinase specific for the skeletal muscle lineage: expression in embryonic muscle, at the neuromuscular junction, and after injury.

  1995cited by this paper
• Dystroglycan-α, a dystrophin-associated glycoprotein, is a functional agrin receptor

  1994cited by this paper
• Dystroglycan binds nerve and muscle agrin.

  1994cited by this paper
• Localization and alternative splicing of agrin mRNA in adult rat brain: transcripts encoding isoforms that aggregate acetylcholine receptors are not restricted to cholinergic regions

  1994cited by this paper
• A role for dystrophin-associated glycoproteins and utrophin in agrin-induced AChR clustering.

  1994cited by this paper
• Identification and purification of an agrin receptor from Torpedo postsynaptic membranes: a heteromeric complex related to the dystroglycans.

  1994cited by this paper
• Comparison of innervation and agrin-induced tyrosine phosphorylation of the nicotinic acetylcholine receptor

  1994cited by this paper
• Dystroglycan-alpha, a dystrophin-associated glycoprotein, is a functional agrin receptor.

  1994cited by this paper
• The ability of agrin to cluster AChRs depends on alternative splicing and on cell surface proteoglycans.

  1993cited by this paper
• Muscle-specific trk-related receptor with a kringle domain defines a distinct class of receptor tyrosine kinases.

  1993cited by this paper
• Agrin released by motor neurons induces the aggregation of acetylcholine receptors at neuromuscular junctions.

  1992cited by this paper
• Mechanism of agrin-induced acetylcholine receptor aggregation.

  1992cited by this paper
• The mechanism of agrin-induced acetylcholine receptor aggregation.

  1991cited by this paper
• The agrin hypothesis.

  1990cited by this paper
• a 3Na + /K + -ATPase Is a Neuronal Receptor for Agrin

  year unknowncited by this paper

• Therapeutic horizons of MuSK in amyotrophic lateral sclerosis: a comprehensive narrative review

  2026cites this paper
• Low Prevalence and Inconsistency of LRP4-IgG Detection in Suspected Myasthenia Gravis: A Multicenter CBA Comparison.

  2026cites this paper
• Neddylation E1 Obligatory Subunit Nae1 Is Critical to Neuromuscular Junction Development and Maintenance

  2025cites this paper
• Muscle-specific tyrosine kinase activation by a peptide-based dimerizer is orientation dependent.

  2025cites this paper
• Bltp1 Is Required for Survival and Normal Development and Function of the Neuromuscular Junction in Mice

  2025cites this paper
• Muscle-specific kinase levels in blood are an early diagnostic biomarker for SOD1-93A mouse model of ALS

  2025cites this paper
• Viral agents in neuromuscular pathology.

  2025cites this paper
• KIAA1429-mediated M6A methylation inhibits osteoclast differentiation via stabilizing Lrp4 mRNA and protects against osteoporosis

  2025cites this paper
• Single-nuclei sequencing of skeletal muscle reveals subsynaptic-specific transcripts involved in neuromuscular junction maintenance

  2025cites this paper
• Muscle-Derived BMP4 Regulates Morphology and Function of Endplates on Extrafusal and Intrafusal Muscle Fibers in Adult Mice

  2025cites this paper
• Five key challenges for the plasma membrane insertion of nicotinic acetylcholine receptors in cellular model systems.

  2025cites this paper
• LRP4+ Astrocytes: A Unique Subpopulation Crucial for Blood Vessel Maintenance and Function in the Somatosensory Cortex of Normal and 5xFAD Mice

  2025influential citation
• Axonal defasciculation is restricted to specific branching points during regeneration of the lateral line nerve in zebrafish

  2025cites this paper
• Axonal defasciculation is restricted to specific branching points during regeneration of the lateral line nerve in zebrafish

  2025cites this paper
• An Agrin–YAP/TAZ Rigidity Sensing Module Drives EGFR‐Addicted Lung Tumorigenesis

  2025cites this paper
• Agrin/Dok‐7‐induced JPH2 phosphorylation in muscle cells is involved in AChR clustering

  2025cites this paper
• Role of Nuclear Envelope Proteins in the Structure and Function of the Neuromuscular Junction: Focus on Subsynaptic Nuclei.

  2025cites this paper
• Biomarkers in autoimmune myasthenia gravis: A narrative review

  2025cites this paper
• Neuron-specific Agrin splicing by Nova RNA-binding proteins regulates conserved neuromuscular junction development in chordates

  2025cites this paper
• Cell models for studying myasthenia gravis.

  2025cites this paper
• The protective role of Agrin and CAF22 in hypertensive nephropathy.

  2025cites this paper
• MuSK cysteine-rich domain antibodies are pathogenic in a mouse model of autoimmune myasthenia gravis

  2025cites this paper
• The Cell Polarity Protein Scribble Is Involved in Maintaining the Structure of Neuromuscular Junctions, the Expression of Myosin Heavy Chain Genes, and Endocytic Recycling in Adult Skeletal Muscle Fibers

  2025cites this paper
• Intracellular protein-lipid interactions drive presynaptic assembly prior to neurexin recruitment.

  2025cites this paper
• Trophic Factors in Muscle‐Nerve Cross‐Talk Signaling Augment Muscle Fiber and Motor Endplate Development

  2025cites this paper
• Defining the Critical Role of LRP4 in Neuromuscular Junctions and Bone Signaling

  2025cites this paper
• Calcium-binding protein 7 expressed in muscle negatively regulates age-related degeneration of neuromuscular junctions in mice

  2024cites this paper
• Neuronal LRP4 directs the development, maturation and cytoskeletal organization of Drosophila peripheral synapses

  2024cites this paper
• G9a promotes muscular atrophy in chronic aging and acute denervation

  2024cites this paper
• ARGX-119 is an agonist antibody for human MuSK that reverses disease relapse in a mouse model of congenital myasthenic syndrome

  2024cites this paper
• Agrin-Lrp4 pathway in hippocampal astrocytes restrains development of temporal lobe epilepsy through adenosine signaling

  2024cites this paper
• A conserved RNA switch for acetylcholine receptor clustering at neuromuscular junctions in chordates

  2024cites this paper
• Cortactin interacts with αDystrobrevin-1 and regulates murine neuromuscular junction morphology.

  2024cites this paper
• Elevated serum levels of C-terminal agrin fragment in acetylcholine receptor antibody-positive myasthenia gravis.

  2024cites this paper
• The MuSK agonist antibody protects the neuromuscular junction and extends the lifespan in C9orf72-ALS mice.

  2024cites this paper
• Acute high‐intensity muscle contraction moderates AChR gene expression independent of rapamycin‐sensitive mTORC1 pathway in rat skeletal muscle

  2024cites this paper
• A class of chemical compounds enhances clustering of muscle nicotinic acetylcholine receptor in cultured myogenic cells.

  2024cites this paper
• Calcitriol ameliorates motor deficits and prolongs survival of Chrne-deficient mouse, a model for congenital myasthenic syndrome, by inducing Rspo2

  2024cites this paper
• Regulation of MiR-206 in denervated and dystrophic muscles and its effect on AChR clustering.

  2024cites this paper
• MuSK Myasthenia Gravis—Potential Pathomechanisms and Treatment Directed against Specific Targets

  2024influential citation
• Deficiency of skeletal muscle Agrin contributes to the pathogenesis of age-related sarcopenia in mice

  2024cites this paper
• A new era in neuromuscular junction research: current advances in self-organized and assembled in vitro models.

  2024cites this paper
• Myosin Va: Capturing cAMP for synaptic plasticity

  2024cites this paper
• Building, Breaking, and Repairing Neuromuscular Synapses.

  2024cites this paper
• YAP/TAZ Drive Agrin-Matrix Metalloproteinase-12 Mediated Diabetic Skin Wound Healing.

  2024cites this paper
• Agonist antibody to MuSK protects mice from MuSK myasthenia gravis

  2024cites this paper
• The collagen ColQ binds to LRP4 and regulates the activation of the Muscle-Specific Kinase–LRP4 receptor complex by agrin at the neuromuscular junction

  2023influential citation
• Structural insights into the assembly of the agrin/LRP4/MuSK signaling complex

  2023cites this paper
• Clinical and Pathologic Features of Congenital Myasthenic Syndromes Caused by 35 Genes—A Comprehensive Review

  2023cites this paper
• C9orf72 poly-GA proteins impair neuromuscular transmission

  2023cites this paper
• Ligand-Dependent Intramolecular Motion of Native Nicotinic Acetylcholine Receptors Determined in Living Myotube Cells via Diffracted X-ray Tracking

  2023cites this paper
• Balancing WNT signalling in early forebrain development: The role of LRP4 as a modulator of LRP6 function

  2023cites this paper
• Intrafusal-fiber LRP4 for muscle spindle formation and maintenance in adult and aged animals

  2023cites this paper
• Identification and validation of plasma AGRN as a novel diagnostic biomarker of hepatitis B Virus-related chronic hepatitis and liver fibrosis/cirrhosis.

  2023cites this paper
• Neuronal LRP4 directs the development, maturation, and cytoskeletal organization of peripheral synapses

  2023cites this paper
• From phosphorylation to phenotype - Recent key findings on kinase regulation, downstream signaling and disease surrounding the receptor tyrosine kinase MuSK.

  2023cites this paper
• Effects of sclerostin injection on soleus and extensor digitorum longus muscle tissue in male mice.

  2023cites this paper
• LRP4-related signalling pathways and their regulatory role in neurological diseases.

  2023cites this paper
• Remodeling of neuromuscular junctions in target muscle following nerve regeneration in mice after delayed peripheral nerve repair.

  2023cites this paper
• Agrin is a novel oncogenic protein in thyroid cancer

  2023cites this paper
• LRP4 site-specific variants in the third β-propeller domain causes congenital myasthenic syndrome type 17.

  2023cites this paper
• Targeting Crosstalk of Signaling Pathways among Muscles-Bone-Adipose Tissue: A Promising Therapeutic Approach for Sarcopenia

  2023cites this paper
• NMJ-related diseases beyond the congenital myasthenic syndromes

  2023cites this paper
• Precision targeting of autoantigen-specific B cells in muscle-specific tyrosine kinase myasthenia gravis with chimeric autoantibody receptor T cells

  2023cites this paper
• IgG1-3 MuSK Antibodies Inhibit AChR Cluster Formation, Restored by SHP2 Inhibitor, Despite Normal MuSK, DOK7, or AChR Subunit Phosphorylation

  2023cites this paper
• Targeting neuromuscular junction to treat neuromuscular disorders.

  2023cites this paper
• Competitive blocking of LRP4–sclerostin binding interface strongly promotes bone anabolic functions

  2022cites this paper
• Endothelial Agrin Is Dispensable for Normal and Tumor Angiogenesis

  2022cites this paper
• Phosphoproteome Profiling of the Receptor Tyrosine Kinase MuSK Identifies Tyrosine Phosphorylation of Rab GTPases

  2022influential citation
• Internalization of Muscle-Specific Kinase Is Increased by Agrin and Independent of Kinase-Activity, Lrp4 and Dynamin

  2022cites this paper
• In Adult Skeletal Muscles, the Co-Receptors of Canonical Wnt Signaling, Lrp5 and Lrp6, Determine the Distribution and Size of Fiber Types, and Structure and Function of Neuromuscular Junctions

  2022cites this paper
• Ultrasound Stimulation Inhibits Morphological Degeneration of Motor Endplates in the Denervated Skeletal Muscle of Rats

  2022cites this paper
• DOK7 Promotes NMJ Regeneration After Nerve Injury

  2022cites this paper
• Proteolytic ectodomain shedding of muscle-specific tyrosine kinase in myasthenia gravis.

  2022cites this paper
• Protein Tyrosine Phosphatase Receptor Type R (PTPRR) Reduces AChR Clustering by Dephosphorylating MuSK

  2022cites this paper
• C9orf72 functions in the nucleus to regulate DNA damage repair

  2022cites this paper
• Severe congenital myasthenic syndromes caused by agrin mutations affecting secretion by motoneurons

  2022cites this paper
• Low-Density Lipoprotein Receptor-Related Protein 8 at the Crossroad between Cancer and Neurodegeneration

  2022cites this paper
• Neuronal Agrin Promotes Proliferation of Primary Human Myoblasts in an Age-Dependent Manner

  2022cites this paper
• Cryo-electron Microscopic Analysis of Single-Pass Transmembrane Receptors.

  2022cites this paper
• Inhibiting Matrix Metalloproteinases Protects Evoked Electromyography Amplitudes and Muscle Tension in the Orbicularis Oris Muscle in a Rat Model of Facial Nerve Injury

  2022cites this paper
• Post-synaptic specialization of the neuromuscular junction: junctional folds formation, function, and disorders

  2022cites this paper
• The cell polarity protein Vangl2 in the muscle shapes the neuromuscular synapse by binding to and regulating the tyrosine kinase MuSK

  2022influential citation
• LRP4 is required for the olfactory association task in the piriform cortex

  2022cites this paper
• Genetic regulation of central synapse formation and organization in Drosophila melanogaster.

  2022cites this paper
• Treatment of acquired autoimmune myasthenia gravis: Where are we today?

  2022cites this paper
• Local BMP signaling: A sensor for synaptic activity that balances synapse growth and function.

  2022cites this paper
• Impaired signaling for neuromuscular synaptic maintenance is a feature of Motor Neuron Disease

  2022influential citation
• Cytoplasmic pool of U1 spliceosome protein SNRNP70 shapes the axonal transcriptome and regulates motor connectivity.

  2022cites this paper
• Constructing and Tuning Excitatory Cholinergic Synapses: The Multifaceted Functions of Nicotinic Acetylcholine Receptors in Drosophila Neural Development and Physiology

  2021cites this paper
• Activation of Muscle-Specific Kinase (MuSK) Reduces Neuromuscular Defects in the Delta7 Mouse Model of Spinal Muscular Atrophy (SMA)

  2021cites this paper
• Resurgence of phosphotyrosine binding domains: Structural and functional properties essential for understanding disease pathogenesis.

  2021cites this paper
• LRPs in WNT Signalling.

  2021cites this paper
• Agrin/Lrp4 signal constrains MuSK-dependent neuromuscular synapse development in appendicular muscle.

  2021cites this paper
• Mechanism of disease and therapeutic rescue of Dok7 congenital myasthenia

  2021cites this paper
• Synapse-specific Lrp4 mRNA enrichment requires Lrp4/MuSK signaling, muscle activity and Wnt non-canonical pathway

  2021influential citation
• Characterization of LRP4/Agrin Antibodies From a Patient With Myasthenia Gravis

  2021cites this paper
• LRP4 mediated synaptic plasticity in the piriform cortex

  2021cites this paper
• Creating stem cell‐derived neuromuscular junctions in vitro

  2021cites this paper
• An Inside Job: Molecular Determinants for Postsynaptic Localization of Nicotinic Acetylcholine Receptors

  2021cites this paper